JPH04272756A - Bag connecting body - Google Patents

Abstract

PURPOSE:To obtain the bag connecting body which decreases the liquid remaining in a bag on a supply side and in tubes at the time of liquid transfer by sealing a sterile and dust-free gas into the bag packed with the liquid. CONSTITUTION:The bag connecting body is filled with a red cell preserving liquid 35 in a platelet housing part 32 of the PC bag 30 before use and is sealed with the sterile and dust-free gas in the platelet housing part 32. This red cell preserving liquid includes, for example, S, A, G, M, liquid, etc. The gas to be sealed is exemplified by inert gases, such as argon, neon and helium, nitrogen, air, etc. The adverse influence that the gases exert on the liquid in the bag is eliminated if such gases are used and the gases are made dust-free and sterile. Further, the whole volume of the red cell preserving liquid 35 can be discharged without allowing the red cell preserving liquid 35 to remain in the platelet housing part 32 in the case of transfer of the red cell preserving liquid 35 to the blood taking bag 1.

Description

[Detailed description of the invention]

0001

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a bag connector.

0002

[Prior Art] When performing a blood transfusion, currently, for reasons such as effective use of blood and reducing the burden on the recipient, the blood obtained from the donor is separated into its components by centrifugation, etc. A system is in place to only transfuse blood for patients who have been diagnosed with cancer. With the introduction of this component transfusion, blood can be used more effectively than the conventional whole blood transfusion.

[0003] In such blood component transfusions, a bag assembly (multiple bag) consisting of a blood collection bag and one or more other bags is used.

[0004] An example of this multiple bag is:
A blood collection bag, a platelet storage bag (hereinafter referred to as PC bag), a plasma storage bag (hereinafter referred to as plasma bag), and an auxiliary bag for storing a buffy coat are connected with a tube, and blood is collected in the blood collection bag. The collected blood is centrifuged to separate it into three components: red blood cells, platelet concentrate, and platelet-poor plasma, and these are separated into blood collection bags,
Store in PC bag and plasma bag.

[0005] When storing red blood cells, useful components other than red blood cells are separated from the blood collection bag into child bags, and then a red blood cell storage solution is put into the blood collection bag in which the red blood cells are stored. The red blood cell preservation solution is placed in a PC bag, and is sent to a blood collection bag after plasma and buffy coat are separated. Thereafter, the platelet concentrate is transferred from the auxiliary bag, which has been centrifuged again, to the empty PC bag.

[0006] Here, the red blood cell preservation solution is transferred by positioning the PC bag higher than the blood collection bag and creating a head gap between the two bags. In liquid transfer using this method, the bag on the receiving side (blood collection bag)
Unless there is a large head difference between the bag (PC bag) and the bag on the supply side (PC bag), smooth and rapid liquid transfer cannot be achieved. Furthermore, since the bag is constructed by stacking sheet materials, an empty PC bag has a flat shape, but liquid remains between the contacting sheet materials due to the action of surface tension or the like. There is also some liquid left inside the tube.

On the other hand, in order to increase the head, it is necessary to lengthen the tube connecting the bags, which is troublesome to handle.

[0008] Remaining of the liquid causes problems such as an inappropriate mixing ratio of the red blood cell preservation solution to the red blood cells.Furthermore, when the platelet concentrate is transferred to the PC bag, the red blood cell preservation remaining in the tube or bag may cause problems. There were drawbacks such as the liquid coming into contact with the platelets and having an adverse effect on the stored platelets.

[0009] In addition, even with bag connectors used for other purposes, there are problems such as liquid remaining in the tube mixing with other liquids during transfer and changing the liquid composition. have.

0010

SUMMARY OF THE INVENTION It is an object of the present invention to provide a bag assembly in which less liquid remains in the bag or tube on the supply side during liquid transfer.

[0011]

[Means for Solving the Problems] Such objects are achieved by the present invention as described below. That is,

(1) It consists of a plurality of bags each having a storage section formed by stacking flexible sheet materials, and a tube that is connected to the storage section of each bag to connect each bag and to transfer liquid between the bags. , at least one of the bags is filled with a liquid, and the bag is filled with the liquid in a bag connecting body that transfers the liquid to another bag with the connection part of the tube facing downward. A connected bag characterized in that a sterile and dust-free gas is sealed inside the bag.

