JP5110314B2 - Sleep improving composition and sleep improving agent - Google Patents

Description

  The present invention relates to a composition for improving sleep, which is obtained by taking it before going to bed, whereby an excellent sleep improving effect, in particular, an effect of increasing deep non-REM sleep time can be obtained.

  Sleep is a state in which the brain is rested, and for higher animals, it is not just a cessation of activity, but an adaptive behavior supported by high physiological functions. If you don't sleep well, your brain's information processing ability will be adversely affected. For example, an unpleasant mood or lack of motivation to feel that sleep is lacking means that the cerebrum is demanding resting due to a decline in the function of the cerebrum rather than a malfunction of the body. However, simply sleeping for a long time does not work very positively, and good quality sleep, that is, deep sleep (non-REM sleep), especially deep sleep (sleep stages 3 and 4 of non-REM sleep) is a high quality life. Tie.

  As technologies relating to sleep, CoQ10 (Patent Document 1: JP 2005-325086 A), theanine (Patent Document 2: JP 2005-289948 A), diphenhydramine hydrochloride (Patent Document 3: JP 2005-179411 A). No. 4), Valeriana plants or extracts thereof (Patent Document 4: JP 2003-183174 A), lavender oil, etc. (Patent Document 5: JP 2000-355545 A) and the like have been proposed. However, there are various causes of insomnia, and it has been desired to have an excellent sleep improvement effect, in particular, an effect of increasing deep non-REM sleep (deep sleep) time. In addition, the following is mentioned as a prior art document relevant to this invention.

JP 2005-325086 A JP 2005-289948 A JP 2005-179111 A JP 2003-183174 A JP 2000-355545 A JP 2005-348656 A JP 2003-284537 A JP 2005-13146 A

  This invention is made | formed in view of the said situation, and it aims at providing the composition which can obtain the outstanding sleep improvement effect, especially the increase effect of deep non-REM sleep (deep sleep) time.

  The present inventor combined (A) a component having an action of enhancing parasympathetic nerve function such as γ-aminobutyric acid (GABA) and (B) a component having an action of promoting peripheral blood flow such as acetic acid. It was found that an excellent sleep improvement effect that cannot be obtained when used alone, in particular, an effect of increasing deep non-REM sleep time, and a deep sleep feeling can be obtained. The present invention is based on the assumption that it is important to improve the blood supply to peripheral tissues among the disturbing factors of deep sleep. As shown in the data described later, the present invention is conventionally effective for sleep. In addition to the component (A) that has been known, the combination of the component (B) that promotes the increase in peripheral blood flow provides a sleep improvement effect that cannot be obtained by the component (A) alone.

Accordingly, the following invention is provided.
[1]. (A) A composition containing γ-aminobutyric acid and / or glycine , and (B) tomato vinegar , wherein the intake of (A) component per sleep is 10 to 3000 mg, (B) component It is a composition containing so that the intake as acetic acid in it may be 50-3000 mg, Comprising : The mass ratio of the acetic acid in (A) component / (B) component is 1 / 0.08-1 / 100 The composition for sleep improvement characterized by the above-mentioned.
[2]. (A) The composition for improving sleep according to [1], wherein the component is γ-aminobutyric acid.
[3]. A composition for improving sleep comprising (A) γ-aminobutyric acid and (B ′) proanthocyanidins.
[4]. The composition for improving sleep according to [ 3 ], wherein the intake amount per sleep of the component (A) is 2 to 3000 mg, and the intake amount of the component (B ′ ) per sleep is 5 to 1000 mg.
[5]. The composition for improving sleep according to [ 3 ] or [ 4 ], wherein the mass ratio of (A) component / (B ′ ) component is 1 / 0.001 to 1/500.
[6]. Furthermore, the composition for improving sleep according to any one of [1] to [ 5 ], further comprising a fragrance having a sedative effect.
[7]. The composition for improving sleep according to [6], wherein the fragrance having a sedative effect is a fragrance selected from lavender, chamomile, clary sage, marjoram, eucalyptus and rosewood.
[8]. Further comprises vitamin of B ₆ and / or calcium [1] to sleep improvement composition according to any one of [7].
[9]. The composition for improving sleep according to any one of [1] to [ 8 ], wherein the dosage form is a drink, concentrated liquid, powder, tablet or jelly.
[10]. The composition for improving sleep according to any one of [1] to [ 9 ], which is taken before going to bed.
[11]. (A) A sleep improving agent containing γ-aminobutyric acid and / or glycine and (B) tomato vinegar as active ingredients.
[12]. The intake amount of component (A) per sleep is 10 to 3000 mg, the intake amount as acetic acid in component (B) is 50 to 3000 mg, and the amount of acetic acid in component (A) / component (B) The sleep improving agent according to [11], wherein the mass ratio is 1 / 0.08 to 1/100.
[13]. (A) A sleep improving agent containing γ-aminobutyric acid and (B ′) proanthocyanidins as active ingredients.
[14]. The sleep improving agent according to [13], wherein the intake amount per sleep of component (A) is 2 to 3000 mg, and the intake amount per sleep of component (B ′) is 5 to 1000 mg.
[15]. The sleep improving agent according to [13] or [14], wherein the mass ratio of component (A) / component (B ′) is 1 / 0.001 to 1/500.

