JP5241104B2 - 外用組成物 - Google Patents
外用組成物 Download PDFInfo
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- JP5241104B2 JP5241104B2 JP2007005181A JP2007005181A JP5241104B2 JP 5241104 B2 JP5241104 B2 JP 5241104B2 JP 2007005181 A JP2007005181 A JP 2007005181A JP 2007005181 A JP2007005181 A JP 2007005181A JP 5241104 B2 JP5241104 B2 JP 5241104B2
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- 239000000203 mixture Substances 0.000 title claims description 85
- 229920000642 polymer Polymers 0.000 claims description 59
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- -1 brown iron oxide Chemical compound 0.000 claims description 27
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- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 14
- 229910052710 silicon Inorganic materials 0.000 claims description 14
- 239000010703 silicon Substances 0.000 claims description 14
- 229920001477 hydrophilic polymer Polymers 0.000 claims description 12
- 239000000126 substance Substances 0.000 claims description 12
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 8
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- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims description 6
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 4
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- WTFXARWRTYJXII-UHFFFAOYSA-N iron(2+);iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3] WTFXARWRTYJXII-UHFFFAOYSA-N 0.000 claims description 3
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 claims description 3
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- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 2
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- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims description 2
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- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 claims description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 2
- CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 claims 1
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- 229960003471 retinol Drugs 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 229920002050 silicone resin Polymers 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- 235000010378 sodium ascorbate Nutrition 0.000 description 1
- 229960005055 sodium ascorbate Drugs 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 229960004718 sulconazole nitrate Drugs 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 229960005349 sulfur Drugs 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 description 1
- 229960000699 terbinafine hydrochloride Drugs 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 210000002105 tongue Anatomy 0.000 description 1
- 210000000515 tooth Anatomy 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229950010121 ufenamate Drugs 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000013585 weight reducing agent Substances 0.000 description 1