(2) The bag in which the gas is sealed is obtained by extracting the gas from the bag and quantitatively filling it with dust-free and sterile gas. body.

(3) Consisting of a plurality of bags in which storage sections are formed by stacking flexible sheet materials, and a tube that is connected to the storage section of each bag to connect the bags and to transfer liquid between the bags. , the bag filled with the liquid is positioned at a higher place than other bags with the connection part of the tube facing downward, and the bag is filled with the liquid in a bag connection body that transfers the liquid to the other bag. 1. A connected bag, characterized in that the bag is provided with a ventilation section for introducing gas into the bag, and the ventilation section is provided with a filter that removes dust and sterilization, and a sealing means that can be opened when necessary.

[0015]

[Operation] Since the storage portion of the bag filled with liquid is made of a flexible sheet material, deformations such as expansion and contraction easily occur depending on the amount of liquid in the bag.

[0016] Liquid transfer between bags via the tube is carried out by discharging the liquid inside the bag by positioning the bag filled with liquid at a high place or by pressing from the outside of the bag. It will be done.

[0017] If gas is sealed in the bag, a space will be formed in the storage section, so by placing the tube connection section on the bottom side, the liquid in the storage section can easily flow into the tube connection section. If the bag is left unattended, a certain amount of bulge will normally remain inside the bag, and a corresponding amount of liquid will remain. Almost all of the liquid is drained. Since the gas is sterile and dust-free, it does not adversely affect the liquid within the container.

In filling the gas, first, the gas in the container is extracted, and a dust-free and sterile gas is quantitatively filled.

On the other hand, if a ventilation portion communicating with the interior of the housing is provided, gas will flow into the housing when the liquid is discharged, and a similar effect can be obtained. When draining the liquid, first open the sealing means. Then, when the gas passes through the filter,
Bacteria and dust are removed and flow into the bag.

[0020] According to such a bag connection body, liquid can be transferred smoothly and quickly without providing a sufficient head.

[0021]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The blood bag connector of the present invention will be described in detail below based on preferred embodiments with reference to the accompanying drawings.

FIG. 1 shows a first embodiment of the bag connector according to the present invention. This bag connection body is constructed by connecting a blood collection bag, a PC bag, a plasma bag, and an auxiliary bag with a tube.

[0023] In FIG. 1, the blood collection bag 1 located on the right side is
Flexible sheet materials made of soft polyvinyl chloride (PVC) are layered and fused (for example, thermal fusion, ultrasonic fusion, etc.) at the seal portion 2 on the periphery to form a bag shape. .

[0024] In the inner part surrounded by this seal part 2,
A blood component storage section 3 is formed in which collected blood or concentrated red blood cells obtained from the blood by centrifugation are stored.

[0025] Two outlet ports 4, 4 each having a peel tab are formed in the upper part of the blood collection bag 1, and an outlet port 5 for connecting to another bag, which will be described later, is formed between them. There is.

One end of a tube 14 is connected to the discharge port 5 via a connecting member 15.

A first branch connector 20 that branches into two is connected to the other end of the tube 14. A tube 21 is further connected to the branch connector 20, and a second branch connector 22 is connected to the other end of the tube 21.

[0028] It is preferable to use a member for the connecting member 15 whose flow path is closed before it is broken, but which opens the flow path when it is broken. members can be used.

Further, one end of a flexible tube 6 is connected to the upper part of the blood collection bag 1 so as to communicate with the blood component storage section 3, and the other end of this tube 6 is connected to the blood collection bag 1 via a hub 7. A needle 8 is attached. Further, a cap 9 that encloses the blood collection needle 8 is attached to the hub 7 .

[0030] The blood component storage section 3 of the blood collection bag 1 contains an anticoagulant such as ACD liquid, CPD liquid, CPDA-1 liquid, etc. as necessary.

