JPH04217606A - Blood suction inhibitor for blood-sucking insect pest - Google Patents
Blood suction inhibitor for blood-sucking insect pestInfo
- Publication number
- JPH04217606A JPH04217606A JP33034990A JP33034990A JPH04217606A JP H04217606 A JPH04217606 A JP H04217606A JP 33034990 A JP33034990 A JP 33034990A JP 33034990 A JP33034990 A JP 33034990A JP H04217606 A JPH04217606 A JP H04217606A
- Authority
- JP
- Japan
- Prior art keywords
- blood
- trioxane
- inhibitor
- sucking
- blood suction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000607479 Yersinia pestis Species 0.000 title claims abstract description 16
- 239000003112 inhibitor Substances 0.000 title claims abstract description 14
- 239000008280 blood Substances 0.000 title abstract description 14
- 210000004369 blood Anatomy 0.000 title abstract description 14
- 241000238631 Hexapoda Species 0.000 title abstract 3
- BGJSXRVXTHVRSN-UHFFFAOYSA-N 1,3,5-trioxane Chemical compound C1OCOCO1 BGJSXRVXTHVRSN-UHFFFAOYSA-N 0.000 claims abstract description 30
- 239000004480 active ingredient Substances 0.000 claims abstract description 5
- 230000002401 inhibitory effect Effects 0.000 abstract description 7
- 241000255925 Diptera Species 0.000 abstract description 3
- 241001465754 Metazoa Species 0.000 abstract description 3
- 241000238876 Acari Species 0.000 abstract description 2
- 206010004194 Bed bug infestation Diseases 0.000 abstract description 2
- 241001414835 Cimicidae Species 0.000 abstract description 2
- 241000258242 Siphonaptera Species 0.000 abstract description 2
- 241000255628 Tabanidae Species 0.000 abstract description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 239000002904 solvent Substances 0.000 description 7
- 239000003381 stabilizer Substances 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000000077 insect repellent Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000008188 pellet Substances 0.000 description 6
- -1 thiocarbamoyl compounds Chemical class 0.000 description 6
- 239000012528 membrane Substances 0.000 description 5
- 238000000859 sublimation Methods 0.000 description 5
- 230000008022 sublimation Effects 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 150000001412 amines Chemical class 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- YYRFKEZGNCUVCQ-UHFFFAOYSA-N 2,6-diethyl-3-methylbenzamide Chemical compound CCC1=CC=C(C)C(CC)=C1C(N)=O YYRFKEZGNCUVCQ-UHFFFAOYSA-N 0.000 description 2
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 2
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 150000002989 phenols Chemical class 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 2
- FQERLIOIVXPZKH-UHFFFAOYSA-N 1,2,4-trioxane Chemical compound C1COOCO1 FQERLIOIVXPZKH-UHFFFAOYSA-N 0.000 description 1
- OCJBOOLMMGQPQU-UHFFFAOYSA-N 1,4-dichlorobenzene Chemical compound ClC1=CC=C(Cl)C=C1 OCJBOOLMMGQPQU-UHFFFAOYSA-N 0.000 description 1
- QSRJVOOOWGXUDY-UHFFFAOYSA-N 2-[2-[2-[3-(3-tert-butyl-4-hydroxy-5-methylphenyl)propanoyloxy]ethoxy]ethoxy]ethyl 3-(3-tert-butyl-4-hydroxy-5-methylphenyl)propanoate Chemical compound CC(C)(C)C1=C(O)C(C)=CC(CCC(=O)OCCOCCOCCOC(=O)CCC=2C=C(C(O)=C(C)C=2)C(C)(C)C)=C1 QSRJVOOOWGXUDY-UHFFFAOYSA-N 0.000 description 1
- ZVVFVKJZNVSANF-UHFFFAOYSA-N 6-[3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoyloxy]hexyl 3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoate Chemical compound CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(CCC(=O)OCCCCCCOC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)=C1 ZVVFVKJZNVSANF-UHFFFAOYSA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 241000256173 Aedes albopictus Species 0.000 description 1
- 229920000298 Cellophane Polymers 0.000 description 1
