JPH1189934A - Pre-filled syringe - Google Patents

Abstract

PROBLEM TO BE SOLVED: To surely prevent first and second cylindrical containers from being carelessly communicated with each other during storage and prevent leakage of liquid in use by providing a communicating means for piercing a rear sealing member of the first cylindrical container and a front end sealing member of the second cylindrical container in a designated order to communicate the first and second cylindrical containers with each other. SOLUTION: In use, when a plunger rod 8 is pressed from a first operating position (storage position) to a second operating position, that is, until a rear sealing member 6 is brought into contact with the front end of a second cylindrical container 2, a front end sealing member 4 is locked by a taper part of a support member 7. In such a condition, a forward side needle 17a of a double ended needle 17 pierces a rear sealing member 5. After that, when the front end sealing member 4 is pressed in a small-diameter part of a support member 7, the rear side needle 17b pierces the second sealing member 4. When a sleeve member 15 is pressed to the first cylindrical container 1 side with the first cylindrical container 1 held, a piercing member 11 is passed through the front end sealing member 3 so that injection in the first cylindrical container 1 is administered from an injection needle 12.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a prefilled syringe which is a disposable syringe pre-filled with a drug, and more particularly, to a first cylindrical container and a second cylindrical container each containing two components. In addition, the first cylindrical container and the second cylindrical container are communicated with each other at the time of use, and the two components are mixed,
The present invention relates to a so-called double syringe type prefilled syringe to which an injection solution is administered after dissolving or dispersing to prepare an injection solution.

[0002]

2. Description of the Related Art For example, U.S. Pat. No. 3,838,689.
As shown in FIG. 17A, a second cylindrical container 42 containing a chemical solution 45 is fitted into a hole 43 of a first cylindrical container 41 containing a powdered medicine 46 via a rubber stopper 44 as shown in FIG. Further, a double syringe type prefilled syringe having a disc stopper 47 in which a rubber stopper 44 seals a lower end opening of the second cylindrical container 42 is disclosed. As shown in FIG. 17B, the plunger rod 50 is connected to the second cylindrical container 42.
When pressed inward, the disk part 47 is pressed by the chemical solution 45 and bends downward, so the second cylindrical container 42
The lower end opening of the second cylindrical container 42 is released, and the lower end opening of the second cylindrical container 42 is opened via the opening 48 of the disc portion 47.
Communicate with 1. As a result, the chemical solution 4 in the second cylindrical container 42
5 is injected into the powdered medicine 46 in the first cylindrical container 41 from the opening 48 to prepare an injection solution. Thereafter, the plunger rod 50 is further pressed, so that the rubber stopper 4
4 and the second cylindrical container 42 function as a piston,
The injection solution in the cylindrical container 41 is administered from the injection needle 51.

However, in this known prefilled syringe, the thin circular plate portion 47 of the rubber stopper 44 is pressed and bent by the plunger rod 50 via the chemical solution 45, thereby bending the first cylindrical container 41 and the second cylindrical shape. The container 42 is communicated through the opening 48 of the disk part 47.
Therefore, in this prefilled syringe, when an external force such as an impact is applied during storage, the disc portion 47 is easily bent, and the first cylindrical container 41 and the second cylindrical container 42 are inadvertently connected. There is fear. Furthermore, in this prefilled syringe, the force required to bend the disk portion 47, that is, the first cylindrical container 41, depends on manufacturing accuracy such as the degree of adhesion of the disk portion 47 to the lower end of the second cylindrical container 42. And the second cylindrical container 42
Since the pressing force to be applied to the plunger rod 50 and the size of the bending of the disk portion 47 tend to vary for each prefilled syringe, the pressing force of the plunger rod 50 at the time of use is different for each prefilled syringe. There is a problem in that fine adjustment is required.

