JPS552658A - Preparation of thiazolidine derivative - Google Patents

Preparation of thiazolidine derivative

Info

Publication number
JPS552658A
JPS552658A JP7565478A JP7565478A JPS552658A JP S552658 A JPS552658 A JP S552658A JP 7565478 A JP7565478 A JP 7565478A JP 7565478 A JP7565478 A JP 7565478A JP S552658 A JPS552658 A JP S552658A
Authority
JP
Japan
Prior art keywords
formula
acid
thiazolidine derivative
compound
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7565478A
Other languages
Japanese (ja)
Inventor
Katsuo Arimura
Osamu Murakami
Taichi Oka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Priority to JP7565478A priority Critical patent/JPS552658A/en
Publication of JPS552658A publication Critical patent/JPS552658A/en
Pending legal-status Critical Current

Links

Landscapes

  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To obtain a thiazolidine derivative useful as hypotensive agents readily, by reducing a specific thiazolidinecarboxylic acid.
CONSTITUTION: A reactive derivative of a compound of formula I is reacted with a compound of formula II to give 3,3'-{3,3'-dithiobis[2(S)-methylpropionyl]}bis [4(R)-thiazolidinecarboxylic acid] of formula III, which is reduced with a combination of zinc, tin, and an acid, e.g. hydrochloric or sulfuric acid, sodium borohydride, sodium or potassium sulfide in water, methanol or dioxane, or their mixture at room temperature, and, if necessary under heating or cooling, to form a thiazolidine derivative of formula IV.
COPYRIGHT: (C)1980,JPO&Japio
JP7565478A 1978-06-21 1978-06-21 Preparation of thiazolidine derivative Pending JPS552658A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7565478A JPS552658A (en) 1978-06-21 1978-06-21 Preparation of thiazolidine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7565478A JPS552658A (en) 1978-06-21 1978-06-21 Preparation of thiazolidine derivative

Publications (1)

Publication Number Publication Date
JPS552658A true JPS552658A (en) 1980-01-10

Family

ID=13582435

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7565478A Pending JPS552658A (en) 1978-06-21 1978-06-21 Preparation of thiazolidine derivative

Country Status (1)

Country Link
JP (1) JPS552658A (en)

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