JP4488852B2 - 体内脂肪低減作用を有する組成物 - Google Patents
体内脂肪低減作用を有する組成物 Download PDFInfo
- Publication number
- JP4488852B2 JP4488852B2 JP2004271412A JP2004271412A JP4488852B2 JP 4488852 B2 JP4488852 B2 JP 4488852B2 JP 2004271412 A JP2004271412 A JP 2004271412A JP 2004271412 A JP2004271412 A JP 2004271412A JP 4488852 B2 JP4488852 B2 JP 4488852B2
- Authority
- JP
- Japan
- Prior art keywords
- composition
- body fat
- coffee
- mannose
- oligosaccharide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Images
Classifications
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Description
1. 1以上10分子以下の、マンノースを主体とした単糖類が結合した、マンオースを主体としたオリゴ糖類を含むことを特徴とする体内脂肪低減作用を有する組成物。
2. 前記マンノースを主体としたオリゴ糖類が、1以上10分子以下のマンノースが結合したオリゴ糖類であることを特徴とする、上記1に記載の体内脂肪低減作用を有する組成物。
3. 前記マンノースを主体としたオリゴ糖類が、マンノースとグルコース、ガラクトース、フルクトースからなる群から選ばれる少なくとも1種の単糖とが、合計で1以上10分子以下結合した、マンノースを主体としたオリゴ糖類であることを特徴とする、上記1に記載の体内脂肪低減作用を有する組成物。
4. 前記マンノースを主体としたオリゴ糖類の含量割合が、組成物中の総固形分に対して60重量%以上である、上記1〜3のいずれか1つに記載の体内脂肪低減作用を有する組成物。
5. 前記マンノースを主体としたオリゴ糖類中のマンノース残基の割合が、70重量%以上である、上記1〜4のいずれか1つに記載の体内脂肪低減作用を有する組成物。
6. 前記マンノースを主体としたオリゴ糖類が、分子中のマンノース単位の数が2〜6のオリゴ糖類であることを特徴とする、上記1〜5のいずれか1つに記載の体内脂肪低減作用を有する組成物。
7. 前記マンノースを主体としたオリゴ糖類が、マンナンを加水分解処理することによって得られるものであることを特徴とする、上記1〜6のいずれか1つに記載の体内脂肪低減作用を有する組成物。
8. 前項のマンナンが、コーヒー豆および/またはコーヒー抽出残渣から得られるものである、上記7に記載の体内脂肪低減作用を有する組成物。
9. 前記マンノースを主体としたオリゴ糖類が、β−1,4−マンノオリゴ糖であることを特徴とする、上記1〜8のいずれか1つに記載の体内脂肪低減作用を有する組成物。
10. 上記1〜9のいずれかに1つに記載の体内脂肪低減作用を有する組成物を含有する経口摂取可能な組成物。
11. 前記経口摂取可能な組成物が飲料である、上記10に記載の組成物。
12. 前記飲料が、液体コーヒー、インスタントコーヒー、またはコーヒーミックス飲料である、上記11に記載の組成物。
13. 前記経口摂取可能な組成物が食品である、上記10に記載の組成物。
14. 上記1〜9のいずれか1つに記載の体内脂肪低減作用を有する組成物を含有し、人の体内脂肪の低減作用を有するものであることを特徴とし、体脂肪が気になる人の飲食用に適したものである旨の表示を付した飲食品。
本発明において「マンノースを主体としたオリゴ糖類」とは、単糖であるマンノースを主たる構成要素とするオリゴ糖類を意味する。ここで「オリゴ糖類」なる語は、一般に単糖類と多糖類との間に位し、一定の小数量の単糖類分子のグリコシル結合からなる物質を指す。すなわち、結合している単糖の数が比較的少ないポリマーのことである。オリゴ糖「類」という場合、構成単糖の数が種々のオリゴ糖が複数含まれる組成物であることを意味する。そしてマンノースを主体としたオリゴ糖「類」という場合は、構成単糖の種類や数が種々のオリゴ糖が複数含まれる組成物を指す。本明細書において「マンノオリゴ糖類」の語は、「マンノースを主体としたオリゴ糖類」の語と同様の意味において用いられる。
本発明の一の態様は、上述のマンノースを主体としたオリゴ糖類を含む、体内脂肪低減作用を有する組成物である。ここで「体内脂肪低減作用を有する組成物」という語は、広く一般に体内の脂肪を低減させる働きのある組成物を意味するが、本明細書では特に皮下脂肪と内臓脂肪を低減させ得る物質を含む混合物全般を意味する。したがって、上記の体内脂肪低減作用を有するオリゴ糖類を用いて、本発明の体内脂肪低減作用を有する組成物を製造することができる。
本発明者らは、先の課題を解決するために、上記の方法により得られた1以上10分子以下のマンノースを主体とした単糖類が結合した、マンノースを主体としたオリゴ糖類を含むことを特徴とする、体内脂肪低減作用を有する組成物を使用して体内脂肪低減効果を研究した結果、内臓脂肪減少効果が顕著に発現することを見出し、本発明を完成するに至った。
実施例1
マンノオリゴ糖の調製
常法により得た焙煎粉砕コーヒーを、商業上使用されるパーコレション系にて抽出し、後に残ったコーヒー抽出残渣を使用した。
ヒト試験用液体コーヒーの調製