[0004] Further, as shown in FIG. 18, Japanese Patent Application Laid-Open No. 1-500803 discloses a first powder accommodating powder 63.
A cylindrical container 61 and a second cylindrical container 62 containing a chemical solution 64 are fitted into the cylindrical main body 60, and a sliding member 66 holding a double-ended needle 65 is attached to a membrane 67 at the rear end of the first cylindrical container 61. A double syringe type pre-filled syringe provided between the membrane 68 at the front end of the second cylindrical container 62 is disclosed. By operating the driving means 70, the second cylindrical container 62 is pressed forward and the double-ended needle 65 penetrates the membranes 67 and 68, so that the first cylindrical container 61 and the second cylindrical container 62 are double-ended. Needle 6
The injection solution is administered from the injection needle 71 in communication with 5.

In the prefilled syringe of FIG. 18, there is no means for regulating the order in which the double-ended needle 65 pierces the membranes 67 and 68 when the driving means 70 is operated to press the second cylindrical container 62 forward. From the double-ended needle 65
When the sliding member 66 is pressed by the membrane 68 after penetrating the membrane 8, an operation of penetrating the membrane 68 with the double-ended needle 65 is likely to occur. That is, this pre-filled syringe has a drawback that the double-ended needle 65 first penetrates the membrane 68 on the side of the drug solution 64 and then penetrates the membrane 67 on the side of the powdered drug 63, so that liquid leakage easily occurs.

[0006]

SUMMARY OF THE INVENTION In view of the above problems of the prior art, the present invention has a first rear sealing member at the rear of a first cylindrical container and a second front end sealing at a front end of a second cylindrical container. By providing communication means for piercing the stop member in a predetermined order to communicate the first cylindrical container and the second cylindrical container, the first cylindrical container and the second cylindrical container at the time of storage can be provided with a simple structure. Provided is a double syringe type prefilled syringe in which inadvertent communication is reliably prevented, and communication operation is reliably performed without liquid leakage at the time of use and without the need to finely adjust the pressing force of the plunger rod. It is intended to be.

[0007]

In order to achieve the above object, a prefilled syringe of the present invention comprises a first cylindrical container having an open front end and a rear end, and a first cylindrical container mounted on the front end of the first cylindrical container. (1) a front end sealing member, a first rear sealing member slidably fitted into the first cylindrical container, and a front end and a rear end which are open, and a first end which is open from a rear end opening of the first cylindrical container. A second cylindrical container movably inserted into the one cylindrical container, a second front end sealing member attached to a front end of the second cylindrical container, and a plunger movably inserted into the second cylindrical container Rod and the second
A second rear sealing member attached to the front end of the plunger rod so as to be slidably fitted into the cylindrical container; and a first rear sealing member and a second front end sealing member by pressing the plunger rod during use. There is provided communication means for piercing the stop member in a predetermined order to communicate the first cylindrical container and the second cylindrical container.

[0008] The communicating means is slidably inserted into the first cylindrical container so as to support the double-ended needle and the double-ended needle between the first rear sealing member and the second front end sealing member. With
In addition, a locking portion for locking the second front end sealing member is provided on the support member, and the double front needle is locked by the locking portion of the support member when the second front end sealing member is used. After penetrating the first rear sealing member, the double front needle may penetrate the second front sealing member by the second front end sealing member climbing over the locking portion of the support member. .

[0009]

Embodiments of the present invention will be described below with reference to the drawings. FIG. 1 shows a double syringe type prefilled syringe according to a first embodiment of the present invention. The pre-filled syringe has an elongated hollow first cylindrical container 1 having a front end and a rear end opened, and an elongated hollow shape having a front end and a rear end opened, and is movable to the first cylindrical container 1. A second cylindrical container 2 to be inserted, a first front end sealing member 3 attached to the front end of the first cylindrical container 1,
A second front end sealing member 4 attached to the front end of the cylindrical container 2,
A first rear sealing member (5) is slidably fitted into the first cylindrical container (1). Two components, for example, powder drug P and drug solution L
Are accommodated in the first cylindrical container 1 and the second cylindrical container 2, respectively.

