JP4685441B2 - Hair growth composition and hair growth enhancer - Google Patents

Hair growth composition and hair growth enhancer Download PDF

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JP4685441B2
JP4685441B2 JP2004382060A JP2004382060A JP4685441B2 JP 4685441 B2 JP4685441 B2 JP 4685441B2 JP 2004382060 A JP2004382060 A JP 2004382060A JP 2004382060 A JP2004382060 A JP 2004382060A JP 4685441 B2 JP4685441 B2 JP 4685441B2
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信比古 三羽
賢司 松林
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Vitamin C60 Bio Research Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof

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Description

本発明は、本発明は育毛を促進させる育毛剤組成物または育毛増強剤に関する。   The present invention relates to a hair restorer composition or a hair growth enhancer that promotes hair growth.

従来、毛髪の成長を促進または維持させることを目的とする育毛剤組成物が多数開発されてきた。たとえば、特許文献１は、殺菌作用と毛包機能賦活作用を有するヒノキチオールを配合した育毛剤を開示する。
特開平２−９１０１４号公報 Conventionally, many hair restorer compositions aimed at promoting or maintaining hair growth have been developed. For example, Patent Document 1 discloses a hair restorer containing hinokitiol having a bactericidal action and a hair follicle function activating action.
Japanese Patent Laid-Open No. 2-91014

従来の育毛剤組成物は、いずれも育毛作用が必ずしも満足できるものではなく、育毛効果が現れるまでに長期間を要していた。長期間にわたって育毛剤組成物を使い続ける結果として、費用が増大したり、育毛作用以外の頭皮異常等を引き起こす場合があった。このため、より効果的に発毛または育毛を促進することができる育毛剤組成物の開発が望まれている。   None of the conventional hair-restoring compositions are satisfactory in hair-growth action, and it takes a long time before the hair-growth effect appears. As a result of continuing to use the hair-restoring agent composition for a long period of time, there are cases where the cost increases or scalp abnormalities other than the hair-restoring action occur. For this reason, development of the hair restorer composition which can accelerate hair growth or hair growth more effectively is desired.

本発明はこうした課題に鑑みてなされたものであり、その目的は、育毛剤組成物の育毛効果を向上させる技術の提供にある。   This invention is made | formed in view of such a subject, The objective exists in provision of the technique which improves the hair restoring effect of a hair restorer composition.

本発明の育毛剤組成物は、フラーレン類を含むことを特徴とする。ここで、フラーレン類は、フラーレンおよびフラーレン誘導体を含む。育毛剤組成物に含まれる育毛成分としては、ヒノキチオール、ヒノキチオール誘導体、グリチルリチン酸、グリチルリチン酸誘導体、グリチルレチン酸、グリチルレチン酸誘導体からなる群より選ばれる１種以上が効果的である。   The hair restorer composition of the present invention is characterized by containing fullerenes. Here, fullerenes include fullerene and fullerene derivatives. As the hair-growth component contained in the hair-growth agent composition, one or more selected from the group consisting of hinokitiol, hinokitiol derivatives, glycyrrhizic acid, glycyrrhizic acid derivatives, glycyrrhetinic acid and glycyrrhetinic acid derivatives are effective.

フラーレン類を育毛剤組成物に添加することにより、育毛効果が迅速に発揮される理由については、必ずしも明らかではないが、フラーレン類の存在下で、育毛成分とフラーレン類とがイオン結合（静電結合）、疎水結合（ファンデアワールス結合）、水素結合、包接体（クラスレート）形成などにより相互に結合して複合体を形成することによって、育毛成分が皮膚等へ浸透しやすくなるためであると推測される。また、少なくともヒノキチオールおよびヒノキチオール誘導体については、光に不安定であるという性質が知られている。フラーレン類を添加することにより、光がフラーレン類に優先的に吸収される結果、ヒノキチオールおよびヒノキチオール誘導体の安定性が向上することが育毛効果の増強に起因している可能性が考えられる。   Although the reason why the hair growth effect is rapidly exerted by adding fullerenes to the hair restorer composition is not necessarily clear, in the presence of fullerenes, the hair growth component and fullerenes are ionically bonded (electrostatic bond). Bonding), hydrophobic bonding (Van der Waals bonding), hydrogen bonding, clathrate formation, and so on, forming a complex to facilitate the hair growth component to penetrate the skin Presumed to be. Further, at least hinokitiol and hinokitiol derivatives are known to be unstable to light. As a result of adding fullerenes, light is preferentially absorbed by fullerenes. As a result, the stability of hinokitiol and hinokitiol derivatives may be improved due to the enhancement of the hair-growth effect.