The plasma bag 10 located in the center of FIG. 1 is made by stacking sheet materials made of soft polyvinyl chloride, and sealing portions 11 on the periphery of the sheets are fused together (for example, thermal fusion, ultrasonic fusion). etc.) and made into a bag.

A plasma storage portion 12 is formed in the inner portion surrounded by the seal portion 11, in which plasma (particularly platelet-poor plasma) separated from the blood in the blood collection bag 1 is stored.

Two outlets 13, 13 with peel tabs are formed at the top of the plasma bag 10.

Furthermore, one end of a flexible tube 23 communicating with the plasma storage section 12 is connected to the side of the discharge port 13 at the top of the bag, and the other end of this tube 23 is connected to the side of the discharge port 13 at the top of the bag. Connected to one branch end. As a result, the blood component storage section 3 of the blood collection bag 1 and the plasma storage section 12 of the plasma bag 10 are connected to the tubes 14, 21,
23 and branch connectors 20 and 22.

The PC bag 30 located on the left side of FIG. 1 is made by stacking sheet materials made of soft polyvinyl chloride, etc.
At the seal portion 31 on the periphery, it is fused (for example, thermal fusion, ultrasonic fusion, etc.) to form a bag-like shape.

[0036] A platelet storage part 32 is formed in the inner part surrounded by this seal part 31, in which platelets separated from blood are stored.

Two outlet ports 33, 33 with peel tabs are formed at the top of the PC bag 30. Furthermore, an outlet 34 for connecting to another bag is formed on the side of the outlet 33 at the top of the bag.

One end of a flexible tube 24 is connected to the discharge port 34 via a connecting member 25.

The other end of the tube 24 is connected to the other branch end of the branch connector 21. In addition,
The connecting member 25 may be the same as the sealing member used for the connecting member 15 described above. As a result, the platelet storage section 32 of the PC bag 30 and the blood component storage section 3 and plasma storage section 12 of the other bags 1 and 10 are connected to the tubes 14, 21, 24 and the branch connectors 20, 2.
2.

The auxiliary bag 40 located on the left side of the blood collection bag 1 in FIG. 1 is a bag mainly for storing a buffy coat. The auxiliary bag 40 is made of resin sheet materials stacked together and fused (for example,
(thermal fusion, ultrasonic fusion, etc.) and made into a bag shape.

[0041] A storage part 42 is formed in the inner part surrounded by the seal part 41, in which the buffy coat separated from the blood in the blood collection bag 1 is stored.

One end of a flexible tube 26 communicating with the storage section 42 is connected to the upper part of the auxiliary bag 40.
The other end of this tube 26 is connected to the first branch connector 2
Connected to the branch end of 0. As a result, the storage section 42 of the auxiliary bag 40 and the blood component storage section 3, plasma storage section 12, and platelet storage section 32 of the other bags 1, 10, and 30 are connected to the tubes 14, 21, 24, 26, and the branch connectors. 20 and 22.

Note that the branch connectors 20 and 22 are made of molded resin such as polyvinyl chloride or polycarbonate.

Next, the constituent materials, sizes, etc. of each bag and tube in the illustrated bag assembly will be explained.

The blood collection bag 1 is made of soft polyvinyl chloride. The use of flexible polyvinyl chloride provides flexibility to withstand centrifugation operations and heat resistance to sterilization.

The plasticizer that can be used in the blood collection bag 1 is not particularly limited, but di(ethylhexyl) phthalate (DEHP) is preferably used as the plasticizer.

[0047] By using this DEHP, when storing red blood cells, DEHP is eluted into the blood collection bag, and its protective effect on red blood cell membranes suppresses hemolysis, making it possible to store red blood cells for a long period of time.

The content of the plasticizer DEHP is preferably 30 to 70 parts by weight based on 100 parts by weight of polyvinyl chloride.

The reason is that if it is less than 30 parts by weight, the bag will have poor flexibility, and if it exceeds 70 parts by weight,
This is because the amount of plasticizer eluted into the bag increases and the strength also decreases.

Further, a stabilizer or the like may be added to the sheet material of the blood collection bag 1. Examples of the stabilizer include epoxy compounds and Ca-Zn stabilizers.