The prefilled syringe further includes a double-ended needle 17 for penetrating the first rear sealing member 5 and the second front-end sealing member 4 to communicate the first cylindrical container 1 and the second cylindrical container 2, and a double-ended needle. 17, a supporting member 7 slidably inserted into the first cylindrical container 1 between the first rear sealing member 5 and the second front end sealing member 4, and a second cylindrical container 2 And a plunger rod 8 which is movably fitted into the plunger. The double-ended needle 17 has a front needle 17a and a rear needle 17b, and a second rear sealing member 6 and a grip 8a which are slidably fitted into the second cylindrical container 2 are respectively provided at the front end of the plunger rod 8. And is attached to the rear end. Further, the projection 2a is provided at the rear end of the second cylindrical container 2, while the claw portion 8b engaging with the projection 2a is provided.
Is provided on the front surface of the grip 8a.

The sleeve member 15 of the front assembly 9 is fitted on the outer periphery of the front end of the first cylindrical container 1, while the finger grip 10 is fitted on the outer periphery of the rear end of the first cylindrical container 1. Is done. Puncture member 1 having a puncture end at the rear
1 is attached to the inner front end of the sleeve member 15. Further, an injection needle unit 14 including an injection needle 12 and a cap 13 that covers the injection needle 12 so as to protect the injection needle 12 is attached to the front end outside 15b of the sleeve member 15. At the time of use, hold the first cylindrical container 1 and hold the sleeve member 15 in the first position.
By pushing toward the cylindrical container 1 side, the first cylindrical container 1
The front end sealing member 3 is pierced by the puncture member 11. Next, by pressing the plunger rod 8, the injection solution I in the first cylindrical container 1 is administered from the injection needle 12 via the puncture member 11.

As shown in FIG. 2, the configuration of the first operation position (storage position) of the prefilled syringe shown in FIG. 1 is such that a tapered portion 7a whose diameter decreases toward the front is formed in a space 7b at the rear of the support member 7. It is provided on the peripheral surface of the rear end portion and functions as a locking portion for locking the second front end sealing member 4. As a result, the second cylindrical container 2 is connected to the plunger rod 8 via the chemical liquid L at the time of use.
, The second front end sealing member 4 is locked by the tapered portion 7 a of the support member 7, the support member 7 advances, and the front needle 17 a of the double-ended needle 17 is moved to the first rear sealing member 5. Pierce. Thereafter, the second front end sealing member 4 is
The second side of the double-sided needle 17 penetrates the second sealing member 4 by fitting over the small diameter portion 7c over the tapered portion 7a. That is, after the front needle 17a penetrates the first rear sealing member 5 on the powdered medicine P side, the rear needle 17b penetrates the second sealing member 4 on the chemical liquid L side. As a result, in the prefilled syringe shown in FIG. 1, liquid leakage hardly occurs.

[0013] Further, as shown in FIG.
It is provided on the inner periphery of the rear end of the sleeve member 15 of the front assembly 9 to prevent the front assembly 9 from being detached from the first cylindrical container 1. In addition, a ridge 10 a is provided on the inner periphery of the finger grip 10 to prevent the second cylindrical container 2 from being detached from the first cylindrical container 1. Furthermore,
While an engaging portion 16a is formed on the outer periphery of a holding piece 16 fixed to the support member 7 so as to hold the double-ended needle 17,
A mating engagement portion 5a that engages with the engagement portion 16a is formed on the peripheral surface of the recess 5b at the rear of the first rear sealing member 5. At the time of use, the second cylindrical container 2 holds the plunger rod 8
When the front side needle 17a of the double-ended needle 17 pierces the first rear sealing member 5, the engaging portion 16a of the holding piece 16 is brought into contact with the mating engaging portion 5a of the first rear sealing member 5. As a result, the support member 7 and the first rear sealing member 5 are integrally fixed to each other.

The operation of the prefilled syringe constructed as described above will be described below with reference to FIGS. 2, 3 and 4. First,
In the first operation position (storage position) of FIGS. 2 and 3A, the first front end sealing member 3 is in contact with the puncturing end of the puncturing member 11, while the first front end sealing member 3 is in contact with the front side needle 17 a of the double-ended needle 17. The rear side needle 17b is in contact with the first rear sealing member 5 and the second front end sealing member 4 in the first cylindrical container 1, respectively. Further, the outer peripheral edge of the front end of the second front end sealing member 4 is in contact with the rear end of the tapered portion 7a of the support member 7 and the plunger rod 8
The second rear sealing member 6 at the front end is fitted into the second cylindrical container 2.

