JPH1171232A - Skin preparation for preventing acne for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject skin preparation for external use, mainly useful as a preparation for preventing and treating acne due to the stimulation of the release of corneum by including alanine. SOLUTION: This skin preparation for external use contains alanine (L- alanine, DL-alanine, D-alanine) in an amount of 0.001-20.0 wt.%, preferably 0.01-10.0 wt.%, based on the external use for the skin, if necessary, further a UV light absorbent, a UV light-blocking agent, a moisturizing agent, a skin- activating ingredient, and various kinds of vitamins, and is prepared in either of wide preparation forms (aqueous solution form, aerosol form, water-oil two layer form, water-oil-powder three layer form and the like). The alanine is prepared e.g. by hydrolyzing silk fibroin and subsequently selectively precipitating the alanine with a selectively precipitating agent such as azobenzene-p- sulfonic acid.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD [0001] The present invention relates to an external preparation for the skin. More specifically, the invention relates to an external preparation for skin having an acne-preventing effect, which is prepared by combining specific amino acids.

[0002]

BACKGROUND OF THE INVENTION Acne is formally called acne vulgaris. 70-80% of patients are concentrated in the age group of 11-25 years, and mild acne may be one of the characteristics of adolescent skin rather than skin disease. However, severe acne is also bad at first glance, often leaving traces after healing,
For some people, acne alone makes them mentally depressed and often affects daily life and social activities. Therefore, it is necessary to perform appropriate treatment as soon as possible from a cosmetic point of view to restore normal and clean skin.

[0003] The cause of acne is thought to be factors involving factors such as enlargement of the sebaceous glands, excessive secretion of sebum, accumulation of sebum in the hair follicle, increased keratinization of the hair follicle, and the influence of bacteria. . Treatment of acne requires treatment with an anti-inflammatory agent if the symptoms become severe. Prevent the development of acne at an earlier stage, or treat it with mild symptoms. It is desired that various means for obtaining be provided.

[0004]

An object of the present invention is to prevent acne from the stage of ordinary skin care and to treat acne in the stage of early rash, which is excellent in safety and efficacy. To provide new means.

[0005]

Means for Solving the Problems The present inventors have made intensive studies to solve this problem, and found that when an alanine, which is a kind of amino acid, is incorporated into an external preparation for skin, this external preparation for skin is excellent. The present inventor has found that the present invention has an effect of preventing acne, and has completed the present invention.

[0006] That is, the present invention provides an external preparation for acne prevention, comprising alanine as an active ingredient. In the present invention, “acne prevention effect” means an effect of preventing acne from occurring and treating acne once it has occurred.

[0007]

Embodiments of the present invention will be described below. The external preparation for skin of the present invention is an external preparation for skin exclusively for the purpose of preventing and treating acne, comprising alanine as an active ingredient.

[0008] The alanine compounded in the external preparation for skin of the present invention is
Any of L-alanine, DL-alanine and D-alanine may be used, but alanine derivatives such as amide derivatives are excluded.

In the present invention, alanine produced by a generally known method can be used. That is, for example, alanine produced by hydrolyzing silk fibroline using a selective precipitant such as azobenzene-p-sulfonic acid, alanine separated from a hydrolyzate of silk by Fischer's ester method, and further by fermentation. The manufactured L-alanine and the like can be used.

[0010] Of course, it is also possible to use a commercially available product.
For L-alanine, for example, alanine (Musashino Chemical Laboratory) (Takeda Pharmaceutical), DL-alanine (Showa Denko)
(Nippon Physical and Chemical) (Ajinomoto), DL-alanine Kyowa (Kyowa Hakko Kogyo) and the like can be used. For L-alanine, for example, L-alanine (Tanabe Seiyaku) (Nippon Chemical) (Ajinomoto) , L-alanine Kyowa (Kyowa Hakko Kogyo) or the like can be used.

