JP4425163B2 - Anti-aging cosmetics - Google Patents

Description

  The present invention relates to an anti-aging cosmetic. Specifically, by using together chlorella extract, estrogen-like agent, active oxygen scavenger, and anti-inflammatory agent, which is a collagen production promoter, the skin wrinkles are still (tension) and have a synergistic effect on elasticity retention The present invention relates to anti-aging cosmetics that maintain a moist and youthful skin.

  In aging skin, along with the decrease in fibroblast activity, qualitative and quantitative changes such as collagen, elastin, and hyaluronic acid, which are dermal matrix components, occur, and aging symptoms such as wrinkles and reduced skin elasticity are observed. Collagen, which accounts for 90% or more of the dermal matrix, has a great effect on wrinkles. Until now, in order to prevent these aging symptoms, matrix metalloproteinase inhibitors, fibroblast proliferation promoters, hyaluronic acid production promoters, collagen production promoters, and the like have been studied (Patent Document 1, Patent Document 2, Patents). (Refer to Literature 3, Patent Literature 4, and Patent Literature 5).

  In addition, the skin is always exposed to oxidative damage from the outside world and the living body. Active oxygen and free radicals generated by external disturbances such as ultraviolet rays, radiation, chemical substances, and dryness and cell metabolism in the body are considered to be one of the factors of skin aging. Active oxygen and free radicals produced by UV rays cause photooxidation damage such as lipid peroxidation, DNA damage, protein denaturation, and metabolic abnormalities, as well as sudden and chronic inflammation and degeneration of extracellular matrix, causing wrinkles and sagging It is thought that it leads to. Many active oxygen scavengers have been studied so far (see Patent Documents 6 and 7).

On the other hand, it is known that estrogens and estrogenic compounds increase skin layer thickness and reduce wrinkle formation in aging skin. Changes in the skin, such as skin dryness, skin elasticity and loss of bulges that occur after menopause are due to a lack of estrogen production. Estrogen therapy prevents or delays many of these changes associated with aging skin. Therefore, compounds having an estrogen-like action have been studied from plant extracts (Non-patent Document 1, Patent Document 8, and Patent Document 9).

However, anti-aging cosmetics that have been studied so far are wrinkles of aging skin, but also in the formulation of actual products to maintain elasticity, moist and youthful skin, Effective results have not been obtained in terms of stability and safety. Conventional publicly known documents are listed below.

Creid et al., Effect of a conjugated estrogen cream on aging facial skin, Maturitas, 19, p. 211, 1994 JP 10-45615 A JP 2003-34631 A JP 2001-158728 A JP 2001-316275 A JP 2002-29923 A JP 2004-168732 A JP 2004-238310 A JP2002-29980 JP-A-2004-67590

  It is an object of the present invention to provide an anti-aging cosmetic useful for maintaining a moist and youthful skin that also exhibits a synergistic effect on the elasticity retention action of wrinkles of aging skin.

In view of such circumstances, the present inventors have demonstrated a synergistic effect on the improvement of skin wrinkles, tension (stretching) and elasticity retention, and anti-aging cosmetics that maintain moist and youthful skin. As a result of intensive research, (A) a chlorella extract having a high collagen production promoting action, (B) one kind mainly selected from a soybean extract, a cuckoo extract, a Pueraria myrifica extract, a red clover extract, etc. An estrogen-like agent comprising the above, (C) an active oxygen scavenger comprising at least one selected from the extract of tea leaf extract, tea extract, button pipi extract, olive leaf extract, and the like, and (D) an extract of mainly dodami. Found an anti-aging effect excellent in cosmetics containing one or more anti-inflammatory agents selected from Altea extract, Aloe vera extract, etc. It has been completed.

