JP6043145B2 - Skin external composition for body odor control - Google Patents

Description

  The present invention relates to an external composition for skin that can suppress body odor.

  In recent years, people's interest in odor has increased. In particular, an increasing number of people are concerned about the body odor peculiar to the elderly, which is thought to occur with aging. This body odor, also called an aging odor, has been reported to be deeply related to the generation of 2-nonenal, an unsaturated aldehyde produced by oxidative degradation of ω7 unsaturated fatty acids on the skin surface (Non-Patent Document 1). ).

  Conventionally, as a technique for preventing such body odor, a method of masking with a perfume or the like, or a method using the odor adsorption effect of charcoal (Patent Document 1) is known. Moreover, the method (patent document 2) using the extract from a root part and rhizome part of a bite mulberry, the method (patent document 3) using condensed-type cachytannin, etc. are proposed. However, development of a more useful composition for suppressing body odor is required.

JP 2002-145747 A JP 2011-183019 A Japanese Patent No. 4212220

S. Haseet al., The Journal of Investigative Dermatology, Vol.116, No.4, 520-524, 2001

  An object of this invention is to provide the novel composition which can exhibit the body odor suppression effect highly.

  As a result of intensive studies to solve the above problems, the present inventors have synergistically significantly increased body odor suppression when a rose family plant extract and a button family plant plant extract are used in combination. The inventors have found that the effect is exhibited and have completed the present invention.

Accordingly, the present invention provides the following.
[Item 1] A skin external composition for body odor suppression, comprising (A) a rose family plant extract and (B) a button family plant extract.
[Item 2] The external composition for skin according to Item 1, which suppresses an aging odor.
[Item 3] The composition for external use of skin according to Item 1 or 2, which suppresses nonenal.
[Item 4] The external composition for skin according to any one of Items 1 to 3, which is used as a leave-on type.
[Item 5] The composition for external use of skin according to any one of Items 1 to 4, comprising a plant extract containing mutinoside A as the component (A).
[Item 6] The external composition for skin according to any one of Items 1 to 5, comprising Age extract as the component (A).
[Item 7] The composition for external use of skin according to any one of Items 1 to 6, comprising a plant extract containing paeoniflorin as the component (B).
[Item 8] The external composition for skin according to any one of Items 1 to 7, comprising a peony extract as the component (B).
[Item 9] A method for suppressing body odor, comprising applying (A) a rose family plant extract and (B) a button family plant extract to a part of the skin where generation of body odor is concerned.

  INDUSTRIAL APPLICABILITY According to the present invention, a useful new skin external composition that can exhibit a body odor suppressing effect to a high degree is provided. Both the Rosaceae rose genus plant extract and the Button family button genus plant extract used in the present invention are natural plant-derived extracts, which are also very useful in that they can be used safely for the human body.

Hereinafter, the present invention will be described in detail.
It should be understood that the terms used in the present specification are used in the meaning normally used in the art unless otherwise specified.

(1. Composition for external use for body odor control)
The external composition for skin odor suppression according to the present invention contains (A) a rose family plant extract and (B) a button family button plant extract.

(A) Rosaceae rose genus plant extract The composition for external use of the body odor control of the present invention contains a rose family rose genus plant extract (hereinafter also simply referred to as component (A)).

  In the present specification, the Rosaceae rose genus plant extract refers to an extract (also referred to as an extract) obtained from a Rosaceae Rosa plant.

Among the Rosaceae roses are the roses (Rosa multiflora), the roasted roses (Rosa roxburghii), the canna roses (Rosa canina), the gallica roses (Rosa
gallica), rose ross (Rosa chinensis), damask rose (Rosa damascena), centifolia rose (Rosa centifolia), hybrid rose (Rosa
hybrida), hermanus (Rosa rugosa), yamahamanas (Rosa moschata), moscata rose (Rosa moschata), Rosa alba (Rosa
alba, Rosa rubiginosa, Rosa rubiginosa, Rosa hirtula, Rosa aciculaisis, Terry Hanoi rose (Rosa wichuraiana), Sakura rose (Rosa)
uchiyamana), Morii Rose (Rosa jasminoides), Fujii Rose (Rosa fujisanensis), Yamai Rose (Rosa)
sambucina, Rosa onoei, Miyakoi rose (Rosa paniculigera), Teri Hanoi rose (Rosa luciae), Carafuto rose (Rosa
amblyotis), gossip rose (Rosa acicularis), gossamer (Rosa nipponensis), naniwaibara (Rosa
laevigata), Kakayanbara (Rosa bracteata), Mokkobara (Rosa banksiae), and the like, but are not limited thereto. From the viewpoint of more surely exhibiting a high effect, preferably the rose family Rosaceae is a rose, Izayoi rose, canina rose, gallica rose, kouxin rose, damask rose, centifolia rose, hybrid rose, hermanus, yamasana, moscata rose, rosa alba , Rosa egreneria, or Rosarbiginosa, particularly preferably rose.

  The organ of the plant belonging to the family Rosaceae that is an extraction target for obtaining the extract is not particularly limited as long as the effects of the present invention can be achieved. For example, flowers, fruits, false fruits, ovary, seeds, leaves, buds, Examples include stems and roots.

  Moreover, the Rosaceae rose genus plant extract can be manufactured in accordance with the preparation method of the plant extract currently performed normally in the said field | area. Specifically, an extract of a rose family rose genus plant is a state in which an organ of a rose family rose genus plant is collected or subjected to a treatment such as drying, shredding, crushing, etc., if necessary. It can be obtained by performing an extraction process.