[0011] In the skin external preparation of the present invention, alanine is present in an amount of 0.001 to 20.0% by weight, preferably 0.1 to 10.0% by weight, based on the skin external preparation. .

[0012] This amount is 0.00
If the amount is less than 1% by weight, the effect of alanine in the external preparation for skin should not be exerted, and the effect of preventing acne is not sufficiently exhibited.
Even if the amount is more than 0% by weight, it is difficult to expect an increase in the effect corresponding to the increase in the amount.

[0013] Thus, the skin external preparation of the present invention, which is capable of preventing acne, mainly by accelerating exfoliation by mixing alanine as an active ingredient in the external preparation for skin is provided. . In the skin external preparation of the present invention, in addition to this active ingredient, other components are blended, as long as the medicinal effect is added to the skin external preparation of the present invention, as long as the intended effect of the present invention is not impaired. Can be blended.

For example, other components capable of preventing acne by a different mechanism of action from alanine, such as anti-inflammatory agents such as indomethacin, ibuprofen piconol and glycyrrhetinic acid; antibiotics such as erythromycin, clindamycin and nadifloxacin; An antibacterial agent; a keratinization inhibitor such as retinoic acid; an antiandrogen such as spironolactone; and the like can be incorporated in the skin external preparation of the present invention.

In order to impart an ultraviolet ray protective effect to the external preparation for skin of the present invention, an ultraviolet ray shielding agent such as an ultraviolet ray absorbing agent or an ultraviolet ray shielding agent may be blended. Examples of the ultraviolet absorber include para-aminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester, N, N-dimethyl PABA ethyl ester, Para-aminobenzoic acid-based ultraviolet absorbers such as N, N-dimethyl PABA butyl ester, N, N-dimethyl PABA tyl ester, anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate, amyl salicylate, menthyl salicylate, homo Salicylic acid ultraviolet absorbers such as menthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, octyl cinnamate, ethyl-4-isopro Rushin'nameto, methyl 2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate,
Propyl-p-methoxycinnamate, isopropyl-
p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl-p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate),
2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-
Cinnamic acid ultraviolet absorbers such as cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate,

2,4-dihydroxybenzophenone,
2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4′-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4′-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4
-N-octoxybenzophenone, 4-hydroxy-3
A benzophenone-based ultraviolet absorber such as carboxybenzophenone, 3- (4′-methylbenzylidene) -d, l
-Camphor, 3-benzylidene-d, l-camphor, urocanic acid, urocanic acid ethyl ester, 2-
Phenyl-5-methylbenzoxazole, 2,2′-hydroxy-5-methylphenylbenzotriazole,
-(2'-hydroxy-5'-t-octylphenyl)
Benzotriazole, 2- (2'-hydroxy-5'-
Methylphenylbenzotriazole, dibenzalazine,
Examples thereof include dianisoylmethane, 4-methoxy-4′-t-butyldibenzoylmethane, and 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one.

When the moisturizing effect is positively imparted to the external preparation for skin of the present invention, a moisturizing agent can be incorporated into the external preparation for skin of the present invention. Examples of the humectant include polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate. , Sodium lactate, bile salts, dl-pyrrolidone carboxylate, short-chain soluble collagen, diglycerin (EO) PO
Examples include an adduct, a primrose extract, a Yarrow extract, and a melilot extract.

Further, in order to impart various medicinal effects to the external preparation for skin of the present invention, medicinal ingredients other than the above-mentioned essential components [eg, skin activating ingredients, amino acids other than alanine (eg, glycine, valine, leucine, isoleucine) ,
Neutral amino acids such as serine, threonine, tryptophan, cystine, cysteine, methionine, proline, and hydroxyproline; acidic amino acids such as aspartic acid, glutamic acid, asparagine, and glutamine; and basic amino acids such as arginine, histidine, lysine, and hydroxylysine. No. Also, as amino acid derivatives,
For example, sodium acyl sarcosine (sodium lauroyl sarcosine), acyl glutamate, acyl β
-Sodium alanine, glutathione, pyrrolidonecarboxylic acid and the like. ), Vitamins (for example, vitamins A, B ₁ , B ₂ , B ₆ , C, E and derivatives thereof, pantothenic acid and derivatives thereof, biotin, etc.)] are incorporated into the skin external preparation of the present invention. be able to.