The present invention is constituted by the following claim 1.
Claim 1: An anti-aging cosmetic (A) comprising the following (A) to (D): Chlorella extract whose main effect is a collagen production promoter (B) An estrogenic agent having a main effect 1 or more types selected from soybean extract, cuckoo extract, Pueraria myrifica extract, red clover extract (C), the main effect is an active oxygen scavenger extract, tea extract, button paste extract, One or more selected from olive leaf extract
(D) A combination of the extracts of any one of the following (A) to (C) whose main effect is an anti-inflammatory agent and has the ability to inhibit hyaluronidase.
(B) Aloe vera extract and docami extract
(B) Aloe vera extract and Altea extract
(C) Aloe vera extract, Dokudami extract, and Altea extract

According to the anti-aging cosmetic composition of the present invention, it is selected from (A) a chlorella extract having a high collagen production promoting effect of the present invention, (B) mainly a soybean extract, a cuckoo extract, a Pueraria myrifica extract, and the like. One or more estrogen-like agents, (C) one or more active oxygen scavengers mainly consisting of extract of bitumen, button pipi extract, olive leaf extract and the like, and (D) mainly extract of dokudami extract, altea extract, aloe vera Since one or more kinds of anti-inflammatory agents composed of extracts, etc. are blended, these synergistic effects prevent and improve skin aging, and maintain a resilient, wrinkle-free, sagging skin condition It has the effect of being able to.
Hereinafter, the present invention will be described in detail.

The chlorella extract used in the present invention is an extract of the genus Chlorella vulgaris, the genus Chlorella of the green alga net. The chlorella extract is obtained by warm-extracting chlorella with water, concentrating, and treating with activated carbon to obtain a 30% 1,3-butylene glycol solution.

The estrogen-like agent used in the present invention may be one that is generally widely used as having a female hormone-like action, and is a soybean extract, a cuckoo extract, a Pueraria myrifica extract, or a red clover extract. As an extraction method, an extract having an increased isoflavonoid content is usually used. The extraction method is not particularly limited, but the one produced by the following method was used.

The soybean extract used in the present invention is an extract of seeds of leguminosae, Glycine soybean (Glycine max). It is widely known that a soybean extract contains isoflavonoids such as daidzin and genistin and has an estrogenic action. Extracts with a normal column treatment and an increased isoflavone concentration are used.

  The cuckoo extract used in the present invention is an extract of the roots of leguminosae, genus Pueraria and pueraria lobata. It is well known that the cuckoo extract contains isoflavones such as puerarin and daidzein and has an estrogenic action. Extracts with a normal column treatment and an increased isoflavone concentration are used.

  The Pueraria myrifica extract used in the present invention is an extract of the roots of leguminosae, pueraria, and pueraria milifica. It is widely known that the Pueraria myrifica extract contains isoflavonoids such as puerarin, daidzin and daidzein and has an estrogenic action. Extracts with a normal column treatment and an increased isoflavone concentration are used.

  Red clover (Trifolium pretense) used in the present invention is a kind of legume, called red clover in Japan, and its component contains isoflavone which is a kind of polyphenol and is known to have a high estrogenic action. It is what.

  The active oxygen scavenger used in the present invention is generally expected to have a widely used active oxygen scavenging action, and is highly effective and safe, such as a bite extract, tea extract, button pi extract, olive leaf It is an extract.

The extract of the bittersweet used in the present invention is an extract of the rhizome of Rosaceae, Sanguisorba, or Sanguisorba officinalis.

The button pi extract used in the present invention is an extract of the root bark of Paeoniaceae, Paeonia, and Button (Paeonia suffruticosa).

The olive leaf extract used in the present invention is an extract of leaves of the family Oleaceae, Olea, and Olea europaea.

Examples of teas used in the present invention include green tea (sencha, roasted tea, gyokuro, kabuse tea, tencha, etc.), oolong tea, non-fermented tea such as black tea, semi-fermented tea, and fermented tea.

The anti-inflammatory agent used in the present invention is mainly a docami extract, an altea extract, an aloe vera extract, etc. having a hyaluronidase inhibitory ability. These are usually used after water extraction and activated carbon treatment.

The Dokudami extract used in the present invention is an extract of whole plants of the family Saururaceae, Houttuynia, and Houttuynia cordata.

The Altea extract used in the present invention is an extract of the roots of Malvaceae, Althaea, and Althaea officinalis.

The aloe vera extract used in the present invention is an extract of mesophyll (Liliaceae), aloe genus (Aloe), and aloe vera (Aloe vera L.) leaf mesophyll.

Next, the extract used in the present invention will be described in detail with reference to production examples.
(Production Example 1) Production of Chlorella Extract 3000 g of purified water is added to 100 g of Chlorella, extracted at 70 ° C. for 5 hours, cooled and filtered. The filtrate is concentrated under reduced pressure to 1000 g. Activated carbon is added to the concentrate, and decolorization and deodorization is performed at 50 ° C. After filtration, 1000 g of 30% 1,3-butylene glycol is added to the filtrate and further filtered to produce a chlorella extract. The product evaporation residue was 2.8%.