[0051] The thickness of the sheet material in the blood component storage section 3 of the blood collection bag 1 is preferably 0.30 to 0.40 mm.
, more preferably 0.35 to 0.40 mm.

[0052] If the thickness of the sheet material is less than 0.30 mm, sufficient strength will not be obtained, and if it exceeds 0.40 mm, the flexibility will decrease, which will affect the operability of blood collection and the ability to drain blood during blood transfusion. be.

[0053] The capacity of the blood collection bag 1 is not particularly limited, but is preferably about 50 to 600 ml, more preferably about 2 ml.
It is said to be about 00 to 500 ml.

[0054] Due to restrictions on the amount of blood to be collected, blood collection bags with a capacity of 200 ml or 400 ml are generally used.

[0055] The constituent material of the sheet material of the plasma bag 10 is not particularly limited, and may be the same as the blood collection bag 1 or the PC bag 30 described later, but is preferably DnDP.
Plasticized PVC or ethylene-vinyl acetate copolymer (
It is preferable to use a polyolefin material such as EVA).

[0056] The thickness of the sheet material in the plasma storage section 12 of the plasma bag 10 is preferably 0.20 to 0.4.
It should be about 5mm. The gas permeability of the plasma bag 10 is not particularly limited, and may be lower than the gas permeability of the PC bag 30 described below.

[0057] The size of the plasma bag 10 is also not particularly limited, but preferably has a capacity of about 100 to 400 ml.

The PC bag 30 is made of soft polyvinyl chloride. By using soft polyvinyl chloride, flexibility to withstand centrifugation operations and shaking storage and heat resistance to sterilization can be obtained, and wrinkles during centrifugation, which affect the dispersibility of platelets, are less likely to occur. Furthermore, since it has flexibility, it is possible to shake platelets uniformly during shaking preservation.

The thickness of the sheet material in the plasma storage section 12 of the PC bag 30 is 40 to 70%, preferably 40 to 60%, of the thickness of the sheet material in the blood component storage section 3 of the blood collection bag 1. More preferably, it is 40 to 50%.

In the bag assembly of this embodiment, since the PC bag 30 is not subjected to centrifugation, the blood collection bag 1
Therefore, the sheet thickness of the PC bag 30 can be made thinner than the sheet thickness of the blood collection bag 1 in this way. however,
If the sheet thickness of the PC bag 30 is less than 40% of the sheet thickness of the blood collection bag 1, the strength of the PC bag will be insufficient and it will be easily damaged. Moreover, if it exceeds 70%, in order to obtain the desired gas permeability, it is necessary to increase the inner surface area of the portion of the platelet storage section that may be involved in gas permeability, which will be described later, and it is not possible to sufficiently downsize the PC bag. All I can do is try to figure it out.

The plasticizer that can be used in the PC bag 30 is not particularly limited, but di(ethylhexyl) phthalate (DEHP) and di-(n-decyl) phthalate (DnDP) are preferably used as the plasticizer.

[0062] When DEHP is used as the plasticizer for the PC bag 30, as in the blood collection bag 1, the PC bag 30
By setting the thickness of the sheet material 0 to 40 to 56% of the thickness of the sheet material of the blood collection bag 1, the capacity of the PC bag 30 can be approximately 20 to 75% of the capacity of the blood collection bag 1.

[0063] Also, Dn is used as a plasticizer for the PC bag 30.
When using DP, the gas permeability of the bag can be further improved.

The content of such a plasticizer is preferably 30 to 70 parts by weight based on 100 parts by weight of polyvinyl chloride.

The reason for this is that if the amount is less than 30 parts by weight, the flexibility of the bag will be poor and the liquid draining ability will be lowered, making it impossible to quickly and reliably drain the liquid, and if it exceeds 70 parts by weight, the inside of the bag will be The amount of plasticizer eluted increases,
This is also because the strength also decreases.

[0066] In addition, the sheet material of the PC bag 30 includes:
Stabilizers similar to those mentioned above can be added.