The external preparation for skin of the present invention includes pharmaceuticals, quasi-drugs (ointments, etc.) and cosmetics (basic cosmetics such as facial cleansers, emulsions, creams, gels, essences (cosmetics), pack masks, etc .; foundations, lipsticks) And other makeup cosmetics; aromatic cosmetics, body cosmetics, etc.]. The form that the external preparation for skin of the present invention can take is not limited to these forms.

The dosage forms are aqueous, solubilizing, emulsifying, powder, oil-liquid, gel, ointment, aerosol,
A wide range of dosage forms such as a water-oil two-layer system and a water-oil-powder three-layer system can be adopted. In the skin preparation for external use of the present invention, it is possible to use a widely known base component or the like depending on the desired form or dosage form in a wide range as long as the intended effect of the present invention is not impaired by its combination. it can.

That is, liquid fats and oils, solid fats and oils, waxes,
Ester oil, hydrocarbon oil, silicone, anionic surfactant, cationic surfactant, amphoteric surfactant, lipophilic nonionic surfactant, hydrophilic nonionic surfactant, lower alcohol, sterols, water soluble Polymer, sequestering agent, neutralizer, pH adjuster, antioxidant, antibacterial,
Fragrances, pigments and the like can also be incorporated into the external preparation for skin of the present invention as long as the desired effects of the present invention are not impaired.

Examples of the powder component include talc, kaolin, mica, sericite (sericite), muscovite, phlogopite,
Synthetic mica, mica, biotite, lithia mica, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, zeolite , Barium sulfate, calcined calcium sulfate (baked gypsum), calcium phosphate, fluoroapatite, hydroxyapatite, ceramic powder, metal soap (zinc myristate, calcium palmitate, aluminum stearate), inorganic powder such as boron nitride, polyamide resin powder ( Nylon powder), polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, benzoquanamine resin powder, polytetrafluoroethylene powder, cellulo Organic powders scan powder such as titanium dioxide, inorganic white pigments such as zinc oxide,

Inorganic red pigments such as iron oxide (iron oxide) and iron titanate; inorganic brown pigments such as γ-iron oxide; inorganic yellow pigments such as yellow iron oxide and loess; black iron oxide; carbon black; Inorganic black pigments such as titanium oxide, inorganic violet pigments such as mango violet and cobalt violet, inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; inorganic blue pigments such as ultramarine blue and navy blue; titanium oxide Coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, pearl pigments such as fish scale foil, aluminum powder, metal powder pigments such as copper powder, red No. 201, red No. 202 , Red 2
04, Red 205, Red 220, Red 226,
Red No. 228, Red No. 405, Orange No. 203, Orange No. 20
Organic pigments such as No. 4, Yellow 205, Yellow 401 and Blue 404, Red No. 3, Red No. 104, Red No. 106
No. Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 2
Organic pigments such as zirconium, barium or aluminum lakes such as No. 02, Yellow No. 203, Green No. 3 and Blue No. 1, and natural pigments such as chlorophyll and β-carotene. However, any powder can be used as long as it can be applied to general cosmetics, and is not limited to the above components.

Examples of liquid fats and oils include avocado oil,
Camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, linseed oil, safflower oil, cottonseed oil, eno oil, Soybean oil, peanut oil, teaseed oil, kaya oil, rice bran oil, sinagiri oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin,
Glycerin trioctanoate, glycerin triisopalmitate and the like can be mentioned.

