JP4217237B2 - Automatic analyzer and its support system - Google Patents

Description

  The present invention relates to an automatic analyzer for analyzing components in a biological sample and a support system thereof, and relates to efficient operation and management of calibration and accuracy management in the automatic analyzer.

  In automated analyzers that analyze reagents in biological samples such as blood and urine using reagents, at the beginning of the analysis process, or at predetermined times determined according to each reagent during the analysis process, or during the analysis process As necessary, calibration, which is a calibration curve calibration operation, and accuracy management for maintaining a good state of the automatic analyzer must be performed.

  The calibration is performed using a standard solution having a predetermined concentration according to each analysis item. In addition, the accuracy control is performed using a control sample having a predetermined concentration according to each analysis item. Calibration and precision management have valid times according to each analysis item. For this reason, it is necessary to perform calibration and accuracy management again after this effective time. Further, when calibration and accuracy management are performed, if the result is not within a predetermined range, it is determined that the failure has occurred, and calibration and accuracy management must be performed again. Further, in each analysis item, when the reagent is taken out from a new reagent bottle, calibration must be performed again.

  U.S. Pat. No. 4,678,755 teaches an automated chemical analyzer that can perform calibration. In this prior art, the calibration time interval is stored for each analysis item, and warning data can be displayed on the display device by the control means for the analysis item for which the effective time of the calibration curve has elapsed. . In addition, when the calibration menu screen is output to the display device, a list of all analysis items handled by the analysis device is displayed, and alarm symbols are attached only to analysis items that have passed their valid time. .

  On the other hand, Japanese Patent Laid-Open No. 7-92171 discloses that a plurality of analyzers are arranged along a container transfer line, and the number of containers corresponding to the analysis processing capability of each analyzer is sequentially distributed to the plurality of analyzers. Teaches the transport system. However, this prior art does not describe anything about calibration and quality control.

  The apparatus described in Japanese Patent Application Laid-Open No. 7-92171 is effective for analyzing a large number of samples, but the number of types of analysis items to be handled becomes extremely large. Therefore, when using an automatic analyzer having a plurality of analysis units similar to that of JP-A-7-92171, the method described in US Pat. No. 4,678,755 can be applied as it is. The work of performing calibration or accuracy control becomes complicated.

  One object of the present invention is to easily notify an operator that it is necessary to perform calibration or accuracy management for each of a plurality of analysis units, and to accurately execute calibration or accuracy management for each analysis unit. It is an object of the present invention to provide an automatic analyzer and its support system.

  Another object of the present invention is to provide a storage medium storing an operation program for causing an automatic analyzer to execute calibration or accuracy management.

  Another object of the present invention is to provide an automatic analyzer having a configuration capable of repeatedly supplying a sample of known concentration used for calibration or accuracy control to a plurality of analysis units.

  It is a further object of the present invention to provide an automatic analyzer operating method capable of easily executing calibration or accuracy management when efficiently operating a plurality of analysis units in an analyzer.

  The automatic analyzer support system according to the present invention is applied to an automatic analyzer in which a plurality of analysis units are arranged along a transport line. This support system includes a display request means for a calibration or accuracy management status check screen, and a plurality of classification headings provided corresponding to the classification of a plurality of statuses related to calibration or accuracy management in accordance with the display request. , And an instruction button for instructing display of detailed information corresponding to each category heading, and a screen display means for causing a state inspection screen to appear, and an analysis item name of the corresponding state when an instruction is given by the instruction button And a control means for controlling to display on the state inspection screen the name of the analysis unit for which calibration or accuracy management of the analysis item is to be executed.

  In a preferred embodiment of the present invention, the display mode of the corresponding category heading is changed with the occurrence of a state corresponding to any one of the plurality of category headings. In addition, when two or more classification headings are notified of occurrence of two or more calibrations or accuracy control conditions for the same analysis item, calibration corresponding to one classification heading Alternatively, as the quality control is executed, the notifications by the remaining other classification headings are canceled.

  In the automatic analyzer according to the present invention, a plurality of analysis units are arranged along a transport line for transporting a sample so that the sample stops at the analysis unit selected according to the analysis item via the transport line. A specific sample rack that holds a specific sample that is repeatedly measured at a predetermined interval, and the specific sample rack is kept waiting, and calibration or accuracy control is executed. Stop by the rack standby unit that sends the specific sample rack to the transport line, and the specific sample rack that is delivered from the specified position on the rack standby unit to the analysis unit that requires calibration or accuracy control via the transport line. And a control means for controlling the operation of the transport line so that the specific sample rack is returned to a predetermined position on the rack standby unit. That.

  In the automatic analyzer operation method according to the present invention, the same specific analysis items are assigned to two or more analysis units, respectively, and a state that requires calibration or accuracy management for the automatic analyzer has occurred. Accordingly, it is a method of accepting an instruction for executing calibration or accuracy management and executing calibration or accuracy management based on the execution instruction in each of two or more analysis units with respect to a specific analysis item.

  According to the automatic analyzer and the support system of the present invention, the analysis item to be calibrated or controlled by accuracy can be easily notified to the operator through the display screen for each cause of necessity, and the identification of the necessity has occurred. Predetermined calibration or quality control can be accurately executed for each analysis unit.

  According to the automatic analyzer of the present invention, a standard sample or a quality control sample can be transported by a transport line whenever necessary, so that an analysis unit in need of a plurality of analysis units is generated. It becomes easy to repeatedly execute calibration or quality control processing of appropriate analysis items.

