JPS57122062A - Novel trans-4-guanidinocyclohexanecarboxylic acid derivative and its preparation - Google Patents

Novel trans-4-guanidinocyclohexanecarboxylic acid derivative and its preparation

Info

Publication number
JPS57122062A
JPS57122062A JP728581A JP728581A JPS57122062A JP S57122062 A JPS57122062 A JP S57122062A JP 728581 A JP728581 A JP 728581A JP 728581 A JP728581 A JP 728581A JP S57122062 A JPS57122062 A JP S57122062A
Authority
JP
Japan
Prior art keywords
compound
trans
preparation
acid derivative
guanidinocyclohexanecarboxylic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP728581A
Other languages
Japanese (ja)
Other versions
JPS642104B2 (en
Inventor
Mutsumi Muramatsu
Toshio Sato
Hiroyasu Sekine
Atsushi Tendou
Yoshio Kikawa
Kaname Kindo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Priority to JP728581A priority Critical patent/JPS57122062A/en
Publication of JPS57122062A publication Critical patent/JPS57122062A/en
Publication of JPS642104B2 publication Critical patent/JPS642104B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:The compound of formulaI[R is H or (substituted) phenyl] and its acid addition salt.
EXAMPLE: trans-4-Guanidinocyclohexanecarboxylic acid 4'-methylphenyl ester hydrochloride.
USE: Pharmaceuticals having protease-inhibiting activity. It exhibits excellent inhibiting activity esp. to proteases such as trypsin, chymotrypsin, kallikrein, urokinase, etc.
PROCESS: The compound of formulaIis prepared by stirring trans-4-aminocyclohexanecarboxylic acid and the compound of formula II (R' is alkoxy or alkylthio) or its salt under ice cooling or at room temp. for 5W several tens hours.
COPYRIGHT: (C)1982,JPO&Japio
JP728581A 1981-01-22 1981-01-22 Novel trans-4-guanidinocyclohexanecarboxylic acid derivative and its preparation Granted JPS57122062A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP728581A JPS57122062A (en) 1981-01-22 1981-01-22 Novel trans-4-guanidinocyclohexanecarboxylic acid derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP728581A JPS57122062A (en) 1981-01-22 1981-01-22 Novel trans-4-guanidinocyclohexanecarboxylic acid derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS57122062A true JPS57122062A (en) 1982-07-29
JPS642104B2 JPS642104B2 (en) 1989-01-13

Family

ID=11661757

Family Applications (1)

Application Number Title Priority Date Filing Date
JP728581A Granted JPS57122062A (en) 1981-01-22 1981-01-22 Novel trans-4-guanidinocyclohexanecarboxylic acid derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS57122062A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0775692A1 (en) * 1994-08-30 1997-05-28 Teikoku Chemical Industry Co., Ltd. Guanidinomethyl cyclohexane carboxylic ester derivative
US6444703B1 (en) 1995-12-22 2002-09-03 Teikoku Chemical Industries Co., Ltd. Cyclohexane carbocyclic ester derivative and cyclodextrin complex and composition for treatment of helicobacter pylori infections
WO2003078381A1 (en) * 2002-03-18 2003-09-25 Tanabe Seiyaku Co., Ltd. PROCESS FOR PREPARATION OF trans-4-AMINOCYCLOHEXANE- CARBOXYLIC ACIDS
WO2005000839A1 (en) * 2003-06-30 2005-01-06 Tanabe Seiyaku Co., Ltd. Process for producing 3-acylaminobenzofuran-2-carboxylic acid derivative
JP2005247824A (en) * 2003-06-30 2005-09-15 Tanabe Seiyaku Co Ltd Method for producing 3-acylaminobenzofuran-2-carboxylic acid derivative

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0775692A1 (en) * 1994-08-30 1997-05-28 Teikoku Chemical Industry Co., Ltd. Guanidinomethyl cyclohexane carboxylic ester derivative
EP0775692B1 (en) * 1994-08-30 2000-12-06 Teikoku Chemical Industry Co., Ltd. Guanidinomethyl cyclohexane carboxylic ester derivative
US6284791B1 (en) 1994-08-30 2001-09-04 Teikoku Chemical Industries Co., Ltd. Guanidinomethyl cyclohexane carboxylic acid ester derivatives
US6831190B1 (en) 1994-08-30 2004-12-14 Teikoku Chemical Industries Co., Ltd. Guanidinomethyl cyclohexane carboxylic acid ester derivatives
US6444703B1 (en) 1995-12-22 2002-09-03 Teikoku Chemical Industries Co., Ltd. Cyclohexane carbocyclic ester derivative and cyclodextrin complex and composition for treatment of helicobacter pylori infections
WO2003078381A1 (en) * 2002-03-18 2003-09-25 Tanabe Seiyaku Co., Ltd. PROCESS FOR PREPARATION OF trans-4-AMINOCYCLOHEXANE- CARBOXYLIC ACIDS
WO2005000839A1 (en) * 2003-06-30 2005-01-06 Tanabe Seiyaku Co., Ltd. Process for producing 3-acylaminobenzofuran-2-carboxylic acid derivative
JP2005247824A (en) * 2003-06-30 2005-09-15 Tanabe Seiyaku Co Ltd Method for producing 3-acylaminobenzofuran-2-carboxylic acid derivative
AU2004252025B2 (en) * 2003-06-30 2007-08-30 Mitsubishi Tanabe Pharma Corporation Process for producing 3-acylaminobenzofuran-2-carboxylic acid derivative
KR100833837B1 (en) * 2003-06-30 2008-06-02 다나베 미츠비시 세이야꾸 가부시키가이샤 Process for preparing 3-acylaminobenzofuran-2-carboxylic acid derivative
US7439368B2 (en) 2003-06-30 2008-10-21 Mitsubishi Tanabe Pharma Corporation Process for producing 3-acylaminobenzofuran-2-carboxylic acid derivative

Also Published As

Publication number Publication date
JPS642104B2 (en) 1989-01-13

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