JPS5466686A - Quinoline-3-carboxylic acid derivative, its preparation, and pharmaceutical composition containig the same - Google Patents

Quinoline-3-carboxylic acid derivative, its preparation, and pharmaceutical composition containig the same

Info

Publication number
JPS5466686A
JPS5466686A JP11471278A JP11471278A JPS5466686A JP S5466686 A JPS5466686 A JP S5466686A JP 11471278 A JP11471278 A JP 11471278A JP 11471278 A JP11471278 A JP 11471278A JP S5466686 A JPS5466686 A JP S5466686A
Authority
JP
Japan
Prior art keywords
carboxylic acid
quinoline
substituted
preparation
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11471278A
Other languages
Japanese (ja)
Other versions
JPS5738581B2 (en
Inventor
Peson Maruseru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB39197/77A external-priority patent/GB1598915A/en
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Priority to JP11471278A priority Critical patent/JPS5466686A/en
Publication of JPS5466686A publication Critical patent/JPS5466686A/en
Publication of JPS5738581B2 publication Critical patent/JPS5738581B2/ja
Granted legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

NEW MATERIAL:6-Halogeno-1-substituted-7-di-substituted-amino-4-OXO-1,4-dihydroquinoline-3- carboxylic acid of formula I (R1 is lower alkyl, lower aralkyl, etc.; R2,3 are lower alkyl or may form together with adjacent N atom a 5-6 membered heterocyclic group; X is halogen), or its salt.
EXAMPLE: 1-Ethy1-6-fluoro-7-(4-methy-1-1-piperadinyl)-4-oxo-1,4-dihydro- quinoline-3-carboxylic acid.
USE: Remedy for infectious diseases of man and animals. A growth rate accelerator for animals. A compound wherein 6-position is substituted with halogen (esp. cl. F), is effective to gram-positive and gram-negative bacteria at low concentration.
PROCESS: The compound I is prepared by the condensation reaction of a quinoline- carboxylic acid II with a sec-amine II at 100-200°C, in the presence of an agent for scavenging the hydrogen halide generated during the reaction (e.g. tert. alkyl amine).
COPYRIGHT: (C)1979,JPO&Japio
JP11471278A 1977-09-20 1978-09-20 Quinoline-3-carboxylic acid derivative, its preparation, and pharmaceutical composition containig the same Granted JPS5466686A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11471278A JPS5466686A (en) 1977-09-20 1978-09-20 Quinoline-3-carboxylic acid derivative, its preparation, and pharmaceutical composition containig the same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB39197/77A GB1598915A (en) 1977-09-20 1977-09-20 1,4-dihydro-quinoline-3-carboxylic acid derivatives process for their preparation and composition containing them
GB1298378 1978-04-03
JP11471278A JPS5466686A (en) 1977-09-20 1978-09-20 Quinoline-3-carboxylic acid derivative, its preparation, and pharmaceutical composition containig the same

Publications (2)

Publication Number Publication Date
JPS5466686A true JPS5466686A (en) 1979-05-29
JPS5738581B2 JPS5738581B2 (en) 1982-08-16

Family

ID=27256913

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11471278A Granted JPS5466686A (en) 1977-09-20 1978-09-20 Quinoline-3-carboxylic acid derivative, its preparation, and pharmaceutical composition containig the same

Country Status (1)

Country Link
JP (1) JPS5466686A (en)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56128764A (en) * 1980-03-14 1981-10-08 Kyorin Pharmaceut Co Ltd Quinolinecarboxylic acid derivative and its preparation
JPS56128765A (en) * 1980-03-14 1981-10-08 Kyorin Pharmaceut Co Ltd Preparation of quinolonecarboxylic acid derivative
JPS5762259A (en) * 1980-09-05 1982-04-15 Kyorin Pharmaceut Co Ltd Preparation of substituted quinolinecarboxylic acid derivative
JPS5777683A (en) * 1980-09-03 1982-05-15 Bayer Ag 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro- naphthyridine-3-carboxylic acids or salts thereof, manufacture and antibacterial thereof as active ingredient
JPS57183762A (en) * 1980-10-02 1982-11-12 Eru Fuotsukusu Jiyu Chiyaaruzu 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7- (1-piperazinyl)-3-quinoline carboxylic acid and metal salts thereof for scald treatment
JPS5874667A (en) * 1981-10-29 1983-05-06 バイエル・アクチエンゲゼルシヤフト 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7- piperazinoquinoline-3-carboxylic acids
JPS591468A (en) * 1982-03-31 1984-01-06 スタ−リング・ドラツグ・インコ−ポレ−テツド Quinoline compound, manufacture and antibacterial
JPS5967269A (en) * 1982-09-09 1984-04-16 ワ−ナ−−ランバ−ト・コンパニ− Antibacterial compound
JPS59163369A (en) * 1983-02-25 1984-09-14 バイエル・アクチエンゲゼルシヤフト Quinolonecarboxylic acids
JPS6056959A (en) * 1983-07-18 1985-04-02 アボツト　ラボラトリ−ズ Quinoline antifungal compound
JPS6222716A (en) * 1985-07-24 1987-01-30 バイエル・アクチエンゲゼルシヤフト Bactricidal preparation for veterinary field
JPS62207258A (en) * 1986-03-06 1987-09-11 Toyama Chem Co Ltd Novel quinoline derivative and salt thereof
US5324735A (en) * 1989-07-21 1994-06-28 Ss Pharmaceutical Co., Ltd. Quinoline carboxylic acid derivatives

