JPH11158062A - Cataplasm for interdigital dermatophytosis - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a cataplasm for interdigital dermatophytosis that has good stickiness to interdigital areas, sufficiently covers the diseased parts and retain the adhesion to the diseased parts without detachment for hours. SOLUTION: This cataplasm for interdigital dermatophytosis comprises the base layer and the adhesive layer that contains an antifungal agent and is supported by the base layer. The cataplasm has the dimension ranging from 5 mm to 15 mm in the widthwise direction at maximum and from 10 mm to 30 mm in the lengthwise direction at maximum. In addition, this cataplasm has a 10% modulus of less than 2.0 N/11 mm.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a patch for athlete's foot, and more particularly, it has excellent adhesive properties, is hardly peeled off during use, and has good concealing properties and operability of an affected part, and has adhesive residue and skin. The present invention relates to a non-irritating patch for athlete's foot.

[0002]

2. Description of the Related Art In general, powdery, liquid, ointment and other athlete's foot drugs are used for treating athlete's foot between toes (between toes). However, these athlete's foot drugs are (1) difficult to apply uniformly and thickly to the skin surface of the affected area. (2) After administration to the skin surface, they adhere to socks, clothes, floors, etc. and fall off. There are drawbacks such as a lack of sustained drug efficacy and (3) poor penetration into the skin. Also, due to these drawbacks, several times a day dosing is required to obtain a sufficient medicinal effect with the athlete's foot drug.

[0003] Furthermore, since ointments (creams) are handled directly by hand, they have to touch the affected area which is extremely contaminated with bacteria during administration. As a result, there has been a problem that the athlete's foot fungus easily infects other parts and various bacteria are easily attached to the affected part. The liquid athlete's foot medicine can be administered without touching the affected part by devising the shape of the container or by using a spray, but it is difficult to adjust the application amount and the application range uniformly.

Conventionally, in order to improve the above-mentioned drawbacks of athlete's foot medicine, a patch for athlete's foot having a drug layer containing athlete's foot medicine, rubber and a tackifier on a support (base) has been proposed. (Japanese Patent Publication No. 55-38927). Since this patch for athlete's foot is used by attaching it to the affected area, it has advantages such as continuous drug efficacy, good penetration into the skin, and no transfer of the drug to socks and clothes. I have. In addition, the patch for athlete's foot is easy to apply, can prevent infection of other parts of the athlete's foot after application, and can prevent invasion of other malignant bacteria to the affected area. However, since the interdigital part has a complicated three-dimensional shape and, in many cases, the affected part is in a narrow part between the fingers, the patch for athlete's foot should be stuck to the affected part in close contact with the affected part. Is difficult.

[0005] Therefore, patches for athlete's foot and therapeutic aids of various shapes and structures have been conventionally proposed in order to facilitate application to the space between toes. For example, Japanese Utility Model Laid-Open No. 63-1409
No. 26 proposes an emergency bandage in which a pad wider than the width of the central portion is adhered to the central portion of the adhesive tape, and the adhesive tape is formed with a notch-shaped constricted portion. In this first-aid bandage, a pad is pressed against the affected area between the toes, and the wide ends of the adhesive tape are adhered to the instep surface and the bottom surface of the foot. Japanese Utility Model Laid-Open Publication No. 63-180029 discloses that a wide sticking portion is formed at the front end side at the center of both end pieces of a rectangular pressure-sensitive adhesive sheet piece, and a narrow sticking portion is formed at the base end side. An adhesive tape for athlete's foot has been proposed in which end pieces of the adhesive sheet formed in the part are integrally connected, and a wide pad is stuck on a central adhesive sheet piece. In this adhesive tape for athlete's foot, a pad is pressed against the affected part, and the wide sticking part is adhered to the instep surface and the bottom surface of the foot.