Examples of solid fats and oils include cocoa butter, coconut oil, horse fat, hardened coconut oil, palm oil, tallow, sheep fat, hardened tallow, palm kernel oil, lard, beef bone fat, mokuro kernel oil, hardened kernel oil Oil, beef tallow, mocro, hardened castor oil and the like.

Examples of waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ibota wax, whale wax, montan wax, nuka wax, lanolin, kapok wax, lanolin acetate, liquid lanolin,
Sugar cane wax, isopropyl lanolin fatty acid, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether and the like. Can be

Examples of the hydrocarbon oil include liquid paraffin, ozokerite, squalene, pristane, paraffin, ceresin, vaseline, microcrystalline wax and the like.

The higher fatty acids include, for example, lauric acid, myristic acid, palmitic acid, stearic acid, behenic (behenic) acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tallic acid, isostearic acid, linoleic acid, linoleic acid Acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and the like.

The higher alcohols include, for example, linear alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, monostearyl glycerin ether (bacyl alcohol), and 2-decyltetradecyl. And branched-chain alcohols such as knol, lanolin alcohol, cholesterol, phytosterol, hexyldecanol, isostearyl alcohol, octyldodecanol, and the like.

Examples of synthetic ester oils include isopropyl myristate, cetyl octoate, octyl dodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyl decyl dimethyl octanoate, Cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexylate, fatty acid ester of dipentaerythritol, N-alkyl glycol monoisostearate, neodicaprate Pentyl glycol, diisostearyl malate, glycerin di-2-heptylundecanoate, trimethylol tri-2-ethylhexylate Bread, trimethylolpropane triisostearate, pentaneerythritol tetra-2-ethylhexylate, glycerin tri-2-ethylhexylate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, trimyristate Glycerin, tri-2-heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleic acid oil, cetostearyl alcohol, acetoglyceride, palmitic acid 2-
Heptylundecyl, diisobutyl adipate, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, ethyl acetate, butyl acetate, amyl acetate, triethyl citrate and the like.

Examples of the silicone include cyclic polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane and methylhydrogenpolysiloxane, and cyclic polysiloxanes such as decamethylpolysiloxane, dodecamethylpolysiloxane and tetramethyltetrahydrogenpolysiloxane. Examples include polysiloxane, silicone resin and silicone rubber forming a three-dimensional network structure.

Examples of the anionic surfactant include soap base materials, fatty acid soaps such as sodium laurate and sodium palmitate, higher alkyl sulfates such as sodium lauryl sulfate and lauryl sulfate K,
POE lauryl sulfate triethanolamine, alkyl ether sulfates such as POE lauryl sodium sulfate, N-acyl sarcosine acids such as lauroyl sarcosine sodium, N-myristoyl-N-methyltaurine sodium, coconut oil fatty acid methyltauride sodium,
Higher fatty acid amide sulfonates such as sodium lauryl methyl tauride, POE oleyl ether sodium phosphate, phosphate ester salts such as POE stearyl ether phosphoric acid, sodium di-2-ethylhexyl sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene Sulfosuccinates such as sodium sulfosuccinate and lauryl polypropylene glycol sodium sulfosuccinate;

Alkyl benzene sulfonates such as sodium linear dodecylbenzenesulfonate, triethanolamine linear dodecylbenzenesulfonate and linear dodecylbenzenesulfonate, monosodium N-lauroylglutamate, disodium N-stearoylglutamate, N-myristoyl-L N-acyl glutamates such as monosodium glutamate, higher fatty acid ester sulfates such as hydrogenated coconut fatty acid sodium glycerin sulfate, sulfated oils such as funnel oil, POE alkyl ether carboxylic acid, POE alkyl allyl ether carboxylate, α-olefin sulfonate, higher fatty acid ester sulfonate, secondary alcohol sulfate, higher fatty acid alkylolamide sulfate, lauroyl monoeta Sodium Ruamidokohaku acid, N
-Palmitoyl aspartate ditriethanolamine, sodium caseinate and the like.