  According to the automatic analyzer operation method of the present invention, it is possible to easily execute calibration or accuracy management when a plurality of analysis units are efficiently operated.

  An embodiment of the present invention will be described with reference to FIGS.

  First, the configuration of an example of an automatic analyzer to which the present invention is applied will be described.

  FIG. 1 is a schematic configuration diagram of an automatic analyzer capable of analyzing serum, plasma, or urine as a biological sample. In the automatic analyzer shown in FIG. 1, an analyzer that supplies a reagent by a dispenser system as shown in FIG. 2 and an analyzer that supplies a reagent by a pipetter system as shown in FIG. 3 are mixed. The analysis units 3A, 3F, and 3G in FIG. 1 are dispenser-type analyzers that have fixed analysis channels and each of a plurality of reagent discharge nozzles is dedicated to each reagent. The analyzers 3B, 3C, 3D, and 3E are pipetter type analyzers that are randomly accessed without the analysis channel being fixed, and dispense one reagent after another according to the analysis item with one reagent pipetting nozzle.

  In FIG. 1, the analysis units 3A to 3G for analyzing the serum have positioned the racks such as the patient sample rack 1, the standard solution rack 74, and the control sample rack 77 taken in from the main transport line 20 at the sampling position. The sampling lines 4A to 4G which are transport paths having a function of returning to the main transport line 20 and the rack identification information provided for each sampling line and the identification information of each sample container on the rack are read. Identification information readers 51 to 57, and reaction units 5A to 5G for optically measuring the reaction liquid by advancing the reaction according to the analysis item of the patient sample, the standard solution, or the control sample and the reagent in the reaction container, And reagent supply units 26 to 29 and 32 to 34, respectively. Of the reagent supply units of each analyzer, 26, 27, 28, and 29 are of the pipetter type, and 32, 33, and 34 are of the dispenser type.

  The patient sample rack sending section 17 has an area where a large number of patient sample racks 1 can be set, and has a sending mechanism for sending the patient sample racks 1 to the main transport line 20 one by one. The rack collection unit 18 has an area for collecting the patient sample racks 1 that store the samples analyzed by any of the analysis units, and has an alignment mechanism that arranges the sample racks so that the sample racks are arranged in an orderly manner. The temporary storage unit 22 temporarily stores the patient sample rack 1 sampled by the analyzer until the measurement result is output. If reexamination is necessary, the sample rack is again transferred to the main via the return line 25. The sample rack is sent out by the line 20, and if re-examination is unnecessary, the sample rack is sent out to the rack collection unit 18.

  The standby unit 70 for a specific sample rack that is repeatedly used, such as the standard solution rack and the control sample rack, displays the identification information of the standard solution rack 74 and the control sample rack 77 input by the operator from the rack input port 75. Rack ID identification device 71 to be read, means for conveying standard solution rack 74 and control sample rack 77 whose identification information has been read by rack ID identification device 71 to rotor 76, and standard solution rack 74 and control sample rack that have been conveyed 77, a sensor 72 for detecting the holding positions of the standard solution rack 74 and the control sample rack 77 on the rotor 76, and a driving means 73 for rotating the rotor 76. When an instruction to execute calibration is given by the overall control computer 40, the rotor 76 is rotated by the driving means 73, and the standard solution containing the analysis items of known concentration necessary for executing the calibration is obtained. The rack 74 containing the container is positioned in the delivery path 80, and the standard liquid rack 74 pulled out from a predetermined position of the rotor 76 is sent out toward the main transport line 20 through the delivery path 80.

  The main transport line 20 selectively stops the standard solution rack 74 to an analysis unit that requires calibration for the analysis item. The sampling mechanism in the analysis unit pipettes a predetermined amount of standard solution from the standard solution rack to the reaction container of the analysis unit.

  Further, when an instruction for execution of accuracy management is given by the overall control computer 40, similarly, after the rotor 76 is rotated by the driving means 73, analysis items necessary for execution of the accuracy management are included. The rack 77 containing the control sample is sent out so as to be transported by the main transport line 20. The standard solution rack 74 for which the sampling for calibration has been completed and the control sample rack 77 for which the sampling for accuracy control has been completed are delivered from the sampling lines 4A to 4G of the analysis unit to the main transport line 20, and then the return line. 25, it is transported to the standby unit 70 and stored in the original holding position on the rotor 76. The stored racks 74 and 77 stand by in the rotor 76 until a calibration or accuracy control command is issued thereafter. The standby unit 70 is maintained at a predetermined temperature so that the standard solution and the control sample do not deteriorate. Here, the configuration using the rotor 76 is used, but other configurations such as an elevator-type holding means may be used in addition to the rotor.

  The control device includes an overall control computer 40, analysis unit side computers 6A to 6G provided corresponding to the respective analysis units, and a floppy (registered trademark) disk memory 41 which is a medium portable external storage device. The analysis unit side computers 6A to 6G share processing of output signals from the photometer of each analysis unit. The overall control computer 40 connected to these computers 6A to 6G controls the operation of each analysis unit, the operation of the rack transport system, and the operation of necessary parts in the system, and the calculation and control necessary for various information processing. Execute. The division of roles between the computers is not limited to this, and can be changed in various ways according to the necessity in the configuration, or the computer on the analysis unit side can be made unnecessary by using only the overall control computer 40. It is. The overall control computer 40 includes a storage unit 45, and is connected to a data input operation unit 42, a CRT 43 that is a display device for displaying information on a screen, and a printer 44 that can output measurement results and the like. ing. As the storage unit 45, for example, a built-in hard disk can be used.