  As a solvent used for the extraction treatment from the Rosaceae plant, any solvent that is widely used in the field can be used. Specifically, water, an organic solvent, or a mixture of water and an organic solvent can be used. A liquid etc. can be mentioned. More specifically, examples of the extraction solvent include lower alcohols having 1 to 5 carbon atoms such as methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, and t-butanol, but are not limited thereto. Not. As the extraction solvent, preferably, water or a mixed liquid of lower alcohol having 1 to 5 carbon atoms and water (hydrous lower alcohol), more preferably water or a mixed liquid of ethanol and water (hydrous ethanol) is used. Can be mentioned. When a hydrous lower alcohol is used as the solvent, the content of the lower alcohol with respect to the total weight of the hydrous lower alcohol is, for example, more than 0 wt% and 80 wt% or less, preferably more than 0 wt% and 50 wt% or less, Preferably, it is more than 0% by weight and 30% by weight or less.

  The extraction treatment for obtaining a rose family rose genus plant extract can be performed by a method well known in the art, for example, about 1 to 50 parts by weight of a solvent with respect to 1 part by weight of a rose family rose genus plant, Preferably, about 5 to 20 parts by weight of a solvent is added, and the mixture is stirred as necessary, and it may be performed for several minutes to several days, preferably 30 minutes to 20 hours, more preferably about 1 hour to 10 hours. About temperature conditions at the time of extraction processing, what is necessary is just to set up suitably according to a kind etc. of a solvent, but usually 10-100 ° C, preferably 50-98 ° C, and more preferably 60-97 ° C is illustrated. Furthermore, the pressure conditions during the extraction treatment are not particularly limited, and may be normal pressure or pressurized conditions. The extraction process may be either batch type or reflux type.

  After performing the said extraction process, a solid content is removed by solid-liquid separation means, such as filtration and centrifugation, A rose department rose plant extract can be obtained by collect | recovering solution fractions. Moreover, about the removed solid content, it may use for an extraction process again and an extract may be collect | recovered, and this can raise extraction efficiency.

  Thus, the Rosaceae genus Rosaceae plant extract obtained by the extraction treatment is in a liquid state, and in the present invention, the extract can be used as it is, but when an organic solvent is contained, it is reduced in pressure. The organic solvent may be removed by distillation or the like. Further, in the present invention, the rose family plant extract may be used in a liquid form as it is, but if necessary, it is subjected to a drying treatment such as reduced pressure drying, freeze drying, spray drying or the like to reduce moisture. Alternatively, it may be used in the form of a concentrated liquid, semi-solid, solid or powder by removing.

  Further, the Rosaceae rose genus plant extract may be further purified by subjecting it to an appropriate purification treatment such as chromatography or solvent separation.

The Rosaceae plant belonging to the genus Rosaceae used in the present invention may be obtained by the extraction treatment as described above, and commercially available products may also be suitably used. Examples of such commercially available products include, for example, Ages extract, Isaiyo rose extract, Isaiyo rose juice, canina rose fruit, canina rose fruit extract, canina rose fruit oil, canina rose seed, canina rose seed extract, canina rose flower, canina rose flower extract, canina rose flower oil, canina rose leaf Extract, gallica rose flower, gallica rose flower extract, gallica rose flower water, gallica rose flower oil, kouxin rose flower extract, saccharomyces / damask rose flower extract Rose flower water, centifolia rose juice, centifolia rose flower oil, damask rose extract, damask rose flower, damask rose flower extract, damask rose flower wax, damask rose flower water, damask rose flower oil, noi rose fruit extract, Thorny flower wax, wild rose extract, hybrid rose ovary extract, hybrid rose flower extract, hybrid rose flower water, hermanus extract, hermanus fruit extract, hermanus flower water, hermanus leaf extract, rose extract, moscata rose oil, moscata rose seed oil, Marketed under the names of Moscata Rose Leaf Extract, Yamahamanus Bud Extract, Rosehip Oil, Rose Water, Rosa Alba Flower Extract, Rosa Egentaria Extract, Rosa Egentaria Seed Oil, Losalviginosa Fruit Extract, Losalviginosa Seed Oil, Losalviginosa Seed Oil PEG-8 Esters The extract of the plant belonging to the family Rosaceae is included.
These Rosaceae rose genus plant extracts may be used alone or in combination of two or more.

  From the viewpoint of more reliably exhibiting a high body odor suppressing effect, Age Extract is preferably used as the component (A). Ages extract is a well-known extract of the genus Rosaceae belonging to the family Rosaceae, which is usually obtained by extraction from false fruits or fruits of Neurose using water-containing ethanol. It is well known that Agez extract contains a kind of flavonoid called multinoside A as its main component. Therefore, it is not desired to be bound by theory, but it is also speculated that this multinoside A may play a part in the mechanism of exerting the body odor suppressing effect of the present invention.

  Therefore, in the present invention, a plant extract containing multinoside A can be suitably used as the component (A).

  In the skin external composition for body odor suppression of the present invention, the content of the component (A) can be appropriately set according to the formulation form of the composition, the degree of required effect, and the like. As an example, (A) component is 0.001-10 weight% with respect to the whole composition, Preferably 0.005-5 weight%, More preferably, 0.01-2 weight% is illustrated.

(B) Button family button genus plant extract The skin external composition for body odor suppression of the present invention is a button family button genus plant extract (hereinafter also simply referred to as component (B)) in addition to the above component (A). Containing.

  In the present specification, the button family button genus plant extract refers to an extract (also referred to as an extract) obtained from a button family button family (Paeoniaceae Paeonia) plant.

The genus of the genus Button family includes peonies (Paeonia lactiflora), Dutch peonies (Paeonia officinalis), peonies (Paeonia japonica), and safflower peonies (Paeonia).
obovata), buttons (Paeonia suffruticosa) and the like, but are not limited thereto. Preferably, the Button family plant is Peonies, Dutch Peonies or Buttons, particularly preferably Peonies.

