JPS5414594A - Preparation of beta-lactamase inhibiting substance - Google Patents

Preparation of beta-lactamase inhibiting substance

Info

Publication number
JPS5414594A
JPS5414594A JP7655777A JP7655777A JPS5414594A JP S5414594 A JPS5414594 A JP S5414594A JP 7655777 A JP7655777 A JP 7655777A JP 7655777 A JP7655777 A JP 7655777A JP S5414594 A JPS5414594 A JP S5414594A
Authority
JP
Japan
Prior art keywords
beta
preparation
inhibiting substance
lactamase inhibiting
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7655777A
Other languages
Japanese (ja)
Inventor
Hamao Umezawa
Masaji Sezaki
Harutaro Yasuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP7655777A priority Critical patent/JPS5414594A/en
Priority to FR7820095A priority patent/FR2396078A1/en
Priority to IT789512A priority patent/IT1103066B/en
Priority to ES471250A priority patent/ES471250A1/en
Publication of JPS5414594A publication Critical patent/JPS5414594A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To separate and purify MC696-SY2-A substance which is a strong βlactamase-inhibitor, by culturing MC696-SY2-producing fungi belonging to Streptomyces genus, and treating the cultured medium with various ion exchange resin, adsorbents, etc.
COPYRIGHT: (C)1979,JPO&Japio
JP7655777A 1977-06-29 1977-06-29 Preparation of beta-lactamase inhibiting substance Pending JPS5414594A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP7655777A JPS5414594A (en) 1977-06-29 1977-06-29 Preparation of beta-lactamase inhibiting substance
FR7820095A FR2396078A1 (en) 1977-06-29 1978-06-27 Beta-lactamase inhibitor prodn. - by cultivating a Streptomyces microorganism and recovering MC 696-SY2-A produced
IT789512A IT1103066B (en) 1977-06-29 1978-06-28 PROCESS FOR THE PRODUCTION OF SUBSTANCES THAT INHIBIT BETA LATTAMASI
ES471250A ES471250A1 (en) 1977-06-29 1978-06-29 Preparation of betaalactamase inhibiting substance

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7655777A JPS5414594A (en) 1977-06-29 1977-06-29 Preparation of beta-lactamase inhibiting substance

Publications (1)

Publication Number Publication Date
JPS5414594A true JPS5414594A (en) 1979-02-02

Family

ID=13608545

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7655777A Pending JPS5414594A (en) 1977-06-29 1977-06-29 Preparation of beta-lactamase inhibiting substance

Country Status (4)

Country Link
JP (1) JPS5414594A (en)
ES (1) ES471250A1 (en)
FR (1) FR2396078A1 (en)
IT (1) IT1103066B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4988570A (en) * 1985-09-11 1991-01-29 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Process for forming a film

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2966446D1 (en) * 1978-09-09 1984-01-05 Beecham Group Plc Beta-lactam compounds, their preparation and use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1363075A (en) * 1970-09-17 1974-08-14 Beecham Group Ltd Enzyme inhibitor
GB1467413A (en) * 1974-03-28 1977-03-16 Beecham Group Ltd Antibiotics

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4988570A (en) * 1985-09-11 1991-01-29 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Process for forming a film

Also Published As

Publication number Publication date
IT7809512A0 (en) 1978-06-28
FR2396078A1 (en) 1979-01-26
FR2396078B1 (en) 1980-11-14
ES471250A1 (en) 1979-10-01
IT1103066B (en) 1985-10-14

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