JP5086612B2 - Emulsified skin external preparation containing hydroxyapatite-treated powder - Google Patents

Description

  The present invention relates to an external preparation for skin, and more particularly to an external preparation for skin suitable for a cosmetic containing a hydroxyapatite-treated powder.

In skin external preparations such as cosmetics, it is very useful to apply an emulsifier form in that both oil-soluble ingredients and water-soluble ingredients can be formulated into the same formulation. For commercial products containing various ingredients, this utility is very large. In addition, since the emulsifier form usually has a stable water-oil interface, inorganic powder components such as titanium dioxide, zinc oxide, iron oxide, mica, titanium mica, and talc are stably dispersed using this interface. It is also used as a dispersion medium. In particular, since inorganic powders are mainly composed of metal oxides, in the case of only oily components or only water-based components, they settle easily due to their large specific gravity, but are distributed at the interface. The dispersion state can be stably maintained by positioning. Moreover, such a requirement, that is, also not suitable as a dosage form of an emulsion formulation containing a firm powder inorganic If not form a dosage form the interface structure can be said. In such conventional interface structures, a structure formed by fatty acid soap and higher alcohol and a network structure formed by organically modified hectorite, polyhydric alcohol and water have been used in the prior art. However, the structure of organically modified hectorite and polyhydric alcohol is formed only in the water-in-oil dosage form, and as long as this system is adopted, the weight of the water-in-oil emulsifier and the finished fat it was WESTERN shaped flame escaped from the yoke, when adopting the structure to make the fatty acid soap and fatty alcohol, stability itself be a good, by decorative finish fatty acid soap, & readily redispersible re In many cases, it was dispersed and exhibited the disadvantage of being easily broken. Since the fatty acid soap is excellent in emulsifying properties, it has an element that can be a double-edged blade when having a makeup.

As a new emulsification structure system to replace the higher alcohol / fatty acid soap structure and organic modified hectorite / polyhydric alcohol / water structure, stearyl lactic acid and acylation are used in the emulsifier form with a small content of inorganic powder. It is known that an emulsifying system made of polyglycerin creates a system having excellent powder dispersibility and stability (see, for example, Patent Document 1). However, even in such a system, the present inventors have found that uniform dispersion is impaired when the amount of inorganic powder increases. Also in this system, there is a need to increase the resistance of the cosmetic film (skin adhesion maintenance) to sweat and sebum. Fatty acid soaps formed by reaction of fatty acids and fatty acids with alkalis play an important role in such makeup disintegration, and a technology that can improve makeup lasting by trapping fatty acids is already known ( For example, see Patent Document 2). However, in the emulsification system, it was difficult to apply this technique due to the above situation.

On the other hand, it is known to produce a stable oil-in-water emulsion system for an emulsion structure system of acyl lactic acid such as stearoyl lactic acid and acylated polyglycerin (for example, Patent Document 3, Patent Document 4, Patent Document 5, Patent Document 6, Patent Document 7, Patent Document 8, and Patent Document 9), and a technique of emulsifying a combination of acyl lactic acid and an anionic surfactant is already known (for example, Patent Document 10). A combination of acylated polyglycerin with a sulfate-based anionic surfactant is not known, and a combination with inorganic powder is not known except for Patent Document 1. In addition, the fatty acid which originates in the skin and / or its coexistence with hydroxyapatite-treated powder (for example, see Patent Document 11 and Patent Document 12) disclosed in Patent Document 11 and Patent Document 12 It is not known that the removal of salt significantly improves the makeup life.

Japanese Patent Laid-Open No. 10-194964 Japanese Patent Laid-Open No. 10-87420 JP 2005-220119 A Japanese Patent Application Laid-Open No. 2001-335496 JP-A-11-276881 Japanese Patent Laid-Open No. 10-194967 JP 2002-53431 A Japanese Patent Laid-Open No. 9-48705 JP-T-2004-532340 JP 2006-63060 A JP-A-4-308513 JP 2000-143443 A

The present invention has been made under such circumstances, and it is an object of the present invention to provide a technique for improving the skin adhesion maintenance in an external preparation for skin containing an oil-in-water emulsifier type inorganic powder. To do.