  According to the composition for improving sleep of the present invention, an excellent sleep improving effect, in particular, a deep non-REM sleep time can be lengthened, and a satisfactory sleep feeling can be obtained when waking up.

  In general, “REM sleep” and “NREM sleep” are repeated for about 90 minutes as one unit during sleep, and deep non-REM sleep, which is a state of deep sleep, is about 3 hours after sleeping. concentrate. One of the sleep disorders is said to be due to the loss of sleep quality due to the disappearance or shortening of this deep non-REM sleep. The “sleep improvement” of the present invention is intended to contribute to the improvement of sleep quality by obtaining a deep sleep feeling by improving the quality and time of this deep non-REM sleep.

The composition for improving sleep of the present invention comprises (A) a component having an action of enhancing parasympathetic nerve function and (B) a component having an action of promoting an increase in peripheral blood flow as a sleep improving agent. It is a composition.
(A) As a suitable component which has the effect | action which raises a parasympathetic nerve function, amino acids, such as (gamma) -aminobutyric acid (GABA), theanine, tryptophan, and glycine, are mentioned. These can be used individually by 1 type or in combination of 2 or more types. Among these, γ-aminobutyric acid is preferable. γ-aminobutyric acid is a component contained in some foods such as vegetables, germinated brown rice, tea and fermented foods, and is involved in the suppression of nerve excitement as one of the neurotransmitters in the brain.

  The preparation method of (gamma) -aminobutyric acid is not specifically limited, The method of extracting from vegetables, fruits, cereals, the method of obtaining from lactic acid bacteria fermentation from milk protein, the method of Unexamined-Japanese-Patent No. 2005-239686, etc. are mentioned.

(A) The intake amount of the component having the effect of enhancing the parasympathetic nerve function is 2 to 3000 mg, preferably 2.2 to 2500 mg, more preferably 2.4 to 2000 mg, and further preferably 2.5 to 2 per sleep. 1500 mg. Particularly preferred is 10 to 1500 mg. According to this, the compounding quantity in the composition for sleep improvement is selected suitably. For example, if it is a composition which ingests 50mL per one sleep, what is necessary is just to mix | blend 2-3000 mg in 50mL of a composition.

  (B) As a suitable component which has the effect | action which accelerates | stimulates the increase in peripheral blood flow, an acetic acid and a polyphenol are mentioned, It can use individually by 1 type or in combination of 2 or more types. Of these, acetic acid is particularly preferred. As acetic acid, acetic acid may be used or vinegar may be blended, but vinegar is preferably blended. Examples of vinegar include fruit vinegar such as rice vinegar, apple vinegar, blueberry vinegar, vegetable vinegar, straw vinegar, malt vinegar, alcohol vinegar, distilled vinegar, concentrated vinegar, black vinegar, moromi vinegar, tomato vinegar, and synthetic vinegar. However, rice vinegar, fruit vinegar, vegetable vinegar, straw vinegar, alcohol vinegar, and tomato vinegar are preferred, and tomato vinegar is particularly preferred.