Next, in the second operation position shown in FIG. 3B, the plunger rod 8 is pressed until the second rear sealing member 6 comes into contact with the front end of the second cylindrical container 2.
After the front needle 17a of the double-ended needle 17 penetrates the first rear sealing member 5 as described above, the rear needle 17b of the double-ended needle 17
Penetrates the second front end sealing member 4, the first cylindrical container 1 and the second cylindrical container 2 communicate with each other, and all the liquid medicine L in the second cylindrical container 2 is passed through the double-ended needle 17. The injection liquid I is prepared because it is injected into the powder medicine P in the first cylindrical container 1. At this time, the second front end sealing member 4 goes over the tapered portion 7a of the support member 7 and is fitted into the small-diameter portion 7c.
Are in contact with the first rear sealing member 5. Further, the first front end sealing member 3 is maintained at the first operation position in contact with the puncturing end of the puncturing member 11. Further, the protrusion 2 of the second cylindrical container 2
a and the claw portion 8b of the plunger rod 8 are engaged with each other, so that the second cylindrical container 2 and the plunger rod 8 are integrally fixed to each other.

Next, in the third operation position shown in FIG. 4A, the first cylindrical container 1 is pushed by pushing the sleeve member 15 toward the first cylindrical container 1 while holding the first cylindrical container 1. The first front end sealing member 3 is pierced by the puncture member 11. next,
By pressing the plunger rod 8, the injection solution I in the first cylindrical container 1 can be administered from the injection needle 12 via the puncture member 11.

Then, after removing the cap 13 and pressing the plunger rod 8 to fill the injection needle 12 with the injection solution I to the tip thereof, the air is evacuated from the injection needle 12, and then the first rear sealing member 5 is removed. By pressing the plunger rod 8 until it comes into contact with the front end of the first cylindrical container 1, the injection solution I is administered from the injection needle 12, and as a result, FIG.
The fourth operation position (B) is reached.

FIG. 5 shows a double syringe type prefilled syringe which is a modification of the double syringe type prefilled syringe of FIG. The supporting member 7 of the prefilled syringe is set to have a longer length toward the rear side than the supporting member 7 of the prefilled syringe in FIG. 1, and the tapered portion 7e and the notch 7d are arranged in order from the rear end face of the cavity 7b toward the front. , A tapered portion 7a and a small diameter portion 7c. In the first operation position (storage position) of FIG. 8A of the prefilled syringe, the second front end sealing member 4 is connected to the tapered portion 7 e of the support member 7.
And fits into the notch 7d, and the second front end sealing member 4
Of the support member 7 is in contact with the rear end of the tapered portion 7a of the support member 7. In this pre-filled syringe in a pre-set state, similarly to the pre-filled syringe in FIG.
It functions as a locking part for locking. The other structure of the prefilled syringe is the same as that of the prefilled syringe of FIG.

Hereinafter, a procedure of assembling the prefilled syringe having the above configuration will be described with reference to FIGS. First,
In the first step of FIG. 6A, the second front end sealing member 4 is
The chemical liquid L is mounted on the front end of the cylindrical container 2 and
Then, the second rear sealing member 4 is fitted into the second cylindrical container 2 so as to seal the second cylindrical container 2. After that, the second cylindrical container 2 is subjected to a sterilization process.

Next, in the second step of FIG. 6B, the first front end sealing member 3 is mounted on the front end of the first cylindrical container 1, and the powdered medicine P is filled in the first cylindrical container 1. After that, the first rear sealing member 5 is slidably fitted into the first cylindrical container 1.

Thereafter, in the third step of FIG. 6C, after the support member 7 supporting the double-ended needle 17 is fitted to the second cylindrical container 2, the support member 7 is inserted through the opening at the rear end of the first cylindrical container 1. First cylindrical container 1
Movably insert

Further, in the fourth step of FIG.
The front assembly 9 on which the injection needle unit 14 including the cap 2 and the cap 13 is mounted is mounted on the front end of the first cylindrical container 1, and the front end of the plunger rod 8 is mounted on the second rear sealing member 6. Thus, the assembly of the prefilled syringe is completed.