  The organ of the genus Buttonaceae plant to be extracted for obtaining the extract is not particularly limited as long as the effects of the present invention can be obtained. For example, as in the case of the component (A), flowers, fruits, false fruits, and children Tufts, seeds, leaves, buds, stems, roots and the like can be used.

  The preparation method (extraction solvent, extraction time, extraction temperature, etc.) for obtaining a button family button genus plant extract is also any method known in the art in the same manner as described for the component (A) above. Can be done.

The button family button genus plant extract used in the present invention may be obtained by the extraction treatment as described above, or a commercially available product may be suitably used. Examples of such commercially available products are commercially available under the names of peony extract, peony root, peony root extract, peony root water, peony flower extract, Dutch peony root extract, Dutch peony flower extract, button extract, button flower water, etc. Can be mentioned extracts of the plant belonging to the genus Buttonaceae.
These button family plant genus plant extracts may be used alone or in combination of two or more.

  From the viewpoint of more reliably exhibiting a high body odor suppressing effect, a peony extract is preferably used as the component (B). A peony extract is a well-known button family plant extract extracted from the root of a peony, usually using water-containing ethanol. It is well known that peony extract contains a kind of monoterpenoid glycoside called paeoniflorin as its main component. Therefore, although not wishing to be bound by theory, it is also speculated that this paeoniflorin may play a part in the mechanism of exerting the body odor suppressing effect of the present invention.

  Therefore, in the present invention, a plant extract containing paeoniflorin can be suitably used as the component (B). Examples of plant extracts containing paeoniflorin include, but are not limited to, peony extract and button extract.

  In the skin external composition for body odor suppression of the present invention, the content of the component (B) can be appropriately set according to the formulation form of the composition, the degree of required effect, and the like. As an example, (B) component is 0.001-10 weight% with respect to the whole composition, Preferably 0.005-5 weight%, More preferably, 0.01-2 weight% is illustrated.

  Furthermore, in the skin external composition for body odor suppression according to the present invention, the ratio of the content of the component (B) to the content of the component (A) is not particularly limited, but the effect of the present invention is more effectively exhibited. From the viewpoint of being able to do so, as an example, the content of the component (B) is 0.0001 to 10,000 parts by weight, preferably 0.001 to 1000 parts by weight, more preferably 0.05 to 200 parts per part by weight of the component (A). The ratio used as a weight part is illustrated.

In order to further enhance the body odor suppressing effect, the composition for external use of the skin of the present invention may further contain other components known to have a body odor suppressing effect. Examples of such components include, but are not limited to, porous materials having an odor-adsorbing action such as charcoal, mud, bentonite, montmorillonite, and kaolin; oyster tannin (butterfly astringent), bite mulberry, tea, American witch hazel (hamamelis), perilla, Examples include plant extracts such as Koganebana (Ogon), cucumber, salamander, parsley and the like.
The content of the above components can be appropriately selected in consideration of the feeling of use and effects on the skin, but is usually about 0.0001 to 20% by weight, preferably about 0.001 to 10% by weight, based on the entire composition. Good.

It is also known that propagation of skin resident bacteria (miscellaneous bacteria such as gram-positive bacteria and gram-negative bacteria) strongly affects the generation of body odor. Therefore, it is preferable that the composition for external use of the present invention further contains an antibacterial component in addition to the components (A) and (B). Examples of such antibacterial components include, but are not limited to, isopropylmethylphenol, benzalkonium chloride, benzethonium chloride, cymene-5-ol, triclocarban, triclosan, chlorhexidine, salicylic acid, acrinol, ethanol, cresol, gluconic acid , Popidone iodine, potassium iodide, iodine, photosensitive element 101, photosensitive element 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride, and the like. Of these, isopropylmethylphenol, benzalkonium chloride, and benzethonium chloride are preferable.
The content of the above components can be appropriately selected in consideration of the feeling of use and effects on the skin, but is usually about 0.0001 to 10% by weight, preferably about 0.001 to 5% by weight, based on the entire composition. Good.

  Moreover, the composition for external use of the skin of the present invention, in addition to the above-mentioned components, adds other useful effects, so that it is an anti-inflammatory component, an anti-aging component, an ultraviolet scattering component, an ultraviolet absorbing component, DNA damage prevention and 1 or 2 types of various components such as a component having a restorative effect, a whitening component, a cell activation component, an astringent component, an antioxidant component, a moisturizing component, a horny soft component, a vitamin, a blood circulation promoting component, and a sebum adsorbing component You may mix | blend in combination above. These components are not particularly limited as long as they can be used in the fields of pharmaceuticals, quasi drugs, cosmetics, and the like, and arbitrary components can be appropriately selected and used. Among them, the anti-inflammatory component is preferable because it can contribute to improvement of rough skin, which is one of the skin troubles that are likely to occur due to aging. It is also preferable to add an anti-aging component.

  Examples of the anti-inflammatory component include glycyrrhizic acids, glycyrrhetinic acids, zinc oxide, allantoin, calamine, guaiazulene, tocopherol acetate, pyridoxine hydrochloride, menthol, camphor, turpentine oil, indomethacin, salicylic acid or derivatives thereof. Preferred are glycyrrhizic acids (for example, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate), glycyrrhetinic acids, or zinc oxide. When the anti-inflammatory component is blended, its content can be appropriately selected in consideration of the feeling of use and effects on the skin, but it is, for example, about 0.0003 to 10% by weight, preferably about 0.01, based on the total composition for external use on the skin. ~ 5% by weight.

