JP4726497B2 - Cosmetics - Google Patents
Cosmetics Download PDFInfo
- Publication number
- JP4726497B2 JP4726497B2 JP2005005895A JP2005005895A JP4726497B2 JP 4726497 B2 JP4726497 B2 JP 4726497B2 JP 2005005895 A JP2005005895 A JP 2005005895A JP 2005005895 A JP2005005895 A JP 2005005895A JP 4726497 B2 JP4726497 B2 JP 4726497B2
- Authority
- JP
- Japan
- Prior art keywords
- mass
- collagen
- fucoidan
- glycerin
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000002537 cosmetic Substances 0.000 title claims description 40
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 63
- 102000008186 Collagen Human genes 0.000 claims description 42
- 108010035532 Collagen Proteins 0.000 claims description 42
- 229920001436 collagen Polymers 0.000 claims description 42
- 229920000855 Fucoidan Polymers 0.000 claims description 33
- 235000011187 glycerol Nutrition 0.000 claims description 33
- 229940105990 diglycerin Drugs 0.000 claims description 20
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 31
- -1 jojoba oil Substances 0.000 description 29
- 238000002360 preparation method Methods 0.000 description 17
- 230000000052 comparative effect Effects 0.000 description 16
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 15
- 229920002472 Starch Polymers 0.000 description 14
- 239000008107 starch Substances 0.000 description 14
- 235000019698 starch Nutrition 0.000 description 14
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 12
- 239000000203 mixture Substances 0.000 description 12
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 235000014113 dietary fatty acids Nutrition 0.000 description 10
- 239000000194 fatty acid Substances 0.000 description 10
- 229930195729 fatty acid Natural products 0.000 description 10
- 239000000499 gel Substances 0.000 description 9
- 229920002125 Sokalan® Polymers 0.000 description 8
- 238000009472 formulation Methods 0.000 description 8
- 229920001296 polysiloxane Polymers 0.000 description 8
- 239000006096 absorbing agent Substances 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 239000004359 castor oil Substances 0.000 description 6
- 235000019438 castor oil Nutrition 0.000 description 6
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 6
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 5
- 241000252233 Cyprinus carpio Species 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 5
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 5
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 5
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 5
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 5
- 229960005323 phenoxyethanol Drugs 0.000 description 5
- 241000251468 Actinopterygii Species 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000004166 Lanolin Substances 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 239000000686 essence Substances 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 235000019388 lanolin Nutrition 0.000 description 4
- 229940039717 lanolin Drugs 0.000 description 4
- 230000003020 moisturizing effect Effects 0.000 description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 150000005846 sugar alcohols Polymers 0.000 description 4
- 239000001993 wax Substances 0.000 description 4
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 229920002907 Guar gum Polymers 0.000 description 3
- 229960003237 betaine Drugs 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 235000010417 guar gum Nutrition 0.000 description 3
- 239000000665 guar gum Substances 0.000 description 3
- 229960002154 guar gum Drugs 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 229920002101 Chitin Polymers 0.000 description 2
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 2
- 239000004386 Erythritol Substances 0.000 description 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 2
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 229920001214 Polysorbate 60 Polymers 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 150000005215 alkyl ethers Chemical class 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 2
- 235000019414 erythritol Nutrition 0.000 description 2
- 229940009714 erythritol Drugs 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
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- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 2
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- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 2
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- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 229940043348 myristyl alcohol Drugs 0.000 description 1
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- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000010466 nut oil Substances 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- HMMGMWAXVFQUOA-UHFFFAOYSA-N octamethylcyclotetrasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 HMMGMWAXVFQUOA-UHFFFAOYSA-N 0.000 description 1
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- ZQTHOIGMSJMBLM-BUJSFMDZSA-N pangamic acid Chemical compound CN(C)CC(=O)OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O ZQTHOIGMSJMBLM-BUJSFMDZSA-N 0.000 description 1
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- 239000012188 paraffin wax Substances 0.000 description 1
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- 235000010987 pectin Nutrition 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
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- 239000011574 phosphorus Substances 0.000 description 1
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- 229920001983 poloxamer Polymers 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
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- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- ONQDVAFWWYYXHM-UHFFFAOYSA-M potassium lauryl sulfate Chemical compound [K+].CCCCCCCCCCCCOS([O-])(=O)=O ONQDVAFWWYYXHM-UHFFFAOYSA-M 0.000 description 1
- 229940116985 potassium lauryl sulfate Drugs 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
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- 238000005185 salting out Methods 0.000 description 1
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- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- BTURAGWYSMTVOW-UHFFFAOYSA-M sodium dodecanoate Chemical compound [Na+].CCCCCCCCCCCC([O-])=O BTURAGWYSMTVOW-UHFFFAOYSA-M 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
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- 229940005581 sodium lactate Drugs 0.000 description 1
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- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- GGXKEBACDBNFAF-UHFFFAOYSA-M sodium;hexadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCC([O-])=O GGXKEBACDBNFAF-UHFFFAOYSA-M 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000018556 stomach disease Diseases 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229940117986 sulfobetaine Drugs 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- PDSVZUAJOIQXRK-UHFFFAOYSA-N trimethyl(octadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)C PDSVZUAJOIQXRK-UHFFFAOYSA-N 0.000 description 1
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000011912 vitamin B7 Nutrition 0.000 description 1
- 239000011735 vitamin B7 Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- 235000007680 β-tocopherol Nutrition 0.000 description 1
- 239000011590 β-tocopherol Substances 0.000 description 1
- 239000002478 γ-tocopherol Substances 0.000 description 1
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
本発明は化粧料に関し、更に詳細には、コラーゲンを安定に配合した化粧料に関する。 The present invention relates to a cosmetic, and more particularly to a cosmetic in which collagen is stably blended.