コーヒー濃縮液にマンノオリゴ糖類を含む組成物、さらにコーヒー固形分濃度が1.1%になるよう水を加えて希釈し、常法に従い殺菌、900ml容ペットボトルに充填した。マンノオリゴ糖類を含む組成物は、900ml容ペットボトル1本あたり9g(1g/100ml)含まれるよう調製した。官能評価した結果、風味良好な液体コーヒーであった。これを試験飲料としてヒト試験に使用した。
液体コーヒーの体内脂肪低減効果
日本肥満学会の肥満度判定基準に従い、Body Mass Indexから判断して肥満(1度)に属する健常成人男性14名、成人女性14名を被験者とした。各種計測値、検査値がほぼ同一になるように2群に分け、一方は試験群として実施例1の液体コーヒーを、他方は対照群として比較例1の液体コーヒーを摂取した。被験者は、試験飲料または対照飲料を一日300ml、8週間連続で摂取した。そして、摂取初日、4週間目、8週間目に来院して、医師の問診と腹部CTスキャン撮影を行った。被験者には、体脂肪減少作用を標榜する医薬品および食品類は摂取させないこととした。また、試験期間中の食生活は試験期間前と大きく変更させないようにさせ、アルコール量は1日当たりビール瓶1本(633ml)相当以下の量に留めるよう指導した。そして、被験者は各来院日前の3日間、間食も含む全食事内容を記録して、栄養摂取量の状況を把握した。
Claims (4)
- 1以上10分子以下の単糖類が結合したオリゴ糖類であって、マンノース残基の割合が70重量%以上であるオリゴ糖類組成物を含有する、食事からの脂肪摂取を低減することによる皮下脂肪および内臓脂肪低減剤。
- 前記オリゴ糖類が、マンナンを加水分解処理することによって得られるものであることを特徴とする、請求項1に記載の皮下脂肪および内臓脂肪低減剤。
- 前記マンナンが、コーヒー豆および/またはコーヒー抽出残渣から得られるものである、請求項2に記載の皮下脂肪および内臓脂肪低減剤。
- 前記オリゴ糖類が、β−1,4−マンノオリゴ糖であることを特徴とする、請求項1に記載の皮下脂肪および内臓脂肪低減剤。
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BRPI0515411-1A BRPI0515411A (pt) | 2004-09-17 | 2005-04-14 | composição de mano-oligossacarìdeo, composição alimentìcia, e, método para a redução das relações de gordura corporal ou gordura abdominal em um ser humano |
PL05734832T PL1809328T3 (pl) | 2004-09-17 | 2005-04-14 | Kompozycja mannooligosacharydu do zmniejszania tkanki tłuszczowej w organizmie |
US11/575,362 US20080213425A1 (en) | 2004-09-17 | 2005-04-14 | Compositions Having Body Fat Reducing Function and Food and Drink Containing the Same |
DK05734832.8T DK1809328T3 (da) | 2004-09-17 | 2005-04-14 | Mannooligosaccharid-sammensætning til kropsfedt-reduktion |
UAA200704232A UA92898C2 (ru) | 2004-09-17 | 2005-04-14 | Применение композиции манноолигосахарида для снижения жировой ткани тела человека |
AU2005290262A AU2005290262B2 (en) | 2004-09-17 | 2005-04-14 | Compositions having body fat reducing function and food and drink containing the same |
CN2005800388622A CN101087621B (zh) | 2004-09-17 | 2005-04-14 | 具有身体脂肪减少功能的组合物以及含该组合物的食物和饮料 |
ES05734832T ES2404694T3 (es) | 2004-09-17 | 2005-04-14 | Composición de manano oligosacárido para la reducción de grasa corporal |
PT5734832T PT1809328E (pt) | 2004-09-17 | 2005-04-14 | Composição de mano-oligossacárido para diminuição da gordura corporal |
KR1020077008570A KR101203778B1 (ko) | 2004-09-17 | 2005-04-14 | 체지방 감소 기능을 갖는 조성물 및 그를 함유하는 식음료 |
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RU2007114280/15A RU2358741C2 (ru) | 2004-09-17 | 2005-04-14 | Композиции, обладающие функцией снижения жировой ткани тела, и продукты питания и напитки, содержащие такие композиции |