  Examples of anti-aging components include retinoids (retinol, retinoic acid, retinal, etc.), pangamic acid, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L-serine, mevalonolactone, and the like. When blending an anti-aging ingredient, the amount of use can be appropriately selected in consideration of the feeling of use and effects on the skin, but for example about 0.0003 to 10% by weight, preferably about 0.01, based on the total composition for external use on the skin. ~ 5% by weight.

  Examples of the ultraviolet scattering component include inorganic compounds such as zinc oxide, titanium oxide, iron oxide, cerium oxide, zirconium oxide, titanium silicate, zinc silicate, anhydrous silicic acid, cerium silicate, hydrous silicic acid, and the like. Inorganic compounds coated with inorganic powders such as hydrous silicic acid, aluminum hydroxide, mica and talc, compounded with resin powders such as polyamide, polyethylene, polyester, polystyrene and nylon, and silicon oil and fatty acid aluminum What was processed with salt etc. is mentioned. Of these, inorganic compounds such as zinc oxide, titanium oxide and iron oxide, and those inorganic compounds coated with inorganic powder such as aluminum hydroxide, hydrous silicic acid, mica and talc, and silicon oil are preferable. In the case of blending an ultraviolet scattering component, the amount used can be appropriately selected in consideration of the feeling of use and effects on the skin, but it is, for example, about 0.001 to 35% by weight, preferably about 0.1%, based on the whole external composition for skin. ~ 25% by weight.

  Examples of the ultraviolet absorbing component include 2-methoxyhexyl paramethoxycinnamate, 2- [4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester, 2,4,6-tris [4- (2-ethylhexyl). Oxycarbonyl) anilino] -1,3,5-triazine, dimethoxybenzylideneoxoimidazolidinepropionate 2-ethylhexyl, 2,4-bis-[{4- (2-ethylhexyloxy) -2-hydroxy} -phenyl]- Examples include 6- (4-methoxyphenyl) -1,3,5-triazine. When the ultraviolet absorbing component is blended, the amount used can be appropriately selected in consideration of the feeling of use and effects on the skin, but for example, about 0.01 to 20% by weight, preferably about 0.1%, based on the total composition for external use on the skin. ~ 15% by weight.

  Examples of the component having an action of preventing and / or repairing DNA damage include, for example, a component derived from an animal (eg, Artemia); a component derived from a plant (eg, cat's claw); DNA, DNA salt, RNA, RNA salt And the like. The compounding amount of the component having the action of preventing and / or repairing DNA damage can be appropriately selected in consideration of the feeling of use and effects on the skin. For example, about 0.001 to 3 wt. %, Preferably about 0.01 to 1% by weight. The amount used in the case of using animal components or plant components is about 0.00001 to 0.1% by weight, preferably about 0.0001 to 0.01% by weight, based on the total amount of the composition for external use in terms of extracts such as extracts.

  Examples of the whitening component include placenta; arbutin; kojic acid; ellagic acid; phytic acid; lucinol; chamomile ET; vitamins such as vitamin A or a derivative thereof, pantothenic acid or a derivative thereof, and the like. Furthermore, a plant component having a whitening effect may be used as a whitening component. Examples of such plant components include Iris (Iris), Almond, Aloe, Ginkgo, Oolong Tea, Ogon, Auren, Hypericum, Adrianthus, Seaweed, Cuckon, Gardenia, Kujin, chlorella, gobaishi, wheat, rice, rice haiga, oryzanol, rice bran, saishin, salamander, perilla, nematode, sakuhakuhi, soybean, natto, tea, toki, shinsenka, garlic, hamamelis, safflower, buttonpi, yokuinin, toki, Amethyst, asenyaku, acebi bracken, oyster, enoki, oyster (Diospyros kaki), catalpa, black bean, gentian, genzin, salsa, green beans, shokuma, jujuu, sage, senko, radish, azalea, azalea, toshin, Ingredients derived from plants such as nigaki, parsley, holly, hop, malbahagi, clove, licorice and the like can be mentioned. When these plant components are used in the composition for external use of the skin of the present invention, the form of the plant component is not particularly limited, but it can usually be used in the form of a plant extract (plant extract) or an essential oil. When the whitening component is blended, the amount used can be appropriately selected in consideration of the feeling of use and effects on the skin, but for example about 0.0003 to 10% by weight, preferably about 0.01 to 5% by weight. The amount used when using a plant extract is about 0.00001 to 20% by weight, preferably about 0.0001 to 15% by weight, more preferably 0.001 to 10%, based on the total amount of the composition for external use in terms of an extract such as an extract. % By weight.

  Examples of the cell activation component include amino acids such as γ-aminobutyric acid and ε-aminocaproic acid: vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride and pantothenic acids: α-hydroxy acids such as glycolic acid and lactic acid: Examples thereof include tannin, flavonoid, saponin, allantoin, and photosensitizer 301. When the cell activating component is blended, the amount used can be appropriately selected in consideration of the feeling of use and effects on the skin. For example, about 0.0003 to 10% by weight, preferably about 0.01 to 5% by weight.

  Examples of the astringent component include metal salts such as alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, zinc sulfate, and aluminum potassium sulfate; organic acids such as tannic acid, citric acid, lactic acid, and succinic acid . When blending an astringent component, the amount used can be appropriately selected in consideration of the feeling of use and effects on the skin, but for example about 0.0003 to 10% by weight, preferably about 0.01 to 10% by weight based on the total composition for external use on the skin. 5% by weight.

  Examples of the antioxidant component include butylhydroxyanisole, dibutylhydroxytoluene, sodium bisulfite, erythorbic acid and its salts, flavonoids, glutathione, glutathione peroxidase, glutathione-S-transferase, catalase, superoxide dismutase, thioredoxin, taurine, thiotaurine And hypotaurine. When the antioxidant component is blended, the amount used can be appropriately selected in consideration of the feeling of use and effects on the skin. For example, it is about 0.00001 to 10% by weight, preferably about 0.0001, based on the total composition for external use on the skin. -5% by weight, more preferably 0.001-5% by weight.