In view of such a situation, the present inventors have made intensive research efforts in search of a technique for improving the skin adhesion maintenance of an external preparation for skin containing an oil-in-water emulsifier type inorganic powder. As a result, 1) acyl lactic acid and / or a salt thereof 0.05 to 5% by mass, 2) acylated polyglycerol 0.1 to 10% by mass, and 3) fatty acid glycerol sulfate 0 as a sulfate anionic surfactant By adding a hydroxyapatite-coated powder as a powder to an oil- in- water emulsifier type skin external preparation containing 0.05 to 0.5% by mass and 4) an inorganic powder, such a skin external application The inventors have found that an agent can be obtained and have completed the invention. That is, the present invention is as follows.
(1) 1) acyl lactic acid and / or its salt 0.05-5 mass%, 2) acylated polyglycerin 0.1-10 mass%, 3) fatty acid glycerin sulfate 0 as sulfate anionic surfactant In the skin external preparation in the form of an oil-in-water emulsifier containing 0.05 to 0.5% by mass and 4) 5 to 30% by mass of an inorganic powder whose surface may be subjected to lipophilic treatment, of which contains a powder of inorganic having a coating layer comprising hydroxyapatite on the surface as a powder you wherein external skin preparation.
(2) The external preparation for skin according to (1), wherein the acyl lactic acid is stearoyl lactic acid.
(3) The inorganic powder which may be subjected to lipophilic treatment is at least one selected from N-acyl amino acid salt coating treatment, methylhydrogenpolysiloxane baking treatment and silane coupling treatment with alkylalkoxysilane. The skin external preparation according to (1) or (2), wherein the surface treatment of the seed is performed.
(4) The external preparation for skin according to any one of (1) to (3), wherein the acylated polyglycerin is decaglycerin pentastearate .
( 5 ) The skin external preparation according to any one of (1) to ( 4) , further comprising an alkylene oxide-modified silicone and / or a glycerin-modified silicone .
( 6 ) The external preparation for skin according to any one of (1) to ( 5) , which is free of fatty acids.

ADVANTAGE OF THE INVENTION According to this invention, in the skin external preparation containing the inorganic powder of an oil-in-water emulsifier form, the technique which improves the skin adhesion maintenance property can be provided.

(1) Acyllactic acid which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing acyllactic acid as an essential component. Preferred examples of the acyl group constituting the acyl lactic acid include an alkyloyl group or an alkeroyl group having a linear, branched or cyclic structure having 8 to 30 carbon atoms. Specific examples of such acyl group include, for example, 2-ethylhexanoyl group, lauroyl group, myristoyl group, palmitoyl group, stearoyl group, isostearoyl group, behenoyl group, oleoyl group, linoloyl group, linolenoyl group. Etc. can be suitably exemplified. Of these, stearoyl lactic acid is particularly preferred. Such acyl lactic acid can be obtained by condensing lactic acid and the corresponding acid chloride in the presence of an alkali such as pyridine or triethylamine using dimethylformamide or the like as a reaction solvent. The acid chloride can be obtained by reacting a fatty acid with a halogenating agent such as thionyl chloride. Such acyl lactic acid can be used as it is, or a part or all of the acyl lactic acid can be derived from an alkali salt. These salts can be used without any particular limitation as long as they are used in skin external preparations, for example, alkali metal salts such as sodium salts and potassium salts, alkaline earth metal salts such as calcium salts and magnesium salts. Preferred examples include organic amine salts such as ammonium salt, triethylamine salt, triethanolamine salt, and monoethanolamine salt, and basic amino acid salts such as lysine salt and alginate. Particularly preferred salts are alkali metal salts, especially sodium salts. Examples of such acyl lactic acid and / or a salt thereof include those that are designated as food additives and marketed, such as calcium stearoyl lactate, and are marketed as cosmetic raw materials such as sodium stearoyl lactate. Some exist. Such commercial products can also be purchased and used. Such a component has a function as an emulsion stabilizer and forms an emulsified structure that suppresses sedimentation of inorganic powders while having a low viscosity together with an acylated polyglycerin described later. In order to exert such effects, the acyl lactic acid is a total of one or two or more kinds of acyl lactic acid, and is 0.05 to 5% by mass, more preferably 0.1 to 1% by mass with respect to the total amount of the external preparation for skin. % Content is preferred.