  Each computer is preinstalled with a program. Each computer executes processing such as control according to the installed program. The program is provided in a state stored in a storage medium such as a floppy disk or a CD-ROM. As the program, in addition to the control program for executing the analysis, a program for supporting the analysis operation of the present invention is installed.

  For example, as shown in the example of FIG. 2, the patient sample rack 1 is composed of a box-shaped container holder in which a plurality of, for example, five patient sample containers 2 containing patient samples are loaded. Various things can be used. For example, as shown in the example of FIG. 2, the standard solution rack 74 and the control sample rack 77 each include a plurality of standard solution containers 78 containing standard solutions or a plurality of control sample containers 79 containing control samples, for example, five each. Although it consists of the box-shaped container holding body loaded, various things can be used besides this shape. Identification information media indicating rack identification information are provided on the outer walls of the patient sample rack 1, the standard solution rack 74, and the control sample rack 77, and the inner solution is provided on the outer walls of the patient sample container 2, the standard solution container 78, or the control sample container 79. An identification information medium indicating identification information is provided. As these identification information media, barcode labels, magnetic recording media, and the like are used. The barcodes provided in the patient sample rack 1, the standard solution rack 74, and the control sample rack 77 have rack number and sample type information. The barcode provided in the patient sample container 2 has information on each sample, for example, information such as a reception number, a reception date, a patient name, a patient number, a sample type, and a sample request analysis item. The standard solution container 78 or the control sample container 79 has information on each standard solution or control sample, for example, information such as the standard solution name or control sample name, ID, and manufacturing lot number.

  The identification information reading device 50 in FIG. 1 inputs the result of reading the identification information (bar code) of the rack and the sample container before being transported by the main transport line 20 to the computer 40. The identification information reader 58 provided in the temporary storage unit 22 reads the barcodes of the rack and the sample container and transmits them to the overall computer 40 when the rack enters and exits the temporary storage unit 22. Here, the rack refers to the patient sample rack 1, the standard solution rack 74, and the control sample rack 77. Here, the specimen container refers to the specimen container 2, the standard solution container 78, and the control specimen container 79.

  Reagent identification information is displayed on the outer wall of the reagent bottles 12, 12A, 12B for various analysis items stored in the reagent supply units of the analysis units 3A to 3G by barcodes. The reagent identification information includes a reagent manufacturing lot number, a reagent bottle size, a usable reagent solution amount, an expiration date, a sequence number that differs for each bottle, an analysis item code, and the like. Such reagent identification information is read by a bar code reader, is associated with each analysis unit 3A to 3G, and is calculated from the set position of the reagent bottle in the reagent supply unit, the amount of liquid that can be used, and the amount dispensed at one time. The number of times the reagent can be analyzed, the type of analysis item, the analysis unit number in which the reagent is stored, and the like are registered in the storage unit 45.

  The main transport line 20 includes a transport belt on which the patient sample rack 1, the standard solution rack 74, or the control sample rack 77 is placed, and a belt driving motor (none of which are shown), and the patient sample rack 1 and the standard solution rack 74. Alternatively, the control device is controlled to continuously transfer the control sample rack 77 to a desired position. Each sampling line 4A-4G can move a conveyance belt intermittently so that a rack may be stopped at a rack drawing-in position, a dispensing position, and a rack delivery position. The patient sample rack 1, the standard solution rack 74, or the control sample rack 77 transported by the main transport line 20 is moved along the row of analysis units, stopped in front of the analysis unit designated by the control device, and immediately The rack is moved to the rack pull-in position of the sampling line by a rack moving mechanism (not shown). And it dispenses with the dispenser mentioned later in a dispensing position. The patient sample rack 1, the standard solution rack 74, or the control sample rack 77 for which the dispensing operation has been completed is delivered by the rack transfer mechanism from the rack delivery position of the sampling line onto the main transport line 20. As the rack transfer mechanism, a moving robot having a rack gripping arm, a mechanism having an extrusion lever for pushing the rack from one of the main transfer line and the sampling line to the other, and the like are used.

  A configuration example of a dispenser type analysis unit will be described with reference to FIG. The reaction unit 5A of the analysis unit 3A is provided with two concentric circles of reaction container rows having translucent reaction vessels 46a, and each of the reaction vessel rows separates a plurality of light beams transmitted from the light source 14a through the reaction vessel 46a. A multi-wavelength photometer 15a for receiving wavelengths is provided. A first reagent nozzle group connected to a dispenser pump 60 having a pipette nozzle connected to the sample pipetter pump 47a and a reagent dispenser pump 60 are provided in the vicinity of the reaction unit 5A so as to act on each reaction container row. A holding unit 64 and a second reagent nozzle group holding unit 66, a first stirring mechanism 65 and a second stirring mechanism 67, and a reaction vessel cleaning mechanism 19a are arranged. In the reagent cooler 62, the reagent bottles 12 of the first reagent and the second reagent (only for necessary analysis items) for a plurality of analysis items are arranged and cooled to a predetermined temperature. The reagent solution in each reagent bottle 12 is supplied to the corresponding reagent discharge nozzle on the reaction container row by the reagent dispenser pump 60 through the tube. In this case, the dispenser type reagent supply unit 32 of the analysis unit 3A shown in FIG. 1 includes the reagent dispenser pump 60 of FIG. 2, the reagent cold storage 62 having a large number of reagent bottles 12, the first reagent nozzle group holding unit 64, A second reagent nozzle group holding unit 66 and the like are included.