SI200531685T SI1809328T1 (sl) | 2004-09-17 | 2005-04-14 | Mano-oligosaharidni sestavek za zmanjĺ anje telesne maĺ äśobe |
PCT/US2005/012823 WO2006036208A1 (en) | 2004-09-17 | 2005-04-14 | Compositions having body fat reducing function and food and drink containing the same |
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US4469681A (en) * | 1979-07-31 | 1984-09-04 | The Rockefeller University | Method and system for the controlled release of biologically active substances to a body fluid |
US4508745A (en) * | 1982-12-30 | 1985-04-02 | General Foods Corporation | Production of a mannan oligomer hydrolysate |
US4484012A (en) * | 1984-02-29 | 1984-11-20 | General Foods Corporation | Production of mannitol and higher manno-saccharide alcohols |
JPS6196947A (ja) * | 1984-10-19 | 1986-05-15 | ゼネラル・フ−ヅ・コ−ポレ−シヨン | マンナンオリゴマーの製造方法 |
CA1324287C (en) | 1988-09-14 | 1993-11-16 | Howard Dave Stahl | Process for hydrolyzing a partially extracted roasted and ground coffee |
JP3043888B2 (ja) * | 1992-02-20 | 2000-05-22 | 森永乳業株式会社 | グルコマンナン部分加水分解物を有効成分とする大腸ガン予防剤 |
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JP2000217546A (ja) * | 1999-01-29 | 2000-08-08 | Showa Sangyo Co Ltd | マンノース含有ヘテロオリゴ糖からなる甘味剤、病原菌感染抑制剤、整腸剤又は澱粉の老化抑制剤及び該剤からなる飲食品、医薬品又は飼料。 |
DE19961182B4 (de) * | 1999-12-18 | 2006-01-12 | Südzucker AG Mannheim/Ochsenfurt | Galactomannan-Oligosaccharide und Verfahren zu deren Herstellung sowie deren Verwendung |
EP1309250A2 (en) * | 2000-08-08 | 2003-05-14 | Advanced Functional Foods International, Inc. | Nutritional supplement for the management of weight |
JP2002262827A (ja) * | 2001-03-13 | 2002-09-17 | Ajinomoto General Foods Inc | マンノオリゴ糖を含有する血清脂質改善組成物 |
JP4684440B2 (ja) * | 2001-03-13 | 2011-05-18 | 味の素ゼネラルフーヅ株式会社 | マンノオリゴ糖を含有する過酸化脂質上昇抑制組成物 |
NZ532004A (en) * | 2001-08-29 | 2006-06-30 | Biotech Pharmacal Inc | D-Mannose contraceptives |
TW200502394A (en) * | 2002-09-16 | 2005-01-16 | Univ California | Biochemical methods for measuring metabolic fitness of tissues or whole organisms |
JP2005145905A (ja) * | 2003-11-18 | 2005-06-09 | National Institute Of Advanced Industrial & Technology | 血圧降下剤及びその製造方法 |
JP5214978B2 (ja) * | 2006-01-24 | 2013-06-19 | 味の素ゼネラルフーヅ株式会社 | 血圧の降下作用及び/または上昇抑制作用を有する組成物およびこれを含有する飲食物 |
JP4771882B2 (ja) * | 2006-07-21 | 2011-09-14 | 味の素ゼネラルフーヅ株式会社 | 糖尿病または糖尿病性合併症の治療、予防、または改善作用を有する組成物およびこれを含有する飲料 |
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2004