(2) Acylated polyglycerin which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing acylated polyglycerin as an essential component. Preferred examples of the acyl group constituting the acylated polyglycerin include an alkyloyl group or alkeroyl group having a linear, branched or cyclic structure having 8 to 30 carbon atoms. Specific examples of such acyl group include, for example, 2-ethylhexanoyl group, lauroyl group, myristoyl group, palmitoyl group, stearoyl group, isostearoyl group, behenoyl group, oleoyl group, linoloyl group, linolenoyl group. Etc. can be suitably exemplified. Of these, stearoyl groups are particularly preferred. Moreover, as polyglycerol, the polyglycerol of 5-15 of a polymerization degree is preferable, and 7-12 are especially preferable. Of such free hydroxylation of polyglycerin, those modified with the acyl group are preferably half or less, and preferably have at least a plurality of acyl groups in the same molecule. Specifically, in the skin external preparation of the present invention, pentaacylated decaglycerin, tetraacylated decaglycerin, tetraacylated octaglycerin and the like can be suitably exemplified. Such an acylated polyglycerin can contain only one species, or a combination of two or more species. In the external preparation for skin of the present invention, such an ingredient works together with the acyllactic acid to form an emulsified structure that suppresses sedimentation of inorganic powders while having low viscosity. In order to exert such effects, the acylated polyglycerin is preferably contained in a total amount of 0.1 to 10% by mass, more preferably 0.2 to 2% by mass, based on the total amount of the external preparation for skin. . The mass ratio of the acylated polyglycerin and the acyl lactic acid is particularly preferably 1: 1 to 5: 1. In order to make such an acylated polyglycerin and acyl lactic acid and / or a salt thereof act to form a stable emulsion structure with low viscosity, acylated polyglycerin, acyl lactic acid, behenyl alcohol, cetyl alcohol, etc. It is possible to make a premix by adding an aqueous alkali solution such as an aqueous sodium hydroxide solution to the other higher alcohol, and then adjusting the premix by adding other ingredients. This is preferable because an emulsion structure having low viscosity and high stability can be created.

(3) Inorganic powder which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention contains 5 inorganic powder whose surface may be lipophilically treated as an essential component. It is characterized by containing -30 mass%, more preferably 10-25 mass%. Such inorganic powders include mica, talc, sericite, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, anhydrous silicic acid (silica), aluminum oxide, barium sulfate, etc., bengara, yellow iron oxide Inorganic pigments such as black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide and zinc oxide, and pearl agents such as titanium mica and bismuth oxychloride. These inorganic powders can be contained either in a form that is not subjected to surface treatment or in a form that is subjected to surface treatment. However, it is preferable that the inorganic powder is contained after subjecting it to a lipophilic treatment because dispersibility is further improved. In the present invention, within the powder of such inorganic and essential and that it contains an inorganic powder having a coating layer comprising hydroxyapatite. A method for producing an inorganic powder having a coating layer containing hydroxyapatite is disclosed in Patent Document 11 or Patent Document 12, and can be produced according to the description of such a document. That is, an inorganic powder serving as a substrate is dispersed in an aqueous solution of a water-soluble calcium salt, and phosphoric acid is added thereto to precipitate hydroxyapatite, which is then deposited on the inorganic powder serving as a substrate. and inorganic powder which becomes, and a particulate hydroxyapatite dispersed in a water-soluble calcium salt solution, and added with phosphoric acid, and an inorganic powder comprising hydroxyapatite and a substrate, a fine powder of hydroxyapatite And a method of constructing a coating layer using the precipitated hydroxyapatite as a binder. In addition to hydroxyapatite, the coating layer can contain metal oxides such as zinc oxide, silica, alumina, and titania. The content of hydroxyapatite in the coating layer is preferably 50% by mass or more. In this way, inorganic powder having a coating layer containing hydroxyapatite can be prepared and used. However, a commercially available powder having a coating layer containing hydroxyapatite can be purchased and used. You can also As an inorganic powder having a coating layer containing such a commercially available hydroxyapatite, “powder la vi” (manufactured by Miyoshi Chemical Co., Ltd .; hydroxyapatite 15 parts by mass and zinc oxide 5 parts by mass is sericite. A preferred example is a powder coated with 80 parts by mass. In the external preparation for skin of the present invention, it is preferable to contain 0.01 to 1% by mass of such inorganic powder having a coating layer containing hydroxyapatite with respect to the total amount of external preparation for skin. It is more preferable to contain 05-0.5 mass%. Such a component adsorbs fatty acid and suppresses the skin adhesion maintenance inhibiting factor of the skin external preparation composition. However, the above-mentioned content is effective when the system of the skin external preparation of the present invention is substantially fatty acid or a salt thereof. This is because the fatty acid or salt thereof that causes a decrease in adhesion maintenance is only derived from a living body and the amount of fatty acid to be adsorbed is small. The amount of hydroxyapatite used for coating in the inorganic powder having a coating layer containing such hydroxyapatite is preferably 1 to 30% by mass with respect to the total amount of such inorganic powder. Preferably, it is 5-20 mass%. Further, the powder of the inorganic system comprising a substrate, various inorganic powders described above can be used, inter alia mica, sericite, talc, titanium mica, titanium sericite, not doped with other metal oxides or, sintered may Tei, titanium dioxide, zinc oxide, red iron oxide, such as yellow iron oxide can be suitably exemplified. Among these, plate-like powders such as mica, sericite, and talc are particularly preferable. These production examples will be described later.