[0006] Further, a treatment member for tinea pedis, in which adhesive tapes are disposed at both ends of a water-absorbing zone made of a water-absorbing material (Japanese Utility Model Application Laid-Open No. 64-56226), a fibrous material having moisture absorption and water absorption, and an adhesive tape Auxiliary dry pad for treating athlete's foot combined with (Japanese Utility Model Laid-Open No. 1-138420), a toe dry zone for preventing athlete's foot having adhesive strips attached to both ends of a dry zone such as gauze (Japanese Utility Model Laid-Open No. 3-9721) A treatment for athlete's foot tobacco that has a water-absorbing polymer inside a string made of highly hygroscopic fiber having deodorant and antibacterial properties and both ends of which are fastened with adhesive tape (Jitsuhei) No. 6-20500), a pad is stuck to the center of the bandage, and a cut is formed in the remaining portion of the bandage along the length direction from the end to the pad, and the pad is cut from both sides perpendicular to the cut. Notch along It has been proposed, such as the provided bandages (Utility Model Registration Publication No. 3003260).

[0007] However, all of these known patches have disadvantages in that, in addition to their complicated shape and structure, they cannot be reliably maintained in the adhered state. That is, in each of the above-mentioned patches, a pad or the like is pressed against the affected area between the toes, and the adhesive surfaces of the adhesive tape at both ends are adhered to the instep surface and the bottom surface of the foot, in some cases, to the toes, Then, in order to securely attach the adhesive tape, the sticking portion of the adhesive tape is widened or a cut is made in the sticking portion. However, patches that have a large area to be applied to the back of the foot or the bottom of the foot may have various effects after application, due to complex movements of the back, bottom of the foot, fingers, or contact with socks or the floor. It was found that they were easily peeled off or loosened and the adhesion between the toes to the affected area was impaired.

[0008]

SUMMARY OF THE INVENTION An object of the present invention is to provide a patch having an adhesive layer containing an antifungal agent formed on a support, which has good adhesion to the interdigital region, It is an object of the present invention to provide a patch for athlete's foot athlete's foot, which can maintain the applied state without falling off over a long period of time while sufficiently concealing it. Another object of the present invention is to provide a patch for athlete's foot athlete's foot, which has good usability and has no adhesive residue or skin irritation. It is a further object of the present invention to provide an athlete's foot patch that can be applied without touching the affected area and that can accurately administer a fixed amount of drug.

The present inventors have conducted intensive studies to overcome the problems of the prior art, and as a result, have found that a patch having an antifungal drug-containing pressure-sensitive adhesive layer formed on a support can be used as a back of the foot. And it is a size that does not substantially protrude on the bottom of the foot,
In addition, the patch for athlete's foot athlete's foot, which has good usability and adhesion to the affected area when it is reduced to a size that can hide the affected area between the toes, is hard to peel off during use, and can maintain the medicinal effect for a long time Was found.

Conventionally, a patch for athlete's foot is securely applied,
In order to prevent peeling, the area of application to the back of the foot, the bottom of the foot, and even the toes was enlarged, but in such a method, it was easy to peel, rather the area of the entire patch It is unexpected that peeling becomes difficult when the value is reduced. The patch for athlete's foot athlete's foot of the present invention has a simple structure, such as a rectangular or oval shape, without any complicated structure. Furthermore, the patch for athlete's foot or foot athlete's foot of the present invention has no adhesive residue or skin irritation. The present invention has been completed based on these findings.

[0011]

According to the present invention, there is provided a patch having a pressure-sensitive adhesive layer containing an antifungal agent formed on a support, wherein the maximum length of the patch in the width direction is 5%. Within the range of ~ 15mm, and the maximum length in the length direction is 10 ~ 30mm
The patch for athlete's foot is characterized by being within the range. The patch has a 10% modulus of 2.0N.
/ 11 mm or less.