  Note that tomato vinegar contains γ-aminobutyric acid as component (A) and acetic acid as component (B). The amount of γ-aminobutyric acid contained in tomato vinegar varies depending on the type of tomato, cultivation time, cultivation place, maturity, etc., but in 100 g of tomato juice for processing, about 50 mg, the variety name “Momotaro” tomato Is said to be contained in about 50 to 140 mg in 100 g of tomato.

  When acetic acid is used, the intake is preferably 50 to 3000 mg, more preferably 80 to 2000 mg, and more preferably 120 to 1500 mg per sleep. According to this, the compounding quantity in the composition for sleep improvement is selected suitably. For example, if it is a composition which ingests 50mL per sleep, what is necessary is just to mix | blend 50-3000 mg in 50mL of compositions.

  The polyphenol is preferably a flavonoid, and examples of the flavonoid include catechin, proanthocyanidins, anthocyanins, anthocyanidins, flavonols, isoflavones and the like. Among these, catechin, proanthocyanidins, anthocyanins, and anthocyanidins are preferable. These can be blended as plant extracts or fruit juices, or purified ones may be used. Specific examples of plant extracts and fruit juices containing these ingredients include green tea extract, grape seed extract, pine bark extract, soybean extract, black bean extract, grape juice, granberry juice, blueberry juice, bilberry juice, apple Fruit juice is preferred.

  When using polyphenol, the intake is preferably 5 to 1000 mg per sleep, more preferably 10 to 800 mg, and still more preferably 20 to 600 mg. According to this, the compounding quantity in the composition for sleep improvement is selected suitably. For example, if it is a composition ingested 50 mL per sleep, 5-1000 mg may be mix | blended in 50 mL of compositions.

  When component (B) is acetic acid, the mass ratio of component (A) / component (B) is preferably 1 / 0.01 to 1/1000, more preferably 1 / 0.08 to 1/800, It is preferably 1/2 to 1/500, particularly preferably 1/2 to 1/300, and most preferably 1/2 to 1/100. If the ratio exceeds 1 / 0.01, blood may not be sufficiently supplied to peripheral tissues. If the ratio is less than 1/1000, the activity of the parasympathetic nervous system may not be dominant.

  When the component (B) is polyphenol, the preferred mass ratio of the component (A) / component (B) is 1 / 0.001 to 1/500, preferably 1 / 0.001 to 1/100, more preferably Is 1 / 0.08 to 1/90, more preferably 1 / 0.1 to 1/80. Further, the lower limit is more preferably 1/40, particularly preferably 1/20, and most preferably 1/12. If the ratio exceeds 1 / 0.001, blood may not be sufficiently supplied to peripheral tissues. If the ratio is less than 1/500, the activity of the parasympathetic nervous system may not be dominant.

  In the composition for improving sleep of the present invention, when a perfume having a sedative action is added alone or in combination of two or more, a deep sleep feeling can be obtained. Examples of the fragrance having a sedative effect include lavender, chamomile, clary sage, marjoram, eucalyptus, rosewood, etc. Among them, lavender and eucalyptus are preferable. The amount of these perfumes consumed per sleep is preferably 0.001 to 3000 mg, and is suitably adjusted according to the strength of the perfumes.

Furthermore, in order to further improve the sleep-improving effect with cooling properties, it is preferable to blend vitamins, minerals, flavors other than the fragrance having the sedative action, etc., alone or in combination of two or more. Examples of vitamins include vitamins B ₁ , B ₂ , B ₆ , B ₁₂ , C, A, D, E, K, niacin, folic acid, pantothenic acid, biotin, ubiquinone, and their respective derivatives. Among _{these, B 1, B 2, B} 6, B 12, C is preferable. It is preferable that the intake amount of vitamin per sleep and the blending amount in the composition for improving sleep conform to the blending limit amount of nutrients of the nutritional functional food.