The powder of the inorganic, the inorganic mineral-based powder other than powder having a coating layer including hydroxyapatite, as the lipophilic treatment, the powder for a skin external preparation such as normal cosmetics For example, N-acyl amino acid salt coating treatment, methyl hydrogen polysiloxane baking treatment, or silane coupling treatment with alkylalkoxysilane can be suitably exemplified. Such surface treatment may be a single type of treatment or two or more types of treatment. A particularly preferable treatment is a form coated with at least an N-acylamino acid salt. The N-acyl amino acid salt preferably has an aliphatic acyl group having 10 to 30 carbon atoms as an acyl group, such as lauroyl group, myristoyl group, palmitoyl group, stearoyl group, isostearoyl group, oleoyl group, and the like. The portion preferably has a lysine residue or a glutamic acid residue, and the salt preferably employs an aluminum salt or a zinc salt. Specific examples include N-lauroyl glutamic acid aluminum salt, N-lauroyl glycine aluminum salt, N-lauroyl glutamic acid zinc salt, N-lauroyl glycine zinc salt, N-stearoyl glutamic acid aluminum salt, N-stearoyl glutamic acid zinc salt and the like. Preferable examples include N-lauroylglutamic acid aluminum salt. Such N-acyl amino acid salt coating is, for example, an aluminum N-stearoyl glutamate coating as an example. An inorganic powder is dispersed in an aqueous solution of sodium N-stearoyl glutamate . An aqueous solution of aluminum chloride may be added to the powder, and aluminum N-stearoyl glutamate may be deposited on the inorganic powder. For this surface treatment, it is appropriate to perform the coating at a mass of 1 to 20% with respect to the mass of the inorganic powder. Production examples are shown below .

<Production Example 1> Production Example of Lipophilicized Powder 100 g of titanium dioxide was dispersed in 500 ml of 1% N-stearoyl sodium glutamate aqueous solution, 125 ml of 1% aluminum chloride aqueous solution was added thereto and gently stirred for 4 hours. N-stearoyl glutamate aluminum was deposited on the titanium dioxide surface. After completion of the reaction, the mixture was centrifuged (3000 g, 10 minutes), and the supernatant was discarded. Further, 1000 ml of water was added, stirred, centrifuged, and washed three times. The precipitated powder was dried, crushed with a breaker, and pulverized with a pulverizer equipped with a 1 mm herringbone screen to obtain a powder 1 which was titanium dioxide coated with N-stearoyl glutamate.

<Manufacture example 2> Manufacture example of lipophilic processing powder The titanium dioxide was replaced with the bengara and it processed in the same way, and the powder 2 was obtained.