- 241000255930 Chironomidae Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229920001328 Polyvinylidene chloride Polymers 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241001138501 Salmonella enterica Species 0.000 description 1
- 241000256103 Simuliidae Species 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- BGYHLZZASRKEJE-UHFFFAOYSA-N [3-[3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoyloxy]-2,2-bis[3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoyloxymethyl]propyl] 3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoate Chemical compound CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(CCC(=O)OCC(COC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)(COC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)COC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)=C1 BGYHLZZASRKEJE-UHFFFAOYSA-N 0.000 description 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- POLCUAVZOMRGSN-UHFFFAOYSA-N dipropyl ether Chemical compound CCCOCCC POLCUAVZOMRGSN-UHFFFAOYSA-N 0.000 description 1
- 150000002019 disulfides Chemical class 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002169 ethanolamines Chemical class 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 description 1
- 229940011051 isopropyl acetate Drugs 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 231100000299 mutagenicity Toxicity 0.000 description 1
- 230000007886 mutagenicity Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 150000003018 phosphorus compounds Chemical class 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000005033 polyvinylidene chloride Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Landscapes
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
【発明の詳細な説明】 〔産業上の利用分野〕 本発明は吸血害虫の吸血阻害剤に関する。[Detailed description of the invention] [Industrial application field] The present invention relates to a blood-sucking inhibitor for blood-sucking pests.
１，３，５−トリオキサン（以下単にトリオキサンと記
す。）は主に衣類用防虫剤として衣類害虫に対する防虫
効果については知られていた。1,3,5-trioxane (hereinafter simply referred to as trioxane) has been known to have an insect repellent effect on clothing pests mainly as an insect repellent for clothing.
上記従来のトリオキサンの生物活性として知られていた
のは、衣類害虫に対してのものである。本発明者らは、
他の害虫に対しても種々の活性を検討した結果、意外に
も、吸血害虫に対する吸血阻害効果があることを見出し
本発明を完成した。The known biological activity of the above-mentioned conventional trioxane is against clothing pests. The inventors
As a result of examining various activities against other pests, we surprisingly discovered that it has a blood-sucking inhibiting effect on blood-sucking pests, and completed the present invention.
本発明はトリオキサンを有効成分として含有することを
特徴とする吸血害虫の吸血阻害剤に係る。The present invention relates to a blood-sucking inhibitor for blood-sucking pests characterized by containing trioxane as an active ingredient.
本発明の吸血阻害剤は、その有効成分として、トリオキ
サンを含有することに基づいて、極めて優れた吸血阻害
効果を奏し得る。The blood sucking inhibitor of the present invention can exhibit extremely excellent blood sucking inhibiting effects because it contains trioxane as its active ingredient.
その吸血阻害効果は、蚊、ノミ、ナンキンムシ、ダニ、
ハエ、ブユ、ヌカカ、アブ等の害虫に対して強力なもの
である。従って本発明の吸血阻害剤は、これを、人体、
動物に直接若しくは間接的に適用することによって、人
体、動物への害虫による吸血を確実に阻害しうるもので
ある。Its blood-sucking inhibiting effect is effective against mosquitoes, fleas, bed bugs, ticks,
It is powerful against pests such as flies, blackflies, midges, and horseflies. Therefore, the blood feeding inhibitor of the present invention has the ability to
By directly or indirectly applying it to animals, it can reliably inhibit blood sucking by pests from humans and animals.
本発明に用いられるトリオキサンは融点６４℃、分子式
Ｃ３Ｈ６Ｏ３の物質であり、空気中常温で安定な昇華固
体である。Trioxane used in the present invention is a substance with a melting point of 64° C. and a molecular formula of C3H6O3, and is a sublimated solid that is stable in air at room temperature.