[0067] In the present invention, the constituent material of the PC bag 30 is plasticized P such as DEHP, DnDP, etc.
Not limited to VC, polyvinyl chloride that does not contain a plasticizer (for example, unplasticized vinyl chloride manufactured by Toagosei Co., Ltd.: NP-resin,
Non-plastic vinyl chloride (S-Medica) manufactured by Sekisui Co., Ltd. may also be used.

[0068] Furthermore, the platelet storage section 32 of the PC bag 30
The amount of CO2 gas permeated in is preferably 3.1 ml.
(CO2)/day・atm・ml (PC) (30℃)
Above, more preferably 3.6ml(CO2)/day・
atm・ml (PC) (30°C) or more, more preferably 4.0ml (CO2)/day・atm・ml (PC
) (30°C) or higher.

[0069] CO2 gas permeation amount is 3.1ml (CO2
)/day atm ml (PC) (30° C.), it becomes difficult to preserve platelets for a long period of time.

[0070] Furthermore, the platelet storage section 32 of the PC bag 30
The O2 gas permeation amount in is preferably 0.6 ml (
O2)/day・atm・ml (PC) (30℃)
Above, more preferably 0.7ml(O2)/day・a
tm・ml (PC) (30°C) or more, more preferably 0.8 ml (O2)/day・atm・ml (PC)
(30°C) or higher.

[0071] O2 gas permeation amount is 0.6 ml (O2)/
This is because if the temperature is less than 30°C, it becomes difficult to preserve platelets for a long period of time.

[0072] With the above-described configuration, a PC bag is provided which can store one or more units of platelets, particularly platelets having a number of more than 4.5 x 1010 platelets for a shelf life of 72 hours or more.

The material of the sheet material of the auxiliary bag 40 is not particularly limited, and may be the same as that of the blood collection bag 1 or the PC bag 30.

The thickness of the sheet material in the storage section 42 of the auxiliary bag 40 is preferably 0.30 to 0.40 m.
It should be about m. The gas permeability of the auxiliary bag 40 is not particularly limited, and may be lower than the gas permeability of the PC bag 30. The size of the auxiliary bag 40 is also not particularly limited, but for example, when the amount of blood to be collected is 400 m1, the size of the auxiliary bag 40 is 80 to 150 m1.
It is preferable to have a capacity of about 1 liter.

The material of tubes 6, 14, 21, 23, 24 and 26 is preferably polyvinyl chloride. If the tubes 6, 14, 21, 23, 24, and 26 are made of polyvinyl chloride, they will have sufficient flexibility and flexibility, making them easy to handle, suitable for occluding with drains, etc. This is because the bondability with the connectors 20 and 22 is improved.

[0076] Also, tubes 6, 14, 21, 23, 2
The types and contents of plasticizers 4 and 26 are not particularly limited. The inner diameter of the tubes 6, 14, 23, 24 and 26 is preferably about 2.0 to 4.5 mm.

In the bag assembly configured as described above, the red blood cell preservation solution 35 is filled into the platelet storage section 32 of the PC bag 30 before use, and the platelet storage section 3 is further filled with the red blood cell storage solution 35.
2 is filled with sterile and dust-free gas. As this red blood cell preservation solution, for example, S. A. G. M. liquid (0
．． 877% sodium chloride, 0.0169% adenine,
0.818% grape, etc., an aqueous solution containing 0.525% D-mannitol), and the like. Examples of the gas to be further sealed include inert gases such as argon, neon, and helium, nitrogen, and air. By using such a gas and making it dust-free and sterile, the gas does not have any adverse effects on the liquid in the bag.

Furthermore, by enclosing such a gas,
When transferring the red blood cell preservation solution 35 to the blood collection bag 1, it is possible to discharge the entire amount of the red blood cell preservation solution 35 without leaving the red blood cell preservation solution 35 in the platelet storage section 32, and the tubes 24, 21, 14 The amount remaining in the tank also decreases. The amount of gas enclosed is determined by the difference in head between the bottom suspension part of the bag 30 and the outlet 5 of the blood collection bag 1 by 30 mm, regardless of the bag capacity.
If it is about cm, it is preferably about 2 to 30 m1, more preferably about 3 to 20 m1. If it is less than the above value,
This is because the effect of gas inclusion is reduced, and if the value is greater than the above value, a sufficient storage capacity for the red blood cell preservation solution cannot be secured.