  As moisturizing ingredients, amino acids such as alanine, serine, leucine, isoleucine, threonine, glycine, proline, hydroxyproline, glucosamine, theanine and derivatives thereof; polyvalent such as glycerin, 1,3-butylene glycol, propylene glycol, polyethylene glycol, etc. Alcohols; sugar alcohols such as sorbitol; phospholipids such as lecithin and hydrogenated lecithin; propylene glycol, heparin, chondroitin, hyaluronic acid or a salt thereof (for example, sodium hyaluronate), acetylated hyaluronic acid or a salt thereof (for example, acetyl) And mucopolysaccharides such as sodium hyaluronate); NMF-derived components such as lactic acid, sodium pyrrolidonecarboxylate, and urea. When a moisturizing component is blended, the amount used can be appropriately selected in consideration of the feeling of use and effects on the skin, but for example about 0.1 to 10% by weight, preferably about 0.5 to 5% by weight.

  Examples of the keratin soft component include lanolin, urea, phytic acid, lactic acid, lactate, glycolic acid, salicylic acid, malic acid, citric acid and the like. When the keratin softening component is blended, the amount used can be appropriately selected in consideration of the feeling of use and effects on the skin. For example, 0.0001 to 50% by weight, preferably about 0.001 with respect to the entire external composition for skin. -50% by weight, more preferably about 0.05-25% by weight.

  Examples of vitamins include retinol derivatives such as retinol, retinol acetate, and retinol palmitate, retinal, retinoic acid, methyl retinoic acid, ethyl retinoic acid, retinol retinoic acid, d-δ-tocopheryl retinoate, α-tocopheryl. Vitamin A such as retinoate, β-tocopheryl retinoate; provitamin A such as β-carotene, α-carotene, γ-carotene, δ-carotene, lycopene, zeaxanthin, cryptoxanthine, echinone; δ-tocopherol, Vitamin Es such as α-tocopherol, β-tocopherol, dl-α-tocopherol succinate, dl-α-tocopherol calcium succinate, δ-tocopherol, tocopherol nicotinate; riboflavin, flavin mononucleotide, Vitamins B2 such as rabin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5′-phosphate sodium, riboflavin tetranicotinate; nicotinic acids such as methyl nicotinate, nicotinic acid, nicotinamide; stearin Ascorbyl acid, L-ascorbyl dipalmitate, Ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate), Ascorbic acid, Sodium ascorbate, Dehydroascorbic acid, Sodium ascorbate phosphate, Magnesium ascorbate phosphate, Ascorbine Vitamin C such as acid glucoside; vitamin D such as methyl hesperidin, ergocalciferol, cholecalciferol; Vitamin Ks such as phylloquinone and farnoquinone; dibenzoyl thiamine, dibenzoyl thiamine hydrochloride, thiamine hydrochloride, thiamine cetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine nitrate, thiamine monophosphate, thiamine lysine salt, Vitamin B1 such as thiamine triphosphate, thiamine monophosphate, thiamine monophosphate, thiamine diphosphate, thiamine diphosphate hydrochloride, thiamine triphosphate, thiamine triphosphate monophosphate; pyridoxine hydrochloride Vitamin B6 such as pyridoxine acetate, pyridoxal hydrochloride, 5'-pyridoxal phosphate, pyridoxamine hydrochloride, vitacobalamin, hydroxocobalamin, deoxyadenosylcobalamin, etc. Folic acids such as folic acid and pteroylglutamic acid; pantothenic acids such as pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-pantethein, D-panthetin, coenzyme A, pantothenyl ethyl ether; Biotins such as biotin and biocytin; in addition, vitamin-like agents such as carnitine, ferulic acid, α-lipoic acid, orotic acid, and γ-oryzanol are included. When blending vitamins, the amount of use can be appropriately selected in consideration of the feeling of use and effects on the skin, but for example about 0.001 to 30% by weight, preferably about 0.1%, based on the total composition for external use. -25% by weight, more preferably about 0.5-20% by weight.

  Examples of the blood circulation promoting component include plants (for example, ginseng, ashitaba, arnica, ginkgo, fennel, entomop, dutch oak, chamomile, roman chamomile, carrot, gentian, burdock, rice, hawthorn, shiitake, hawthorn, prunus, nematode, and senkyu. , Assembly, thyme, clove, chimpi, spruce, sprout, spruce, carrot, garlic, butcher bloom, grape, button, maronier, melissa, yuzu, yokinein, rosemary, rosehip, chimpi, spruce, spruce, peach, apricot, Ingredients derived from walnut, corn); tocopherol nicotinate, glucosyl hesperidin, hesperidin. When blending the blood circulation promoting component, the amount of use can be appropriately selected in consideration of the feeling of use and effects on the skin, but for example, about 0.00001 to 10% by weight, preferably 0.0001 to the total amount of the external composition for skin. 5% by weight, more preferably about 0.001 to 5% by weight. The amount used in the case of using a plant-derived component is about 0.00001 to 20% by weight, preferably about 0.0001 to 15% by weight, more preferably 0.001 to 10% by weight.

  Examples of the sebum adsorbing component include talc, mica, hydroxyapatite, zinc oxide, aluminum silicate, and the like. Of these, mica, hydroxyapatite, and zinc oxide are preferable, and mica is particularly preferable. When the sebum adsorbing component is blended, the amount used can be appropriately selected in consideration of the feeling of use and effects on the skin. For example, it is about 0.001 to 35% by weight, preferably about 0.1%, based on the total composition for external use on the skin. ~ 25% by weight.