従来、コラーゲンは優れた保湿効果を持つことから化粧剤等の外用組成物に配合されており、また、抗シワ、タルミへの効果もあると言われ、その有効性から各種の化粧料などに応用されている。これまでコラーゲンの由来は牛、豚や鶏由来のものが主であった。しかし、近年、狂牛病問題などの発生があり、また、水産加工工程で発生する大量の魚皮よりコラーゲンを抽出する技術の進歩により魚類由来の海洋性コラーゲンの配合が注目されている。一方、化粧料に代表される外用組成物の多くは保湿性を付与するためにグリセリンなどが配合されている。しかしながら、グリセリンなどを多量に配合するとコラーゲンの溶解性が低下し、白濁・沈殿が起こるためにあまり大量のグリセリンなどを配合することができなかった。そのためコラーゲン等の蛋白質含有製剤において多量のグリセリンなどを含有できる外用組成物が求められてきた。１，２−ペンタンジオールや１，２−ヘキシレングリコールがコラーゲンの安定配合に有効であるという報告がある（例えば、特許文献１を参照）。一方、フコイダンは、その粘性や保湿性に着目し、皮膚に使用した時のスベスベ感、しっとり感の賦与、余分な皮脂の除去など使用感の改善を目的とした応用化が検討されている（例えば、特許文献２，３，４を参照）。しかし、フコイダンにグリセリン又はジグリセリンを高濃度に含有した製剤におけるコラーゲンなどの溶解性向上作用があることは知られていなかった。 Conventionally, collagen has been blended in cosmetics and other external compositions because it has an excellent moisturizing effect, and is also said to have anti-wrinkle and tarmi effects. Applied. Until now, collagen originated mainly from cows, pigs and chickens. However, in recent years, there have been problems such as mad cow disease, and due to advances in technology for extracting collagen from a large amount of fish skin generated in the fishery processing process, the incorporation of marine collagen derived from fish has attracted attention. On the other hand, many of the compositions for external use represented by cosmetics are blended with glycerin or the like in order to impart moisture retention. However, when a large amount of glycerin or the like is blended, the solubility of collagen is lowered, and white turbidity / precipitation occurs, so that a large amount of glycerin or the like cannot be blended. Therefore, an external composition capable of containing a large amount of glycerin or the like in a protein-containing preparation such as collagen has been demanded. There is a report that 1,2-pentanediol and 1,2-hexylene glycol are effective for stable blending of collagen (see, for example, Patent Document 1). Fucoidan, on the other hand, focuses on its viscosity and moisturizing properties, and its application for the purpose of improving the feeling of use, such as providing a smooth feeling when used on the skin, giving a moist feeling, and removing excess sebum, is being investigated ( For example, see Patent Documents 2, 3, and 4.) However, it has not been known that fucoidan has an action of improving the solubility of collagen or the like in a preparation containing glycerin or diglycerin at a high concentration.
本発明は、この様な状況下為されたものであり、コラーゲンを含有する皮膚外用剤において、グリセリン又はジグリセリンを高濃度に含有させた状態においても、均一に溶解しており、且つ、保存時においても澱などの経時変化を抑制できる手段を提供することを課題とする。 The present invention has been made under such circumstances, and in a skin external preparation containing collagen, even in a state where glycerin or diglycerin is contained at a high concentration, it is uniformly dissolved and stored. It is an object of the present invention to provide means capable of suppressing changes with time such as starch even at times.
本発明者らは、この様な状況に鑑みて、コラーゲンを含有する化粧料において、高濃度のグリセリン又はジグリセリンを含有しても均一な溶解状態を維持し、且つ、経時変化においても安定な化粧料を得る手段を求めて鋭意研究努力を重ねた結果、フコイダン０．０００５〜０．１質量％を共存させることにより、製剤系の均一化と経時での安定性が向上することを見出し、本発明を完成させるに至った。即ち、本発明は以下に示すとおりである。
（１） １）フコイダンと、２）コラーゲンと、３）グリセリン又はジグリセリンと、４）１−ヒドロキシ−１，１−ジホスホン酸を含有し、
前記フコイダンの含有量が、化粧料全量に対して、総量で０．０００５〜０．１質量％であり、
前記グリセリン又はジグリセリンの含有量が、化粧料全量に対して総量で３０〜９０質量％であることを特徴とする化粧料。
（２） コラーゲンが、海洋性コラーゲンである（１）に記載の化粧料。
（３） フコイダンとコラーゲンの比率が、フコイダン／コラーゲン＝１０／１〜１／１０であることを特徴とする、（１）又は（２）に記載の化粧料。
（４）パック料であることを特徴とする、（１）〜（３）の何れかに記載の化粧料。
In view of such a situation, the present inventors maintain a uniform dissolved state even in the case of containing a high concentration of glycerin or diglycerin in cosmetics containing collagen, and are stable even over time. As a result of earnest research efforts in search of means for obtaining cosmetics, it was found that the coexistence of 0.0005 to 0.1% by mass of fucoidan improves the uniformity of the formulation system and the stability over time, The present invention has been completed. That is, the present invention is as follows.
(1) 1) and fucoidan, 2) and collagen, 3) and glycerine or Jiguriseri down, 4) contains a 1-hydroxy-1,1-diphosphonic acid,
The content of the fucoidan is 0.0005 to 0.1% by mass with respect to the total amount of the cosmetic,
Cosmetics characterized in that the content of glycerin or diglycerin is 30 to 90% by mass in total with respect to the total amount of cosmetics.
(2) The cosmetic according to (1), wherein the collagen is marine collagen.
(3) The cosmetic according to ( 1) or (2), wherein the ratio of fucoidan to collagen is fucoidan / collagen = 10/1 to 1/10.
(4) The cosmetic according to any one of (1) to (3) , which is a pack fee.
本発明によれば、コラーゲンと高濃度のグリセリン又はジグリセリンを含有する化粧料において、フコイダンを共存させることにより、製剤系の均一化、更には、保存時の澱の生成などの経時的変化を抑制する手段を提供することができる。 According to the present invention, in cosmetics containing collagen and a high concentration of glycerin or diglycerin, coexistence of fucoidan makes the formulation system uniform, and further changes over time such as the formation of starch during storage. Means for suppressing can be provided.