  Individual patient sample racks 1 supplied from the rack delivery unit 17 are transported by the main transport line 20 and transferred to the sampling line 4A of the analysis unit 3A when analysis processing by the analysis unit 3A is necessary. The patient sample on the patient sample rack 1 that has arrived at the dispensing position is pipetted into the reaction container 46a by a predetermined amount by the pipette nozzle of the dispenser 48a. In the reaction container 46a, a reagent corresponding to the analysis item is discharged at a predetermined position on the reaction container row, and the reaction proceeds. After a predetermined time, the optical characteristics of the reaction solution in the reaction vessel 46a are measured by the multiwavelength photometer 15a. The signal output from the multiwavelength photometer 15a is processed by the logarithmic converter 30a and the analog / digital converter 31a under the control of the analysis unit side computer 6A, and is transmitted to the overall control computer 40.

  The individual standard solution racks 74 supplied from the standby unit 70 are transported by the main transport line 20 and transferred to the sampling line 4A of the analysis unit 3A when calibration in the analysis unit 3A is necessary. Here, the calibration refers to an operation of measuring a sample (standard solution) having a known concentration and creating a calibration curve.

  The standard solution on the standard solution rack 74 that has reached the dispensing position is pipetted into the reaction vessel 46a by a predetermined amount by the pipette nozzle of the dispenser 48a. In this reaction container, the reagent corresponding to the analysis item is discharged at a predetermined position on the reaction container row, and the reaction proceeds. After a predetermined time, the optical characteristics of the reaction solution in the reaction vessel 46a are measured by the multiwavelength photometer 15a.

  The signal output from the multi-wavelength photometer 15a is processed by the logarithmic converter 30a and the analog / digital converter 31a under the control of the analysis unit side computer 6A. Based on this data, the computer 6A obtains a calibration curve formula to create a calibration curve, determines the success or failure of the calibration, and transmits this success or failure to the overall control computer 40. Here, the success of calibration means that a calibration curve is created, and the created calibration curve does not deviate greatly from the calibration curve obtained experimentally in the past. It means that a calibration curve is not created, or that the created calibration curve deviates greatly from a calibration curve obtained experimentally in the past. The analysis unit computer 6A is provided with calibration curve data obtained empirically in the past and data relating to the deviation allowance range, and the success or failure of the calibration is determined based on this data.

  The analysis unit side computer 6A does not determine whether the calibration is successful or not, and transmits information regarding the obtained calibration curve formula to the overall control computer 40. The obtained calibration curve data and data related to the deviation allowance range may be prepared to determine the success or failure of the calibration.

  The individual control sample racks 77 supplied from the standby unit 70 are transported by the main transport line 20 and transferred to the sampling line 4A of the analysis unit 3A when accuracy management in the analysis unit 3A is required. Here, accuracy control means that a sample (control sample) with a known concentration is measured and it is determined whether or not the measurement result is within a predetermined range. It is an operation to check whether or not a proper state is maintained.

  The control sample on the control sample rack 77 that has reached the dispensing position is pipetted into the reaction container 46a by a predetermined amount by the pipette nozzle of the dispenser 48a. In the reaction container 46a, a reagent corresponding to the analysis item is discharged at a predetermined position on the reaction container row, and the reaction proceeds. After a predetermined time, the optical characteristics of the reaction solution in the reaction vessel 46a are measured by the multiwavelength photometer 15a.

  The signal output from the multi-wavelength photometer 15a is processed by the logarithmic converter 30a and the analog / digital converter 31a under the control of the analysis unit side computer 6A. Based on this data, the analysis unit side computer 6A determines whether or not the quality control is successful. Here, success in accuracy management means a state in which accuracy is measured and the measured accuracy maintains a predetermined accuracy. The failure in accuracy management refers to a state where the accuracy is not measured or the measured accuracy does not maintain a predetermined accuracy. The determined accuracy management success / failure is transmitted to the overall control computer 40.

  The analysis unit side computer 6A does not determine whether or not the accuracy management is successful, and transmits only information on whether or not the measurement is possible and information on the measured value when measurement is possible to the overall control computer 40, and the overall control computer. In 40, it may be determined whether or not the quality control is successful.

  The dispenser-type analysis units 3F and 3G have the same configuration as the analysis unit 3A.

  Next, a configuration example of a pipetter type analysis unit will be described with reference to FIG. In the reaction container 46b arranged in the reaction section 5B of the analysis unit 3B, the reaction between the sample and the reagent relating to a predetermined analysis item is advanced. The patient sample rack 1 moved from the main transport line 20 to the sampling line 4B (FIG. 1) is positioned at the dispensing position, and the sample indicated by the pipette nozzle of the dispenser 48b is collected and transferred to the reaction container 46b. A predetermined amount of specimen is discharged. The dispenser 48b has a pipetter pump 47b. The reaction unit 5B is maintained at a constant temperature (for example, 37 ° C.) by a constant temperature liquid supplied from the constant temperature bath 10.

  The pipetter type reagent supply unit 26 of the analysis unit in FIG. 3 includes two reagent disks 26A and 26B for the first reagent and the second reagent. In the reagent bottles 12A and 12B including various reagents prepared for many types of analysis items, reagent identification information is displayed by bar codes on the outer wall surfaces thereof. After the reagent bottles 12A and 12B are placed on the reagent disks 26A and 26B, the reagent identification information of each reagent bottle is read by the barcode readers 23A and 23B, and the information is set on the reagent disk of the reagent bottle. , The corresponding analysis item, the analysis unit number in which the reagent bottle is set, and the like are registered in the storage unit 45. The reagent dispensers 8A and 8B include a reagent pipette pump 11 connected to each pipetter nozzle capable of turning and moving up and down.