本発明の育毛剤組成物によれば、発毛または育毛効果が向上する。   According to the hair restorer composition of the present invention, the hair growth or hair growth effect is improved.

本発明者らは、フラーレン類を育毛剤組成物に添加することにより、育毛成分による育毛効果が増強され、育毛がより促進されることを見いだした。フラーレン類が育毛成分の育毛効果を増強させる育毛増強剤として利用できることは、これまで全く予想もされていなかった。   The present inventors have found that by adding fullerenes to the hair-growing composition, the hair-growth effect by the hair-growth component is enhanced and hair-growth is further promoted. It has never been expected that fullerenes can be used as a hair-growth enhancer that enhances the hair-growth effect of the hair-growth component.

本発明に係る育毛剤組成物に含まれるフラーレン類としては、フラーレン、フラーレン誘導体、フラーレンおよびフラーレン誘導体の混合物を挙げることができる。   Examples of fullerenes contained in the hair restorer composition according to the present invention include fullerenes, fullerene derivatives, and fullerenes and mixtures of fullerene derivatives.

フラーレンは炭素からなる球殻状の分子であり、種々のものが知られている。本発明では、その目的を満たす限り限定されないが、たとえば、Ｃ６０、Ｃ７０、Ｃ７６、Ｃ７８、Ｃ８０、Ｃ８２、Ｃ８４、Ｃ８６、Ｃ８８、Ｃ９０、Ｃ９２、Ｃ９４、Ｃ９６、Ｃ９８、Ｃ１００等またはこれら化合物の２量体、３量体等を用いることができる。これらフラーレンの中でも好ましいのは、Ｃ６０、Ｃ７０、またはこれらの２量体、３量体である。Ｃ６０、Ｃ７０は構造がシンプルであり、一般的に用いられるアーク放電法や燃焼法における生成率が高いため、工業的に必要な量を確保しやすい。特にＣ６０は構造が対称であるという利点もある。これらフラーレンは複数を併用してもよいが、複数を併用する場合、好ましいのはＣ６０およびＣ７０を用いることである。 Fullerene is a spherical shell molecule made of carbon, and various types are known. In the present invention, it is not limited as long as it satisfies the object, but for example, C 60 , C 70 , C 76 , C 78 , C 80 , C 82 , C 84 , C 86 , C 88 , C 90 , C 92 , C 94 , C 96 , C 98 , C 100 or the like, or dimers, trimers or the like of these compounds can be used. Among these fullerenes, C 60 , C 70 , or a dimer or trimer thereof is preferable. Since C 60 and C 70 have a simple structure and a high production rate in a generally used arc discharge method or combustion method, it is easy to ensure an industrially required amount. In particular, C 60 has an advantage that the structure is symmetrical. These fullerenes may be used in combination a plurality, but if used in combination a plurality, preferred is to use C 60 and C 70.

また、本明細書においてフラーレン誘導体とは、フラーレンを構成する少なくとも一つの炭素に有機化合物の一部分を形成する原子団や無機元素からなる原子団が結合した化合物をいう。フラーレン誘導体を得るために用いるフラーレンとしては、本発明の目的を満たす限り限定されず、上記具体的に示したフラーレンのいずれを用いてもよい。   In this specification, the fullerene derivative refers to a compound in which an atomic group forming a part of an organic compound or an atomic group composed of an inorganic element is bonded to at least one carbon constituting the fullerene. The fullerene used for obtaining the fullerene derivative is not limited as long as the object of the present invention is satisfied, and any of the fullerenes specifically shown above may be used.

フラーレン誘導体としては、たとえば、水素化フラーレン、酸化フラーレン、水酸化フラーレン、ハロゲン（Ｆ、Ｃｌ、Ｂｒ、Ｉ）化フラーレン、フレロイド、メタノフラーレン等を用いることができる。これらフラーレン誘導体のうち、水素化フラーレン、水酸化フラーレン、および酸化フラーレンを用いることが好ましい。これは、水素化フラーレン、水酸化フラーレン、および酸化フラーレンは、フラーレンと比較して極性が大きくて化合物との相溶性が高いのみならず、フラーレンからの基本的な反応により得られるものであり、広く工業的に用いられることが期待されるからである。なお、これらフラーレン誘導体も、複数種類を併用しても構わない。   As the fullerene derivative, for example, hydrogenated fullerene, oxide fullerene, fullerene hydroxide, halogenated (F, Cl, Br, I) fullerene, fulleroid, methanofullerene, or the like can be used. Of these fullerene derivatives, hydrogenated fullerene, hydroxylated fullerene, and oxidized fullerene are preferably used. This is because hydrogenated fullerenes, hydroxylated fullerenes, and oxidized fullerenes are not only more polar and more compatible with compounds than fullerenes, but are also obtained by basic reactions from fullerenes, This is because it is expected to be widely used industrially. These fullerene derivatives may also be used in combination.