[0079] A method of enclosing a sterile and dust-free gas as described above is explained by enclosing the gas using an enclosing device as shown in FIG. The illustrated device is composed of a gas suction system 51, an enclosure system 52, and a medicinal liquid delivery system 53.
Each of the systems is switched by switching valves 54 and 55, respectively.

[0080] Each bag is sterilized, for example, by autoclaving,
After sterilization by OG sterilization or the like, or before sterilization, as explained above, the P plate having the platelet storage part 32 is
The C bag 30 is connected to this device, and the gas inside the PC bag 30 is first extracted by the suction system 51 by the decompression device 511 . The suction system 51 is provided with a pressure sensor 512, and the pressure reducing device 511 is controlled based on the sensor value, and the switching valve 54 switches to the enclosure system 52 when a predetermined pressure is reached. In addition, the suction system 51 is provided with a buffer valve 513 to prevent the pressure within the suction system 51 from dropping below a certain pressure, thereby preventing damage to the entire system. Reference numeral 514 in the figure is a pressure gauge.

Next, gas is sealed into the PC bag 30 from the filling system 52. The gas is supplied to the gas compressor 52
After being sterilized and dusted by a gas filter 522, it passes through the switching valves 54 and 55 and is sent to the PC.
It is sent into the bag 30. The amount of gas to be sealed is set in advance, and the amount of gas to be sealed is defined by sealing at a predetermined pressure for a predetermined time. Specifically, when the content of the PC bag 30 is about 150 to 300 ml, the amount is 0.5 to 5 g/
The time may be about 0.5 to 2 seconds at a pressure of about cm2. The pressure within the system is determined based on the detected value of the pressure sensor 523.

After filling the gas, the switching valve 55 located downstream of the switching valve 54 is switched, and the red blood cell preservation solution is fed from the liquid feeding system 53. A predetermined amount of the red blood cell preservation solution is fed by the liquid feeding pump 531. At this time, sterilization and dust removal are performed by the filter 532. As described above, the PC
Gas and red blood cell preservation solution are sealed into the bag 30. Note that the injection order of the gas and the red blood cell preservation solution may be reversed.

Next, a method of using the illustrated bag connector will be explained.

1) Place the blood collection bag 1 in a low place or place it in an automatic blood collection device, and with the tube 14 blocked (before the connecting member 15 breaks), puncture the blood collection needle 8 into the blood donor's blood vessel. Collect blood. Thereby, the collected blood is introduced into the blood storage section 3 of the blood collection bag 1 through the tube 6.

2) The tube 6 is closed with a cleanser, etc., and the blood collection bag 1 is centrifuged to separate red blood cells and plasma containing other components.

3) Close the tubes 24 and 26 with a cleanser or the like, release the blockage of the tube 14 (breakage of the sealing member of the connecting member 15), press the blood collection bag 1, and collect the separated supernatant plasma. is introduced into the plasma storage section 12 of the plasma bag 10 via tubes 14, 21 and 23.

4) When the buffy coat located at the interface between plasma and red blood cells reaches the upper end of the blood storage section 3, the pressure on the blood collection bag 1 is stopped, and the tube 23 is occluded with a cleanser or the like.

5) The tube 26 is unoccluded, the blood collection bag 1 is further pressed, and the buffy coat inside the blood collection bag 1 is introduced into the storage section 42 of the auxiliary bag 40 through the tube 26.

6) After the buffy coat and a small amount of red blood cells have been introduced into the blood collection bag 1, the tube 14
is occluded with a cleanser or the like, the tube 23 is unoccluded, and a small amount of plasma is introduced from the plasma bag 10 into the auxiliary bag 40.

7) When the introduction is completed, the tubes 23 and 26 are closed with a clamp or the like, and the tube 24 is unoccluded (rupture of the sealing member of the connecting member 25).