  The column of reaction containers 46b into which patient specimens have been dispensed is rotated and a predetermined amount of reagent solution is aspirated by the reagent dispenser 8A from the reagent bottle 12A positioned at the reagent inhalation position according to the type of analysis item, The first reagent is discharged into the reaction container 46b at the reagent addition position. After the contents are stirred by the stirring mechanism 13A at the stirring position, the reaction container row is transferred a plurality of times, and when the reaction container 46b reaches the second reagent addition position, the reagent dispenser 8B determines the reagent according to the analysis item. The reagent solution is sucked from the reagent bottle 12B positioned at the suction position, and the reagent is discharged into the reaction container. Next, the contents of the reaction vessel are stirred by the stirring mechanism 13B. Thereafter, the reaction container 46b passes through the light beam from the light source 14b as the reaction container row rotates, and the light transmitted through the reaction solution in the reaction container 46b is detected by the multiwavelength photometer 15b.

  The signal of the wavelength corresponding to the analysis item is processed by the logarithmic converter 30b and the analog / digital converter 31b controlled by the analysis unit side computer 6B, and the digital signal is transmitted to the overall control computer 40. The measured reaction container 46b is cleaned by the cleaning mechanism 19b and reused.

  When calibration in the analysis unit 3B is necessary, the standard solution rack 74 is transferred to the sampling line 4B of the analysis unit 3B. The standard solution rack 74 is positioned at the dispensing position, the standard solution indicated by the pipette nozzle of the dispenser 48b is collected, and a predetermined amount of the standard solution is discharged to the reaction vessel 46b. About this standard solution, reaction is advanced like the above-mentioned reaction of the patient sample. The signal of the wavelength of the reaction solution is processed by a logarithmic converter 30b and an analog / digital converter 31b controlled by the analysis unit side computer 6B. Based on this data, the analytical unit side computer 6B obtains a calibration curve formula to create a calibration curve, determines whether calibration has succeeded, and transmits this success / failure to the overall control computer 40. The analysis unit side computer 6B includes calibration curve data obtained empirically in the past and data related to the deviation allowance range, and the success or failure of the calibration is determined based on this data.

  The analysis unit side computer 6B does not determine the success or failure of the calibration, and transmits information on the obtained calibration curve formula to the overall control computer 40. In the overall control computer 40, it is obtained empirically in the past. It is also possible to prepare the calibration curve data and the data relating to the deviation allowable range, and determine whether the calibration is successful.

  When accuracy management in the analysis unit 3B is required, the control sample rack 77 is transferred to the sampling line 4B of the analysis unit 3B. The control sample rack 77 is positioned at the dispensing position, the control sample indicated by the pipette nozzle of the dispenser 48b is collected, and a predetermined amount of the control sample is discharged to the reaction container 46b. About this control sample, reaction is advanced similarly to the reaction of the above-mentioned patient sample.

  The signal of the wavelength of the reaction solution is processed by a logarithmic converter 30b and an analog / digital converter 31b controlled by the analysis unit side computer 6B. Based on this data, it is determined whether the predetermined accuracy is maintained in the analyzer-side computer 6A, and the result is transmitted to the overall control computer 40.

  Note that the analysis unit side computer 6A does not determine whether or not the predetermined accuracy is maintained, and transmits only the measurement value to the overall control computer 40, and whether or not the predetermined accuracy is maintained in the overall control computer 40. You may make it perform determination.

  The analysis units 3C, 3D, and 3E have the same configuration as the analysis unit 3B.

  Next, the operation of the embodiment apparatus of FIG. 1 will be described.

  Before the sample rack 1 is set in the rack delivery unit 17 and before the standard solution rack 74 and the control sample rack 77 are set in the standby unit 70, the analysis items requested for the inspection instruction from the requester for each sample are displayed. These are registered in advance in the overall control computer 40 from the operation unit 42 together with each sample number. Analysis condition information of each analysis item, information on calibration, and information on accuracy management are stored in the floppy disk memory 41. When the same analysis item is assigned to two or more analysis units, the analysis condition information to be used in common by a plurality of analysis units is the reagent to be used, the measurement wavelength in the photometer, the sample collection amount, etc. .

  Information on calibration includes calibration time interval, calibration execution format (standard solution or calibrator to be used), calibration curve creation method, information on acceptable range of calibration curve, calibration execution condition (in any case, calibration) To execute the action). Information on accuracy management includes accuracy management time interval, accuracy management execution format (control sample to be used), information on tolerance of accuracy, accuracy management execution condition (when to perform accuracy management), etc. . Among these, the calibration curve creation method, the information regarding the allowable range of the calibration curve, and the information regarding the allowable range of accuracy are also stored in storage means (not shown) of the analysis unit side computers 6A to 6G.

  Among the analysis condition information, the information stored corresponding to each reagent bottle includes the number of necessary reagents from the first reagent to the fourth reagent, the reagent bottle code consisting of a 5-digit number, and the dispensed amount of the reagent. , The number of analyzable tests per reagent bottle.

