JPS5598188A - Novel cephalosporin and its preparation - Google Patents

Novel cephalosporin and its preparation

Info

Publication number
JPS5598188A
JPS5598188A JP553779A JP553779A JPS5598188A JP S5598188 A JPS5598188 A JP S5598188A JP 553779 A JP553779 A JP 553779A JP 553779 A JP553779 A JP 553779A JP S5598188 A JPS5598188 A JP S5598188A
Authority
JP
Japan
Prior art keywords
formula
fluorouracil
compound
preparation
gram
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP553779A
Other languages
Japanese (ja)
Inventor
Fujio Matsuda
Kozo Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Priority to JP553779A priority Critical patent/JPS5598188A/en
Publication of JPS5598188A publication Critical patent/JPS5598188A/en
Pending legal-status Critical Current

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  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formula I [R1 is (un)substituted alkyl, cycloalkyl, cycloalkenyl group, etc.; X is O or S; Y is substituent which does not take part in the reaction], its salt or ester.
EXAMPLE: 7-[ D-α-Fluorouracil-1-carbonylaminophenylacetamide ]-3-methyl-3-cephem-4-carboxylic acid.
USE: Antibacterials effective against Gram-positive and Gram-negative bacteria, having carcinostatic actions.
PROCESS: A cephalosporin of formula II or its derivative is reacted with a reactive derivative of 5-fluorouracil of formula III (Z is F, Cl, Br, I, H, or 1W5C alkoxy group), e.g. an acid halide, in the presence of a base, e.g. an alkali hydroxide, as a reaction accelerator or neutralizing agent in an inert solvent, e.g. methanol, at -50W80°C to give the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP553779A 1979-01-23 1979-01-23 Novel cephalosporin and its preparation Pending JPS5598188A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP553779A JPS5598188A (en) 1979-01-23 1979-01-23 Novel cephalosporin and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP553779A JPS5598188A (en) 1979-01-23 1979-01-23 Novel cephalosporin and its preparation

Publications (1)

Publication Number Publication Date
JPS5598188A true JPS5598188A (en) 1980-07-25

Family

ID=11613932

Family Applications (1)

Application Number Title Priority Date Filing Date
JP553779A Pending JPS5598188A (en) 1979-01-23 1979-01-23 Novel cephalosporin and its preparation

Country Status (1)

Country Link
JP (1) JPS5598188A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62258367A (en) * 1986-04-02 1987-11-10 Chisso Corp 5-fluorouracil derivative and production thereof
EP0705606A1 (en) * 1994-09-21 1996-04-10 PLIVA, farmaceutska, kemijska, prehrambena i kozmeticka industrija dionicko drustvo Use of 5-Thia-1,4-diazabicyclo [4.2.0] octane-3,8-dioxo compounds in antitumor therapy

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62258367A (en) * 1986-04-02 1987-11-10 Chisso Corp 5-fluorouracil derivative and production thereof
EP0705606A1 (en) * 1994-09-21 1996-04-10 PLIVA, farmaceutska, kemijska, prehrambena i kozmeticka industrija dionicko drustvo Use of 5-Thia-1,4-diazabicyclo [4.2.0] octane-3,8-dioxo compounds in antitumor therapy

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