The injection needle unit 14 and the front assembly 9 may be stored separately until use.

Hereinafter, the operation of the prefilled syringe having the above configuration will be described with reference to FIGS. First, FIG.
In the first operation position (storage position) of (A), while the first front end sealing member 3 is in contact with the puncturing end of the puncturing member 11, the front needle 17a and the rear needle 17b of the double-ended needle 17 are connected. ,
The first rear sealing member 5 and the second front end sealing member 4 in the first cylindrical container 1 are in contact with each other. Further, the outer peripheral edge of the front end of the second front end sealing member 4 is in contact with the rear end of the tapered portion 7a of the support member 7, and the second rear sealing member 6 at the front end of the plunger rod 8 is a second cylinder. It is fitted into the container 2.

Next, in the second operation position shown in FIG. 8B, the plunger rod 8 is pressed until the second rear sealing member 6 comes into contact with the front end of the second cylindrical container 2.
The second front end sealing member 4 is locked by the tapered portion 7 a of the support member 7, and the front needle 17 a of the double-ended needle 17 penetrates the first rear sealing member 5. Thereafter, the second front end sealing member 4 is press-fitted into the small diameter portion 7c of the support member 7, so that the rear side needle 17b of the double-ended needle 17 penetrates the second sealing member 4.

Next, similarly to the prefilled syringe shown in FIG. 1, at the third operation position shown in FIG. 9A, the sleeve member 15 is pushed toward the first cylindrical container 1 while holding the first cylindrical container 1. Thereby, the first front end sealing member 3 of the first cylindrical container 1 is pierced by the puncture member 11. Next, by pressing the plunger rod 8, the injection solution I in the first cylindrical container 1 can be administered from the injection needle 12 via the puncture member 11.

Then, similarly to the prefilled syringe of FIG. 1, the cap 13 is removed and the plunger rod 8 is removed.
Is pressed to fill the injection needle 12 with the injection solution I to the tip thereof, thereby evacuating the air from the injection needle 12 and then plunging until the first rear sealing member 5 comes into contact with the front end of the first cylindrical container 1. When the rod 8 is pressed, the injection solution I is administered from the injection needle 12, and reaches the fourth operation position in FIG. 9B.

FIG. 10 shows a double syringe type prefilled syringe according to a second embodiment of the present invention. As clearly shown in FIG. 11 showing the first operation position (storage position) of the prefilled syringe, a conical second front end sealing member 4 and a conical shape embedded in the second front end sealing member 4. The puncturing end of the puncturing member 25 is covered with the thin film 4 a of the second front end sealing member 4. A locking claw 27 for locking the front end of the first cylindrical container 1 is provided on the sleeve member 15 of the front assembly 9 so as to surround the puncture member 11. Further, in this prefilled syringe, a stopper 26 for fixing the volume in the second cylindrical container 2 and for stabilizing the pressing stroke of the plunger rod 8 is detachably attached to the grip 8a of the plunger rod 8.

Further, in FIG. 11, the recess 5b of the first rear sealing member 5 has a flat portion 5c for receiving the second front end sealing member 4 in the first operation position of the prefilled syringe, and a flat portion 5c. A tapered portion 5d whose diameter decreases toward the front,
It has an enlarged diameter portion 5e provided in front of the tapered portion 5d. The other structure of the prefilled syringe is the same as that of the prefilled syringe of FIG.

The operation of the prefilled syringe having the above configuration will be described below with reference to FIGS. First,
In the first operation position (storage position) in FIG.
The first front end sealing member 3 is in contact with the puncturing end of the puncturing member 11 while the puncturing end of the puncturing member 25 is in contact with the second front end sealing member 4.
Abuts on the first rear sealing member 5 via the thin film 4a. Further, the second rear sealing member 6 at the front end of the plunger rod 8 is fitted into the second cylindrical container 2. At this time, the second
The front end sealing member 4 is received in the flat portion 5c (FIG. 11) of the first rear sealing member 5.