  As the reagent bottles are stored in the reagent supply units 26 to 29 and 32 to 34 of the respective analysis units 3A to 3G, the reagent identification information of each reagent bottle is associated with the analysis unit number and is sent to the overall control computer 40. be registered. In this case, the same type of reagent for analysis items is stored in a plurality of analyzers in the same group that handle the same sample type. Here, it is assumed that serum samples are handled by all the analysis units 3A to 3G. Among them, the reagent supply unit 32 of the analysis unit 3A stores, for example, reagent bottles for GOT and GPT which are liver function test items with a large number of sample requests and calcium, UA and BUN which are emergency test items. In the reagent supply unit 26 of the analysis unit 3B, for example, reagent bottles for GOT and GPT which are liver function test items and other analysis items with a small number of test requests are stored. In the reagent supply unit 27 of the analysis unit 3C, for example, calcium, UA, BUN which are emergency test items and reagent bottles for other analysis items with a small number of test requests are stored. Accordingly, the liver function test item can be analyzed by the two analysis units 3A and 3B. The emergency inspection items can be analyzed by the two analysis units 3A and 3C. It is determined by the operator according to the actual situation of the laboratory of each facility what kind of analysis item reagent is stored in which number of analysis units.

  As each reagent bottle 12, 12A, 12B is stored in each reagent supply unit, the reagent identification information provided in the reagent bottle is read, and the reagent bottle code is used as a key, and is already registered as analysis condition information. And the analysis items corresponding to the reagent bottle, the size of the bottle, the number of tests that can be analyzed, the setting position of the reagent bottle, and the like are associated with each other and registered in the overall control computer 40. At the same time, the maximum possible number of analyzes based on the total number of reagent bottles for the same kind of analysis items in a plurality of analysis units capable of analyzing the same kind of analysis items is also registered and displayed on the CRT 43 as necessary.

  After the corresponding reagents for the analysis items required for each analysis unit are stored, calibration for all analysis items that can be analyzed by that analysis unit is performed for each analysis unit prior to sample analysis processing. Is done. The analysis unit side computer determines whether the calibration is successful. In the case where the same analysis item is assigned to two or more analysis units, the same standard solution is dropped by the analysis units and sampled.

  When the execution of the calibration is completed successfully, the fact that the calibration is successful and the calibration curve formula obtained as the calibration result are stored in the storage unit 45 of the overall control computer 40. The calibration result is used for concentration calculation when the corresponding analysis item is analyzed in each analysis unit.

  When the execution of the calibration is terminated due to failure, the analysis unit side computer transmits to the overall control computer 40 that the calibration has failed. The overall control computer 40 displays on the calibration support screen (described later) of the CRT 43 that the calibration has failed. On this calibration support screen, a button is displayed as an area for inputting an instruction to display information about an analysis item for which calibration has failed, and an operator can instruct display of this button via the operation unit 42. Is displayed, information about the failed analysis item is displayed and a process for re-executing the failed calibration is started.

  When the execution of calibration for all analysis items in all analysis units is completed successfully, the quality control for all analysis items that can be processed by the analysis unit is performed for each analysis unit. Is done. The analysis unit side computer determines success / failure of accuracy management, and transmits the determined success / failure to the overall control computer 40.

  When the execution of quality control fails and ends, the overall control computer 40 displays on the quality management support screen (described later) of the CRT 43 that the quality management has failed. On this accuracy management support screen, a button is displayed as an area for inputting an instruction to display information on an analysis item for which accuracy management has failed, and the operator instructs to display this button via the operation unit 42. Is input, information on the failed analysis item is displayed, and the failed quality control is re-executed.

  When the execution of quality control in all the analysis units is completed successfully, analysis processing of analysis items that can be analyzed by the analysis unit is started for each analysis unit.

  When the analysis process is started, the identification information or the sample container of the sample rack 1 is extracted as one of the detection racks 1 placed on the rack delivery unit 17 is pushed out toward the main transport line 20. Two pieces of identification information are read by the identification information reading device 50. Based on the read information, the sample type on the sample rack 1 is determined by the overall control computer 40, and an analysis unit group that is set in advance for the sample type is selected. One of the analysis unit groups is determined as the sample transport destination. Here, for example, a serum sample is determined, and a group of analysis units 3A, 3B, and 3C to which the sample rack is to be transported is selected.

  Furthermore, the sample number and the registered status of the analysis item are collated with the reading of the sample identification information, the analysis item instructed to be measured for each sample on the sample rack 1 is determined, and each analysis item of each sample is determined. The overall control computer 40 determines whether the analysis processing should be performed by any of the analysis units 3A, 3B, and 3C. In this case, the overall control computer 40 monitors the number of analysis items for which analysis processing has already been instructed for each analysis unit and how much time is required until the end of the dispensing of these samples. In particular, regarding a specific analysis item that can be analyzed by a plurality of analysis units, it is determined by which analysis unit it is efficient to analyze the analysis item. For example, regarding GOT and GPT which are specific analysis items, it is determined whether the analysis unit with the smallest number of samples waiting to be processed at that time is 3A or 3B, and the one with the shorter waiting time is set as the designated analysis unit.

  In addition to such a method of automatically specifying an analysis unit for analyzing a specific analysis item according to the degree of busyness among a plurality of analysis units, an operator can process each analysis item from the operation unit 42 in advance. A designation method in which the priority order of analysis units to be used is input is also possible.

  The sample rack 1 having a sample to be analyzed for a specific analysis item and whose transport destination (for example, the analysis unit 3B) is determined is continuously transported to the designated analysis unit 3B by the main transport line 20 and the sampling line of the analysis unit 3B. It stops before the entrance to 4B. Next, the sample rack 1 is moved to the sampling line 4B, and a predetermined sample is dispensed to the reaction unit 5B by the sample dispenser 48b at the dispensing position, and then returned to the main transport line 20. When analysis items to be analyzed by another analysis unit 3C remain in the sample on the sample rack 1, the sample rack 1 is transported to the analysis unit 3C by the main transport line 20 and transferred to the sampling line 4C. The sample is dispensed.