<Manufacture example 3> Manufacture example of lipophilic treatment powder Titanium dioxide was replaced with yellow iron oxide, and it treated similarly and obtained powder 3.

<Manufacture example 4> Manufacture example of lipophilic processing powder The titanium dioxide was replaced with talc and it processed similarly and obtained the powder 4.

<Production Example 5> Production Example of Powder Having Hydroxyapatite Coating Layer 85.2 g of diammonium phosphate was dissolved in 4.5 l of water to form a solution, and 1 kg of sericite was added thereto and dispersed uniformly. Next, with stirring and cooling, aqueous ammonia was gradually added to adjust the pH of the system to 9.0, and a solution prepared by dissolving 156.1 g of calcium nitrate in 500 ml of water was gradually added. After completion of the addition, the mixture was further stirred for 1 hour, and the resulting slurry was centrifuged (3000 g, 10 minutes). The supernatant was discarded, and 2 l of water was added again to disperse, followed by centrifugation and washing. This washing operation was performed three times. Thereafter, the dehydrated powder by centrifugation was dried at a temperature of 110 ° C. to obtain hydroxyapatite-coated (about 2 mass%) sericite (powder 5).

<Production Example 6> Production Example of Powder Having Hydroxyapatite Coating Layer In the same manner as in Production Example 5, sericite was replaced with mica and treated to produce hydroxyapatite coating (about 2% by mass) mica (powder 6). )

<Production Example 7> Production Example of Powder Having Hydroxyapatite Coating Layer In the same manner as in Production Example 5, sericite is replaced with talc and treated to produce hydroxyapatite coating (about 2% by mass) talc (powder 7 )

(4) Sulfate-based anionic surfactant that is an essential component of the skin external preparation of the present invention The skin external preparation of the present invention is characterized by containing fatty acid glycerin sulfate as an essential component as a sulfate-based anionic surfactant. The The fatty acid residue (acyl group) constituting the fatty acid glycerol sulfate ester salt is preferably those having 10 to 30 carbon atoms, such as lauroyl group, myristoyl group, palmitoyl group, stearoyl group, isostearoyl group, behenoyl group, An oleoyl group and the like can be suitably exemplified, and coconut oil fatty acid residues, beef tallow fatty acid residues, palm oil fatty acid residues and the like which are natural mixtures thereof can also be used. Of these, coconut oil fatty acid glyceryl sulfate is most preferable. These salts can be used without any particular limitation as long as they are used in skin external preparations, for example, alkali metal salts such as sodium salts and potassium salts, alkaline earth metal salts such as calcium salts and magnesium salts. Preferred examples include organic amine salts such as ammonium salt, triethylamine salt, triethanolamine salt, and monoethanolamine salt, and basic amino acid salts such as lysine salt and alginate. Particularly preferred salts are alkali metal salts, especially sodium salts. Such components have the effect of improving the dispersibility of the inorganic powder, which may be oleophilic, in the system and reducing the thixotropy. In order to achieve such an effect, one or more selected from the fatty acid glycerin sulfates may be used as 0 . It contained at 05 to 0.5 wt%. This is because if the amount is too small, the above-described effect may not be achieved, and if the amount is too large, the stability of the system may be impaired.

(5) the external preparation for skin of the external preparation for skin of the Invention The present invention contain the essential components, wherein the oil-in-water emulsion formulations. Or mow oil emulsifier forms, outermost phase is the generic name for emulsifier type is the aqueous phase, also encompasses composite multilayer dosage forms, such as water-in-oil-in-water (W / O / W) dosage form. The external preparation for skin of the present invention can be applied without particular limitation as long as it is administered externally to the skin. For example, cosmetics including quasi-drugs, external preparations for skin, and general-purpose items for external use are suitable. It can be illustrated. Particularly preferred are cosmetics. This is because the application range of inorganic powder is wide.