Next, in the second operation position shown in FIG. 12B, the plunger rod 8 is pressed until the stopper 26 comes into contact with the finger grip 10 so that the liquid passage hole in the front side surface of the puncture member 25 is formed. Is the second front end sealing member 4
Is pressed by the first rear sealing member 5 through the thin film 4a.
As a result, the puncturing member 25 continuously pierces the thin film 4a of the second front end sealing member 4 and the first rear sealing member 5 in this order. At this time, when the thin film 4a is pierced, the puncture member 25
Is pressed by the first rear sealing member 5, so that the liquid does not leak into the recess 5b. As a result, the first cylindrical container 1
And the second cylindrical container 2 communicate with each other via the puncture member 25. At this time, the second front end sealing member 4 goes over the tapered portion 5d (FIG. 11) of the first rear sealing member 5 and fits into the enlarged diameter portion 5e (FIG. 11).

Further, in the third operation position shown in FIG. 13A, the stopper 26 is connected to the grip 8 of the plunger rod 8.
When the plunger rod 8 is further removed while the plunger rod 8 is pressed, the first rear sealing member 5 is retracted together with the second cylindrical container 2.

Thereafter, in the fourth operation position shown in FIG. 13B, the plunger rod 8 is pressed until the second rear sealing member 6 comes into contact with the front end of the second cylindrical container 2, thereby causing the second operation. All the liquid medicines L in the cylindrical container 2 are in the first cylindrical container 1
The injection solution I is prepared by being injected into the powder medicine P in the inside.
At this time, the projection 2a of the second cylindrical container 2 and the claw 8b of the plunger rod 8 are engaged with each other.

Next, in the fifth operation position in FIG. 14A, the first cylindrical container 1 is pushed by pushing the sleeve member 15 toward the first cylindrical container 1 while holding the first cylindrical container 1. The first front end sealing member 3 is pierced by the puncture member 11. Next, by pressing the plunger rod 8, the injection solution I in the first cylindrical container 1 is injected through the puncture member 11 into the injection needle 1.
2 can be administered. At this time, the front end of the first cylindrical container 1 is locked by the locking claw 27 of the front assembly 9.

Then, after removing the cap 13 and pressing the plunger rod 8 to fill the injection needle 12 with the injection liquid I to the tip thereof to bleed air from the injection needle 12, the first rear sealing member 5 is removed. By pressing the plunger rod 8 until the plunger rod 8 comes into contact with the front end of the first cylindrical container 1, the injection solution I is administered from the injection needle 12, and as a result, FIG.
The robot reaches the sixth operation position (B).

FIGS. 15A, 15B and 16
(A) and FIG. 16 (B) show a first example of a double syringe type prefilled syringe according to the third embodiment of the present invention.
The operation position (storage position) to the fourth operation position are shown. In this prefilled syringe, the long first rear sealing member 5 is employed, and the second front end sealing member 4 is locked in the recess 5b at the rear of the first rear sealing member 5, and A long puncturing member 30 extending inside the second cylindrical container 2 to the second front end sealing member 4 is attached to the front end of the second rear sealing member 6.
A deep hole 5f is formed in the front portion of the first rear sealing member 5 for receiving the puncturing end of the puncturing member 30 pierced through the second front end sealing member 4 and the first rear sealing member 5. While the second
A locking projection 5g for locking the front end sealing member 4 in the recess 5b is provided at the rear end of the recess 5b of the first rear sealing member 5. Further, the puncture member 30 has a liquid feed hole extending in the axial direction, and a radial horizontal hole (not shown) communicating with the liquid feed hole is opened in a side wall near the base of the puncture member 30. By adopting the long first rear sealing member 5,
The liquid tightness at the time of preparing and administering the injection solution I is further improved.
The other structure of the prefilled syringe is the same as that of the prefilled syringe of FIG.