本発明において、トリオキサンとしては、固体、液体を
問わない。固体の場合は粉状もしくは粒状または成形品
として使用しうる。例えばペレットの成形は、トリオキ
サン粉粒体の圧縮成形または溶融トリオキサンの注型成
形あるいは押出成形により行なうことが出来る。In the present invention, trioxane may be either solid or liquid. If it is solid, it can be used in powder or granule form or as a molded product. For example, pellets can be formed by compression molding of trioxane powder or by casting or extrusion molding of molten trioxane.
又液体の場合は、本発明に用いられる溶媒としては、ト
リオキサン溶液とした場合に防虫剤として速効性がある
ことおよび残香性が少ないことより、トリオキサンより
も低沸点であることが好ましい。好ましい溶媒の代表例
は、水、メタノール、エタノール、１−プロパノール、
２−プロパノールなどのアルコール類、ジエチルエーテ
ル、ジプロピルエーテル、ジイソプロピルエーテルなど
のエーテル類、アセトン、エチルメチルケトンなどのケ
トン類および酢酸メチル、酢酸エチル、酢酸イソプロピ
ルなどのエステル類、ジエチルメタトルアミドである。In the case of a liquid, it is preferable that the solvent used in the present invention has a lower boiling point than trioxane, since it is quickly effective as an insect repellent and has less residual odor when made into a trioxane solution. Representative examples of preferred solvents include water, methanol, ethanol, 1-propanol,
Alcohols such as 2-propanol, ethers such as diethyl ether, dipropyl ether, diisopropyl ether, ketones such as acetone, ethyl methyl ketone, esters such as methyl acetate, ethyl acetate, isopropyl acetate, and diethyl metatoluamide. be.
中でも水、エタノール、２−プロパノール、ジエチルエ
ーテル、ジイソプロピルエーテル、アセトンおよび酢酸
エチル、ジエチルメタトルアミドは不快臭がなく人体に
対する安全性が高いので特に好ましい。Among them, water, ethanol, 2-propanol, diethyl ether, diisopropyl ether, acetone, ethyl acetate, and diethyl metatoluamide are particularly preferred because they have no unpleasant odor and are highly safe for the human body.
溶媒は防虫剤の使用目的により適宜選択される。たとえ
ばエーテル類は残香がきわめて少なく、しかも速効性が
大きい。ケトン類およびエステル類はトリオキサンの溶
媒性が高いので、高濃度の溶媒とすることができる。エ
タノールは人体に対する安全性が特に大きい。The solvent is appropriately selected depending on the intended use of the insect repellent. For example, ethers have very little residual fragrance and are fast-acting. Since ketones and esters have high solvent properties for trioxane, they can be used as highly concentrated solvents. Ethanol is particularly safe for humans.
本発明においてトリオキサンの濃度は溶媒により異なる
が、一般に１０〜９０重量％程度が好ましい。トリオキ
サン濃度が低いほど速効性が高まり、トリオキサン濃度
が高いほど持続性が増大する。In the present invention, the concentration of trioxane varies depending on the solvent, but is generally preferably about 10 to 90% by weight. The lower the concentration of trioxane, the faster the effect, and the higher the concentration of trioxane, the longer the persistence.
上記トリオキサンには、安定剤を添加してもよく、この
ような安定剤としては、立体障害性フェノール類、ジス
ルフィド類、アミン類、チオカルバモイル化合物および
有機三価リン化合物などがある。これら安定剤の添加量
は安定剤の種類その他の条件により異なるが通常は１〜
１０００ｐｐｍ程度である。A stabilizer may be added to the trioxane, and examples of such stabilizers include sterically hindered phenols, disulfides, amines, thiocarbamoyl compounds, and organic trivalent phosphorus compounds. The amount of these stabilizers added varies depending on the type of stabilizer and other conditions, but usually 1~
It is about 1000 ppm.
