JPS54138559A - Preparation of 5-aryl-hydantoin - Google Patents

Preparation of 5-aryl-hydantoin

Info

Publication number
JPS54138559A
JPS54138559A JP4625478A JP4625478A JPS54138559A JP S54138559 A JPS54138559 A JP S54138559A JP 4625478 A JP4625478 A JP 4625478A JP 4625478 A JP4625478 A JP 4625478A JP S54138559 A JPS54138559 A JP S54138559A
Authority
JP
Japan
Prior art keywords
diglyoxyltriureide
acid
aryl
formula
aryl compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4625478A
Other languages
Japanese (ja)
Inventor
Arahiko Eguchi
Fusayoshi Kakizaki
Kunisuke Izawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Priority to JP4625478A priority Critical patent/JPS54138559A/en
Publication of JPS54138559A publication Critical patent/JPS54138559A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the title substance valuable as an intermediate for the synthesis of α-aryl-α-aminoacetic acids which are modifiers of semisynthetic penicillin efficiently, by reacting a safe and inexpensive aryl compound with a novel diglyoxyltriureide.
CONSTITUTION: An aryl compound of formula I: (R1 is OH or lower alkoxy group; R2 and R3 are H, OH, alkyl groups, halogens, etc.), e.g. an unsubstituted phenol, is reacted with diglyoxyltriureide in an acid medium, preferably acetic acid- sulfuric acid mixture, 5W35% hydrochloric acid, or sulfuric acid, at room temperature to reflux one for 30 minWseveral hr to give the objective substance of formula II. The diglyoxyltriureide is novel and obtained from urea and glyoxylic acid. In the reaction with the aryl compound, the diglyoxyltriureide is assumed to form two molecules of carbonium ion intermediates (formula III) under acid conditions.
COPYRIGHT: (C)1979,JPO&Japio
JP4625478A 1978-04-19 1978-04-19 Preparation of 5-aryl-hydantoin Pending JPS54138559A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4625478A JPS54138559A (en) 1978-04-19 1978-04-19 Preparation of 5-aryl-hydantoin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4625478A JPS54138559A (en) 1978-04-19 1978-04-19 Preparation of 5-aryl-hydantoin

Publications (1)

Publication Number Publication Date
JPS54138559A true JPS54138559A (en) 1979-10-27

Family

ID=12742034

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4625478A Pending JPS54138559A (en) 1978-04-19 1978-04-19 Preparation of 5-aryl-hydantoin

Country Status (1)

Country Link
JP (1) JPS54138559A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647694A (en) * 1984-03-12 1987-03-03 Alkaloida Vegyeszeti Gyar Process for the preparation of D1-β-aryl amino acids

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647694A (en) * 1984-03-12 1987-03-03 Alkaloida Vegyeszeti Gyar Process for the preparation of D1-β-aryl amino acids

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