  The remaining amount of the reagent in the reagent bottle for each analysis item in each analysis unit is monitored by the overall control computer 40. As a method for monitoring the remaining amount of the reagent, a method based on detecting the reagent liquid level in the reagent bottle at the time of dispensing the reagent by the liquid level detector provided in the reagent pipette nozzle, or dispensing of the reagent. In this case, a method of subtracting the number of analyzes that has been input in advance is employed. In any of the methods, whether or not the amount of reagent for the analysis item is insufficient is determined by determining whether or not the remaining number of analyzable times has reached a predetermined value by the overall control computer 40. The As the predetermined value in this case, the remaining number is set to a small number such as zero, once, or twice.

  Further, for example, when it is determined that the GOT reagent of the designated analysis unit 3B is insufficient, the GOT analysis process by the analysis unit 3B is stopped, and at the same time, the GOT of the analysis unit 3A in which sufficient GOT reagent remains is The switching operation of the analysis unit is controlled so that the analysis process can be performed. Therefore, the sample to be subjected to the GOT analysis process thereafter is transported to another analysis unit 3A having the next priority and subjected to the GOT analysis process.

  The control device in the embodiment of FIG. 1 grasps which analysis unit is instructed to perform analysis processing, calibration, and accuracy management of each analysis item, and those data are stored in the storage unit 45. . The overall control computer 40 stores information on which analysis unit is performing analysis processing, calibration, and accuracy management of each analysis item in a memory table, and when there is a request from the operator, The information is listed and displayed on the CRT 43 as a drawing.

  In the embodiment apparatus of FIG. 1, each analysis unit 3A to 3G can be instructed to start and stop the operation by a key operation of the operation unit 42, and based on instruction information from such an operation unit. The overall control computer 40 causes the sample rack 1 from the rack sending unit 17 to be transported via the main transport line 20 only to the remaining analysis units other than the analysis unit that has been stopped. Especially at night, when the number of requested specimens is small and the time required for specimen testing is urgent, such as at night, only the minimum required analysis units should be in operation and the remaining analysis units stopped. Can be used. In the time zone when the number of requested samples increases, the plurality of analysis units that have been stopped are restarted.

  Further, in the embodiment apparatus of FIG. 1, when an abnormal situation occurs in one of the analysis units and the analysis process by the analysis unit becomes impossible, the same analysis process is controlled to be replaced by another analysis unit. The apparatus instructs transport of the sample rack to another analysis unit and analysis processing by another analysis unit. For example, by setting the reagents for a plurality of analysis items in duplicate in the two analysis units 3B and 3C, the analysis processing for the plurality of analysis items can be performed without interruption.

  While performing analysis processing in the automatic analyzer as described above, calibration and accuracy management must be performed at predetermined time intervals determined in advance for each analysis item or for each predetermined number of samples. . In addition, when the reagent in the reagent bottle is consumed and a reagent bottle is added, calibration may be required for the reagent in the added reagent bottle.

  The automatic analyzer support system of the present invention is a support system for performing calibration and accuracy management prior to the analysis process in the automatic analyzer as described above or during the analysis process in the automatic analyzer. The support system will be described.

  First, a calibration support screen displayed on the CRT 43 of the automatic analyzer by the support system will be described. This support screen functions as a calibration state check screen.

  FIG. 4 shows an example of the calibration support screen. When the calibration button 423, which is a button integrated with display input on the screen, is instructed by the operator, the display of the calibration button 423 is reversed and a calibration support screen is displayed. On this screen, a display portion as a calibration state check screen is a portion including a display region 400 and a display region 410. First, these display regions will be described.

  When the calibration button 423 is instructed by the operator and the calibration support screen is displayed, the display in the display area 410 has not been performed yet. On the calibration support screen, a display other than the display area 410 is displayed.

  In the display area 400, a plurality of classification headings provided corresponding to the classification of the plurality of calibration states, that is, display blocks 401 to 404 that are a plurality of indicators that classify and symbolize the state of the analyzer in advance are displayed. Is done. Further, in the display area 400, instruction buttons or reception buttons 405 to 408 provided corresponding to those display blocks and receiving a display instruction are displayed. Each of the display blocks 401 to 404 serving as classification headings is changed in its own display mode when the state of the analyzer includes an event symbolized by the display block.

The Pre-Setting display block 401 in the display area 400 blinks when an analysis item corresponding to calibration that needs to be performed regularly, such as calibration to be performed prior to analysis processing in the automatic analyzer, is registered. . When the Pre-Setting display block 401 blinks and the operator instructs the button 405, the analysis item name of the calibration that needs to be performed regularly is displayed in the display area 410, and the displayed analysis item is displayed. Calibration is started.

  The Calib.Now display block 402 in the display area 400 blinks when there is an analysis item whose calibration time interval has passed. When the Calib.Now display block 402 blinks and the operator instructs the button 406, the corresponding analysis item name is displayed in the display area 410, and calibration of the displayed analysis item is activated.

  The Calib.Failed display block 403 in the display area 400 blinks when there is an analysis item in which a calibration failure has occurred. When the Calib. Failed display block 403 blinks and the operator instructs the button 407, the corresponding analysis item name is displayed in the display area 410, and calibration of the displayed analysis item is activated.

  The Change Over display block 404 in the display area 400 blinks when there is an analysis item in which the necessity of calibration accompanying the addition of the reagent bottle exists. When the operator designates the button 408 when the Change Over display block 404 flashes, the analysis item name to which a new reagent is added is displayed in the display area 410, and the calibration of the displayed analysis item is performed. It is activated.