立体阻害性フェノールに特に制限はなく、たとえば２，
６−ジ−ｔ−ブチル−ｐ−クレゾールのような比較的低
分子のものでもよいが、防虫剤としての使用状態からし
て、安定剤は揮発性の低いものが好ましい。たとえば、
立体障害性フェノールの中では、ペンタエリトリトール
−テトラキス〔３−（３，５−ジ−ｔ−ブチル−４−ヒ
ドロキシフェニル）プロピオナート〕、１，６−ヘキサ
ンジオール−ビス〔３（３，５−ジ−ｔ−ブチル−４−
ヒドロキシフェニル）プロピオナート〕、およびトリエ
チレングリコール−ビス〔３−（３−ｔ−ブチル−４−
ヒドロキシ−５−メチルフェニル）プロピオナート〕な
どが特に好ましい。アミン類の中ではエタノールアミン
類特にトリエタノールアミンなどの高沸点アミンが好ま
しい。There are no particular restrictions on the sterically inhibiting phenol, such as 2,
Although a relatively low-molecular stabilizer such as 6-di-t-butyl-p-cresol may be used, it is preferable that the stabilizer has low volatility in view of its use as an insect repellent. for example,
Among the sterically hindered phenols, pentaerythritol-tetrakis[3-(3,5-di-t-butyl-4-hydroxyphenyl)propionate], 1,6-hexanediol-bis[3(3,5-di -t-butyl-4-
hydroxyphenyl)propionate], and triethylene glycol-bis[3-(3-t-butyl-4-
Hydroxy-5-methylphenyl)propionate] and the like are particularly preferred. Among the amines, high boiling point amines such as ethanolamines, particularly triethanolamine, are preferred.
所望により本発明の防虫剤に少量の着香剤を加えること
もできるが、トリオキサン本来の快香があるので、強い
て必要ではない。またトリオキサンには、公知の害虫防
除効果を有する薬剤を添加することができる。If desired, a small amount of flavoring agent can be added to the insect repellent of the present invention, but this is not strictly necessary since trioxane has its own pleasant scent. Furthermore, a known agent having a pest control effect can be added to trioxane.
トリオキサンはそれ自体の昇華速度が大きいので、十分
な速効性を有し、かつ使用状態における昇華速度の調節
範囲が広い。吸血阻害剤を膜材で包装し使用時にその一
部を切除する方法などにより、昇華を制限して使用期間
を長くすることができる。膜材は物理化学的に安定なも
のほど良いが、通常ポリエチレンおよびポリプロピレン
、セロファン、ポリ塩化ビニリデン程度の安定性で足り
る。ポリエチレンおよびプロピレンは好ましい膜材であ
る。また多孔質フィルムまたは紙などの通気性膜材を用
いて昇華速度を調節することもできる。Since trioxane itself has a high sublimation rate, it has sufficient rapid action and the sublimation rate can be adjusted over a wide range under the conditions of use. Sublimation can be limited and the period of use can be extended by packaging the blood absorption inhibitor in a membrane material and cutting off a portion of the membrane before use. The more stable the membrane material is physically and chemically, the better; however, polyethylene, polypropylene, cellophane, and polyvinylidene chloride are usually sufficient. Polyethylene and propylene are preferred membrane materials. The sublimation rate can also be adjusted by using a breathable membrane material such as a porous film or paper.
包装形態として、ｐ−ジクロロベンゼン製剤と同様に円
盤状のペレットを方形に包装することができる。また円
柱状ペレットの側面を緊密に被覆し、円柱底面の少なく
とも一方の側に、底面から離れるのに従って次第に断面
積が小さくなるような空間を設けた形に包装すれば、そ
の適当な箇所で包装材を切除して適切な面積の開口とす
ることにより、昇華速度を調節することができる。As a packaging form, disc-shaped pellets can be packaged in a rectangular shape similar to the p-dichlorobenzene preparation. In addition, if the cylindrical pellets are packaged in such a way that the side surfaces are tightly covered and a space is provided on at least one side of the bottom of the cylinder so that the cross-sectional area gradually decreases as the distance from the bottom increases, the pellets can be wrapped at the appropriate location. By cutting the material to create openings of appropriate area, the sublimation rate can be adjusted.