Examples of minerals include calcium, iron, phosphorus, magnesium, potassium, selenium, and zinc. It is preferable that the intake amount of the mineral per sleep and the blending amount in the composition for improving sleep conform to the blending limit amount of nutrients of the nutritional functional food. As vitamins and minerals, vitamin B ₆ and / or calcium is preferably used.

  Flavors include lemon, orange, grapefruit, lime, mandarin, tangerine, apple, banana, cherry, grape, melon, peach, strawberry, milk, cream, butter, cheese, yogurt, coffee, tea, green tea, oolong tea, cocoa, Examples include cola, vanilla, peppermint, spearmint, cinnamon, nutmeg, pepper, garlic, ginger, clove, almond, peanut, hazelnut, macadamia nut, tomato, onion, garlic, celery, parsley, strawberry and lychee.

  When using a flavor, the intake is preferably 0.1 mg to 1000 mg per sleep.

  In the composition for improving sleep of the present invention, as an auxiliary to nutritional components, plant extracts other than components (A) and (B), fermenting microorganisms, carotenoids, carnitines, dietary fibers, unsaturated fatty acids, chitin / chitosan, You may mix | blend fermentation microorganisms, such as propolis, collagen, isoflavone, lactic acid bacteria, and bifidobacteria. Other ingredients that can be used in foods can be used without limitation. Acidulants such as those other than fruit juices described in [0016] above, corrigents such as other fruit juices, excipients, pH adjusters, emulsifiers, thickeners, preservatives, solubilizers, colorants, (A) Examples include amino acids other than the components.

  The dosage form of the sleep improving composition of the present invention can be a drink (beverage), a concentrated liquid, a powder, a tablet, a jelly, or the like. It can be obtained by mixing water (remainder).

  The composition for improving sleep of the present invention is preferably taken before going to bed, more preferably taken immediately before going to bed and 120 minutes before going to bed.

EXAMPLES Hereinafter, although an Example, a reference example, and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example.

[ Examples 1-5, Reference Examples 1-5, Comparative Examples 1-5]
The drink composition (50 mL; 1) shown in Tables 1-4 was prepared, and the deep sleep amount, the peripheral blood flow improvement effect, and the feeling of deep sleep were evaluated based on the following method. The results are also shown in the table.

(1) Measurement of deep sleep amount Three women in their 30s took one drink composition 30 minutes before bedtime, and EEG, eye movement, electromyogram, respiratory exercise, electrocardiogram, oxygen saturation during bedtime A polysomnographic examination was performed overnight to record the degree and movement of the lower limbs, and the depth of sleep was analyzed. An overnight polysomnograph (Fukuda Denshi) was used for the measurement. The amount of deep sleep was the total time of stages 3 and 4 of non-REM sleep, which is a state where the brain is resting. Results are shown as average values.
(2) Measurement of peripheral blood flow improvement effect (measurement of blood vessel width)
Five cold women were allowed to take one drink composition, and the blood vessel width of the fingers before and after taking the drink composition was measured with a peripheral blood vessel monitoring device (Astrim SU manufactured by Sysmex Corporation). As a result, the percentage of peripheral blood vessel width after ingesting the drink composition when the peripheral blood vessel width before ingesting the drink composition is taken as 100% is the rate of change in peripheral blood vessel width (%) before and after ingestion of the drink composition, The average value is shown (n = 5).
(3) Evaluation of a feeling of deep sleep 10 women who are dissatisfied with sleep in their 30s are divided into 2 groups of 5 each, and one group takes 1 test drink composition at 30 minutes before bedtime for 1 week. Then, one placebo was taken for one week 30 minutes before going to bed at an interval of one week. In the other group, one placebo was previously taken for 30 minutes before bedtime for 1 week, and one test drink composition was taken for 1 week 30 minutes before bedtime at an interval of 1 week. For each subject, symptoms during drinking were evaluated according to the following evaluation criteria. A result is shown by the average value of 10 persons.
<Evaluation criteria>
0: The feeling of deep sleep did not change between the test drink composition and the placebo.
1: Compared with placebo, a slightly sleepy feeling was obtained when the test drink composition was ingested.
2: A feeling of deep sleep was obtained when the test drink composition was ingested compared to placebo.