Examples of the cationic surfactant include alkyltrimethylammonium salts such as stearyltrimethylammonium chloride and lauryltrimethylammonium chloride, distearyldimethylammonium dialkyldimethylammonium chloride, and poly (N, N′-dimethyl-3, Alkylpyridinium salts such as 5-methylenepiperidinium) and cetylpyridinium chloride, alkyl quaternary ammonium salts, alkyldimethylbenzylammonium salts, alkylisoquinolinium salts, dialkylmorphonium salts, POE alkylamines, alkylamine salts, Examples thereof include polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalkonium chloride, benzethonium chloride and the like.

Examples of the amphoteric surfactant include 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium and 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyl. Imidazoline amphoteric surfactants such as roxy disodium salt, 2-heptadecyl-N-carboxymethyl-
N-hydroxyethyl imidazolinium betaine, lauryl dimethylamino acetate betaine, alkyl betaine,
Betaine-based surfactants such as amidobetaine and sulfobetaine are exemplified.

Examples of the lipophilic nonionic surfactant include sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, Sorbitan fatty acid esters such as penta-2-ethylhexyl diglycerol sorbitan, tetra-2-ethylhexyl diglycerol sorbitan, mono-cottonseed oil fatty acid glycerin, glycerin monoerucate, glycerin sesquioleate, glyceryl monostearate, α,
Glycerin polyglycerin fatty acids such as glycerin α'-oleate pyroglutamate and glyceryl monostearate; propylene glycol fatty acid esters such as propylene glycol monostearate; hydrogenated castor oil derivatives; glycerin alkyl ether;

Examples of the hydrophilic nonionic surfactant include POE sorbitan fatty acid esters such as POE sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate, and POE-sorbitan. Sorbit Monolaurate, POE-Sorbit Monooleate, POE
-POE sorbitol fatty acid esters such as sorbit pentaoleate and POE-sorbit monostearate, POE glycerin fatty acid esters such as POE-glycerin monostearate, POE-glycerin monoisostearate and POE-glycerin triisostearate; POE monooleate, POE distearate,
POE fatty acid esters such as POE monodioleate and ethylene glycol cysteate, POE lauryl ether, POE oleyl ether, POE stearyl ether, POE behenyl ether, POE alkyl ethers such as POE2-octyldodecyl ether, POE cholestanol ether, POE octyl POE alkyl phenyl ethers such as phenyl ether, POE nonyl phenyl ether, POE dinonyl phenyl ether, Bluronic type such as bruronic, POE.
POE / POP alkyl ethers such as POP cetyl ether, POE / POP2-decyltetradecyl ether, POE / POP monobutyl ether, POE / POP hydrogenated lanolin, POE / POP glycerin ether, and tetraPOE / tetraPOP ethylenediamine such as Tetronic Condensates,

POE castor oil, POE hardened castor oil, P
OE hydrogenated castor oil monoisostearate, POE hydrogenated castor oil triisostearate, POE hydrogenated castor oil monopyroglutamic acid monoisostearate diester, P
OE hardened castor oil POE castor oil hardened castor oil derivative such as maleic acid, POE beeswax lanolin derivative such as POE sorbitol beeswax, coconut fatty acid diethanolamide, alkanolamide such as lauric acid monoethanolamide, fatty acid isopropanolamide, POE propylene glycol Fatty acid ester, POE alkylamine, POE fatty acid amide, sucrose fatty acid ester, PO
E nonylphenylformaldehyde condensate, alkylethoxydimethylamine oxide, trioleyl phosphoric acid, and the like.

Examples of natural water-soluble polymers include, for example, gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed (quince), alge colloid (cassow extract), starch (rice, corn) , Potato, wheat), plant polymers such as glycyrrhizic acid, microbial polymers such as xanthan gum, dextran, succinoglucan, pullulan, collagen,
Animal-based polymers such as casein, albumin, and gelatin are exemplified.