  The various components as described above can be used singly or in combination of two or more.

  In addition to the above-described components, the composition for external use of the present invention may be appropriately blended with components usually used in the fields of pharmaceuticals, quasi drugs, cosmetics, etc., depending on the application or dosage form. The components that can be blended are not particularly limited, but for example, bases or carriers, surfactants, viscosity modifiers, antioxidants, preservatives, pH adjusters, chelating agents, stabilizers, irritation reducers, preservatives Additives such as colorants, dispersants, and fragrances can be blended. In addition, these components can be mix | blended individually by 1 type or in combination of 2 or more types.

  As a base or carrier, water-based bases such as water; liquid paraffin, squalane, petrolatum, gelled hydrocarbon (such as plastibase), ozokerite, α-olefin oligomer, hydrocarbon such as light liquid paraffin; methyl polysiloxane, Cross-linked methylpolysiloxane, highly polymerized methylpolysiloxane, cyclic silicone, alkyl-modified silicone, cross-linked alkyl-modified silicone, amino-modified silicone, polyether-modified silicone, polyglycerin-modified silicone, cross-linked polyether-modified silicone, cross-linked alkylpoly Ether-modified silicone, silicone-alkyl chain co-modified polyether-modified silicone, silicone-alkyl chain co-modified polyglycerin-modified silicone, polyether-modified branched silicone, polyglycerin-modified branch system Silicone oils such as corn, acrylic silicone, phenyl-modified silicone, and silicone resin; higher alcohols such as cetanol, cetostearyl alcohol, stearyl alcohol, and behenyl alcohol; cellulose derivatives such as ethyl cellulose, hydroxypropyl cellulose, and hydroxypropyl methylcellulose; polyvinylpyrrolidone Carrageenan; polyvinyl butyrate; polyethylene glycol; dioxane; butylene glycol adipate polyester; isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, pentaerythritol tetra-2-ethylhexanoate, jojoba Esters such as oil; dextrin, maltodextrin Lower alcohols such as ethanol and isopropanol; ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, Glycol ethers such as propylene glycol monoethyl ether, propylene glycol monopropyl ether, dipropylene glycol monoethyl ether, dipropylene glycol monopropyl ether; polyethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin, isoprene glycol, di Glycerin, dipropyre Polyhydric alcohols such as Nglycol; An aqueous base is preferable, and water is more preferable. When the external composition for skin of the present invention contains water, the amount of the composition can be appropriately selected in consideration of the feeling of use and effects on the skin. For example, about 30 to 97% by weight with respect to the entire external composition for skin. %, Preferably 50 to 95% by weight, more preferably 60 to 90% by weight.

Examples of the surfactant include POE-branched alkyl ethers such as polyoxyethylene (hereinafter referred to as POE) -octyldodecyl alcohol and POE-2-decyltetradecyl alcohol; POE
POE-alkyl ethers such as oleyl alcohol ether and POE-cetyl alcohol ether; sorbitan esters such as sorbitan monooleate, sorbitan monoisostearate and sorbitan monolaurate; POE-sorbitan monooleate, POE-sorbitan monoisostea And POE-sorbitan esters such as POE-sorbitan monolaurate; glycerol fatty acid esters such as glycerol monooleate, glycerol monostearate, and glycerol monomyristate; POE-glycerol monooleate, POE-glycerol monostearate And POE-glycerin fatty acid esters such as POE-glycerin monomyristate; POE-dihydrocholesterol ester, POE-hardened castor oil, and POE-hardened castor oil isostearate and other POE-hardened castor oil fatty acid esters; POE-octylphenyl ether and other POE-alkyl aryl ethers; monoisostearyl glyceryl ether and monomyristyl glyceryl ether and other glycerin alkyl ethers; POE-mono POE-glycerin alkyl ethers such as stearyl glyceryl ether and POE-monomyristyl glyceryl ether; polyglycerin fatty acid esters such as diglyceryl monostearate, decaglyceryl decastearate, decaglyceryl decaisostearate, and diglyceryl diisostearate Various nonionic surfactants such as: lecithin, hydrogenated lecithin, saponin, surfactin sodium, cholesterol, bile acids, etc. Natural can be exemplified a surfactant derived.

  As viscosity modifiers, thickeners such as xanthan gum, carboxymethylcellulose, hydroxyethylcellulose, partially crosslinked polyacrylic acid, montmorillonite, hectorite, saponite, vermiculite, nontrite, sauconite, laponite; propylene glycol, ethanol, propanol, isopropanol, ethylene Examples thereof include viscosity reducing agents such as glycol, polyethylene glycol, polypropylene glycol, glycerin, polyglycerin, sorbitol, pentaerythritol, benzenesulfonate, and lower alkylbenzenesulfonate having about 1 to 4 carbon atoms.

  Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, ascorbic acid derivative, tocopherol, tocopherol derivative, erythorbic acid, L-cysteine hydrochloride and the like.

  Examples of preservatives or preservatives include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, paraoxybenzoate Examples thereof include benzyl benzoate, methyl paraoxybenzoate, phenoxyethanol, benzyl alcohol, chlorobutanol, sorbic acid and its salts, chlorhexidine gluconate, alkanediol and the like.

  Examples of pH adjusters include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate, etc.), inorganic bases (potassium hydroxide, hydroxide) Sodium), organic bases (triethanolamine, diisopropanolamine, triisopropanolamine, etc.).

  As a chelating agent, for example, as a chelating agent, ethylenediaminetetraacetic acid (edetic acid), ethylenediaminetetraacetic acid salt (sodium salt (sodium edetate: Japanese Pharmacopoeia, EDTA-2Na etc.), potassium salt etc.), phytic acid, Examples include gluconic acid, polyphosphoric acid, and metaphosphoric acid. Of these, sodium edetate is preferable.