The operation of the prefilled syringe having the above configuration will be described below with reference to FIGS. First, in the first operation position (storage position) of FIG. 15A, the first front end sealing member 3 is in contact with the puncture end of the puncture member 11, while the puncture end of the puncture member 30 is in the second front end. It is in contact with the sealing member 4. Further, the second end of the front end of the plunger rod 8
The rear sealing member 6 is fitted into the second cylindrical container 2.

Next, in the second operation position shown in FIG. 15B, the puncture is performed by pressing the plunger rod 8 until the second rear sealing member 6 comes into contact with the front end of the second cylindrical container 2. Since the member 30 continuously penetrates the second front end sealing member 4 and the first rear sealing member 5 in this order and enters the deep hole 5f of the first rear sealing member 5, the side hole of the puncturing member 30 is formed. The first cylindrical container 1 and the second cylindrical container 2 communicate with each other through a liquid feed hole, and all the chemicals L in the second cylindrical container 2 are filled with the powdered medicine P in the first cylindrical container 1. To prepare injection solution I. At this time, the projection 2a of the second cylindrical container 2 and the claw 8b of the plunger rod 8 are engaged with each other.

Further, in the third operation position shown in FIG. 16A, the sleeve member 15 is pushed toward the first cylindrical container 1 while holding the first cylindrical container 1, so that the first cylindrical container 1 is moved. The first front end sealing member 3 is penetrated by the puncture member 11. Next, by pressing the plunger rod 8, the injection solution I in the first cylindrical container 1 is injected through the puncture member 11 into the injection needle 1.
2 can be administered.

Then, after removing the cap 13 and pressing the plunger rod 8 to fill the injection needle 12 with the injection liquid I to the tip thereof to bleed air from the injection needle 12, the first rear sealing member 5 is removed. By pressing the plunger rod 8 until it comes into contact with the front end of the first cylindrical container 1, the injection solution I is administered from the injection needle 12, and as a result, FIG.
The fourth operation position (B) is reached.

[0041]

In the prefilled syringe of FIG. 1 of the present invention, after the double-ended needle 17 pierces the first rear sealing member 5 on the side of the powdered medicine P, the second front end sealing member 4 on the side of the chemical liquid L is moved.
, So that inadvertent communication between the first cylindrical container 1 and the second cylindrical container 2 during storage is reliably prevented, and there is no liquid leakage during use, and the plunger is not used. A remarkable effect is obtained in that the communication operation is reliably performed without the need to finely adjust the pressing force of the rod 8. Also, FIG.
In the prefilled syringe of No. 0, the puncturing member 25 embedded in the second front end sealing member 4 is a thin film 4a of the second front end sealing member 4.
And the first rear sealing member 5 are pierced continuously in this order, so that the first cylindrical container 1 and the second cylindrical container 2 can be inadvertently stored with a simple structure. The preferable effect is obtained that the communication is reliably prevented, and the communication operation is reliably performed without liquid leakage during use and without the need to finely adjust the pressing force of the plunger rod 8. Further, in the pre-filled syringe of FIG. 15, the long puncturing member 30 continuously pierces the second front end sealing member 4 and the long first rear sealing member 5 in this order, thereby forming the first rear sealing member. 5
1 is formed so as to enter the deep hole 5f of FIG.
In addition to the above-described effects of the prefilled syringe of No. 0, a desirable effect that the liquid tightness at the time of preparing and administering the injection solution I is further improved is obtained.

[Brief description of the drawings]

FIG. 1 is an exploded cross-sectional view of a double syringe type prefilled syringe according to a first embodiment of the present invention.

FIG. 2 is an enlarged partial cross-sectional view of the double syringe prefilled syringe of FIG. 1 at a first operation position (storage position).

FIGS. 3A and 3B are cross-sectional views showing a first operation position (storage position) and a second operation position of the double syringe type prefilled syringe of FIG. 1, respectively.