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION The support used in the present invention is preferably a flexible or stretchable film, nonwoven fabric or woven fabric. The support is 10
Those having a% modulus of 2.0 N / 11 mm or less are preferred. When a patch having an excessively large 10% modulus is applied to an affected area, a strong stress is applied to even a slight displacement of the skin at the application site, and as a result, peeling, skin irritation, and adhesive residue are likely to occur. The 10% modulus of the patch is more preferably 0.1 to 2.0 N / 11 m.
m, more preferably in the range of 0.3 to 1.8 N / 11 mm.

As the support, for example, films such as polyethylene films and polyurethane films; nonwoven fabrics such as polyester nonwoven fabric, polyurethane nonwoven fabric, styrene-hydrogenated isoprene-styrene block copolymer nonwoven fabric;
Woven fabrics such as polyester woven fabric and rayon woven fabric; Further, a nonwoven fabric or a woven fabric can be used by laminating with a film in order to prevent volatilization due to permeation of a drug. The film may be laminated with an aluminum foil or a vapor-deposited aluminum film.

The antifungal used in the present invention is not particularly limited as long as it has an antifungal action.
Halogenated phenol antifungals, antibiotic antifungals, fatty acid antifungals, naphthiomate antifungals, imidazole antifungals, allylamine antifungals, morpholine antifungals, triazole antifungals And the like. The amount of the antifungal agent is not particularly limited, but is usually used in the range of 0.01 to 10 parts by weight based on 100 parts by weight of the adhesive.

The pressure-sensitive adhesive used in the present invention includes an acrylic pressure-sensitive adhesive, a rubber-based pressure-sensitive adhesive, a silicone-based pressure-sensitive adhesive and the like, and is selected as needed according to adhesion, skin irritation, drug efficacy and the like. Examples of the acrylic pressure-sensitive adhesive include homopolymers or copolymers of acrylate monomers such as butyl acrylate, isononyl acrylate, 2-ethylhexyl acrylate, and 2-hydroxyethyl acrylate, and acrylate-based monomers thereof. Copolymers of monomers with other monomers such as vinyl acetate, acrylic acid and the like can be mentioned. Examples of the rubber-based pressure-sensitive adhesive include a composition in which a tackifier resin, a softener, and the like are blended with a rubber base such as a polyisoprene rubber or a styrene-isoprene-styrene block copolymer. If necessary, additives such as an antioxidant, a transdermal absorption enhancer, and a filler can be added to the pressure-sensitive adhesive.

The patch having the antifungal drug-containing pressure-sensitive adhesive layer formed on the support is prepared by applying an antifungal drug-containing pressure-sensitive adhesive solution onto the support in accordance with a conventional method, followed by drying. Can be made. Alternatively, the patch may be prepared by applying a pressure-sensitive adhesive solution on a temporary support that has been subjected to a release treatment, drying it, and then transferring it onto the support. The patch for athlete's foot athlete's foot of the present invention can be usually obtained by cutting the patch obtained above into a predetermined size using a punching die. The shape of the patch for athlete's foot toads of the present invention is not particularly limited, but is preferably rectangular, elliptical, oval, octagonal, or the like. In terms of remarkably excellent peeling resistance, an ellipse (a) as shown in FIG.
It is more preferable that the rectangular shape has no acute angle portion smaller than a right angle, such as an octagon (c) in which the corners at both ends are cut.

In the patch for athlete's foot, the patch of the present invention has a maximum length in the width direction of 5 to 15 mm and a maximum length in the length direction of 10 to 30 mm. It is necessary. Here, the width direction of the patch corresponds to the width direction between the toes (interval between the fingers), and the length direction corresponds to the length direction between the toes (from the instep to the sole). The maximum length in each direction corresponds to the length of each piece when the shape of the patch is rectangular, but means the longest width in the width direction and the length direction when the patch is elliptical. I do.