Examples of the stabilizer include sodium polyacrylate, dibutylhydroxytoluene, and bitylhydroxyanisole.
Examples of the irritation reducing agent include licorice extract and sodium alginate.

  Examples of the fragrances include terpenoids such as menthol, camphor, borneol, geraniol, cineol, anethole, limonene, eugenol. These may be any of d-form, l-form, or dl-form. From the viewpoints of sensory and safety such as refreshing feeling and fragrance, 1-menthol, d-menthol, dl-menthol, d-camphor, dl-camphor , D-borneol and dl-borneol are preferred, and l-menthol is particularly preferred. The terpenoids can be used in the state of being contained in essential oils, and preferred essential oils include eucalyptus oil, bergamot oil, peppermint oil, cool mint oil, spearmint oil, fennel oil, mint oil, cinnamon oil, rose oil and the like. is there.

  The above additives can be used singly or in combination of two or more.

  The composition for external use of the skin of the present invention can be prepared in various forms according to a conventional method by blending the above components (A) and (B) and further blending additional components as necessary. The dosage form can be any dosage form suitable for application to the skin. Specific examples include lotions, gels, emulsions, creams, ointments, mousses, sheets (substrate support), aerosols, sprays, and the like. These preparations can be produced by methods commonly used by those skilled in the art, for example, according to the method described in the 16th revised Japanese Pharmacopoeia General Rules for Preparations. From the viewpoint of excellent usability when applied to the skin, it is preferably a lotion, gel, emulsion or cream. When an oily base and an aqueous base are included, such as emulsions, creams and ointments, they may be W / O type or O / W type, but O / W type is more preferable.

  In addition, the composition for external use of the skin of the present invention is compatible with the point that it is easy to spread when applied to the skin and the point that it is easy to apply firmly to the part where the body odor (especially aging odor) is concerned. It is preferable to have an appropriate viscosity. From such a viewpoint, the viscosity (25 ° C.) of the external composition for skin of the present invention is not particularly limited, but is preferably about 1 to 50000 mPa · s, more preferably about 100 to 30000 mPa · s, and still more preferably 1000 It should be about 10000 mPa · s. Mainly, the composition for external use with the above viscosity can be obtained by appropriately selecting the type and amount of the viscosity modifier.

In the present specification, the viscosity (25 ° C.) is a viscosity measured with a single cylindrical rotational viscometer (Brookfield viscometer) in accordance with the viscosity measurement method described in the 16th revised Japanese Pharmacopoeia general test method. Say. Specifically, it refers to the value measured using RB-80H (Toki Sangyo). Selection of conditions such as rotor and rotational speed is based on the machine's instruction manual and the viscosity at 25 ° C. taking measurement.
A description of a single cylindrical rotational viscometer is given below. A single cylindrical rotational viscometer is a viscometer that measures torque when a cylinder in a liquid is rotated at a constant angular velocity. By establishing experimentally device constant K _B by using the previously viscometer calibration standard solution, to calculate the viscosity of the liquid η by the following equation.
η = K _B
× T / ω
η: Viscosity of liquid (mPa · s)
K _B : Equipment constant (rad / cm ³ )
ω: Angular velocity (rad / s)
T: Torque acting on the cylindrical surface (10 ^-7 N · m)

  The composition for external use of the skin of the present invention is usually required to have a liquidity of pH 2.0 to 9.0, preferably from the viewpoint of low irritation to skin and mucous membranes and good usability when applied to the skin. Is preferably pH 3.0 to 8.0, more preferably pH 4.0 to 7.5, and particularly preferably about pH 5.0 to 7.0.

  The composition for external use of the skin of the present invention can exert a particularly excellent inhibitory effect on Nonenal, which is considered to be a cause of an aging odor, as shown in the following test examples. Therefore, the composition for external use of the present invention is particularly preferably used for people who are concerned about an aging odor. In view of such a viewpoint, the composition for external application of body odor for suppressing body odor according to the present invention is suitable for people in their 30s or later, particularly those in their 40s or later, who are concerned about aging odors. The aging odor is said to be more common in men who have more sweat secretion than women and who tend to increase sebum secretion due to intake of tobacco and large amounts of alcohol. Therefore, the skin external composition for body odor suppression of the present invention is particularly beneficial to men who are concerned about aging odors.

  The external composition for skin of the present invention is preferably applied to a part of the skin where body odor (especially aging odor) is anxious by means of application or spraying. Specifically, the composition for external use of the skin of the present invention is applied to a site (for example, behind the ear, neckline, armpit, chest, back, scalp, nose, sole of foot, etc.) where the amount of nonenal is large. Thus, an even higher body odor (especially aging odor) suppressing effect can be exhibited. The amount to be applied is not particularly limited as long as the effect of the present invention can be exhibited. For example, when applied to the whole body, an appropriate amount (about 0.1 to 10 g) is applied once to several times a day. Or just spray.

  The composition for external use for suppressing body odor of the present invention, after being applied to the skin as described above, stays on the skin and exhibits a body odor suppressing effect by suppressing body odor-causing substances (nonenal). be able to. In view of such a viewpoint, it is particularly preferable that the external composition for skin of the present invention is used as a leave-on type that does not wash off after application to the skin. By staying on the skin as it is without being washed away, the body odor (especially age-related odor) can be effectively suppressed.

(2. Body odor control method)
As described above, it has been confirmed that body odor can be effectively suppressed by using a combination of a rose family plant extract and a button family button plant extract.
Therefore, the present invention is characterized in that (A) a rose family plant extract and (B) a button family plant extract are applied to a part of the skin where the generation of body odor is anxious. The body odor suppression method is provided.
In the above method, the types of components (A) and (B) and their blending ratios, the types of other components that can be blended, their blending ratios, usage modes, etc. It is the same as that described in “

  EXAMPLES The present invention will be described in detail below based on examples, but the present invention is not limited to these examples.