トリオキサンの急性毒性は低く、マウス腹腔内致死量は
薬８５００ｍｇ／Ｋｇとされている。トリオキサンに変
異原性がないことは、マウス、ラット、ショウジョウバ
エ、およびサルモネラ菌に対して証明されている。また
トリオキサンには麻酔性もない。The acute toxicity of trioxane is low, and the intraperitoneal lethal dose for mice is said to be 8,500 mg/Kg of the drug. The non-mutagenicity of trioxane has been demonstrated in mice, rats, Drosophila, and Salmonella enterica. Trioxane also has no anesthetic properties.
本発明はトリオキサン及びその誘導体を吸血害虫に適用
することにより、きわめて優れた吸血阻害作用を発揮す
る。The present invention exhibits an extremely excellent blood-sucking inhibiting effect by applying trioxane and its derivatives to blood-sucking pests.
以下に本発明を実施例にもとづき詳細に説明する。 The present invention will be explained in detail below based on examples.
実施例１
トリオキサン（純度９９．９重量％以上）粉粒体を圧縮
成形して、直径２０ｍｍ、厚さ５ｍｍの白色円盤状ペレ
ットの本発明の吸血阻害剤を得た。Example 1 Trioxane (purity 99.9% by weight or more) powder was compression molded to obtain the blood feeding inhibitor of the present invention in the form of white disc-shaped pellets with a diameter of 20 mm and a thickness of 5 mm.
実施例２
トリオキサン（純度９９．２重量％以上）粒体に安定剤
としてトリフェニルホスフィン３００ｐｐｍを加えた後
、造粒し、粒径２〜５ｍｍの本発明吸血阻害剤を得た。Example 2 After adding 300 ppm of triphenylphosphine as a stabilizer to trioxane (purity 99.2% by weight or more) granules, the mixture was granulated to obtain a blood absorption inhibitor of the present invention having a particle size of 2 to 5 mm.
実施例３〜１０
トリオキサン（純度９９．９重量％以上）粉粒体を、所
定の濃度となるように各種の溶媒に溶解して下記第１表
の液状の本発明吸血阻害剤を得た。Examples 3 to 10 Powdered trioxane (purity 99.9% by weight or more) was dissolved in various solvents to a predetermined concentration to obtain liquid blood feeding inhibitors of the present invention shown in Table 1 below.
試験例
ベイトボックス（高さ２５×巾２５×奥行２５ｃｍ）と
リリースケージ（高さ２０×巾２０×奥行３０ｃｍ）と
をガラス管（直径５ｃｍ、長さ２０ｃｍ）で連結し、ベ
イトボックス内には３％砂糖水を含ませた脱脂綿を入れ
た水入りポリカップ及び被吸血体マウスをくるんだ金属
ネットを載せた台、実施例１で得たトリオキサンペレッ
トを入れた皿をそれぞれ並べて設置し、リリースケージ
内には上記と同じ水入りポリカップだけを設置し上記総
量を２４℃４０〜４５％ＲＨの実験室内に設定し、試験
を行なった。試験時間は、おおむね午後５時〜翌朝８時
で、翌朝８時にベイトボックス内とリリースケージ内に
存する個体数とその吸血率を調べるとともに死亡（また
は）ノックダウン個体数を調べた。Test example A bait box (height 25 x width 25 x depth 25 cm) and a release cage (height 20 x width 20 x depth 30 cm) were connected with a glass tube (diameter 5 cm, length 20 cm), and inside the bait box A water-filled polycup containing absorbent cotton soaked in 3% sugar water, a table with a metal net wrapped around the blood-sucked mouse, and a dish containing the trioxane pellets obtained in Example 1 were placed side by side to form a release cage. Only the same water-filled polycup as above was installed inside the chamber, and the total amount was set in a laboratory room at 24° C. and 40% to 45% RH, and the test was conducted. The test time was approximately 5:00 pm to 8:00 the next morning, and at 8:00 the next morning, the number of individuals existing in the bait box and release cage and their blood-sucking rate was investigated, as well as the number of dead (or) knocked down individuals.