The maximum length in the width direction of the patch for athlete's foot is 5
If it is less than mm, it is difficult to sufficiently cover the diseased part of athlete's foot when applied to the intertoes of an average adult, and if it exceeds 15 mm, peeling due to turning over tends to occur. The maximum length in the width direction is preferably 7 to 13
mm. If the maximum length in the length direction of the patch for athlete's foot is less than 10 mm, it is difficult to sufficiently cover the diseased part of athlete's foot on the basis of the average adult, and it is also too small to handle easily. Difficult to apply accurately to parts. If the maximum length in the length direction exceeds 30 mm, an extra sticking portion is formed on the back side of the foot or the bottom side of the foot, and this portion is the most movable portion around the toe, so it is strong during sticking. It is stressed and causes peeling, skin irritation and glue residue. The maximum length in the length direction is preferably 12 to 26 mm. The patch for athlete's foot athlete's foot of the present invention is preferably placed in a packaging bag or box or the like in which many pieces are temporarily attached to release paper, and stored, transported,
Can be sold. FIG. 1 is a schematic view showing a case where the patch for athlete's foot is affixed between toes.

[0019]

The present invention will be described more specifically below with reference to examples and comparative examples. Methods for measuring physical properties and various properties are as follows. (1) 10% modulus JIS K7113 “Plastic tensile test method”
According to the above, the specified strain yield strength was measured, and the modulus value was calculated. Specifically, width 11mm, length 50m
The tensile stress when the patch of m was distorted by 10% in the length direction was measured and defined as a 10% modulus value. (2) Adhesiveness The patch was applied to the third and fourth interdigital regions of healthy adult feet, and after 24 hours of daily life, the adhesiveness was evaluated according to the following criteria. ：: Almost no peeling after 24 hours. ×: Pretty peeling or falling off during 24 hours. (3) Glue residue The patch was applied between the third and fourth toes of a healthy adult foot, peeled off after 24 hours, and the state of the glue residue was observed and evaluated according to the following criteria. ：: No glue remaining ×: Glue remaining (4) Concealing Property of Affected Area The patch was applied to the third and fourth interdigital parts of healthy adult feet, and the concealing property of the affected area was evaluated according to the following criteria. However, the size of the affected part is 4m in width from the observation result of the athlete's foot patient.
m, length 8 mm, and the size was previously marked on the interdigital region. ：: sufficiently concealed, ×: part of the affected part is exposed. (5) Usability (Ease of Use) The patch was applied to the third and fourth interdigital parts of healthy adult feet, and the usability was evaluated according to the following criteria. ：: It was stuck to the affected part neatly. ×: It was not stuck to the affected part neatly. (6) Skin irritation The patch was applied to the third and fourth interdigital parts of healthy adult feet, and the skin irritation was evaluated according to the following criteria. ：: No irritation was observed. ×: Skin irritation such as redness or edema was observed.

Example 1 Styrene-isoprene-styrene block copolymer (JSR 5 manufactured by Nippon Synthetic Rubber Co., Ltd.)
000) 52 parts by weight, isoprene rubber (manufactured by Kuraray Co., Ltd., I
R-10) 48 parts by weight, 150 parts by weight of an alicyclic saturated hydrocarbon resin (manufactured by Arakawa Chemical Industries, Inc., Alcon P125), and liquid isoprene rubber (manufactured by Kuraray Co., LIR-30) 3
0 parts by weight were dissolved in 420 parts by weight of a mixed solution of toluene and hexane, and then 2.8 parts by weight of an anti-tineamyces drug (econazole nitrate) dissolved in 17 parts by weight of methanol was added.
After stirring, an adhesive solution was prepared. This pressure-sensitive adhesive solution is applied to a release-treated surface of polyethylene terephthalate (Lumirror, manufactured by Toray Industries, Inc., thickness: 75 μm) with a uniform thickness using an applicator, and then dried at 120 ° C. for 3 minutes. To remove the solvent. The thickness of the pressure-sensitive adhesive layer after drying was 50 μm. Surface of adhesive layer (adhesive surface)
Then, a flexible urethane nonwoven fabric is laminated, and 4k
The pressure-sensitive adhesive sheet was pressed at a pressure of g to produce an adhesive sheet. From the pressure-sensitive adhesive sheet obtained in this way, using a punch, a width of 8 m
A rectangular test piece having a length of 15 mm and a length of 15 mm was prepared. Table 1 shows the shape of the patch and the results.