（１）本発明の皮膚外用剤の必須成分であるフコイダン
フコイダンは、フコースを主たる構成糖とする硫酸化多糖であり、抗潰瘍作用と、胃潰瘍等の原因菌であるヘリコバクター・ピロリの胃壁への接着を阻害する作用を持つため、飲食品に添加して日常的に摂取する事により、胃疾患の予防及び治療に役立たせる事などが報告されている（特開平７−１３８１６６号公報）。このフコイダン は、特に暖海性の海産褐藻類オキナワモズク（Ｃｌａｄｏｓｉｐｈｏｎｏｋａｍｕｒａｎｕｓ ＴＯＫＩＤＡ）等藻類の藻体構成成分として多量に含有されている。このオキナワモズクに含まれるフコイダンは、α１−３結合したフコースと硫酸化フコースから構成される糖鎖の一部にウロン酸残基が結合し、部分的にアセチル基も含んだ構造の多糖体である。フコイダンは、藻体からの、熱水による抽出物や、水とともにホモジネートし、遠心分離などの操作により、水不溶分を取り除くことにより、簡単に抽出することができる。このようなフコイダンの含有量は、０．０００５〜０．１質量％、より好ましくは０．００１〜０．０１質量％になるように抽出物の総量を調整して含有させることが好ましい。フコイダンの量が少なすぎると本発明の澱などの生成抑制効果が得られず、多すぎると、フコイダン自身のヌルヌル感が効き過ぎて感触的に使用しにくくなるからである。このようなフコイダンとしては、（株）ホクガンより、分子量分布１０，０００〜３００，０００のものが市販されており、このものを購入して使用することができ、好ましい。
(1) Fucoidan as an essential component of the external preparation for skin of the present invention Fucoidan is a sulfated polysaccharide containing fucose as a main constituent sugar, and has anti-ulcer action and gastric ulcer and other causative bacteria such as Helicobacter pylori to the stomach wall. It has been reported that since it has an action of inhibiting adhesion, it is useful for the prevention and treatment of gastric diseases by adding it to foods and beverages and taking it on a daily basis (JP-A-7-138166). This fucoidan is contained in large quantities as a constituent of algal bodies of algae such as the marine brown alga Okinawa mozuku (Cladosiphonokamuranus TOKIDA), which is particularly warm water. Fucoidan contained in this Okinawa mozuku is a polysaccharide with a structure in which a uronic acid residue is bonded to a part of a sugar chain composed of α1-3 linked fucose and sulfated fucose and partially contains an acetyl group. is there. Fucoidan can be easily extracted by removing water-insoluble matter by an operation such as extraction from hot water with hot water or homogenization with water and centrifugation. It is preferable to adjust the total amount of the extract so that the fucoidan content is 0.0005 to 0.1% by mass, more preferably 0.001 to 0.01% by mass. This is because if the amount of fucoidan is too small, the effect of inhibiting the formation of starch and the like of the present invention cannot be obtained, and if too much, fucoidan's own slimy feeling is too effective and it is difficult to use it in the touch. It is in such a fucoidan, than Corp. north bank, a molecular weight distribution 10,000 to 300,000 are commercially available, can be used to buy this product, preferred.
（２） 本発明の化粧料の必須成分であるコラーゲン
本発明のコラーゲンは、起源動物としては、例えば、鮭、金目鯛、平目、鱈、鮪、鮫などの魚類を用い、その骨、皮、腱、ウキブクロ等より、洗浄、脱脂、酸濾過、酵素処理、塩析、透析、熱処理等の手段を経て、水溶性コラーゲン成分を抽出した後、得られる海洋性のコラーゲンが挙げられる。本発明の皮膚外用剤に於いては、このような海洋性コラーゲンとフコイダンの比率は、フコイダン／コラーゲン＝１０／１〜１／１０、さらに言えば５／１〜１／５であることが好ましい。海洋性コラーゲンの量が少なすぎる場合には、製剤系にコラーゲンが均一に溶解しており本発明の意味が無く、多すぎると、本発明の澱などの生成抑制効果が充分に発揮されない場合があるからである。このようなコラーゲンとしては、市販品があり、ＧＡＴＴＥＦＯＳＳＥ社より「パンコーゲン マリン」の名称で約０．５質量％水溶液のものが市販されており、このものを使用することができ、好ましい。
(2) Collagen which is an essential component of the cosmetic of the present invention The collagen of the present invention uses, for example, fish such as carp, goldfish carp, flat eyed carp, carp, carp, coral, and the bone, skin, Examples include marine collagen obtained after extracting water-soluble collagen components from means such as tendons, duckweeds, etc. through means such as washing, degreasing, acid filtration, enzyme treatment, salting out, dialysis, and heat treatment. In the skin external preparation of the present invention, the ratio of such marine collagen to fucoidan is preferably fucoidan / collagen = 10/1 to 1/10, more preferably 5/1 to 1/5. . When the amount of marine collagen is too small, the collagen is uniformly dissolved in the preparation system and there is no meaning of the present invention, and when it is too large, the production inhibitory effect such as starch of the present invention may not be sufficiently exhibited. Because there is. As such collagen, there is a commercially available product, and an aqueous solution of about 0.5% by mass in the name of “Pangkogen Marine” is commercially available from GATTEFOSSE, and this can be used and is preferable.
（３）本発明の化粧料の必須成分であるグリセリン又はジグリセリン
本発明の化粧料で、使用するグリセリン又はジグリセリンは、それぞれを単独で使用しても、混合して使用しても構わないが、その総量が製剤系全体の３０〜９０質量％であれば構わない。このようなグリセリン又はジグリセリンの、製剤系における含有割合の低い範囲では、コラーゲンの溶解性不良の問題は生じない。そのため、本発明のグリセリン又はジグリセリンの製剤系における割合は３０％以上、好ましくは３５％以上、より好ましくは４０％以上である。これは、グリセリン又はジグリセリン濃度が３０％以上で、不均一化の問題が生じてき、３５％以上でより顕著となってくるからである。上限は、９０％以下、好ましくは８０％以下、より好ましくは７０％以下である。これは、グリセリン又はジグリセリン濃度が高すぎると本発明の効果が得られなくなるからである。
(3) Glycerin or diglycerin which is an essential component of the cosmetic of the present invention The glycerin or diglycerin used in the cosmetic of the present invention may be used alone or in combination. However, the total amount may be 30 to 90% by mass of the whole preparation system. In such a range where the content ratio of glycerin or diglycerin in the preparation system is low, the problem of poor solubility of collagen does not occur. Therefore, the ratio in the formulation system of glycerin or diglycerin of the present invention is 30% or more, preferably 35% or more, more preferably 40% or more. This is because when the glycerin or diglycerin concentration is 30% or more, the problem of non-uniformity occurs, and when it is 35% or more, it becomes more prominent. The upper limit is 90% or less, preferably 80% or less, more preferably 70% or less. This is because the effect of the present invention cannot be obtained if the glycerin or diglycerin concentration is too high.