- 2004-09-17 JP JP2004271412A patent/JP4488852B2/ja not_active Expired - Lifetime
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2005
- 2005-04-14 KR KR1020077008570A patent/KR101203778B1/ko active IP Right Grant
- 2005-04-14 EP EP05734832A patent/EP1809328B1/en not_active Not-in-force
- 2005-04-14 US US11/575,362 patent/US20080213425A1/en not_active Abandoned
- 2005-04-14 UA UAA200704232A patent/UA92898C2/ru unknown
- 2005-04-14 PT PT5734832T patent/PT1809328E/pt unknown
- 2005-04-14 CA CA2580652A patent/CA2580652C/en not_active Expired - Fee Related
- 2005-04-14 RU RU2007114280/15A patent/RU2358741C2/ru not_active IP Right Cessation
- 2005-04-14 DK DK05734832.8T patent/DK1809328T3/da active
- 2005-04-14 CN CN2005800388622A patent/CN101087621B/zh not_active Expired - Fee Related
- 2005-04-14 PL PL05734832T patent/PL1809328T3/pl unknown
- 2005-04-14 BR BRPI0515411-1A patent/BRPI0515411A/pt not_active Application Discontinuation
- 2005-04-14 AU AU2005290262A patent/AU2005290262B2/en not_active Revoked
- 2005-04-14 WO PCT/US2005/012823 patent/WO2006036208A1/en active Application Filing
- 2005-04-14 ES ES05734832T patent/ES2404694T3/es active Active
- 2005-04-14 SI SI200531685T patent/SI1809328T1/sl unknown
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2007
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006169135A (ja) * | 2004-12-14 | 2006-06-29 | Ajinomoto General Foods Inc | マンノオリゴ糖類を含有する抗アレルゲン組成物 |
JP2009275047A (ja) * | 2009-06-30 | 2009-11-26 | Ajinomoto General Foods Inc | 体内脂肪低減作用を有する組成物およびこれを含有する飲食物 |
Also Published As
Publication number | Publication date |
---|---|
PL1809328T3 (pl) | 2013-08-30 |
KR20070083684A (ko) | 2007-08-24 |
PT1809328E (pt) | 2013-04-08 |
SI1809328T1 (sl) | 2013-10-30 |
CN101087621B (zh) | 2013-01-02 |
CA2580652A1 (en) | 2006-04-06 |
AU2005290262A1 (en) | 2006-04-06 |
RU2007114280A (ru) | 2008-10-27 |
CN101087621A (zh) | 2007-12-12 |
EP1809328A1 (en) | 2007-07-25 |
WO2006036208A1 (en) | 2006-04-06 |
EP1809328A4 (en) | 2007-11-14 |
AU2005290262B2 (en) | 2012-01-12 |
CA2580652C (en) | 2013-02-12 |
UA92898C2 (ru) | 2010-12-27 |
IL181858A0 (en) | 2007-07-04 |
BRPI0515411A (pt) | 2008-07-22 |
JP2006083127A (ja) | 2006-03-30 |
EP1809328B1 (en) | 2013-03-13 |
US20080213425A1 (en) | 2008-09-04 |
DK1809328T3 (da) | 2013-04-15 |
RU2358741C2 (ru) | 2009-06-20 |
KR101203778B1 (ko) | 2012-11-21 |
ES2404694T3 (es) | 2013-05-28 |
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