(Production Example 2) Production of soybean extract After adding 1000 g of purified water to 100 g of soybean and leaving it to stand overnight, 2000 g of purified water is further added, extracted at 80 ° C. for 8 hours, cooled, and then filtered. The filtrate is concentrated under reduced pressure to 100 g. The concentrated solution is passed through a column packed with synthetic adsorbent Diaion HP-20. After washing with a 30 vol% ethanol solution, elution is performed with a 50 vol% ethanol solution. The eluate is evaporated to dryness under reduced pressure, 100 g of 50% 1,3-butylene glycol solution is added and dissolved, and then the soybean extract is filtered. To make. The product evaporation residue was 0.56%.

(Manufacture example 3) Manufacture of a cocoon extract 2000 mL of absolute ethanol is added to 100g of konkon, and it extracts at room temperature for 5 days. This is filtered, and the filtrate is concentrated to dryness under reduced pressure, and then dissolved in 200 mL of a 50 vol% ethanol solution. The solution is passed through a column packed with synthetic adsorbent Diaion HP-20 and equilibrated with 50 vol% ethanol. After washing with a 50 vol% ethanol solution, elution is performed with a 70 vol% ethanol solution. The eluate is evaporated to dryness under reduced pressure, and 300 g of 50% 1,3-butylene glycol solution is added and dissolved. To make. The product evaporation residue was 1.53%.

(Production Example 4) Production of Pueraria myrifica extract To 100 g of Pueraria myrifica, 2000 g of a 30 vol% ethanol solution is added and extracted at room temperature for 3 days. This is filtered, and the filtrate is concentrated to 200 g under reduced pressure. The concentrated solution is passed through a column packed with synthetic adsorbent Diaion HP-20. After washing with 30 vol% ethanol solution, elution was performed with 70 vol% ethanol solution, the eluate was dried under reduced pressure, and the dried product was dissolved in 300 g of 50% 1,3-butylene glycol, followed by filtration to Pueraria myrifica. Make an extract. The evaporation residue of the product was 1.31%.

(Manufacture example 5) The manufacturing method of a red clover extract 2,000 g of 30 vol% ethanol solutions are added to 100 g of red clovers, and it extracts at 50 degreeC for 8 hours. This is filtered, and the filtrate is concentrated to dryness under reduced pressure. The dried product is dissolved in 200 g of 50% 1,3-butylene glycol and filtered to produce a red clover extract. The evaporation residue of the product was 1.84%.

(Manufacture example 6) The manufacturing method of a bitter melon extract 1000g of 50vol% ethanol solutions are added to 100g of bitter berries, and it extracts at room temperature for 3 days. This is filtered, and the filtrate is concentrated to dryness under reduced pressure. The dried product is dissolved in 1000 g of 30% 1,3-butylene glycol, and then filtered to produce the extract. The product evaporation residue was 1.74%.

(Manufacture example 7) The manufacturing method of a button pea extract 2000g of 50% ethanol solutions are added to 100g of button pie, and it extracts at room temperature for 3 days. This is filtered, and the filtrate is concentrated to dryness under reduced pressure. The dried product is dissolved in 1000 g of 30% 1,3-butylene glycol and filtered to produce a button pi extract. The evaporation residue of the product was 1.13%.

(Production Example 8) Production method of olive leaf extract To 100 g of olive leaf, 2000 g of a 50 vol% ethanol solution is added and extracted at 50 ° C for 8 hours. This is filtered, and the filtrate is concentrated to dryness under reduced pressure. The dried product is dissolved in 1000 g of 30% 1,3-butylene glycol and filtered to produce an olive leaf extract. The product evaporation residue was 1.52%.

(Manufacture example 9) The manufacturing method of a tea extract Add 2000g of 50vol% ethanol to 100g of green tea, and this is filtered for 3 days at room temperature. The filtrate is concentrated to dryness under reduced pressure. The dried product is dissolved in 1000 g of 30% 1,3-butylene glycol and then filtered to obtain a tea leaf extract. The product evaporation residue was 1.95%.