（４）本発明の化粧料の構成要素である１−ヒドロキシエタン−１，１−ジホスホン酸。
本発明は、フコイダンが、高濃度の多価アルコール含有製剤中でのコラーゲンの析出の抑制作用を有することに関するものであるが、１−ヒドロキシエタン−１，１−ジホスホン酸はこのようなフコイダンの効果を増強するものである。このような作用を有する１−ヒドロキシエタン−１，１−ジホスホン酸は、０．０１〜０．５％含有することが好ましい。このような作用を有する１−ヒドロキシエタン−１，１−ジホスホン酸は、６０％水溶液がコギニスジャパンより、「ターピナルＳＬ」として市販されており、このものを購入して使用することができ、好ましい。
(4) 1-hydroxyethane-1,1-diphosphonic acid, which is a constituent of the cosmetic of the present invention.
The present invention relates to the fact that fucoidan has an inhibitory action on the precipitation of collagen in a high-concentration polyhydric alcohol-containing preparation, but 1-hydroxyethane-1,1-diphosphonic acid is such a fucoidan. The effect is enhanced. It is preferable to contain 0.01-0.5% of 1-hydroxyethane-1,1-diphosphonic acid having such an action. 1-Hydroxyethane-1,1-diphosphonic acid having such action is commercially available as “Turpinal SL” from Koginis Japan as a 60% aqueous solution, which can be purchased and used. preferable.
（５）本発明の皮膚外用剤
本発明の皮膚外用剤は、１）フコイダンと、２）コラーゲンと、３）グリセリン又はジグリセリンとを含有することを特徴とする。本発明の皮膚外用剤に於いては、この様な必須成分以外に、本発明を妨げない範囲で、通常皮膚外用剤で使用される任意成分を含有することが出来る。この様な任意成分としては、例えば、マカデミアナッツ油、アボガド油、トウモロコシ油、オリーブ油、ナタネ油、ゴマ油、ヒマシ油、サフラワー油、綿実油、ホホバ油、ヤシ油、パーム油、液状ラノリン、硬化ヤシ油、硬化油、モクロウ、硬化ヒマシ油、ミツロウ、キャンデリラロウ、カルナウバロウ、イボタロウ、ラノリン、還元ラノリン、硬質ラノリン、ホホバロウ等のオイル、ワックス類、流動パラフィン、スクワラン、プリスタン、オゾケライト、パラフィン、セレシン、ワセリン、マイクロクリスタリンワックス等の炭化水素類、オレイン酸、イソステアリン酸、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、ベヘン酸、ウンデシレン酸等の高級脂肪酸類、セチルアルコール、ステアリルアルコール、イソステアリルアルコール、ベヘニルアルコール、オクチルドデカノール、ミリスチルアルコール、セトステアリルアルコール等の高級アルコール等、イソオクタン酸セチル、ミリスチン酸イソプロピル、イソステアリン酸ヘキシルデシル、アジピン酸ジイソプロピル、セバチン酸ジ−２−エチルヘキシル、乳酸セチル、リンゴ酸ジイソステアリル、ジ−２−エチルヘキサン酸エチレングリコール、ジカプリン酸ネオペンチルグリコール、ジ−２−ヘプチルウンデカン酸グリセリン、トリ−２−エチルヘキサン酸グリセリン、トリ−２−エチルヘキサン酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、テトラ−２−エチルヘキサン酸ペンタンエリトリット等の合成エステル油類、ジメチルポリシロキサン、メチルフェニルポリシロキサン、ジフェニルポリシロキサン等の鎖状ポリシロキサン、オクタメチルシクロテトラシロキサン、デカメチルシクロペンタシロキサン、ドデカメチルシクロヘキサンシロキサン等の環状ポリシロキサン、アミノ変性ポリシロキサン、ポリエーテル変性ポリシロキサン、アルキル変性ポリシロキサン、フッ素変性ポリシロキサン等の変性ポリシロキサン等のシリコーン油等の油剤類、脂肪酸セッケン（ラウリン酸ナトリウム、パルミチン酸ナトリウム等）、ラウリル硫酸カリウム、アルキル硫酸トリエタノールアミンエーテル等のアニオン界面活性剤類、塩化ステアリルトリメチルアンモニウム、塩化ベンザルコニウム、ラウリルアミンオキサイド等のカチオン界面活性剤類、イミダゾリン系両性界面活性剤（２−ココイル−２−イミダゾリニウムヒドロキサイド−１−カルボキシエチロキシ２ナトリウム塩等）、ベタイン系界面活性剤（アルキルベタイン、アミドベタイン、スルホベタイン等）、アシルメチルタウリン等の両性界面活性剤類、ソルビタン脂肪酸エステル類（ソルビタンモノステアレート、セスキオレイン酸ソルビタン等）、グリセリン脂肪酸類（モノステアリン酸グリセリン等）、プロピレングリコール脂肪酸エステル類（モノステアリン酸プロピレングリコール等）、硬化ヒマシ油誘導体、グリセリンアルキルエーテル、ＰＯＥソルビタン脂肪酸エステル類（ＰＯＥソルビタンモノオレエート、モノステアリン酸ポリオキエチレンソルビタン等）、ＰＯＥソルビット脂肪酸エステル類（ＰＯＥ−ソルビットモノラウレート等）、ＰＯＥグリセリン脂肪酸エステル類（ＰＯＥ−グリセリンモノイソステアレート等）、ＰＯＥ脂肪酸エステル類（ポリエチレングリコールモノオレート、ＰＯＥジステアレート等）、ＰＯＥアルキルエーテル類（ＰＯＥ２−オクチルドデシルエーテル等）、ＰＯＥアルキルフェニルエーテル類（ＰＯＥノニルフェニルエーテル等）、プルロニック型類、ＰＯＥ・ＰＯＰアルキルエーテル類（ＰＯＥ・ＰＯＰ２−デシルテトラデシルエーテル等）、テトロニック類、ＰＯＥヒマシ油・硬化ヒマシ油誘導体（ＰＯＥヒマシ油、ＰＯＥ硬化ヒマシ油等）、ショ糖脂肪酸エステル、アルキルグルコシド等の非イオン界面活性剤類、必須成分に分類されないポリエチレングリコール、エリスリトール、ソルビトール、キシリトール、マルチトール、プロピレングリコール、ジプロピレングリコール、イソプレングリコール、１，３−ブタンジオール、１，２−ペンタンジオール、２，４−ヘキシレングリコール、１，２−ヘキサンジオール、１，２−オクタンジオール等の多価アルコール類、ピロリドンカルボン酸ナトリウム、乳酸、乳酸ナトリウム等の保湿成分類、グアガム、クインスシード、カラギーナン、ガラクタン、アラビアガム、ペクチン、マンナン、デンプン、キサンタンガム、カードラン、メチルセルロース、ヒドロキシエチルセルロース、カルボキシメチルセルロース、メチルヒドロキシプロピルセルロース、コンドロイチン硫酸、デルマタン硫酸、グリコーゲン、ヘパラン硫酸、ヒアルロン酸、ヒアルロン酸ナトリウム、トラガントガム、ケラタン硫酸、コンドロイチン、ムコイチン硫酸、ヒドロキシエチルグアガム、カルボキシメチルグアガム、デキストラン、ケラト硫酸，ローカストビーンガム，サクシノグルカン，カロニン酸，キチン，キトサン、カルボキシメチルキチン、寒天、ポリビニルアルコール、ポリビニルピロリドン、カルボキシビニルポリマー、ポリアクリル酸ナトリウム、ベントナイト等の増粘剤、表面を処理されていても良い、マイカ、タルク、カオリン、合成雲母、炭酸カルシウム、炭酸マグネシウム、無水ケイ酸（シリカ）、酸化アルミニウム、硫酸バリウム等の粉体類、表面を処理されていても良い、ベンガラ、黄酸化鉄、黒酸化鉄、酸化コバルト、群青、紺青、酸化チタン、酸化亜鉛の無機顔料類、表面を処理されていても良い、雲母チタン、魚燐箔、オキシ塩化ビスマス等のパール剤類、レーキ化されていても良い赤色２０２号、赤色２２８号、赤色２２６号、黄色４号、青色４０４号、黄色５号、赤色５０５号、赤色２３０号、赤色２２３号、橙色２０１号、赤色２１３号、黄色２０４号、黄色２０３号、青色１号、緑色２０１号、紫色２０１号、赤色２０４号等の有機色素類、ポリエチレン末、ポリメタクリル酸メチル、ナイロン粉末、オルガノポリシロキサンエラストマー等の有機粉体類、パラアミノ安息香酸系紫外線吸収剤、アントラニル酸系紫外線吸収剤、サリチル酸系紫外線吸収剤、桂皮酸系紫外線吸収剤、ベンゾフェノン系紫外線吸収剤、糖系紫外線吸収剤、２−（２’−ヒドロキシ−５’−ｔ−オクチルフェニル)ベンゾトリアゾール、４−メトキシ−４’−ｔ−ブチルジベンゾイルメタン等の紫外線吸収剤類、エタノール、イソプロパノール等の低級アルコール類、ビタミンＡ又はその誘導体、ビタミンＢ6塩酸塩，ビタミンＢ6トリパルミテート，ビタミンＢ6ジオクタノエート，ビタミンＢ2又はその誘導体，ビタミンＢ12，ビタミンＢ15又はその誘導体等のビタミンＢ類、α−トコフェロール，β−トコフェロール，γ−トコフェロール，ビタミンＥアセテート等のビタミンＥ類、ビタミンＤ類、ビタミンＨ、パントテン酸、パンテチン、ピロロキノリンキノン等のビタミン類などが好ましく例示できる。これらの中では、カルボキシビニルポリマーは、これを共存させることにより、製剤系に粘度を付与することができ、製剤系の不均一化や澱の生成を抑制させる効果があり、当該カルボキシビニルポリマーを０．０１〜２質量％、さらに言えば０．１〜１質量％含有されることも好ましい形態の一つである。