- 229940045860 white wax Drugs 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Images
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
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- A61K8/893—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by an alkoxy or aryloxy group, e.g. behenoxy dimethicone or stearoxy dimethicone
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Description
項1.(A)薬効成分、(B)粉末成分、(C)高分子および(D)溶剤を含有する外用組成物であって、
当該組成物を収容する収容部と、
前記収容部を外部と連通する開口部と、
前記開口部を覆うように設けられた多数のブラシ毛からなる塗布部とを備える薬液用塗布具に充填するための外用組成物。
項2.外用組成物の総重量に対して、(B)粉末成分を6〜40重量%の割合で含有する、項1に記載の外用組成物。
項3.(C)高分子が親油性高分子である、項1又は2に記載の外用組成物。
項4.前記親油性高分子がシリコン系高分子である、項3に記載の外用組成物。
項5.外用組成物の総重量に対して、親油性高分子を3〜60重量%の割合で含有する、項3又は4に記載の外用組成物。
項6.(C)高分子が親水性高分子である、項1又は2に記載の外用組成物。
項7.外用組成物の総重量に対して、親水性高分子を0.1〜10重量%の割合で含有する、項6に記載の外用組成物。
項8.項1〜7のいずれかに記載の外用組成物を収容した収容部と、
前記収容部を外部と連通する開口部と、
前記開口部を覆うように設けられた多数のブラシ毛からなる塗布部とを備える薬液用塗布具。
<塗布具>
このような本発明の液状外用組成物は、例えば、図1に示すような塗布具1に充填して使用することができる。本発明における塗布具1は、本発明の外用組成物を収容する収容部2と、収容部2を外部と連通する開口部3と、開口部3を覆うように設けられた多数のブラシ毛4aからなる塗布部4とを備える。このような塗布具としては、液状化粧品の塗布用として公知のものを使用してもよい。
実施例1
以下の手順で外用組成物を調製した。
(1)油溶性成分:
グリチルレチン酸ステアリル(薬効成分)
油溶性高分子(シリコン系高分子)
流動パラフィン(溶剤)
スクワラン(溶剤)
モノオレイン酸ソルビタン(溶剤(界面活性剤))
ポリオキシエチレンアルキルエーテル(溶剤(界面活性剤))
を混合し、溶解させる。
(2)(1)で調製した溶液に、粉末成分(平均粒子径:0.01〜50μm)を混合、分散させる。
(3)別に、水溶性成分:
リン酸L−アルコルビルマグネシウム(薬効成分)
水(溶剤)
濃グリセリン(溶剤)
パラオキシ安息香酸メチル(防腐剤)
水酸化ナトリウムおよびクエン酸(pH調整剤)
水溶性高分子
を混合し、溶解させる。
(4)(2)に(3)を投入し、乳化させて外用組成物を調製した。
表1〜4に示す処方にしたがって、実施例1と同様の方法を用いて外用組成物を調製した。
試験例1 特性確認試験
調製した各外用組成物(実施例1〜49及び比較例1〜7)に対して、下記試験を行い、(1)減量、(2)流動性、(3)使用感について評価した。
(1)減量
調製した各外用組成物をそれぞれ塗布具に充てんした。塗布具は、図1に示すように、収容部と、収容部を外部と連通する開口部と、開口部を覆うように設けられた多数のブラシ毛からなる塗布部とを備えたノック機構を備えたもの(収容部は円柱状(直径:1.0cm、高さ:2.5cm)であり、開口部のパイプは内径:0.1cm、長さ:1.5cmであり;塗布部のブラシ毛は材質:ポリアミド樹脂(30デニール)、幅:0.5cm、厚み:0.4cm、パイプ先端から毛先までの長さ:1.0cmであるものを使用した。
外用組成物を塗布具に充填し、外用組成物25mgを塗布部のブラシ毛全体に馴染ませた後、全体の重量を測定した(放置前の重量)。その後、塗布部が上方に、ノック機構が下方になるように立て、40℃、10%(湿度)で10日間放置した後、重量を測定した(放置後の重量)。測定後、放置前の重量に対する放置後の重量変化を以下の計算式にしたがって算出した。各試験についてN=3で行い、その平均値から下記基準にしたがい評価した。
<減量の計算式>
[(放置前の重量―放置後の重量)/放置前の重量]×100=減量(%)
<減量の評価基準>
★:5%未満
◎:5%以上8%未満
○:8%以上10%未満
×:10%以上
得られた結果を表1−4に併せて示す。比較例1−7の結果から、それぞれ、粉末成分及び高分子のみの使用では、外用組成物の重量がかなり減量してしまうことが確認された。これに対し、実施例1−49の結果から、粉末成分及び高分子を組み合わせて使用すると減量を防ぐことができることが明らかとなった。
ガラス板上に実施例1−49の各組成物を10g置き、ガラス板を45度傾けた際に組成物が傾けた方向に流れ動くかどうかで流動性を評価した。
その結果、実施例31を除いて、いずれも流れ動くという結果を得た。よって、実施例4、7および16と、実施例31とを比較することにより、粉末の配合量が40%以下であると、製剤の流動性がとくに良くなることがわかった。
N=10にて、実施例1−49の各組成物を肌に塗布した際の使用感(ベタツキ)・塗りやすさを以下の5段階で評価してもらい、その平均値から下記基準にしたがい評価した。
<評価基準>
5点:良い
4点:やや良い
3点:どちらでもない
2点:やや悪い
1点:悪い
<○×判断基準>
○:平均4点以上
×:平均4点未満
その結果、実施例31および32を除いてはすべて○という結果を得た。実施例2と32とを比較することにより、シリコンの配合量が60%以下であると、製剤にべたつきが出ず、使用感がとくに優れることがわかった。
表5および6に記載の処方にしたがって、実施例と同様に外用組成物を調製した。
2 収容部
3 開口部(パイプ)
4 塗布部
4a ブラシ毛
Claims (5)
- (A)薬効成分、(B)粉末成分6〜40重量%、(C)親油性高分子3〜60重量%および/または親水性高分子2〜10重量%および(D)溶剤を含有する外用組成物であって、
上記親油性高分子が、シリコン系高分子、
上記親水性高分子が、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、ヒドロキシエチルメチルセルロース、ヒドロキシプロピルメチルセルロース、カルボキシメチルセルロース、カルボキシメチルエチルセルロース、メチルセルロース、エチルセルロース、カルボキシビニルポリマー、ポリビニルピロリドン、カルメロースナトリウム、キサンタンガムおよびカラギーナンからなる群から選択される少なくとも1種、及び