(Manufacture example 10) 3000 g of water is added to 100 g of dokudami extract and is extracted at 70 ° C. for 8 hours. This is filtered, activated carbon is added to the filtrate, and the mixture is treated at 50 ° C. After filtration, the filtrate is concentrated to dryness under reduced pressure. The dried product is dissolved in 1000 g of 30% 1,3-butylene glycol, and then filtered to produce a docami extract. The product evaporation residue was 1.38%.

(Production Example 11) Altea extract To 100 g of Altea, add 2000 g of water, and extract at 70 ° C. for 8 hours. This is filtered, activated carbon is added to the filtrate, and the mixture is treated at 50 ° C. After filtration, the filtrate is concentrated to dryness under reduced pressure. The dried product is dissolved in 1000 g of 30% 1,3-butylene glycol, followed by filtration to produce an Altea extract. The product evaporation residue was 1.75%.

(Manufacture example 12) Aloe vera extract Activated carbon is added to the juice obtained by squeezing the raw mesophyll of Aloe vera, and after aloin is adsorbed and removed, it is concentrated under reduced pressure. Isopropyl alcohol is added to the concentrated solution to aggregate the Aloe vera polysaccharide. The aggregate is collected by filtration and dried to obtain Aloe vera polysaccharide powder. Aloe vera polysaccharide powder is dissolved in 30% 1,3-butylene glycol 0.5% to produce an aloe vera extract.

The anti-aging cosmetic composition of the present invention can be blended in skin external preparations and bath preparations, but the blending amount is not particularly specified. Depending on the type of product to be blended, properties, quality, and expected effect, it is preferably 0.0001% to 0.5%, especially 0.001% to 0.2% in terms of dry solids. It is preferable in terms of effect.

The anti-aging cosmetic composition of the present invention can be produced by using components and additives used in pharmaceuticals, quasi-drugs, cosmetics and the like, as necessary, within a range that does not impair the effects of the present invention. . For example, purified water, lower alcohols, polyhydric alcohols, fats and oils, waxes, mineral oils, fatty acids, powders, metal soaps, pH adjusters, surfactants, thickeners, pigments, extraction from plant, animal and microbial raw materials Products, vitamins, amino acids, hormones, bactericides, antiseptics, keratolytic agents, enzymes, refreshing agents, stabilizers, metal ion chelators, blood circulation promoters, whitening agents, UV inhibitors, antioxidants, Essential oils, deodorants, fragrances and the like can be used as appropriate.

The anti-aging cosmetic of the present invention is not limited to general skin cosmetics, but includes pharmaceuticals, quasi drugs, medicinal cosmetics and the like. The dosage form of the external preparation for skin according to the present invention may be any of solubilization system, emulsification system, powder dispersion system, etc., and the use is made up of basic cosmetics such as skin lotion, emulsion, cream, pack, etc., foundations, etc. Regardless of cosmetics, shampoos, rinses, soaps, body shampoos and other toiletries, bath preparations, etc.

Next, each screening test for each extract used in the present invention will be described.
(Reference Test 1) Evaluation of Collagen Production Promoting Action For testing the collagen production promoting action of the chlorella extract, the lyophilized state after the activated carbon treatment shown in Production Example 1 was 0.01 with PBS (−). A test solution was prepared as a% solution. Normal human skin fibroblasts were seeded in a 96-well plate using MEM containing 0.5% FBS so as to be 2.0 × 10 ⁴ cells / well, cultured for 24 hours, and washed with PBS (−). Thereafter, the medium is replaced with a serum-free medium to which the sample has been added, and cultured for 48 hours. After culture, type I collagen contained in the culture supernatant was quantified by ELISA. 100 μL of the culture supernatant was added to the ELISA plate and stored at room temperature for 18 hours. After washing with PBS containing 0.05% Tween-20 (PBS-T), blocking was performed with 1% skim milk / PBS-T for 2 hours. The mixture was treated with an anti-human type I collagen antibody and a peroxidase standard anti-rat IgG antibody, and developed with a color kit for peroxidase. The amount of type I collagen contained in the culture supernatant was determined from the absorbance at 450 nm and calculated as per unit protein. The Lowry method was used for protein quantification. The control was evaluated as a relative value with the amount of type I collagen as 100. The result was 152.3%.