フラーレンは、たとえば、抵抗加熱法、レーザー加熱法、アーク放電法、燃焼法などにより得られたフラーレン含有スートから抽出分離することによって得られる。この際、必ずしも完全に分離する必要はなく、性能を損なわない範囲でフラーレンの含有率を調整することができる。   Fullerenes can be obtained, for example, by extraction and separation from fullerene-containing soot obtained by a resistance heating method, a laser heating method, an arc discharge method, a combustion method, or the like. At this time, it is not always necessary to completely separate, and the content of fullerene can be adjusted within a range that does not impair the performance.

また、フラーレン誘導体は、フラーレンに対して従来公知の方法を適用して合成することができる。たとえば、求核剤との反応（求核付加反応）、環化付加反応、光付加（環化）反応、酸化反応、還元反応、ラジカル反応等を利用して、所望のフラーレン誘導体を得ることができる。   The fullerene derivative can be synthesized by applying a conventionally known method to fullerene. For example, a desired fullerene derivative can be obtained by utilizing a reaction with a nucleophile (nucleophilic addition reaction), a cycloaddition reaction, a photoaddition (cyclization) reaction, an oxidation reaction, a reduction reaction, a radical reaction, or the like. it can.

フラーレン類の配合量は、育毛剤組成物の全体の質量に対して、０．０１〜３０質量％であることが好ましく、０．１〜１０質量％であることがより好ましい。フラーレン類の配合量が０．０１質量％未満、または３０質量％より大きいと育毛促進効果または育毛増強効果が減退する。   The blending amount of fullerenes is preferably 0.01 to 30% by mass, and more preferably 0.1 to 10% by mass with respect to the total mass of the hair restorer composition. When the blending amount of fullerenes is less than 0.01% by mass or greater than 30% by mass, the effect of promoting hair growth or the effect of enhancing hair growth decreases.

フラーレン類を含有する育毛剤組成物に含まれる育毛成分として効果が顕著であると認められる物質としては、ヒノキチオール、ヒノキチオール誘導体、グリチルリチン酸、グリチルリチン酸誘導体、グリチルレチン酸、グリチルレチン酸誘導体からなる群より選ばれる１種以上が挙げられる。   The substance recognized as having a remarkable effect as a hair-restoring ingredient contained in a hair-restoring composition containing fullerenes is selected from the group consisting of hinokitiol, hinokitiol derivatives, glycyrrhizic acid, glycyrrhizic acid derivatives, glycyrrhetinic acid, glycyrrhetinic acid derivatives 1 type or more to be mentioned.

ヒノキチオール誘導体としては、ヒノキチオールを一般的な化学変換等により導かれるものであれば特に制限はないが、ヒノキチオールの水酸基の水素原子をアシル基、アルキル基、ヒドロキシアルキル基などの官能基で置換した誘導体や、ヒノキチオールの有機塩、金属塩または金属錯体誘導体が挙げられる。   The hinokitiol derivative is not particularly limited as long as hinokitiol is derived by general chemical conversion, etc., but a derivative in which the hydrogen atom of the hydroxyl group of hinokitiol is substituted with a functional group such as an acyl group, an alkyl group, or a hydroxyalkyl group. And organic salts, metal salts or metal complex derivatives of hinokitiol.

グリチルリチン酸誘導体としては、グリチルリチン酸ジカリウム、グリチルリチン酸アンモニウムなどのグリチルリチン酸塩が挙げられる。   Examples of the glycyrrhizic acid derivative include glycyrrhizinate such as dipotassium glycyrrhizinate and ammonium glycyrrhizinate.

なお、育毛剤組成物の溶媒は、フラーレン類および育毛成分が適度に溶解すれば、水または水を主成分とする水性溶液、有機溶媒のいずれでも構わない。ただし、ヒノキチオールは、水に難溶性であるため、溶媒としてエタノールを用いることが望ましい。   The solvent of the hair restorer composition may be water, an aqueous solution containing water as a main component, or an organic solvent as long as the fullerenes and the hair growth component are appropriately dissolved. However, since hinokitiol is hardly soluble in water, it is desirable to use ethanol as a solvent.

