JPS57123183A - Pyrroloimidazole derivative and its preparation - Google Patents

Pyrroloimidazole derivative and its preparation

Info

Publication number
JPS57123183A
JPS57123183A JP948481A JP948481A JPS57123183A JP S57123183 A JPS57123183 A JP S57123183A JP 948481 A JP948481 A JP 948481A JP 948481 A JP948481 A JP 948481A JP S57123183 A JPS57123183 A JP S57123183A
Authority
JP
Japan
Prior art keywords
compound
formula
formulai
lower alkyl
basic catalyst
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP948481A
Other languages
Japanese (ja)
Inventor
Tetsuji Tawara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Priority to JP948481A priority Critical patent/JPS57123183A/en
Publication of JPS57123183A publication Critical patent/JPS57123183A/en
Pending legal-status Critical Current

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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formulaI(R is H or lower alkyl; R1 and R2 are H, lower alkyl, halogen, etc.;Ar is phenyl or pyridyl which may have a substituent group).
EXAMPLE: 7-(o-Chlorobenzoyl)-5-ethyl-1H-pyrrolo [1,2-a] imidazole-2(3H)-one.
USE: An anti-inflammatory and analgesic agent, antithrombotic agent and an intermediate therefor having anti-inflammatory analgesic and inhibitory action on blood platelet aggregation.
PROCESS: A compound of formula IIis subjected to the desulfurizing ring closing reaction in the presence of a basic catalyst to give the compound of formulaI. The reaction is carried out in an inert solvent, e.g. pyridine, picoline or benzene, in the presence of a strongly basic catalyst, e.g. Li, Na, K, sodium hydride or lithium hydride, in a molar amount of 0.1W3 times that of the compound of formula II under heating. The compound of formula III which is a by-product will not be formed at all.
COPYRIGHT: (C)1982,JPO&Japio
JP948481A 1981-01-24 1981-01-24 Pyrroloimidazole derivative and its preparation Pending JPS57123183A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP948481A JPS57123183A (en) 1981-01-24 1981-01-24 Pyrroloimidazole derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP948481A JPS57123183A (en) 1981-01-24 1981-01-24 Pyrroloimidazole derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS57123183A true JPS57123183A (en) 1982-07-31

Family

ID=11721509

Family Applications (1)

Application Number Title Priority Date Filing Date
JP948481A Pending JPS57123183A (en) 1981-01-24 1981-01-24 Pyrroloimidazole derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS57123183A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5059237A (en) * 1985-08-13 1991-10-22 Sumitomo Chemical Company, Limited Butenoic acid derivatives and use as herbicides
WO2003024967A3 (en) * 2001-09-19 2003-09-04 Aventis Pharma Sa Indolizines as kinase protein inhibitors

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5059237A (en) * 1985-08-13 1991-10-22 Sumitomo Chemical Company, Limited Butenoic acid derivatives and use as herbicides
WO2003024967A3 (en) * 2001-09-19 2003-09-04 Aventis Pharma Sa Indolizines as kinase protein inhibitors
US7148215B2 (en) 2001-09-19 2006-12-12 Aventis Pharma S.A. Chemical compounds
EA007983B1 (en) * 2001-09-19 2007-02-27 Авентис Фарма С.А. Indolizines as kinase protein inhibitors
CN100391958C (en) * 2001-09-19 2008-06-04 安万特医药股份有限公司 Chemical compounds

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