(Reference test 2) Evaluation of estrogenic action The estrogenic action was measured by examining the effect of estrogenic activity on the growth of estrogen-dependent cells in the extract (In vitro cell. Dev. Biol. 28A, 595-602). , 1992). MCF-7 cells derived from human breast cancer cells were suspended at a density of 5 × 10 ⁴ cells / mL using Eagles MEM (phenol red removed) containing 5% FBS (charcoal dextran treatment) and 1 mM sodium pyruvate. The cell suspension (0.1 mL) was seeded on a 96-well microculture plate and cultured at 37 ° C. under 5% CO ₂ for 24 hours. Thereafter, samples of various concentrations were added to the culture plate and cultured for 6 days. After culturing, the cell concentration was measured by the MTT reduction method to obtain an estrogen-like action. High estrogen-like action was confirmed in the soybean extract, cuckoo extract, Pueraria myrifica extract, and red clover extract used in the present invention.

(Reference Example 3)
The active oxygen scavenging ability was measured by measuring the SOD-like activity and DPPH radical scavenging ability using the extracts of Production Examples 5-8. SOD-like activity followed the NBT method (Beauchamps et al. Method Anal. Bioche., 44, 279-287, 1971 in combination with the XOD system). DPPH radical (diphenylpicrylhydrazyl radical) scavenging ability was measured by dissolving DPPH radical (Sigma) in ethanol to make a 0.1 mM solution, taking 3 mL of 0.1 mM DPPH radical solution in a test tube, and adding each concentration to purified water. After adding 0.5 mL of the diluted test solution and allowing to stand at room temperature for 10 minutes, the absorbance was measured at a wavelength of 517 nm. The test results are shown in Table 2.

(Test Example 4) Evaluation of Hyaluronidase Activity Inhibitory Action Hyaluronidase is a hydrolase of hyaluronic acid distributed in connective tissue, activated during inflammation, destroying the matrix of connective tissue, and inflammatory cells and blood vessels. It is thought to play a role in increasing permeability. It is also known as a pro-inflammatory enzyme and is known to be inhibited by anti-inflammatory agents and anti-allergic agents. Therefore, the hyaluronidase activity inhibitory action is regarded as one of the antiallergic activities. As a positive control, cromoglycate sodium (manufactured by Fujisawa Pharmaceutical Co., Ltd.) whose inhibitory activity was already known was used in the test. The test method was performed by applying the Morgan-Elson method. Add 0.1 mL of hyaluronidase (Sigma, Type IV-S, final enzyme activity 400 Nfunit / mL) to 0.2 mL of a solution obtained by diluting an appropriate amount of the sample with 0.1 M acetate buffer (adjusted to pH 3.5). After standing at 37 ° C. for 20 minutes, 0.2 mL of an acetic acid buffer solution (0.1 mg / mL) of compound 48/80 (Sigma) is added as an activator, and further left at 37 ° C. for 20 minutes. . To this is added 0.5 mL of potassium hyaluronate (manufactured by Wako Pure Chemical Industries) solution (final concentration 0.4 mg / mL), and the mixture is allowed to stand at 37 ° C. for 40 minutes. Next, 0.2 mL of 0.4N sodium hydroxide solution was added on ice to stop the reaction, and then 50 mL of water was added to 4.95 g of boric acid, and pH 9. was adjusted with 1N sodium hydroxide solution. (1), then add water to make 100 mL), mix and heat in a boiling water bath for 3 minutes to inactivate the enzyme. Next, it is cooled to room temperature on ice, p-dimethylaminobenzaldehyde reagent (manufactured by Wako Pure Chemical Industries, Ltd., 10 g of 10N hydrochloric acid solution 12.5 mL and acetic acid 87.5 mL are mixed and dissolved, and immediately before use, 10 times with acetic acid. 6 mL) is added and allowed to stand at 37 ° C. for 20 minutes, and then the absorbance is measured at 585 nm. In addition, the sample solution containing acetate buffer instead of the sample solution was used as a control, each sample solution and control sample without enzyme was used as a blank, the inhibition activity rate was determined by the following formula, and the sample concentration was adjusted to 50 % Inhibitory activity concentration (IC50) was determined.
Inhibition rate (%) = [1- (absorbance of sample solution−absorbance of sample solution blank) / (absorbance of control solution−absorbance of control solution blank)] × 100
A high hyaluronidase activity inhibitory action was confirmed in the dokudami extract, altea extract, and aloe vera extract used in the present invention.