The external preparation for skin of the present invention can contain any component that is usually used in external preparations for skin such as cosmetics in addition to the essential components. Examples of such optional ingredients include macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, and hardened coconut oil. Oil, wax, oils such as beeswax, molasses, hydrogenated castor oil, beeswax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax; , Hydrocarbons such as microcrystalline wax; higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid; cetyl alcohol, stearyl alcohol, isostearyl Higher alcohols such as alcohol, behenyl alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol; cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate; dimethylpolysiloxane, methylphenylpoly Linear polysiloxanes such as oxane and diphenylpolysiloxane; cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexanesiloxane; amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, Oil agents such as silicone oils such as modified polysiloxanes such as fluorine-modified polysiloxanes; Anionic surfactants not classified as sulfuric acid anionic surfactants such as fatty acid soaps (sodium laurate, sodium palmitate, etc.); stearyltrimethyl chloride Cationic surfactants such as ammonium, benzalkonium chloride and laurylamine oxide; imidazoline-based amphoteric surfactants (2-cocoyl-2-imidazolinium hydroxide- 1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), and amphoteric surfactants such as acylmethyltaurine; sorbitan fatty acid esters (sorbitan monostearate, sesquiskies) Sorbitan oleate, etc.), glycerin fatty acids (eg glyceryl monostearate), propylene glycol fatty acid esters (eg propylene glycol monostearate), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monoole) Acid, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fatty acid esters (POE-glycerin) Monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkyl phenyl ethers (POE nonylphenyl ether, etc.), Pluronic type , POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), sucrose fatty acid ester, alkyl Nonionic surfactants such as glucoside; polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, propylene glycol, dipropylene glycol Polyhydric alcohols such as coal, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexanediol, 1,2-hexanediol, 1,2-octanediol; sodium pyrrolidonecarboxylate, lactic acid, lactic acid moisturizing ingredients such as sodium; but it may also have been surface treated, organic pearl agents such as fish phosphorus foil; good red No. 202 be laked, red No. 228, red No. 226, yellow No. 4, Blue 404, Yellow 5, Red 505, Red 230, Red 223, Orange 201, Red 213, Yellow 204, Yellow 203, Blue 1, Green 201, Purple 201, Red 204 Organic dyes such as polyethylene powder; organic powders such as polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer; Benzoic acid UV absorbers; anthranilic acid UV absorbers; salicylic acid UV absorbers; cinnamic acid UV absorbers; benzophenone UV absorbers; sugar UV absorbers; 2- (2'-hydroxy- UV absorbers such as 5′-t-octylphenyl) benzotriazole and 4-methoxy-4′-t-butyldibenzoylmethane; lower alcohols such as ethanol and isopropanol; vitamin A or a derivative thereof, vitamin B ₆ hydrochloric acid Vitamin Bs such as salt, vitamin B ₆ tripalmitate, vitamin B ₆ dioctanoate, vitamin B ₂ or derivatives thereof, vitamin B ₁₂ , vitamin B ₁₅ or derivatives thereof; α-tocopherol, β-tocopherol, γ-tocopherol, vitamin Vitamin E such as E acetate, vitamin D, vitamin H, pantothenic acid, Preferred examples include vitamins such as pantethine and pyrroloquinoline quinone; and antibacterial agents such as phenoxyethanol. Among these, in order to further improve the dispersibility of the powder, it is preferable to contain an alkylene oxide-modified silicone and / or a glycerin-modified silicone. The total content of such components is preferably 0.01 to 1% by mass, and more preferably 0.05 to 0.5% by mass, based on the total amount of the external preparation for skin. The skin external preparation of this invention can be manufactured by processing this essential component and an arbitrary component according to a conventional method.

  Hereinafter, the present invention will be described in more detail with reference to examples, but it is needless to say that the present invention is not limited to such examples.