また、育毛剤組成物は、本発明の効果を減じない範囲内であれば、香料、界面活性剤、殺菌剤、酸化防止剤、紫外線吸収剤、pH調整剤、防腐剤、および保湿剤のうち１種類以上を含んでもよい。   Further, the hair-restoring agent composition is a perfume, a surfactant, a bactericidal agent, an antioxidant, an ultraviolet absorber, a pH adjuster, a preservative, and a moisturizer as long as the effects of the present invention are not reduced. One or more types may be included.

以上説明したように、育毛剤組成物にフラーレン類を添加することにより、育毛効果が増強され、育毛に要する期間が短縮される。これにより、育毛に要するコストや手間が低減される。
（実施例） As described above, by adding fullerenes to the hair restorer composition, the hair growth effect is enhanced and the period required for hair growth is shortened. Thereby, the cost and labor required for hair growth are reduced.
(Example)

以下、実施例および比較例に基づいて育毛促進効果を検証した。   Hereinafter, the effect of promoting hair growth was verified based on Examples and Comparative Examples.

図１に、実施例１および２、ならびに比較例１および２の成分を示した。実施例１は、育毛成分としてヒノキチオールを含み、これに加えてフラーレンを含有する。比較例１は実施例１との対比のため、ヒノキチオールを含むが、フラーレンを含まない。実施例２は、育毛成分としてグリチルリチン酸を含み、これに加えてフラーレンを含有する。比較例２は実施例２との対比のため、グリチルリチン酸を含むが、フラーレンを含まない。   FIG. 1 shows the components of Examples 1 and 2 and Comparative Examples 1 and 2. Example 1 contains hinokitiol as a hair-growth component, and in addition to this, fullerene. Comparative Example 1 contains hinokitiol but does not contain fullerene for comparison with Example 1. Example 2 contains glycyrrhizic acid as a hair-growth component and, in addition, fullerene. Comparative Example 2 contains glycyrrhizic acid but does not contain fullerene for comparison with Example 2.

各実施例、比較例ともに溶媒としてエタノールを用いた。用いたフラーレンはＣ６０である。育毛成分およびフラーレンの質量％は、溶媒を含めた全体の質量に対する割合を示す。   In each example and comparative example, ethanol was used as a solvent. The fullerene used is C60. The mass% of the hair-growth component and fullerene indicates a ratio with respect to the total mass including the solvent.

育毛促進効果は、マウス毛成長促進効果試験法により確かめた。マウス毛成長促進効果試験法は下記の要領により実施された。   The hair growth promoting effect was confirmed by the mouse hair growth promoting effect test method. The mouse hair growth promoting effect test method was performed as follows.

（マウス毛成長促進効果試験）
Ｃ３Ｈマウス（雄・７週齢）の背部中央の体毛を毛剃りし、剃毛部分の右側に試料を１日１回、一匹当り０．２ｍｌ塗布した。一試料につき、１０匹のマウスを使用した。試料塗布直後、５日後、１０日後および１５日後にマウス背部の写真撮影を行うとともに、毛刈り面積および発毛面積を算出し、発毛率（％）を求めた。各試料ごとに、マウス１０匹の発毛率の平均値を算出し、毛成長促進効果を判定した。なお、コントロールとして、剃毛部分に試料を塗布しないマウスを用意し、発毛しないことを確かめた。 (Mouse hair growth promoting effect test)
The body hair at the center of the back of C3H mice (male, 7 weeks old) was shaved, and 0.2 ml of the sample was applied to the right side of the shaved portion once a day. Ten mice were used per sample. Immediately after application of the sample, 5 days later, 10 days later and 15 days later, the back of the mouse was photographed, and the hair cutting area and hair growth area were calculated to determine the hair growth rate (%). For each sample, the average value of the hair growth rate of 10 mice was calculated, and the hair growth promoting effect was determined. As a control, a mouse that did not apply the sample to the shaved part was prepared, and it was confirmed that no hair growth occurred.

図２−５は、Ｃ３Ｈマウスの剃毛部分に図１に示した成分の各試料を塗布した後の発毛状態を示す。また、図６は、Ｃ３Ｈマウスの剃毛部分に何も塗布しなかった場合の発毛状態を示す。図７は、各試料およびコントロールの発毛率の経時変化を示す。   FIG. 2-5 shows a hair growth state after each sample of the components shown in FIG. 1 is applied to the shaved portion of a C3H mouse. FIG. 6 shows the hair growth state when nothing is applied to the shaved portion of the C3H mouse. FIG. 7 shows changes over time in the hair growth rate of each sample and control.

