JPS567785A - Preparation of theobromine derivative - Google Patents
Preparation of theobromine derivativeInfo
- Publication number
- JPS567785A JPS567785A JP8381779A JP8381779A JPS567785A JP S567785 A JPS567785 A JP S567785A JP 8381779 A JP8381779 A JP 8381779A JP 8381779 A JP8381779 A JP 8381779A JP S567785 A JPS567785 A JP S567785A
- Authority
- JP
- Japan
- Prior art keywords
- theobromine
- alkali
- solvent
- reaction
- carbonate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the titled compound useful as a remedy for cerebral thrombosis economically, by carrying out both the reaction of theobromine and 1,3-dibromopropane in the presence of an alkali in a solvent and the reaction of the residue after distillation of the solvent and acetylacetone in one pot.
CONSTITUTION: Theobromine (or an alkali salt of theobromine) is reacted with 1,3-dibromopropane in the presence of an alkali carbonate (e.g., potassium carbonate, sodium carbonate, etc.,) or an alkali hydroxide (e.g., KOH, NaOH, etc.) in a solvent having small solubility of an alkali salt of theobromine prepared in the reaction (e.g., methyl ethyl ketone, acetone, etc.) and the solvent is distilled away. The resulting residue is reacted with acetylacetone in the presence of the alkali carbonate in ethanol.These reactions are carried out in one pot to give a compound shown by the formula. The number of the process is reduced and good yields are obtained.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8381779A JPS567785A (en) | 1979-07-02 | 1979-07-02 | Preparation of theobromine derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8381779A JPS567785A (en) | 1979-07-02 | 1979-07-02 | Preparation of theobromine derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS567785A true JPS567785A (en) | 1981-01-27 |
Family
ID=13813227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8381779A Pending JPS567785A (en) | 1979-07-02 | 1979-07-02 | Preparation of theobromine derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS567785A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011028835A1 (en) | 2009-09-02 | 2011-03-10 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| WO2013155465A1 (en) | 2012-04-13 | 2013-10-17 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| EP3199203A1 (en) | 2008-02-29 | 2017-08-02 | Concert Pharmaceuticals Inc. | Substitued xanthine derivatives |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55122780A (en) * | 1979-03-13 | 1980-09-20 | Maruko Seiyaku Kk | Preparation of theobromine derivative |
-
1979
- 1979-07-02 JP JP8381779A patent/JPS567785A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55122780A (en) * | 1979-03-13 | 1980-09-20 | Maruko Seiyaku Kk | Preparation of theobromine derivative |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3199203A1 (en) | 2008-02-29 | 2017-08-02 | Concert Pharmaceuticals Inc. | Substitued xanthine derivatives |
| WO2011028835A1 (en) | 2009-09-02 | 2011-03-10 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| WO2013155465A1 (en) | 2012-04-13 | 2013-10-17 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
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