[Examples 6 to 9 ]
A drink for improving sleep having the composition shown in Table 5 is prepared by mixing and dissolving tomato vinegar, L-carnitine, calcium gluconate, nicotinamide, vitamins, fruit juice, sweetener, preservative and colorant, and then preliminarily added to water. Dispersed γ-aminobutyric acid was added, and a fragrance and the remaining water were added, mixed and dissolved, filtered, and sterilized to prepare. All of these drinks for improving sleep showed a good sleep improving effect.

[Example 10 ]
Jelly agent 50 parts by weight of granulated sugar, 0.02 part by weight of sucralose, 50 parts by weight of starch syrup, 100 parts by weight of orange juice, 480 parts by weight of water, 5 parts by weight of carrageenan, 5 parts by weight of locust bean gum, 1.2 parts by weight of sodium citrate Parts, fragrance 1.5 parts by weight, γ-aminobutyric acid 5 parts by weight, tomato vinegar 12 parts by weight (acetic acid equivalent 0.6 parts by weight), calcium gluconate 1 part by weight, vitamin B ₂ 0.02 parts by weight, vitamin B ₆ 0.02 parts by mass, 0.2 parts by mass of vitamin C, and 0.8 parts by mass of an emulsifier were dissolved by heating. Then, it was poured into a mold and left overnight to obtain a jelly. This jelly agent showed a good sleep improving effect.

Claims (15)

(A) A composition containing γ-aminobutyric acid and / or glycine , and (B) tomato vinegar , wherein the intake of (A) component per sleep is 10 to 3000 mg, (B) component It is a composition containing so that the intake as acetic acid in it may be 50-3000 mg, Comprising : The mass ratio of the acetic acid in (A) component / (B) component is 1 / 0.08-1 / 100 The composition for sleep improvement characterized by the above-mentioned. The composition for improving sleep according to claim 1, wherein the component (A) is γ-aminobutyric acid. A composition for improving sleep comprising (A) γ-aminobutyric acid and (B ′) proanthocyanidins. The composition for improving sleep according to claim 3 , wherein the intake amount per sleep of the component (A) is 2 to 3000 mg, and the intake amount per sleep of the component (B ' ) is 5 to 1000 mg. The sleep improving composition according to claim 3 or 4, wherein the mass ratio of (A) component / (B ' ) component is 1 / 0.001 to 1/500. Furthermore, the composition for sleep improvement of any one of Claims 1-5 containing the fragrance | flavor which has a sedative effect. The composition for improving sleep according to claim 6, wherein the fragrance having a sedative action is a fragrance selected from lavender, chamomile, clary sage, marjoram, eucalyptus and rosewood. Furthermore, any one sleep improvement composition according to claim 1-7, containing a vitamin of B ₆ and / or calcium. The composition for sleep improvement according to any one of claims 1 to 8 , wherein the dosage form is a drink, concentrated liquid, powder, tablet or jelly. The composition for improving sleep according to any one of claims 1 to 9 , which is taken before going to bed. (A) A sleep improving agent containing γ-aminobutyric acid and / or glycine and (B) tomato vinegar as active ingredients. The intake amount of component (A) per sleep is 10 to 3000 mg, the intake amount as acetic acid in component (B) is 50 to 3000 mg, and the amount of acetic acid in component (A) / component (B) The sleep improving agent according to claim 11, wherein the mass ratio is 1 / 0.08 to 1/100. (A) A sleep improving agent containing γ-aminobutyric acid and (B ′) proanthocyanidins as active ingredients. The sleep improving agent according to claim 13, wherein the intake amount per sleep of the component (A) is 2 to 3000 mg, and the intake amount of the component (B ') per sleep is 5 to 1000 mg. The sleep improving agent according to claim 13 or 14, wherein the mass ratio of the component (A) / the component (B ') is 1 / 0.001 to 1/500.