JPS56142299A - Preparation of oligonucleotide - Google Patents

Preparation of oligonucleotide

Info

Publication number
JPS56142299A
JPS56142299A JP4606480A JP4606480A JPS56142299A JP S56142299 A JPS56142299 A JP S56142299A JP 4606480 A JP4606480 A JP 4606480A JP 4606480 A JP4606480 A JP 4606480A JP S56142299 A JPS56142299 A JP S56142299A
Authority
JP
Japan
Prior art keywords
group
formula
compound
conditions
monophosphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4606480A
Other languages
Japanese (ja)
Inventor
Morio Ikehara
Eiko Otsuka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WAKINAGA YAKUHIN KK
Wakunaga Pharmaceutical Co Ltd
Original Assignee
WAKINAGA YAKUHIN KK
Wakunaga Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WAKINAGA YAKUHIN KK, Wakunaga Pharmaceutical Co Ltd filed Critical WAKINAGA YAKUHIN KK
Priority to JP4606480A priority Critical patent/JPS56142299A/en
Publication of JPS56142299A publication Critical patent/JPS56142299A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Saccharide Compounds (AREA)

Abstract

PURPOSE: To obtain the corresponding compound without a protecting group thereof which is an intermediate for a carcinostatic agent, by subjecting a novel adenosine- 5'-monophosphate(2'-5') trimeric compound to the decomposing conditions.
CONSTITUTION: An adenosine-5'-monophosphate(2'-5') trimeric compound expressed by formula I [group of formula III is the skeleton of adenine riboside; Ac and Ac' are acyl; Ph and Ph' are (substituted)phenyl; NB is o-nitro-4-and/or 5-(substituted)benzyl] is subjected to the hydrolytic conditions of the phosphoric acid anilide group, e.g. the reaction with isoamyl nitrite, the hydrolytic conditions of the phenyl phosphate group, e.g. the reaction with aqueous ammonia, the hydrolytic conditions of the acylated amino group and hydroxyl group, e.g. the reaction with aqueous ammonia, and the decomposing conditions of the nitrobenzyl ether group, e.g. ultraviolet light irradiation, to give adenosine-5'-monophosphate(2'-5') trimer of formula II. A compound of formula IV having an activity to inhibit the protein synthesis can be obtained from the compound of formula II.
COPYRIGHT: (C)1981,JPO&Japio
JP4606480A 1980-04-08 1980-04-08 Preparation of oligonucleotide Pending JPS56142299A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4606480A JPS56142299A (en) 1980-04-08 1980-04-08 Preparation of oligonucleotide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4606480A JPS56142299A (en) 1980-04-08 1980-04-08 Preparation of oligonucleotide

Publications (1)

Publication Number Publication Date
JPS56142299A true JPS56142299A (en) 1981-11-06

Family

ID=12736570

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4606480A Pending JPS56142299A (en) 1980-04-08 1980-04-08 Preparation of oligonucleotide

Country Status (1)

Country Link
JP (1) JPS56142299A (en)

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