以上の結果から、実施例１のようにヒノキチオールに加えて、フラーレンを含有する試料は、フラーレンを含有しない比較例１に比べて、試料塗布後１５日目における発毛率が大幅に増加することが確認された。同様に、実施例２のようにグリチルリチン酸に加えて、フラーレンを含有する試料は、フラーレンを含有しない比較例２に比べて、試料塗布後１５日目における発毛率が大幅に増加することが確認された。   From the above results, the sample containing fullerene in addition to hinokitiol as in Example 1 has a significantly increased hair growth rate on the 15th day after the sample application compared to Comparative Example 1 containing no fullerene. Was confirmed. Similarly, the sample containing fullerene in addition to glycyrrhizic acid as in Example 2 may have a significantly increased hair growth rate on the 15th day after application of the sample compared to Comparative Example 2 containing no fullerene. confirmed.

興味深い結果として、実施例１および実施例２の育毛剤組成物を用いた場合には、試料を塗布した剃毛部分右側のみならず、剃毛部分左側にも発毛が認められることが確認された。このため、本発明の育毛剤組成物を育毛したい領域に部分的に塗布するだけで、育毛したい領域全体を育毛できる可能性がある。これにより、育毛剤組成物の塗布量が低減するため、コスト低減が期待される。   As an interesting result, it was confirmed that hair growth was observed not only on the right side of the shaved part to which the sample was applied but also on the left side of the shaved part when using the hair restorer compositions of Example 1 and Example 2. It was. For this reason, there is a possibility that the entire region desired to grow hair can be grown only by partially applying the hair restorer composition of the present invention to the region desired to grow hair. Thereby, since the application quantity of a hair restorer composition reduces, cost reduction is anticipated.

本発明は、上述の各実施の形態に限定されるものではなく、当業者の知識に基づいて各種の設計変更等の変形を加えることも可能であり、そのような変形が加えられた実施の形態も本発明の範囲に含まれうるものである。   The present invention is not limited to the above-described embodiments, and various modifications such as design changes can be added based on the knowledge of those skilled in the art. The form can also be included in the scope of the present invention.

実施例１および２、ならびに比較例１および２の成分を示す表である。2 is a table showing components of Examples 1 and 2 and Comparative Examples 1 and 2. Ｃ３Ｈマウスの剃毛部分に実施例１の育毛剤組成物を塗布した後の発毛状態を示す写真である。It is a photograph which shows the hair growth state after apply | coating the hair restorer composition of Example 1 to the shaved part of a C3H mouse. Ｃ３Ｈマウスの剃毛部分に実施例２の育毛剤組成物を塗布した後の発毛状態を示す写真である。It is a photograph which shows the hair growth state after apply | coating the hair restorer composition of Example 2 to the shaved part of a C3H mouse. Ｃ３Ｈマウスの剃毛部分に比較例１の育毛剤組成物を塗布した後の発毛状態を示す写真である。It is a photograph which shows the hair growth state after apply | coating the hair restorer composition of the comparative example 1 to the shaved part of a C3H mouse. Ｃ３Ｈマウスの剃毛部分に比較例２の育毛剤組成物を塗布した後の発毛状態を示す写真である。It is a photograph which shows the hair growth state after apply | coating the hair restorer composition of the comparative example 2 to the shaved part of a C3H mouse. Ｃ３Ｈマウスの剃毛部分に何も塗布しなかった場合の発毛状態を示す写真である。It is a photograph which shows the hair growth state when nothing is apply | coated to the shaved part of a C3H mouse. 各試料およびコントロールの発毛率の経時変化を示す表である。It is a table | surface which shows the time-dependent change of the hair growth rate of each sample and control.

Claims (2)

フラーレン類と、ヒノキチオールおよびヒノキチオール誘導体からなる群より選ばれる１種以上の育毛成分とを含むことを特徴とする育毛剤組成物。 A hair restorer composition comprising fullerenes and at least one hair-restoring component selected from the group consisting of hinokitiol and a hinokitiol derivative . ヒノキチオールおよびヒノキチオール誘導体からなる群より選ばれる１種以上の育毛成分の育毛効果を増強させる育毛増強剤であって、
フラーレン類を含有したことを特徴とする育毛増強剤。 A hair-growth enhancer that enhances the hair-growth effect of one or more hair-growth ingredients selected from the group consisting of hinokitiol and hinokitiol derivatives,
A hair - growth-enhancing agent characterized by containing fullerenes.
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