(5) External preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing 1) fucoidan, 2) collagen, and 3) glycerin or diglycerin. In the external preparation for skin of the present invention, in addition to such essential components, optional components that are usually used in external preparations for skin can be contained within a range that does not interfere with the present invention. Examples of such optional ingredients include macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, and hardened coconut oil. Oil, wax, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum, oil, wax, liquid wax, liquid paraffin, squalane, bean wax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin , Hydrocarbons such as microcrystalline wax, higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, cetyl alcohol, stearyl alcohol, isostearyl Alcohol, behenyl alcohol, octyldodecanol, higher alcohol such as myristyl alcohol, cetostearyl alcohol, etc., cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate, dimethylpolysiloxane, methylphenylpoly Loxane, linear polysiloxane such as diphenylpolysiloxane, cyclic polysiloxane such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexanesiloxane, amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, Oil agents such as silicone oil such as modified polysiloxane such as fluorine-modified polysiloxane, anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, triethanolamine ether of alkyl sulfate, chloride Cationic surfactants such as stearyltrimethylammonium, benzalkonium chloride, laurylamine oxide, imidazoline-based amphoteric surfactants (2-cocoyl-2-imida Zolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), amphoteric surfactants such as acylmethyltaurine, sorbitan fatty acid esters (sorbitan) Monostearate, sorbitan sesquioleate, etc.), glycerin fatty acids (eg, glyceryl monostearate), propylene glycol fatty acid esters (eg, propylene glycol monostearate), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fatty acid ester Tells (POE-glycerol monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkylphenyl ethers (POE nonylphenyl) Ethers, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), Nonionic surfactants such as sucrose fatty acid esters and alkyl glucosides, polyethylene glycol not classified as essential components, erythritol, sorbitol, xylitol, maltitol, propylene glycol, dipro Polyhydric alcohols such as lenglycol, isoprene glycol, 1,3-butanediol, 1,2-pentanediol, 2,4-hexylene glycol, 1,2-hexanediol, 1,2-octanediol, pyrrolidone carvone Moisturizing ingredients such as sodium acid, lactic acid, sodium lactate, guar gum, quince seed, carrageenan, galactan, gum arabic, pectin, mannan, starch, xanthan gum, curdlan, methylcellulose, hydroxyethylcellulose, carboxymethylcellulose, methylhydroxypropylcellulose, chondroitin Sulfuric acid, dermatan sulfate, glycogen, heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum, keratan sulfate, chondroitin, mucoitin sulfate, hydroxy Ethyl guar gum, carboxymethyl guar gum, dextran, keratosulfuric acid, locust bean gum, succinoglucan, caronic acid, chitin, chitosan, carboxymethyl chitin, agar, polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymer, sodium polyacrylate, bentonite, etc. Thickener, surface treated, mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silica, silica, aluminum oxide, barium sulfate, etc. Bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide inorganic pigments, surface may be treated, mica titanium, fish phosphorus foil, oxy Pearls such as bismuth chloride, raked Red 202, Red 228, Red 226, Yellow 4, Blue 404, Yellow 5, Red 505, Red 230, Red 223, Orange 201, Red 213, Yellow 204, Organic dyes such as yellow No. 203, blue No. 1, green No. 201, purple No. 201, red No. 204, organic powders such as polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer, paraaminobenzoic acid UV absorbers, anthranilic acid UV absorbers, salicylic acid UV absorbers, cinnamic acid UV absorbers, benzophenone UV absorbers, sugar UV absorbers, 2- (2'-hydroxy-5'-t- UV absorbers such as octylphenyl) benzotriazole, 4-methoxy-4′-t-butyldibenzoylmethane, ethanol, isopropyl Lower alcohols such as diols, vitamin A or its derivatives, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 or its derivatives, vitamin B such as vitamin B12, vitamin B15 or its derivatives, α- Preferred examples include vitamin E such as tocopherol, β-tocopherol, γ-tocopherol, vitamin E acetate, vitamin D, vitamin H, pantothenic acid, panthetin, pyrroloquinoline quinone and the like. Among these, the carboxyvinyl polymer can impart viscosity to the formulation system by coexisting it, and has the effect of suppressing the heterogeneity of the formulation system and the formation of starch. It is also one of the preferred forms that it is contained in an amount of 0.01 to 2% by mass, more specifically 0.1 to 1% by mass.
又、本発明の化粧料は、高濃度のグリセリン又はジグリセリンを含有しており、その保湿性を活かして保湿化粧料に適用するのが好ましい。特に、コラーゲンを均一に溶解させることから、均一で透明タイプのゲル状化粧料への適用が好適である。このようなものとして、化粧水、エッセンス、ゲル状マッサージ料、ゲル状パック料が例示できる。また、均一で透明な外観を活かして、スクラブなどの粒子を混入してアクセントを持たせた、透明マッサージ料、透明パック料などへの適用も可能である。 The cosmetic of the present invention contains a high concentration of glycerin or diglycerin, and is preferably applied to the moisturizing cosmetic taking advantage of its moisture retention. In particular, since collagen is uniformly dissolved, application to a uniform and transparent gel cosmetic is suitable. Examples of such materials include lotions, essences, gel massage materials, and gel pack materials. In addition, using a uniform and transparent appearance, it can also be applied to transparent massage fees, transparent pack fees, etc. that are accented with particles such as scrubs.
以下に、実施例を挙げて、本発明について更に詳細に説明を加えるが、本発明が実施例にのみ限定されることがないことは言うまでもない。 Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to the examples.
以下に示す処方に従って、本発明の化粧料であるゲル状パック料を作成した。即ち、イ）、ロ）、ハ）、ニ）の成分を良く混合した後、攪拌下イ）に、ロ）、ハ）、ニ）の順で徐々に加え、本発明の化粧料である、ゲル状パック１を得た。実施例１のゲル状パック１において、フコイダンを純水に置換したものを比較例１とした。 According to the prescription shown below, the gel-like pack material which is the cosmetics of this invention was created. That is, after the components a), b), c) and d) are mixed well, they are gradually added to b), c) and d) in the order of b), c) and d) in the order of the cosmetic of the present invention. A gel-like pack 1 was obtained. Comparative Example 1 was obtained by replacing fucoidan with pure water in the gel pack 1 of Example 1.
イ）
グリセリン ２５．０００質量％
ジグリセリン １２．０００質量％
エタノール ５．０００質量％
エチルパラベン ０．１００質量％
フェノキシエタノール ０．３００質量％
カルボキシビニルポリマー ０．９００質量％
純水 ２５．０００質量％
ロ）
水酸化カリウム ０．７６０質量％
純水 ６．５００質量％
ハ）
ターピナル ＳＬ（１−ヒドロキシエチル−１，１−ジホスホン酸）０．０５０質量％
純水 １．０００質量％
ニ）
パンコーゲンマリン １．０００質量％
（コラーゲン量として、約０．００５質量％）
フコイダン ０．００１質量％
純水 ２２．３８９質量％
I)
Glycerin 25.000% by mass
Diglycerin 12.000% by mass
Ethanol 5.000 mass%
Ethylparaben 0.100% by mass
Phenoxyethanol 0.300% by mass
Carboxyvinyl polymer 0.900 mass%
Pure water 25.000% by mass
B)
Potassium hydroxide 0.760 mass%
Pure water 6.500% by mass
C)
Turpinal SL (1-hydroxyethyl-1,1-diphosphonic acid) 0.050% by mass
Pure water 1.000 mass%
D)
Pankogen Marine 1.000% by mass
(About 0.005 mass% as the amount of collagen)
Fucoidan 0.001% by mass
Pure water 22.389% by mass
以下に示す処方に従って、本発明の化粧料であるゲル状パックを作成した。即ち、イ）、ロ）、ハ）、ニ）の成分を良く混合した後、攪拌下イ）に、ロ）、ハ）、ニ）の順で徐々に加え、本発明の化粧料である、ゲル状パック２を得た。実施例２のゲル状パック２において、フコイダンを純水に置換したものを比較例２とした。 A gel-like pack, which is a cosmetic of the present invention, was prepared according to the formulation shown below. That is, after the components a), b), c) and d) are mixed well, they are gradually added to b), c) and d) in the order of b), c) and d) in the order of the cosmetic of the present invention. A gel-like pack 2 was obtained. In gel pack 2 of Example 2 was Comparative Example 2 obtained by substituting the fucoidan in pure water.
