JPS57118570A - Novel 3-phenyl-4-quinazolone derivative - Google Patents
Novel 3-phenyl-4-quinazolone derivativeInfo
- Publication number
- JPS57118570A JPS57118570A JP390481A JP390481A JPS57118570A JP S57118570 A JPS57118570 A JP S57118570A JP 390481 A JP390481 A JP 390481A JP 390481 A JP390481 A JP 390481A JP S57118570 A JPS57118570 A JP S57118570A
- Authority
- JP
- Japan
- Prior art keywords
- positions
- formula
- alkyl
- quinazolone
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 4-quinazolone derivative shown by the formulaI(R1 and R3 are lower alkyl; R2 is alkoxycarbonyl, R1WR3 are linked in this order to 5 and 6 positions, 6 and 7 positions, or 7 and 8 positions, respectively; R4 is H, halogen, alkyl, CF3, or NO2; R5 and R6 are H or alkyl; with the proviso that when R1WR3 are linked to 6, 7, and 8 positions, and R4 and R5 are H, R6 is not alkyl).
EXAMPLE: 3-( o-Chlorophenyl )-6-ethoxycarbonyl-5, 7-dimethyl-2-( N-methylcarbamoyloxymethyl)-4(3H)-quinazolone.
USE: A vasoldilator, blood stream improver, hypotensor, or arteriosclerosis alleviating agent.
PROCESS: For example, a 2-hydroxymethyl-4-quinazolone derivative shown by the formula II is reacted with an isocyanate shown by the formula II is reacted with an isocyanate shown by the formula R5NCO (when R6 in the formulaIis H) or a carbamine derivative shown by the formula III, to give a compound shown by the formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP390481A JPS57118570A (en) | 1981-01-16 | 1981-01-16 | Novel 3-phenyl-4-quinazolone derivative |
AU79172/82A AU543928B2 (en) | 1981-01-16 | 1982-01-04 | 4(311)-quinazolinone derivatives |
US06/337,454 US4451467A (en) | 1981-01-16 | 1982-01-06 | 4(3H)-Quinazolinone derivatives, process for production thereof, and pharmaceutical compositions comprising said compounds |
EP82100273A EP0056637B1 (en) | 1981-01-16 | 1982-01-15 | 4(3h)-quinazolinone derivatives, process for production thereof and pharmaceutical compositions comprising said compounds |
CA000394290A CA1167442A (en) | 1981-01-16 | 1982-01-15 | 4(3h)-quinazolinone derivatives, process for production thereof, and pharmaceutical compositions comprising said compounds |
DE8282100273T DE3264802D1 (en) | 1981-01-16 | 1982-01-15 | 4(3h)-quinazolinone derivatives, process for production thereof and pharmaceutical compositions comprising said compounds |
ES508765A ES8304097A1 (en) | 1981-01-16 | 1982-01-15 | 4(3H)-quinazolinone derivatives, process for production thereof and pharmaceutical compositions comprising said compounds. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP390481A JPS57118570A (en) | 1981-01-16 | 1981-01-16 | Novel 3-phenyl-4-quinazolone derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57118570A true JPS57118570A (en) | 1982-07-23 |
Family
ID=11570174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP390481A Pending JPS57118570A (en) | 1981-01-16 | 1981-01-16 | Novel 3-phenyl-4-quinazolone derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57118570A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008156358A (en) * | 2004-02-13 | 2008-07-10 | Banyu Pharmaceut Co Ltd | Fused ring 4-oxopyrimidine derivative |
JP2009149658A (en) * | 2002-02-06 | 2009-07-09 | Novartis Ag | Quinazolinone derivatives and their use as cb agonists |
JP4994552B2 (en) * | 1999-09-16 | 2012-08-08 | キュリス,インコーポレイテッド | Hedgehog signaling pathway mediators, compositions and related uses |
-
1981
- 1981-01-16 JP JP390481A patent/JPS57118570A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4994552B2 (en) * | 1999-09-16 | 2012-08-08 | キュリス,インコーポレイテッド | Hedgehog signaling pathway mediators, compositions and related uses |
JP2009149658A (en) * | 2002-02-06 | 2009-07-09 | Novartis Ag | Quinazolinone derivatives and their use as cb agonists |
JP2008156358A (en) * | 2004-02-13 | 2008-07-10 | Banyu Pharmaceut Co Ltd | Fused ring 4-oxopyrimidine derivative |
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