As the semi-synthetic water-soluble polymer, for example,
Starch-based polymers such as carboxymethyl starch and methylhydroxypropyl starch, methylcellulose, nitrocellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, cellulose sodium sulfate, hydroxypropylcellulose, sodium carboxymethylcellulose (CM
C), cellulosic polymers such as crystalline cellulose and cellulose powder, and alginic acid polymers such as sodium alginate and propylene glycol alginate.

Examples of the synthetic water-soluble polymer include vinyl polymers such as polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone and carboxyvinyl polymer (Carbopol), polyethylene glycol 20,000, 4,000,000, and the like. Polyoxyethylene polymer such as 600,000, polyoxyethylene polyoxypropylene copolymer copolymer polymer, acrylic polymer such as sodium polyacrylate, polyethyl acrylate, polyacrylamide, polyethyleneimine, cationic polymer And the like.

Examples of the inorganic water-soluble polymer include bentonite, silicic acid A1Mg (Vegum), laponite, hectorite, silicic anhydride and the like.

Examples of the thickener include gum arabic,
Carrageenin, karaya gum, tragacanth gum, carob gum, quince seed (quince), casein, dextrin, gelatin, sodium pectate, sodium alginate, methylcellulose, ethylcellulose,
CMC, hydroxyethylcellulose, hydroxypropylcellulose, PVA, PVM, PVP, sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, dialkyldimethylammonium cellulose sulfate, xanthan gum, aluminum magnesium silicate, bentonite,
Hectorite and the like.

As the sequestering agent, for example, 1-
Hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, tetrasodium edetate, sodium citrate, sodium polyphosphate, metaphosphoric acid Examples include sodium, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid and the like.

As the lower alcohol, for example, methanol, ethanol, propanol, isopropanol,
Isobutyl alcohol, t-butyl alcohol and the like.

Examples of the polyhydric alcohol include ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, and 2,3-butyl glycol.
Butylene glycol, pentamethylene glycol, 2-
Dihydric alcohols such as butene-1,4-diol, hexylene glycol and octylene glycol; trihydric alcohols such as glycerin, trimethylolpropane and 1,2,6-hexanetriol; and tetrahydric alcohols such as pentaerythritol Pentahydric alcohols such as xylitol, sorbitol, hexahydric alcohols such as mannitol,
Polyhydric alcohol polymers such as diethylene glycol, dipropylene glycol, triethylene glycol, polypropylene glycol, tetraethylene glycol, diglycerin, polyethylene glycol, triglycerin, tetraglycerin, and polyglycerin;

Ethylene glycol monomethyl ether,
Ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono 2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, ethylene glycol isopropyl ether, ethylene glycol Dihydric alcohol alkyl ethers such as dimethyl ether, ethylene glycol diethyl ether and ethylene glycol dibutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, die Len glycol butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol Dihydric alcohol alkyl ethers such as propylene glycol ethyl ether and dipropylene glycol butyl ether,

Ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diadibate, ethylene glycol disuccinate, diethylene glycol monoethyl ether acetate, diethylene glycol mono Dihydric alcohol ether esters such as butyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, propylene glycol monophenyl ether acetate, xyl alcohol, seralkyl alcohol, and batyl alcohol Glycerin mono-alkyl ether,
Sorbitol, maltitol, maltotriose, mannitol, sucrose, erythritol, glucose, fructose, amylolytic sugar, maltose, xylitolose, sugar alcohols such as amylolytic sugar reducing alcohol,
Glysolid, tetrahydrofurfuryl alcohol,
POE tetrahydrofurfuryl alcohol, POP butyl ether, POP / POE butyl ether, tripolyoxypropylene glycerin ether, POP glycerin ether, POP glycerin ether phosphoric acid, PO
P. POE pentane erythritol ether and the like.