FIGS. 4A and 4B are cross-sectional views respectively showing a third operation position and a fourth operation position of the double syringe type prefilled syringe of FIG. 1;

FIG. 5 is an exploded sectional view showing a double syringe type prefilled syringe which is a modified example of the double syringe type prefilled syringe of FIG. 1;

6 (A), (B) and (C) are cross-sectional views respectively showing a first step, a second step and a third step of assembling the double syringe type prefilled syringe of FIG. 5;

FIG. 7 is a sectional view showing a fourth step of assembling the double syringe type prefilled syringe of FIG. 5;

8 (A) and 8 (B) are cross-sectional views showing a first operation position (storage position) and a second operation position of the double syringe type prefilled syringe of FIG. 5, respectively.

FIGS. 9A and 9B are cross-sectional views showing a third operation position and a fourth operation position of the double syringe type prefilled syringe of FIG. 5, respectively.

FIG. 10 is an exploded sectional view of a double syringe type prefilled syringe according to a second embodiment of the present invention.

FIG. 11 is an enlarged partial cross-sectional view of the double syringe type prefilled syringe of FIG. 10;

12A and 12B are cross-sectional views showing a first operation position (storage position) and a second operation position of the double syringe type prefilled syringe of FIG. 10, respectively.

13A and 13B are respectively a third operating position and a fourth operating position of the double syringe type prefilled syringe of FIG.
It is sectional drawing which shows an operation position.

14A and 14B are respectively a fifth operating position and a sixth operating position of the double syringe type prefilled syringe of FIG.
It is sectional drawing which shows an operation position.

FIGS. 15A and 15B are cross-sectional views respectively showing a first operation position (storage position) and a second operation position of a double syringe type prefilled syringe according to a third embodiment of the present invention.

16A and 16B are respectively a third operation position and a fourth operation position of the double syringe type prefilled syringe of FIG.
It is sectional drawing which shows an operation position.

FIG. 17 is a cross-sectional view showing an example of a conventional double syringe type prefilled syringe.

FIG. 18 is a cross-sectional view showing another example of a conventional double syringe type prefilled syringe.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 1st cylindrical container 2 2nd cylindrical container 3 1st front end sealing member 4 2nd front end sealing member 5 1st rear sealing member 6 2nd rear sealing member 8 plunger rod 9 front assembly 10 finger grip 12 Injection needle 14 Injection needle unit 17 Double-ended needle 25 Puncture member 26 Stopper 30 Puncture member

Claims (4)

[Claims] 1. A first cylindrical container having an open front end and a rear end, a first front end sealing member mounted on a front end of the first cylindrical container, and slidably fitted into the first cylindrical container. A first rear sealing member, a second cylindrical container having a front end and a rear end opened, and a second cylindrical container movably inserted into the first cylindrical container from an opening at a rear end of the first cylindrical container; A second front end sealing member attached to a front end of the second cylindrical container, a plunger rod movably inserted into the second cylindrical container, and a slidably fitted into the second cylindrical container. By pressing the plunger rod at the time of use and the second rear sealing member attached to the front end of the plunger rod, the first rear sealing member and the second front end sealing member are pierced in a predetermined order to form the first cylindrical member. A prefilled syringe comprising: a communicating means for communicating the container with the second cylindrical container. 2. A communication device for supporting a double-ended needle and a double-ended needle between a first rear sealing member and a second front end sealing member.
A supporting member slidably inserted into the first cylindrical container,
In addition, a locking portion for locking the second front end sealing member is provided on the support member, and the double front needle is locked by the locking portion of the support member when the second front end sealing member is used. 2. The double-ended needle penetrates the second front end sealing member when the second front end sealing member climbs over the locking portion of the support member after penetrating the first rear sealing member. The prefilled syringe according to 1. 3. The communication means includes a puncturing member embedded in the second front end sealing member so as to cover the puncturing end with a thin film of the second front end sealing member. 2. The prefilled syringe according to claim 1, wherein the thin film of the front end sealing member and the first rear sealing member are continuously pierced in this order. 4. The communication means includes an elongated puncturing member attached to the front end of the second rear sealing member and extending in the second cylindrical container, and the first rear sealing member is elongated. Along with
A deep hole is provided in the front part of the first rear sealing member, and further, when used,
The pre-filled syringe according to claim 1, wherein the puncturing member is configured to continuously pierce the second front end sealing member and the first rear sealing member in this order and to enter the deep hole.