イ）
グリセリン ４２．０００質量％
エチルパラベン ０．１００質量％
フェノキシエタノール ０．３００質量％
カルボキシビニルポリマー ０．９００質量％
純水 ２５．０００質量％
ロ）
水酸化カリウム ０．７６０質量％
純水 ６．５００質量％
ハ）
ターピナル ＳＬ（１−ヒドロキシエチル−１，１−ジホスホン酸）０．０５０質量％
純水 １．０００質量％
ニ）
パンコーゲンマリン ２．０００質量％
（コラーゲン量として、約０．０１０質量％）
フコイダン ０．１００質量％
純水 ２１．２９０質量％
I)
Glycerin 42.000% by mass
Ethylparaben 0.100% by mass
Phenoxyethanol 0.300% by mass
Carboxyvinyl polymer 0.900 mass%
Pure water 25.000% by mass
B)
Potassium hydroxide 0.760 mass%
Pure water 6.500% by mass
C)
Turpinal SL (1-hydroxyethyl-1,1-diphosphonic acid) 0.050% by mass
Pure water 1.000 mass%
D)
Pankogen Marine 2.000% by mass
(About 0.010 mass% as the amount of collagen)
Fucoidan 0.100% by mass
Pure water 21.290 mass%
（比較例３）
以下に示す処方に従って、多価アルコール含量の少ない比較例３の化粧料を作成した。即ち、イ）、ロ）、ハ）、ニ）の成分を良く混合した後、攪拌下イ）に、ロ）、ハ）、ニ）の順で徐々に加え、比較例３とした。
イ）
グリセリン １５．０００質量％
エチルパラベン ０．１００質量％
フェノキシエタノール ０．３００質量％
カルボキシビニルポリマー ０．９００質量％
純水 ２５．０００質量％
ロ）
水酸化カリウム ０．７６０質量％
純水 ６．５００質量％
ハ）
ターピナル ＳＬ（１−ヒドロキシエチル−１，１−ジホスホン酸）０．０５０質量％
純水 １．０００質量％
ニ）
パンコーゲンマリン ２．０００質量％
（コラーゲン量として、約０．０１０質量％）
純水 ４８．３９０質量％
(Comparative Example 3)
According to the formulation shown below, a cosmetic material of Comparative Example 3 having a low polyhydric alcohol content was prepared. That is, after the components a), b), c) and d) were mixed well, they were gradually added to b) in the order of b), c) and d) to obtain Comparative Example 3.
I)
Glycerin 15.000% by mass
Ethylparaben 0.100% by mass
Phenoxyethanol 0.300% by mass
Carboxyvinyl polymer 0.900 mass%
Pure water 25.000% by mass
B)
Potassium hydroxide 0.760 mass%
Pure water 6.500% by mass
C)
Turpinal SL (1-hydroxyethyl-1,1-diphosphonic acid) 0.050% by mass
Pure water 1.000 mass%
D)
Pankogen Marine 2.000% by mass
(About 0.010 mass% as the amount of collagen)
Pure water 48.390% by mass
（比較例４）
以下に示す処方に従って、多価アルコール含量の多い比較例４の化粧料を作成した。即ち、イ）、ロ）、ハ）、ニ）の成分を良く混合した後、攪拌下イ）に、ロ）、ハ）、ニ）の順で徐々に加え、比較例４とした。
イ）
グリセリン ７０．０００質量％
ジグリセリン ２０．０００質量％
カルボキシビニルポリマー ０．５００質量％
純水 ２．０００質量％
ロ）
水酸化カリウム ０．５５０質量％
純水 ３．５００質量％
ハ）
ターピナル ＳＬ（１−ヒドロキシエチル−１，１−ジホスホン酸）０．０２０質量％
純水 ０．５００質量％
ニ）
パンコーゲンマリン １．０００質量％
（コラーゲン量として、約０．００５質量％）
純水 １．９３０質量％
(Comparative Example 4)
A cosmetic of Comparative Example 4 having a high polyhydric alcohol content was prepared according to the formulation shown below. That is, after the components a), b), c) and d) were mixed well, they were gradually added in the order of b), c) and d) to a) under stirring to obtain Comparative Example 4.
I)
Glycerin 70.000% by mass
Diglycerin 20.000 mass%
Carboxyvinyl polymer 0.500 mass%
Pure water 2,000% by mass
B)
Potassium hydroxide 0.550 mass%
Pure water 3.500% by mass
C)
Turpinal SL (1-hydroxyethyl-1,1-diphosphonic acid) 0.020% by mass
Pure water 0.500% by mass
D)
Pankogen Marine 1.000% by mass
(About 0.005 mass% as the amount of collagen)
Pure water 1.930% by mass
＜試験例１＞
実施例１、比較例１、実施例２，比較例２、比較例３、比較例４のゲル状化粧料に関して、作成直後、及び５℃３ヶ月保存時の外観に関して、観察を行った。作成直後の外観に関しては、５５０ｎｍでの吸光度を蒸留水を対照として測定した。均一透明なものを○、不均一なものを×とした。さらに、長期保存による澱形成を調べた。保存条件は５℃で３ヶ月とした。澱の形成の程度は、肉眼観察での４段階評価（スコア１：澱なし、スコア２：極僅かに澱を認める、スコア３：僅かに澱を認める、スコア４：明瞭に澱を認める）として求めた。
<Test Example 1>
Regarding the gel cosmetics of Example 1, Comparative Example 1, Example 2, Comparative Example 2, Comparative Example 3, and Comparative Example 4, observations were made on the appearance immediately after the preparation and when stored at 5 ° C. for 3 months. Regarding the appearance immediately after the preparation, the absorbance at 550 nm was measured using distilled water as a control. Uniform and transparent ones were marked with ◯, and non-uniform ones with x. Furthermore, starch formation by long-term storage was examined. The storage condition was 3 months at 5 ° C. The degree of starch formation was evaluated by a four-level evaluation by visual observation (score 1: no starch, score 2: very slightly starch, score 3: slightly starch, score 4: clearly starch) Asked.