上記粉末成分が、黄酸化鉄、赤酸化鉄、黒酸化鉄、褐色酸化鉄、酸化チタン、タルク、酸化亜鉛、デンプン、ステアリン酸マグネシウム、ステアリン酸アルミニウム、ステアリン酸亜鉛、カオリン、ベントナイト、カーボンブラック、軽質無水ケイ酸および薬用炭からなる群から選択される少なくとも1種であり;
当該組成物を収容する収容部と、
前記収容部を外部と連通する開口部と、
前記開口部を覆うように設けられた多数のブラシ毛からなり、使用後にブラシ毛間に薬液を保持させる塗布部
とを備える薬液用塗布具に充填するための外用組成物。 - 粉末成分の平均粒子径が0.01〜50μmである、請求項1に記載の外用組成物。
- 上記(C)高分子が、親油性高分子のみから構成されるか、または親水性高分子のみから構成される外用組成物であって、親油性高分子のみから構成される場合の(C)高分子の割合が、粉末成分1重量部に対して0.075〜10重量部であり、親水性高分子のみから構成される場合の(C)高分子の割合が、粉末成分1重量部に対して0.0025〜1.7重量部である、請求項1または2に記載の外用組成物。
- 請求項1〜3のいずれかに記載の外用組成物を収容した収容部と、
前記収容部を外部と連通する開口部と、
前記開口部を覆うように設けられた多数のブラシ毛からなり、使用後にブラシ毛間に薬液を保持させる塗布部
とを備える薬液用塗布具。 - ブラシ毛の材質が、ポリアミド、ポリエステル、ポリエチレンテレフタレート、ポリエチレン、高密度ポリエチレン、中密度ポリエチレン、低密度ポリエチレン、及びポリプロピレンからなる群から選択される少なくとも1種の合成樹脂である、請求項4に記載の薬液用塗布具。
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007005181A JP5241104B2 (ja) | 2007-01-12 | 2007-01-12 | 外用組成物 |
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MX2011009861A (es) * | 2009-03-20 | 2011-09-29 | Procter & Gamble | Cabezal de cepillo para uso en un recipiente para dispensar una composicion. |
DE202010012043U1 (de) * | 2010-08-31 | 2010-11-11 | Sanderstrothmann Gmbh | Vorrichtung zur Dosierung einer säurehaltigen Zusammensetzung |
JP6005344B2 (ja) * | 2011-07-05 | 2016-10-12 | 科研製薬株式会社 | 爪白癬薬用塗布具 |
JP2013215448A (ja) * | 2012-04-10 | 2013-10-24 | Kobayashi Pharmaceutical Co Ltd | 皮膚外用製品 |
JP2016023184A (ja) * | 2014-07-24 | 2016-02-08 | 丸山 政雄 | 変形爪矯正用処理剤 |
WO2018079219A1 (ja) | 2016-10-28 | 2018-05-03 | ニプロ株式会社 | 塗布具および薬液塗布具 |
WO2021215256A1 (ja) | 2020-04-20 | 2021-10-28 | 大成化工株式会社 | 薬液塗布容器の中栓、およびそれを備える薬液塗布容器 |
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JPS5917801Y2 (ja) * | 1981-08-11 | 1984-05-23 | 伸晃化学株式会社 | 開口装置付液体容器 |
JPS58126845U (ja) * | 1982-02-22 | 1983-08-29 | 小林製薬株式会社 | 携帯型液剤塗擦容器 |
JPS6368511A (ja) * | 1986-09-11 | 1988-03-28 | Nippon Terupen Kagaku Kk | 化粧料 |
JP2854114B2 (ja) * | 1990-09-10 | 1999-02-03 | 花王株式会社 | 口腔用組成物 |
FR2666962B1 (fr) * | 1990-09-26 | 1996-06-14 | Oreal | Composition antifongique sous forme de spray sec. |
JPH07252114A (ja) * | 1994-01-28 | 1995-10-03 | Pentel Kk | 液状化粧料 |
JP3778324B2 (ja) * | 1998-03-30 | 2006-05-24 | 株式会社資生堂 | 水中油型乳化組成物 |
JP3681930B2 (ja) * | 1999-08-17 | 2005-08-10 | ポーラ化成工業株式会社 | 毛髪用の化粧料 |
JP2001302476A (ja) * | 2000-04-17 | 2001-10-31 | Lion Corp | 歯磨組成物 |
JP4590067B2 (ja) * | 2000-06-09 | 2010-12-01 | 株式会社資生堂 | 乳化組成物 |
US20040131560A1 (en) * | 2002-10-04 | 2004-07-08 | The Procter & Gamble Company | Oral compositions and use thereof |
JP2005068028A (ja) * | 2003-08-28 | 2005-03-17 | Rohto Pharmaceut Co Ltd | 皮膚外用剤 |
FR2865360B1 (fr) * | 2004-01-22 | 2006-05-26 | Oreal | Applicateur comportant un element d'application solidaire, lors de l'utilisation, d'un recipient contenant un produit a appliquer |
JP4951785B2 (ja) * | 2004-04-13 | 2012-06-13 | 鈴木油脂工業株式会社 | 抗菌性微粒子、その製造法及び該抗菌性微粒子を含む化粧料又は殺菌殺虫剤 |
JP2005330242A (ja) * | 2004-05-21 | 2005-12-02 | Shiseido Co Ltd | W/o型エマルジョン製剤 |
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