<Test Example 1: Body odor suppression evaluation>
Using each test plant extract shown in Table 1 below, the trans-2-nonenal inhibitory effect was evaluated.

Specifically, it was performed as follows. First, 5 μL each of 1% (w / w) trans-2-nonenal dissolved in an ethanol solvent was added to a 500 mL Erlenmeyer flask. Subsequently, the plant extract shown in Examples 1-3 and Comparative Examples 1-2 was added 0.5g (total amount). At this time, as a control, an Erlenmeyer flask to which only trans-2-nonenal was added and no plant extract was added was prepared together. Mono
Trap DCC18 (silica monolith collector, manufactured by GL Sciences Inc.) was suspended on a silicon rubber in an Erlenmeyer flask, sealed, and allowed to stand at room temperature for 2 hours. 2 hours later, Mono
Trap DCC18 was recovered and placed in an MT Extract Cup (manufactured by GL Sciences Inc.) for solvent extraction, and 1 mL of chloroform was added thereto, followed by irradiation with ultrasonic waves for 5 minutes. Each extract thus obtained was subjected to gas chromatography (GC) measurement under the measurement conditions described later, thereby quantifying trans-2-nonenal.

(GC measurement conditions)
・ Model: Gas Chromatograph GC-17A (manufactured by Shimadzu Corporation)
・ Column: DB-WAX 30m × 0.53mmφ × 1μm (Agilent
Technologies)
・ Carrier gas: He, pressure: 100kPa,
Total flow rate: 272ml / min
・ Split ratio 20: 1
・ Temperature: 60 ℃ → Temperature rise (20 ℃ / min) → 200 ℃, 7min
・ Inlet: 250 ℃, Detector: 250 ℃ (FID)
・ Injection volume: 1μl

Based on the values measured for each example, comparative example, and control under the above GC measurement conditions, the trans-2-nonenal inhibition rate was calculated according to the following formula I.
trans-2-nonenal inhibition rate (%) = {(value in control−value in each example or comparative example) / value in control} × 100 (formula I)

  The results are also shown in the bottom column of Table 1 above. As is clear from this result, when the Ages extract, which is a rose family plant extract, and the peony extract, which is a button family plant extract, are used in combination, the remarkably high nonenal inhibitory effect. Was observed to be demonstrated.

  Hereinafter, formulation examples of the present invention will be shown.

<Prescription Formulation Example 1: Gel Agent>
1,3-butylene glycol 3% by weight
Concentrated glycerin 3% by weight
Peonies extract 1% by weight
Ages extract 1% by weight
Cha extract 0.5% by weight
Hamamelis extract 0.1% by weight
Acrylic acid / alkyl methacrylate copolymer 0.2% by weight
Sodium edetate hydrate 0.05% by weight
Triethanolamine 0.2% by weight
Methyl paraoxybenzoate 0.05% by weight
Fragrance 0.01% by weight
Purified water balance
Total 100% by weight

<Prescription Formulation Example 2: Lotion>
1,3-butylene glycol 3% by weight
Concentrated glycerin 3% by weight
Peonies extract 1% by weight
Ages extract 1% by weight
Xanthan gum 0.1% by weight
Triethanolamine 0.2% by weight
Fragrance 0.01% by weight
Ethanol 3% by weight
Purified water balance
Total 100% by weight

<Prescription Formulation Example 3: Emulsion>
Isononyl isononanoate 2% by weight
2% by weight of cyclopentasiloxane
Sorbitan monostearate 0.3% by weight
Behenez-20 0.35 wt%
1,3-butylene glycol 3% by weight
Concentrated glycerin 3% by weight
Peonies extract 0.8% by weight
Ages extract 0.8% by weight
Acrylic acid / alkyl methacrylate copolymer 0.25% by weight
Sodium edetate hydrate 0.05% by weight
0.25% by weight of triethanolamine
Methyl paraoxybenzoate 0.05% by weight
Fragrance 0.01% by weight
Purified water balance
Total 100% by weight

Claims (13)

A composition for external use on skin for suppressing aging odor , comprising (A) a rose family plant extract and (B) a button family plant extract. The composition for external use of skin according to claim 1, which suppresses nonenal. The external composition for skin according to claim 1 or 2 , which is used as a leave-on type. The external composition for skin according to any one of claims 1 to 3 , comprising a plant extract containing multinoside A as the component (A). The external composition for skin according to any one of claims 1 to 4 , comprising Age extract as the component (A). (B) The composition for external use of the skin in any one of Claims 1-5 containing the plant extract containing a paeoniflorin as a component. The external composition for skin according to any one of claims 1 to 6 , comprising peony extract as component (B). (A) Composition for external use of skin in any one of Claims 1-7 whose content of a component is 0.001 to 10 weight% with respect to the whole composition. (B) Composition for external use of skin in any one of Claims 1-8 whose content of a component is 0.001 to 10 weight% with respect to the whole composition. The external composition for skin according to any one of claims 1 to 9, which is contained at a ratio such that the content of the component (B) is 0.0001 to 10,000 parts by weight per part by weight of the component (A). The composition for external skin according to any one of claims 1 to 10, wherein the viscosity of the composition for external skin (25 ° C) is 1 to 50000 mPa · s. The composition for external skin according to any one of claims 1 to 11, wherein the pH of the composition for external skin is 2.0 to 9.0. (A) and the rose species plant extract and (B) peony peony extract, characterized in that the body odor generation is applied to the area of skin to be worried, body odor suppression method.