実施例１、実施例２のゲル状化粧料は、作成直後も透明であり、その後の澱の生成も認められなかった。実施例１からフコイダンを除去した比較例１は作成直後は透明であったが長期保存時に澱の生成が認められた。コラーゲン量の多い比較例２は、作成直後から不透明で不均一であった。グリセリン又はジグリセリン量の少ない比較例３は透明均一であったが、グリセリン又はジグリセリン量の非常に多い比較例４は作成直後から不透明で不均一な系となった。 The gel cosmetics of Example 1 and Example 2 were transparent immediately after production, and no subsequent starch formation was observed. Comparative Example 1 from which fucoidan was removed from Example 1 was transparent immediately after preparation, but formation of starch was observed during long-term storage. Comparative Example 2 with a large amount of collagen was opaque and non-uniform immediately after production. Comparative Example 3 having a small amount of glycerin or diglycerin was transparent and uniform, but Comparative Example 4 having a very large amount of glycerin or diglycerin was an opaque and non-uniform system immediately after preparation.
以下に示す処方に従って、本発明の化粧料であるエッセンスを作成した。即ち、イ）、ロ）、ハ）、ニ）の成分を良く混合した後、攪拌下イ）に、ロ）、ハ）、ニ）の順で徐々に加え、エッセンスを得た。
イ）
グリセリン ２０．０００質量％
ジグリセリン ４５．０００質量％
エチルパラベン ０．１００質量％
フェノキシエタノール ０．３００質量％
純水 １５．０００質量％
ロ）
カルボキシビニルポリマー ０．１００質量％
純水
ハ）
ターピナル ＳＬ（１−ヒドロキシエチル−１，１−ジホスホン酸）０．０５０質量％
純水 １．０００質量％
ニ）
パンコーゲンマリン １．０００質量％
（コラーゲン量として、約０．００５質量％）
フコイダン ０．０００５質量％
純水 １７．４４９５質量％
The essence which is the cosmetics of this invention was created according to the prescription shown below. That is, after the components a), b), c) and d) were mixed well, they were gradually added to b) in the order of b), c) and d) to obtain an essence.
I)
Glycerin 20.000 mass%
Diglycerin 45.000% by mass
Ethylparaben 0.100% by mass
Phenoxyethanol 0.300% by mass
Pure water 15.000% by mass
B)
Carboxyvinyl polymer 0.100% by mass
Pure water)
Turpinal SL (1-hydroxyethyl-1,1-diphosphonic acid) 0.050% by mass
Pure water 1.000 mass%
D)
Pankogen Marine 1.000% by mass
(About 0.005 mass% as the amount of collagen)
Fucoidan 0.0005% by mass
Pure water 17.4495 mass%
以下に示す処方に従って、本発明の化粧料であるゲル状マッサージ料を作成した。即ち、イ）、ロ）、ハ）、ニ）の成分を良く混合した後、攪拌下イ）に、ロ）、ハ）、ニ）、ホ）の順で徐々に加え、ゲル状マッサージ料を得た。
イ）
グリセリン ２５．０００質量％
ジグリセリン １２．０００質量％
エタノール ５．０００質量％
エチルパラベン ０．１００質量％
フェノキシエタノール ０．３００質量％
カルボキシビニルポリマー １．９００質量％
純水 ２５．０００質量％
ロ）
水酸化カリウム １．７６０質量％
純水 ６．５００質量％
ハ）
ターピナル ＳＬ（１−ヒドロキシエチル−１，１−ジホスホン酸）０．２００質量％
純水 １．０００質量％
ニ）
ミロネクトン ０．００１質量％
海藻エキス ０．１００質量％
パンコーゲンマリン ０．１００質量％
（コラーゲン量として、約０．０００５質量％）
フコイダン ０．００１質量％
純水 ２０．３３８質量％
ホ）
アビセル ０．７００質量％
According to the prescription shown below, the gel-like massage material which is the cosmetics of the present invention was prepared. That is, after mixing the ingredients of a), b), c) and d) well, gradually add b), c), d) and e) to the mixture under agitation, and add the gel massage material. Obtained.
I)
Glycerin 25.000% by mass
Diglycerin 12.000% by mass
Ethanol 5.000 mass%
Ethylparaben 0.100% by mass
Phenoxyethanol 0.300% by mass
Carboxyvinyl polymer 1.900 mass%
Pure water 25.000% by mass
B)
Potassium hydroxide 1.760% by mass
Pure water 6.500% by mass
C)
Turpinal SL (1-hydroxyethyl-1,1-diphosphonic acid) 0.200% by mass
Pure water 1.000 mass%
D)
Milonecton 0.001% by mass
Seaweed extract 0.100% by mass
Pankogen Marine 0.100% by mass
(The amount of collagen is about 0.0005 mass%)
Fucoidan 0.001% by mass
Pure water 20.338% by mass
E)
Avicel 0.700% by mass
本発明は、ゲル状化粧料、エッセンスなどの化粧料に応用できる。 The present invention can be applied to cosmetics such as gel cosmetics and essences.
Claims (4)
前記フコイダンの含有量が、化粧料全量に対して、総量で０．０００５〜０．１質量％であり、
前記グリセリン又はジグリセリンの含有量が、化粧料全量に対して、総量で３０〜９０質量％であることを特徴とする化粧料。 1) and fucoidan, 2) and collagen, 3) and glycerine or Jiguriseri down, 4) contains a 1-hydroxy-1,1-diphosphonic acid,
The content of the fucoidan is 0.0005 to 0.1% by mass with respect to the total amount of the cosmetic,
Cosmetics characterized by content of the said glycerin or diglycerin being 30-90 mass% in total with respect to cosmetics whole quantity .
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| JP5255777B2 (en) * | 2007-03-26 | 2013-08-07 | 株式会社ファンケル | Collagen triple helical structure stabilizer |
| JP5653573B2 (en) * | 2007-09-20 | 2015-01-14 | 富士フイルム株式会社 | Gel sheet and sheet cosmetic using the same |
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| JPH0714850B2 (en) * | 1987-09-29 | 1995-02-22 | 喜郎 板谷 | Cosmetics |
| JP2644531B2 (en) * | 1988-06-01 | 1997-08-25 | 三省製薬株式会社 | Cosmetics |
| JP2000229832A (en) * | 1999-02-09 | 2000-08-22 | Shiseido Co Ltd | Skin lotion |
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