Examples of the monosaccharide include tricarbonates such as D-glyceryl aldehyde and dihydroxyacetone, tetracarbons such as D-erythrose, D-erythrulose, D-threose and erythritol, L-arabinose, D-xylose, and the like. Pentoses such as L-lyxose, D-arabinose, D-ribose, D-ribulose, D-xylulose, D-xylulose, D-glucose, D-talose, D-
Psicose, D-galactose, D-fructose, L
-Hexoses such as galactose, L-mannose, D-tagatose, heptose such as aldoheptose and heptulose;
Octanose such as octulose, 2-deoxy-D-ribose, 6-deoxy-L-galactose, 6-deoxy-
Deoxy sugars such as L-mannose, D-glucosamine, D
-Amino sugars such as galactosamine, sialic acid, aminouronic acid and muramic acid, and uronic acids such as D-glucuronic acid, D-mannuronic acid, L-guluronic acid, D-galacturonic acid and L-iduronic acid.

The oligosaccharides include, for example, sucrose, guntianose, umbelliferose, lactose, brantose, isoliqunoses, α, α-trehalose,
Raffinose, liqunoses, umbilicin, stachyose bell bath courses and the like.

Examples of the polysaccharide include cellulose, quince seed, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, gum arabic, heparan sulfate, hyaluronic acid, tragacanth gum, keratan sulfate, chondroitin, xanthan gum, mucoitin sulfate, guar gum, dextran Keratosulfuric acid, locust bean gum, succinoglucan, caronic acid and the like.

As the organic amine, for example, monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methyl-1 -Pronol and the like.

As the synthetic resin emulsion, for example,
An acrylic resin emulsion, a polyethyl acrylate emulsion, an acrylic resin liquid, a polyacryl alkyl ester emulsion, a polyvinyl acetate resin emulsion, and the like are included.

Examples of the pH adjusting agent include buffers such as lactic acid-sodium lactate and citric acid-sodium citrate.

Examples of the antioxidant include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, gallic esters and the like.

As the antioxidant aid, for example, phosphoric acid,
Examples thereof include citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, kephalin, hexametaphosphate, phytic acid, and ethylenediaminetetraacetic acid.

These base components can be combined in the skin external preparation of the present invention in an appropriate combination in accordance with the formulation according to the desired form. The specific prescription of the skin external preparation of the present invention will be described in Examples described later.

[0058]

EXAMPLES The present invention will be described more specifically with reference to examples and the like. However, it should not be construed that the technical scope of the present invention is limited by these examples.
In addition, in this example and the like, the blending amount represents the weight% in the object to which the component is blended, unless otherwise specified.
First, a skin external preparation (lotion) of the present invention having the following formulation was prepared by completely dissolving these components in purified water.

[Example 1] Lotion Lotion Ingredients% by weight Ethanol 10.0 Carboxyvinyl polymer 0.3 POE (15) Oleyl ether 0.8 Glycerin 1.0 DL-alanine 5.0 Methylparaben 0.1 Purified water residue Extra

Acne Prevention Effect Judgment Test The acne prevention effect of the skin external preparation of the present invention of Example 1 was determined by the following method (a skin external preparation from which DL-alanine was removed from the formulation of Example 1 below was used as a control). And). The test subjects were men and women in their teens and twenties suffering from acne, and 20 subjects in each group applied the test article to the cheeks of the face twice a day (morning and evening), and performed a continuous test for 4 weeks. After the continuous use test, the acne prevention effect was evaluated based on the following criteria based on the sight of the subject himself.
The effective rate per subject was determined.

<Evaluation Criteria> Significant effect: The number and size of acne were significantly reduced, and symptoms were improved. Effective: reduced the number and size of acne and reduced symptoms. Somewhat effective: There was a tendency to reduce the number and size of acne. No effect: The number and size of acne were not reduced or worsened.

Here, the results of this test are described. Example 1 Alanine-extracted product Male Female Male Female Significantly effective 3 550 1 Effective 6 8 6 2 Slightly effective 9 4 5 5 No effect 2 3 9 12 Effective rate (the ratio of “effective or more” to the whole) 45% 65% 30% 15%

From these results, it has been clarified that it is possible to exert an acne-preventing effect by incorporating alanine as an active ingredient in an external preparation for skin.