[Examples 2 to 5 and Comparative Examples 1 to 5] Except that the type of the urethane nonwoven fabric of the support was changed and the shape and size of the patch were changed as shown in Table 1, Each patch was prepared in the same manner as in Example 1. Table 1 shows the results.

[0022]

[Table 1]

As is clear from the results in Table 1, the patch of the present invention has a maximum width in the range of 5 to 15 mm and a maximum length in the length direction of 10 to 30 mm. (Examples 1 to 5) have various shapes, all of which can sufficiently cover the diseased part when applied to the interdigital region. Good results were obtained in practical performance such as residual and irritation to the skin. On the other hand, the patch (Comparative Example 1) having a maximum length in the width direction of less than 5 mm could not cover the affected part, and could not expect a sufficient therapeutic effect. With the patch having a maximum length of 20 mm in the width direction (Comparative Example 2), although the affected area was sufficiently covered, the patch reached not only the center between the toes but also to the upper side of the toes, and peeled off due to daily activities. Was. A patch having a maximum length in the longitudinal direction of less than 10 mm (Comparative Example 3) was attempted to be administered to a narrow interdigital region, but failed several times. Furthermore, when the length direction is this size, the affected part cannot be covered sufficiently, and it has become clear that a sufficient therapeutic effect cannot be expected.

The patch having a maximum length in the length direction of 40 mm (Comparative Example 4) was too long, resulting in poor usability. Although the size in the width direction and the length direction can sufficiently cover the intertoes, a part of the size protrudes from the instep side and the bottom side of the foot.
Of the protruding part, especially the part on the back side of the foot,
Great stress was applied by walking and the like, and many peeling were observed. Also, due to this stress, many skin irritating reactions such as redness were observed in the affixed portion on the instep side of the foot after peeling, and at the same time, residual adhesive was observed. Patch with 10% modulus exceeding 2.0 N / 11 mm (Comparative Example 5)
Although both the maximum length in the width direction and the maximum length in the length direction were within the ranges specified in the present invention, strong stress was applied during application, and redness was observed in the central portion between toes after peeling.

[0025]

According to the present invention, there is provided an adhesive patch comprising an antifungal agent-containing pressure-sensitive adhesive layer formed on a support, which has good adhesion to the interdigital region and sufficiently covers the affected area. A patch for athlete's foot athlete's foot that can maintain an applied state without falling off for a long time while being provided. The patch for athlete's foot toes of the present invention has good usability and has no adhesive residue or skin irritation. The patch for athlete's foot or foot athlete's foot of the present invention can be applied without touching the affected area, and can accurately administer a certain amount of drug.

[Brief description of the drawings]

BRIEF DESCRIPTION OF DRAWINGS FIG. 1 is a schematic diagram of a case where a patch for athlete's foot is applied between toes.

FIG. 2 shows examples of the shape of the patch for athlete's foot of the present invention (a) to
It is a figure showing (c).

[Explanation of symbols]

 1: Patch for athlete's foot

Claims (2)

[Claims] 1. A patch comprising a support and a pressure-sensitive adhesive layer containing an antifungal agent formed thereon, wherein the maximum length of the patch in the width direction is within a range of 5 to 15 mm. A patch for athlete's foot athlete's foot, wherein the maximum length in the width direction is within a range of 10 to 30 mm. 2. The patch has a 10% modulus of 2.0 N /
The patch for athlete's foot athlete's foot according to claim 1, which is 11 mm or less.