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited only to these examples.
(Examples 1-2)
A lotion was prepared according to the following formulation. That is, the prescription ingredients were stirred at room temperature and solubilized to obtain a lotion.
(Ingredient) (wt%)
(1) 1,3-butylene glycol 6.0%
(2) Glycerin 5.0%
(3) Essential component or comparative component (Table 2) 5.0%
(4) Pentylene glycol 3.0%
(5) Phenoxyethanol 0.5%
(6) Purified water residue

(Example 3)
Examples 1 and 2 and Comparative Example 1 using a photoaging model using brown guinea pigs (30 weeks of age)
The dullness improvement was tested using ˜7 lotions. The back of five brown guinea pigs was shaved and irradiated with 0.5 × MED (minimum erythema concentration) ultraviolet rays for 5 days to create a soot model. Guinea pigs are provided with a 2 cm x 2 cm application site on the back, 0.01 mL of sample / time / day,
This was applied for 8 weeks. As a control example, an essential component of the example skin lotion was replaced with purified water. The photoaging improvement effect was compared with the average dullness of the control group 24 hours after the last application, on the basis of ++: markedly improved, +: clearly improved, ±: slightly improved,-: not improved Determination was made for each guinea pig. The results are shown in Table 3 . Thereby, it turns out that the lotion of Example 1 and 2 which is the cosmetics for anti-aging of this invention is excellent in the photoaging improvement effect compared with the lotion of a comparative example.

(Example 4) Anti-aging test of skin In order to examine the anti-aging effect of skin, the following method was used to reduce wrinkles using creams containing the extracts used in Examples 1 and 2 and Comparative Example 2 above. An evaluation test was conducted on the improvement effect and the improvement effect on skin elasticity and sagging.

  Randomly extracted healthy women aged 30-50 years old were divided into 4 groups, and the subjects were divided into 4 groups, and the cream containing the essential ingredients and comparative ingredients and the control cream containing purified water instead of the essential ingredients were applied to the facial skin. After using for 2 months every day, the improvement effect on wrinkles and the improvement effect on skin elasticity and sagging were examined.

(Examples 5 to 6) Cream The following components (1) to (10) and the following components (11) to (15) were dissolved by heating at 75 ° C. to make A solution and B solution, respectively. Liquid B was added to liquid A and emulsified to prepare a cream.
(Ingredient) (wt%)
(1) Jojoba oil 3.0%
(2) Squalane 2.0%
(3) Methyl polysiloxane 0.5%
(4) Stearyl alcohol 0.5%
(5) Cetyl alcohol 0.5%
(6) Tri (capryl / capric acid) glyceryl 12.5%
(7) Glyceryl monostearate 5.0%
(8) 1.5% diglyceryl monostearate
(9) Decaglyceryl monostearate 3.0%
(10) Preservative appropriate amount (11) Xanthan gum 0.1%
(12) Essential component or comparative component 4.0%
(13) 1,3-butylene glycol 5.0%
(14) Preservative appropriate amount (15) Purified water residue

"Improvement effect on wrinkles"
The condition of wrinkles in the corners of the eyes was visually evaluated.
(Criteria)
Remarkable effect: Wrinkles almost disappeared.
Effective: Wrinkles are not very noticeable.
Slightly effective: Wrinkles are less noticeable than before.
No effect: No change.
"Improvement effect on skin elasticity and sagging"
Visual evaluation of skin elasticity and sagging was performed.
(Criteria)
Significant effect: There is a lot of skin and no sagging compared to before use.
Effective: There is a slight difference in skin compared to before use, and there is no sagging.
Slightly effective: There was still skin on the skin before use, and sagging decreased.
No effect: No change.
Table 4 shows the test results.

  As is apparent from Table 3, when the creams of the examples were used, it was observed that the wrinkles of the outer corners of the eyes and the skin were softened and sagging as compared with the case of using the creams of the comparative examples. It was. As a result, one or more estrogen-like agents selected from chlorella extract, soybean extract, cuckoo extract, Pueraria myrifica extract, oleum extract, button pipi extract, olive leaf extract with high collagen production promoting action The anti-aging effect excellent in the cosmetics which mix | blended the 1 or more types of active oxygen scavenger which consists of a thing, and the 1 or more types of anti-inflammatory agent which consists of a Dokudami extract, Altea extract, and an Aloe vera extract was confirmed.

Furthermore, the formulation example of this invention is shown below.