8) The PC bag 30 is placed higher than the blood collection bag 1 with the outlet 34 facing downward, and the red blood cell preservation solution 35 is introduced into the blood collection bag 1 by the difference in height between the two bags. At this time, the gas 36 in the PC bag 30 is on the opposite side (upper side) of the outlet 34, and the red blood cell preservation solution 35 flows out from below. The gas 35 forms a space within the PC bag 30, and substantially the entire amount is discharged from the PC bag 30 without remaining between the sheet materials that are brought into close contact with each other due to surface tension. Furthermore, the gas inside the PC bag 30 is transferred to the tube 24
, 21, and 14, and the amount of red blood cell preservation solution 35 remaining in the tube is also reduced. Furthermore, since the liquid can be discharged without providing a sufficient head, the length of the tube may be short.

9) By sealing and cutting the tubes 14 and 23 with a tube sealer, the blood collection bag 1 and the plasma bag 10 are separated as shown in FIG.

10) Auxiliary bag 40 and PC bag 3
The connected bag assembly of No. 0 is centrifuged again, and the blood in the auxiliary bag 40 is separated into platelet concentrate, red blood cells, and white blood cells.

11) The platelet concentrate separated at the upper side in the auxiliary bag 40 is introduced into the PC bag 30 to obtain a platelet concentrate preparation.

12) The auxiliary bag 40 is
6 with a tube sealer, cut and discard.

[0096] As described above, when transferring the platelet concentrate, since only a small amount of the red blood cell preservation solution remains in the PC bag 30 or the tube, the adverse effects of the red blood cell preservation solution on the platelet concentrate are extremely small.

Note that as a means for transferring the red blood cell preservation solution from the PC bag 30 to the blood collection bag 1, the PC bag 30 may be pressed from the outside with the outlet 34 facing downward. In this case, the inner diameter of the tubes 24, 21, 14 is 2
．． About 0 to 4.0 mm, more preferably 2.5 to 3.5
It is good if it is about mm.

Next, a second embodiment shown in FIG. 4 will be explained. In this embodiment, a ventilation section 60 is provided in the PC bag 30. The vent 60 is provided at the end opposite to the outlet 34 and is connected to the tube 62 and the sealing means 6.
1 and a filter 64. The tube 62 communicates with the inside of the platelet storage section 32, and as shown in FIG. 5, a sealing means 61 is connected to the tip. The sealing means 61 is composed of a cylindrical body 611 made of a flexible material similar to a tube, and a sealing member 612 tightly fixed within the cylindrical body 611. Sealing member 6
12 is a cylindrical body with one end closed, and a small-diameter broken part 613 is formed on the outer periphery, and communication is made possible by bending and breaking the closed end (solid columnar part) 614 at the broken part 613. It is composed of The material of the sealing member 612 may be, for example, polyvinyl chloride, polycarbonate, thermoplastic polyester elastomer, or the like.

A filter 64 is connected to the other end of the sealing means 61 via a tube 62. filter 6
4 is covered with a cylindrical filter holding material 63 and connected to the tube 62.

[0100] If necessary, a flat plate-like protrusion 615 (in FIG. (The short side is shown when viewed from the direction perpendicular to the side.)
is formed, and after cutting the solid columnar part 614, the solid columnar part 6
It is desirable that the 14 sides do not block the tubular body 62.

On the other hand, a filter 64 that allows gas to pass through but not blood is attached to the end of the tubular body 62.

This filter 64 is made by powdering polyethylene, polypropylene, nylon, etc. and putting it into a mold.
It can be constructed from a sintered body formed by heating and compressing.

[0103] Instead of the above sintered body, a membrane filter in which polyester resin aggregate is coated with polyvinyl chloride may be used.

Other materials that can be used for the membrane filter include polytetrafluoroethylene laminated to a polyethylene nonwoven fabric, and an acetate membrane coated with silicone resin.

[0105] The ventilation resistance of the filter 64 is determined when the air pressure difference is 0.
．． 2 kg/cm2, the ventilation amount is 1 to 5 m1/
It is good if it is about sec, more preferably about 3 to 5 m1.