  In accordance with the formulation shown below, a foundation (make-up cosmetic), which is an external preparation for skin of the present invention, was prepared. That is, prescription ingredients A, B, and C are each heated to 80 ° C., uniformly mixed, gradually added to B under stirring, further added with D, dispersed with a disperser, and stirred. Lower water was gradually added, and the mixture was stirred and cooled to obtain a cosmetic 1 in the form of an oil-in-water emulsifier. In the same manner, Comparative Example 1 in which “Nikkol SGC-80N” was substituted with sodium cetyl lactate, Comparative Example 2 in which decaglycerin pentastearate was substituted with POE (2) stearate, Comparative Example 3 substituted with “SGC-80N” was also prepared, stored at 20 ° C. for 24 hours, and constant weighted. Then, the appearance was characterized by an emulsified state (average particle diameter; μm) by microscopic observation (300 times). The powder dispersibility (the total number of masses of powders having a diameter of 100 μm or more in five fields of view; pieces) and the viscosity (B-type viscometer No. 4 rotor, 12 revolutions per minute; mPa · s) were observed. In addition, it was stored at 40 ° C. for 1 month, and the appearance properties were also examined. The results are shown in Table 2. From this, it can be seen that the external preparation for skin of the present invention has excellent powder dispersibility and excellent usability.

<Test Example 2>
In order to confirm the effect of “powder la vi” of cosmetic 1, replace “powder la vi” of cosmetic 1 with sericite to prepare Comparative Example 4 and conduct a skin adhesion test. went. That is, two 2 cm × 4 cm portions were prepared on the inner part of the forearm without pretreatment, 40 μl of cosmetic 1 was applied to one portion with 40 μl of Comparative Example 4 with a glass rod, Allow to stand for 10 minutes, measure the color difference with a Konica Minolta color difference meter CR400 against a standard white plate, place under warm running water for 2 minutes, then lightly wipe with a paper towel, leave for 10 minutes, and again against the standard white plate The color difference was measured. The color difference before and after the warm water treatment was calculated, and the small color difference was evaluated as good skin adhesiveness. The color difference (ΔE) due to the treatment of the cosmetic 1 was 0.32, and the color difference (ΔE) of Comparative Example 4 was 0.67. The effect of the powder having a coating layer containing hydroxyapatite was confirmed.

  A foundation (cosmetics 2) was prepared in the same manner as in Example 1 by replacing the N-stearoyl aluminum glutamate treated powder of cosmetic 1 with a normal powder. No abnormalities were observed in the appearance even after storage at 20 ° C. and 40 ° C. for 1 month, the average emulsified particle size was 1.7 μm, and the powder dispersibility was 3 powder agglomerates (total of 5 fields) And the viscosity was 7200 mPa · s. Although it was confirmed that a normal powder can be used for the external preparation for skin of the present invention, it is also understood that a powder that has been surface-treated with at least aluminum N-stearoyl glutamate is preferable. Further, in the evaluation of Test Example 2, the cosmetic 2 had a color difference (ΔE) of 0.38. It was also confirmed that skin adhesion maintenance was improved.

  In the same manner as in Example 1, cosmetics 3 to 5 were prepared according to the formulation shown below and evaluated according to the method of Test Example 2. The results are shown in Table 5. The powder having a coating layer containing any hydroxyapatite had an effect of improving skin adhesion maintenance.

  The present invention can be applied to external preparations for skin such as cosmetics.

Claims (6)

1) 0.05 to 5% by mass of acyl lactic acid and / or a salt thereof, 2) 0.1 to 10% by mass of acylated polyglycerol, and 3) 0.05 to 0.05 of fatty acid glycerol sulfate as a sulfate-based anionic surfactant In an oil-in-water emulsifier type skin external preparation containing 0.5% by mass and 4) 5 to 30% by mass of an inorganic powder whose surface may be subjected to lipophilic treatment, the inorganic powder to that, the external preparation for skin characterized by comprising a powder of inorganic having a surface coating layer comprising hydroxyapatite as. The external preparation for skin according to claim 1, wherein the acyl lactic acid is stearoyl lactic acid. The inorganic powder which may be subjected to lipophilic treatment is at least one surface selected from N-acylamino acid salt coating treatment, methylhydrogenpolysiloxane baking treatment and silane coupling treatment with alkylalkoxysilane The external preparation for skin according to claim 1 or 2, wherein the preparation is treated. The external preparation for skin according to any one of claims 1 to 3, wherein the acylated polyglycerin is decaglycerin pentastearate. Furthermore, alkylene oxide modified silicone and / or glycerin modified silicone are contained, The skin external preparation in any one of Claims 1-4 characterized by the above-mentioned. The external preparation for skin according to any one of claims 1 to 5 , which is free of fatty acids.