Hereinafter, formulation examples of the skin external preparation of the present invention will be further described. In addition, when the above-mentioned test for judging the effect of acne was carried out on these external preparations for skin of the present invention, an effective rate of 70% or more was recognized in both men and women.

Example 2 Cream Ingredients% by Weight Stearic Acid 2.0 Stearyl Alcohol 7.0 Hydrogenated Lanolin 2.0 Squalane 5.0 2-Octyldodecyl Alcohol 6.0 POE (25) Cetyl Alcohol Ether 0 Glycerin monostearate 2.0 1,3-butylene glycol 5.0 Edetate trisodium 0.1 L-alanine 5.0 Sodium glycyrrhetinate 0.1 Vitamin E acetate 0.3 Ethyl paraben 0.3 Purification Water residue

<Preparation method> 1,3-butylene glycol, trisodium edetate, and L-alanine were added to purified water, and the mixture was maintained at 70 ° C to obtain an aqueous phase. In addition, other components were mixed, heated and melted, kept at 70 ° C., and this was made into an oil phase. The oil phase was added to the water phase to carry out preliminary emulsification, and after uniform emulsification with a homomixer, the mixture was cooled to 30 ° C. and filled to obtain a cream.

Example 3 Lotion Formulation Component Weight% (Phase A) Sorbitol 3.0 Glycerin 3.0 Resorcin 0.02 DL-Alanine 1.0 Purified Water Residue (Phase B) POE (60) Cured Castor Oil 0.5 Methyl paraben 0.1 Ethanol 20.0

<Production Method> Each component of phase A was mixed and dissolved, and a mixed solution of phase B was added thereto with stirring to prepare a lotion as a homogeneous solution.

Example 4 Packing Ingredients% by Weight (Phase A) Polyvinyl Alcohol 12.0 Glycerin 3.0 Polyethylene Glycol 1500 1.0 L-Alanine 10.0 Purified Water Residue (Phase B) Ethanol 10.0 POE (15) Oleyl alcohol ether 2.0 Methyl paraben 0.2

<Production Method> Each component of phase A was heated to 70 ° C. and dissolved by stirring, and a mixed solution of phase B was uniformly mixed with stirring, cooled, and filled to prepare a pack.

Example 5 Emulsion Emulsion Ingredients% by Weight Stearic Acid 2.5 Cetyl Alcohol 1.5 Vaseline 5.0 Liquid Paraffin 10.0 POE (10) Monooleate 2.0 Polyethylene Glycol 1500 3.0 Tri Ethanolamine 1.0 L-alanine 3.0 sodium bisulfite 0.01 ethyl paraben 0.3 carboxyvinyl polymer 0.05 purified water residue

<Production method> A carboxyvinyl polymer was dissolved in a small amount of purified water (phase A). Polyethylene glycol 1500, triethanolamine and L-alanine were added to the remaining purified water, and dissolved by heating to 70 ° C (aqueous phase). Further, other components were mixed and dissolved and kept at 70 ° C. (oil phase). The oil phase was added to the water phase to perform preliminary emulsification, the phase A was added, and the mixture was uniformly emulsified with a homomixer, cooled to 30 ° C. and filled to obtain an emulsion.

[0073]

According to the present invention, there is provided an external acne-preventing skin preparation having an excellent acne-preventing effect.

Claims (3)

[Claims] 1. An alanine compounded as an active ingredient.
An external preparation for acne prevention. 2. The composition according to claim 1, wherein the content of alanine is 0.001% by weight or more and 20.0% by weight or less based on the external preparation for skin.
The external preparation for acne according to the above description. 3. The external preparation for acne according to claim 1, wherein the content of alanine is 0.01% by weight or more and 10.0% by weight or less based on the external preparation for skin.