[0106] Here, the order of connecting the sealing means 61 and the filter 64 may be reversed. When discharging the red blood cell preservation solution from the PC bag 30, the sealing means 61 breaks the solid columnar part 614 of the sealing member 612 and closes the ventilation part 60.
to open.

[0107] With the above configuration, P
When transferring the red blood cell preservation solution from the C bag 30 to the blood collection bag 1, gas is appropriately introduced from the ventilation section 60 as the red blood cell preservation solution is discharged, so that the discharge of the red blood cell preservation solution is substantially the same as in the first embodiment. Completely done.

[0108] It should be noted that a configuration may be used in which pressurized gas is forcibly fed into the bag from the ventilation section 60 using, for example, a compressor or an air pump. For example, the filter may be a simple ventilation filter made of polypropylene, polyvinylidene dichloride, polytetrachloroethylene, or the like.

Note that the present invention is not limited to the bag connectors of the above embodiments, but may be any bag connectors that introduce liquid between bags, and is not limited to the above applications.

[0110]

As explained above, according to the bag connector of the present invention, the liquid can be quickly and almost completely drained from the bag, and there is less liquid remaining in the tube, so that mixing of the remaining liquid, etc. This eliminates disadvantages such as the liquid in the bag being adversely affected and the liquid composition being altered. Also,
Since there is no need to provide a high head for liquid transfer, the length of the tube can be shortened and a compact bag connector is provided.

[Brief explanation of the drawing]

FIG. 1 is an overall side view showing a bag connector according to a first embodiment of the present invention.

FIG. 2 is a schematic diagram showing the configuration of an enclosure device for sealing gas into a bag.

FIG. 3 is an overall side view showing the bag assembly of the first embodiment with the plasma bag and blood collection bag removed.

FIG. 4 is an overall side view showing a bag connector according to a second embodiment of the present invention.

FIG. 5 is a sectional view of a ventilation section provided in the bag.

[Explanation of symbols]

1 Blood collection bag 2
Seal part 3 Blood component storage parts 4, 5
Discharge port 6 Tube 7 Hub 8 Blood collection needle 9 Cap 10 Plasma bag 11 Seal portion 12 Platelet storage portion 13
Discharge port 14 Tube 15 Connecting members 20, 22 Branch connector 21 Tubes 23, 24 Tube 26 Tube 30 PC bag 31 Seal portion 32 Platelet storage portion 33
Outlet port 34 Outlet port 35 Red blood cell preservation solution 36
Gas 40 Auxiliary bag 41 Seal part 42 Storage part 50 Enclosing device 51 Suction system 511 Pressure reducing device 512 Pressure sensor 513 Buffer valve 514 Pressure gauge 52 Enclosing system 521 Gas compressor 522
Gas filter 523 Pressure sensor 53 Liquid feeding system 531 Liquid feeding pump 532 Filters 54, 55 Switching valve 60 Venting section 61 Sealing means 611 Cylindrical body 612 Sealing member 613 Broken portion 614 Closed end 62 Tube 63 Filter holding material 64
filter

Claims (3)

[Claims] [Claim 1] Consisting of a plurality of bags each having a storage section formed by stacking flexible sheet materials, and a tube connected to the storage section of each bag to connect each bag and to transport liquid between the bags, At least one of the bags is filled with a liquid, and the bag filled with the liquid is transferred to another bag with the connection part of the tube facing downward. A connected bag characterized in that a sterile and dust-free gas is sealed inside. 2. The bag assembly according to claim 1, wherein the gas-filled bag is obtained by extracting the gas from the bag and quantitatively filling the bag with dust-free and sterile gas. 3. Consisting of a plurality of bags each having a storage section formed by stacking flexible sheet materials, and a tube connected to the storage section of each bag to connect each bag and to transport liquid between the bags, The bag filled with the liquid is positioned at a higher place than other bags with the connection part of the tube facing downward, and the bag filled with the liquid is transferred to the other bag. 1. A connected bag assembly, characterized in that a ventilation part is provided for introducing gas into the bag, and the ventilation part is provided with a filter having a dust-removing and sterilizing effect, and a sealing means that can be opened when necessary.