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56128765A (en) * 1980-03-14 1981-10-08 Kyorin Pharmaceut Co Ltd Preparation of quinolonecarboxylic acid derivative
JPS56128764A (en) * 1980-03-14 1981-10-08 Kyorin Pharmaceut Co Ltd Quinolinecarboxylic acid derivative and its preparation
JPS62161728A (en) * 1980-09-03 1987-07-17 バイエル・アクチエンゲゼルシヤフト Antibacterial
JPH0316344B2 (en) * 1980-09-03 1991-03-05 Bayer Ag
JPS5777683A (en) * 1980-09-03 1982-05-15 Bayer Ag 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro- naphthyridine-3-carboxylic acids or salts thereof, manufacture and antibacterial thereof as active ingredient
JPH0314811B2 (en) * 1980-09-03 1991-02-27 Bayer Ag
JPS6356224B2 (en) * 1980-09-03 1988-11-07 Bayer Ag
JPS62161763A (en) * 1980-09-03 1987-07-17 バイエル・アクチエンゲゼルシヤフト 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro- naphthylidine or - quinoline-3-carboxylic acids or salts and manufacture
JPH0130823B2 (en) * 1980-09-05 1989-06-22 Kyorin Seiyaku Kk
JPS5762259A (en) * 1980-09-05 1982-04-15 Kyorin Pharmaceut Co Ltd Preparation of substituted quinolinecarboxylic acid derivative
DE3135125A1 (en) * 1980-09-05 1982-06-03 Kyorin Seiyaku K.K., Tokyo Process for preparing 6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid compounds
JPS57183762A (en) * 1980-10-02 1982-11-12 Eru Fuotsukusu Jiyu Chiyaaruzu 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7- (1-piperazinyl)-3-quinoline carboxylic acid and metal salts thereof for scald treatment
JPS6362510B2 (en) * 1981-10-29 1988-12-02
JPS6322076A (en) * 1981-10-29 1988-01-29 バイエル・アクチエンゲゼルシヤフト Quinoline derivative
JPS5874667A (en) * 1981-10-29 1983-05-06 バイエル・アクチエンゲゼルシヤフト 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7- piperazinoquinoline-3-carboxylic acids
JPH0463067B2 (en) * 1981-10-29 1992-10-08 Bayer Ag
JPS591468A (en) * 1982-03-31 1984-01-06 スタ−リング・ドラツグ・インコ−ポレ−テツド Quinoline compound, manufacture and antibacterial
JPH0368863B2 (en) * 1982-03-31 1991-10-30 Sterling Drug Inc
JPS5967269A (en) * 1982-09-09 1984-04-16 ワ−ナ−−ランバ−ト・コンパニ− Antibacterial compound
JPS59163369A (en) * 1983-02-25 1984-09-14 バイエル・アクチエンゲゼルシヤフト Quinolonecarboxylic acids
JPH0146512B2 (en) * 1983-07-18 1989-10-09 Abbott Lab
JPS6056959A (en) * 1983-07-18 1985-04-02 アボツト　ラボラトリ−ズ Quinoline antifungal compound
JPS6222716A (en) * 1985-07-24 1987-01-30 バイエル・アクチエンゲゼルシヤフト Bactricidal preparation for veterinary field
JPS62207258A (en) * 1986-03-06 1987-09-11 Toyama Chem Co Ltd Novel quinoline derivative and salt thereof
US5324735A (en) * 1989-07-21 1994-06-28 Ss Pharmaceutical Co., Ltd. Quinoline carboxylic acid derivatives

Also Published As

Publication number Publication date
JPS5738581B2 (en) 1982-08-16

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