なお、リリースケージ内にヒトスジシマカを放逐後は、
実験質内を暗黒状態にしておいた。In addition, after releasing Aedes albopictus into the release cage,
The inside of the experimental material was kept in darkness.
試験結果を下記第２表に記した。The test results are shown in Table 2 below.
注）ａ：供試個体数に占める割合（％）ｂ：存在場所別
の吸血率（％）
ｃ：存在場所別のノックダウン率（％）〔発明の効果〕
本発明は、上述のように吸血害虫に対しきわめて優れた
吸血阻害効果を有するものであり、吸血害虫の吸血阻害
剤として有用である。Note) a: Proportion to the number of test individuals (%) b: Blood feeding rate (%) by location c: Knockdown rate (%) by location [Effects of the Invention] The present invention has the following advantages: It has an extremely excellent blood-sucking inhibitory effect on blood-sucking pests, and is useful as a blood-sucking inhibitor for blood-sucking pests.
特許出願人 アース製薬株式会社 同 三菱瓦斯化学株式会社Patent applicant Earth Pharmaceutical Co., Ltd. Mitsubishi Gas Chemical Co., Ltd.
Claims (1)
る吸血害虫の吸血阻害剤。A blood-sucking inhibitor for blood-sucking pests characterized by containing trioxane as an active ingredient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33034990A JPH04217606A (en) | 1990-11-30 | 1990-11-30 | Blood suction inhibitor for blood-sucking insect pest |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33034990A JPH04217606A (en) | 1990-11-30 | 1990-11-30 | Blood suction inhibitor for blood-sucking insect pest |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH04217606A true JPH04217606A (en) | 1992-08-07 |
Family
ID=18231625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP33034990A Pending JPH04217606A (en) | 1990-11-30 | 1990-11-30 | Blood suction inhibitor for blood-sucking insect pest |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH04217606A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014504586A (en) * | 2010-12-27 | 2014-02-24 | インターベツト・インターナシヨナル・ベー・ベー | Transsurface topical isoxazoline formulation |
| US9226489B2 (en) | 2011-03-18 | 2016-01-05 | Ecolab Usa Inc. | Heat system for killing pests |
-
1990
- 1990-11-30 JP JP33034990A patent/JPH04217606A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014504586A (en) * | 2010-12-27 | 2014-02-24 | インターベツト・インターナシヨナル・ベー・ベー | Transsurface topical isoxazoline formulation |
| US9532978B2 (en) | 2010-12-27 | 2017-01-03 | Intervet Inc. | Topical localized isoxazoline formulation |
| US10864195B2 (en) | 2010-12-27 | 2020-12-15 | Intervet Inc. | Topical localized isoxazoline formulation |
| US9226489B2 (en) | 2011-03-18 | 2016-01-05 | Ecolab Usa Inc. | Heat system for killing pests |
| US10070639B2 (en) | 2011-03-18 | 2018-09-11 | Ecolab Usa Inc. | Heat system for killing pests |
| US11013226B2 (en) | 2011-03-18 | 2021-05-25 | Ecolab Usa Inc. | Heat system for killing pests |
| US11737445B2 (en) | 2011-03-18 | 2023-08-29 | Ecolab Usa Inc. | Heat system for killing pests |
| US12063921B2 (en) | 2011-03-18 | 2024-08-20 | Ecolab Usa Inc. | Heat system for killing pests |
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