(Example 7) Toner lotion The following components (8) to (10) are mixed and dissolved to prepare a solution A. Separately, the following components (1) to (7) and (11) are mixed and dissolved to prepare a solution B, A liquid and B liquid were mixed uniformly and the lotion was adjusted.
(Ingredient) (wt%)
(1) Quince Seed Extract 8.0%
(2) Glycerol 3.0%
(3) 1,3-butylene glycol 5.0%
(4) Chlorella extract (Production Example 1) 2.0%
(5) Cuckoo extract (Production Example 3) 1.0%
(6) Button pi extract (Production Example 7) 1.0%
(7) Aloe vera extract (Production Example 12) 1.0%
(8) Polyoxyethylene sorbitan laurate 1.2%
(9) Ethyl alcohol 5.0%
(10) Preservative appropriate amount (11) Purified water residue

(Example 8) Emulsion The following components (1) to (10), and separately (11) to (15) and (17) are heated and dissolved at 75 ° C. to make A liquid and B liquid, respectively. In addition, it emulsified, it cooled to 50 degreeC, stirring, the component (16) was added, and the emulsion was prepared.
(Ingredient) (wt%)
(1) Jojoba oil 1.0%
(2) Squalane 2.0%
(3) Behenyl alcohol 1.0%
(4) Tri (capryl / capric acid) glyceryl 2.0%
(5) Tetraglycerin condensed silinoleic acid 0.1%
(6) Propylene glycol monooleate 0.5%
(7) Glycerol monostearate 1.0%
(8) Hexaglyceryl monomyrestate 1.0%
(9) Decaglyceryl monomyristate 0.5%
(10) Preservative appropriate amount (11) Chlorella extract (Production Example 1) 3.0%
(12) Soybean extract (Production Example 2) 2.0%
(13) Olive leaf extract (Production Example 8) 2.0%
(14) Dokudami extract (Production Example 10) 1.0%
(15) 1,3-butylene glycol 3.0%
(16) Fragrance 0.1%
(17) Purified water residue

(Example 9) Soap The following ingredients were mixed and manufactured according to a conventional method for manufacturing soap.
(Ingredient) (wt%)
(1) Soap base 53.2%
(2) Scroll 19.4%
(3) Jojoba oil 0.25%
(4) Chlorella extract (Production Example 1) 2.5%
(5) Cuckoo extract (Production Example 3) 2.0%
(6) Warmoko extract (Production Example 6) 2.0%
(7) Altea extract (Production Example 11) 1.0%
(8) Concentrated glycerin 6.5%
(9) Hydroxyethane diphosphonic acid 0.15%
(10) Normal water Residual

(Example 10) Cleansing Gel The following components (1) to (3), and separately (4) to (7) and (9) were dissolved by heating at 70 ° C. to make A liquid and B liquid, respectively. And stir until uniform. Cooling to 50 ° C. with stirring, component (8) was added to make a cleansing gel.
(Ingredient) (wt%)
(1) Hexaglyceryl monomyristate 20.0%
(2) Liquid paraffin 58.8%
(3) Preservative appropriate amount (4) Chlorella extract (Production Example 1) 1.0%
(5) Cuckoo extract (Production Example 3) 0.5%
(6) Olive leaf extract (Production Example 8) 0.5%
(7) Aloe vera extract (Production Example 12) 0.5%
(8) Concentrated glycerin 5.9%
(9) Sorbitol 5.0%
(10) Perfume appropriate amount (11) Purified water residue

  The cosmetics of Examples 7 to 10 were all excellent in skin anti-aging effects.

Claims (1)

Anti-aging cosmetics characterized by containing the following (A) to (D) (A) Chlorella extract whose main effect is a collagen production promoter (B) Soybean extract whose main effect is an estrogenic agent 1 or more types selected from a product, a cuckoo extract, a Pueraria myrifica extract, and a red clover extract (C) Warmoko extract, tea extract, button pipi extract, olive leaf extract whose main effect is an active oxygen scavenger 1 or more types selected from
(D) A combination of the extracts of any one of the following (A) to (C) whose main effect is an anti-inflammatory agent and has the ability to inhibit hyaluronidase.
(B) Aloe vera extract and docami extract
(B) Aloe vera extract and Altea extract
(C) Aloe vera extract, Dokudami extract, and Altea extract