  Next, contents displayed in the display area 410 will be described. The column of Test 411 displays the analysis item name to be calibrated. The column of A.Unit 412 displays the analysis unit name to be calibrated. In the blank 413 column, the elapsed time / calibration interval (valid time) is displayed when the calibration to be performed is calibration using one type of standard solution having a concentration of 0. In the column of Span 414, when the calibration to be performed is calibration using a standard solution having a known concentration other than 0, the elapsed time / calibration interval (effective time) is displayed. In the 2 Points 415 column, when the calibration to be performed is calibration using two types of standard solutions of known concentrations, the elapsed time / calibration interval (effective time) is displayed. In the Full 416 column, the elapsed time / calibration interval (effective time) is displayed when the calibration to be performed is calibration using three or more kinds of standard solutions having known concentrations.

  In FIG. 4, it is necessary to calibrate the analysis items AST, ALT, and ALP in the analysis unit 3D using one type of standard solution having a concentration of 0. The elapsed time / calibration interval is AST, Both ALT and ALP are displayed as 10/100. Further, it is necessary to calibrate the analysis item LDH in the analysis unit 3E using one kind of standard solution with a concentration of 0, and the elapsed time / calibration interval is displayed as 15/100. ing. Furthermore, the analysis item TP needs to be calibrated in the analysis unit 3E using one type of standard solution having a known concentration other than 0 or two types of standard solutions having a known concentration. Elapsed time / calibration The interval of 15/100 is displayed when using a standard solution with a known concentration other than 0, and 115/200 when using a standard solution with two known concentrations. . Further, it is necessary to perform the calibration of the analysis item UN in the analysis unit 3F by using one kind of standard solution having a concentration of 0, and the elapsed time / calibration interval is displayed as 15/100. ing. Furthermore, the analysis item CRE needs to be calibrated in the analysis unit 3F using one type of standard solution with a known concentration other than 0, or two types of standard solutions with a known concentration. Elapsed time / calibration The interval of 15/100 is displayed when using a standard solution with a known concentration other than 0, and 115/200 when using a standard solution with two known concentrations. . Further, it is necessary to calibrate the analysis item CRP in the analysis unit 3D using two types of standard solutions of known concentrations, or three or more types of standard solutions of known concentrations, and the elapsed time / calibration interval. Is displayed as 50/100 when using two types of standard solutions with known concentrations, and 50/200 when using standard solutions with three or more types of known concentrations.

  Any one of the buttons 405 to 408 is instructed, and a list of analysis items in a state corresponding to the display area 410 is displayed. At the same time, information on the standard solution necessary for calibration of each analysis item is displayed for each analysis item. It is possible to output from the printer 44 in correspondence with the above.

  In addition, when the number of analysis items displayed in the display area 410 is large and not all can be displayed at once, the analysis items can be displayed by scrolling with buttons 451 and 452.

  Next, buttons other than those described above that are displayed on the calibration support screen will be described. When the Work Place button 421 is instructed by the operator, a function screen is displayed. When the Reagent button 422 is instructed by the operator, a reagent bottle management screen is displayed. When the quality control button 424 is instructed by the operator, a quality management support screen (which will be described later) is displayed. When the Utility button 425 is instructed by the operator, a system setting screen for performing basic settings for moving the apparatus is displayed. When the Caliburation Trace button 431 is instructed by the operator, the history of calibration performed in the past is displayed. When the Instrument Factor button 432 is instructed by the operator, a factor for correcting the bias of each analysis unit is displayed. When the Reaction Monitor button 433 is instructed by the operator, data for checking a reaction state for each analysis item is displayed. When the Working Information button 434 is instructed by the operator, detailed information on the calibration result is displayed. When the Save button 435 is instructed by the operator, the list displayed on the screen is saved. When the Help button 436 is instructed by the operator, help information is displayed.

  The Stop button 441 is a button for stopping the automatic analyzer. The Log off button 442 is a button for exiting from the display screen. The S.Stop button 443 is a button for stopping sampling, and the Alarm button 444 is a button for notifying an abnormality of the apparatus. The System Overview button 445 is a button for displaying the state of the rack movement in order to know whether the rack is flowing normally. The Print button 446 is a button for instructing printing, and the Start button 447 is a button for starting the automatic analyzer.

  Next, an accuracy management support screen displayed on the CRT 43 of the automatic analyzer by the support system will be described. This support screen functions as an inspection screen for the quality control state.

  FIG. 5 shows an example of the accuracy management support screen. When the quality control button 524, which is a button integrated with display input on the screen, is instructed by the operator, the display of the quality control button 524 is reversed and the quality control support screen is displayed. On this screen, a display part as an inspection screen for the quality control state is a part including a display area 500 and a display area 510. First, these display areas will be described.

  When the Quality Control button 524 is instructed by the operator and the quality control support screen is displayed, the display in the display area 510 is not yet performed. A display other than the display area 510 is displayed on the accuracy management support screen.

  In the display area 500, display blocks 501 to 503, which are a plurality of classification headings provided corresponding to the classification of a plurality of states of quality control, that is, a plurality of indicators that classify and symbolize the state of the analysis apparatus in advance are displayed. In addition, instruction buttons or reception buttons 505 to 407 that are provided corresponding to the display blocks and receive display instructions are displayed. Each of the display blocks 501 to 503 serving as classification headlines is changed in its own display mode when the state of the analyzer includes an event symbolized by the display block.

  The Pre-Setting display block 501 in the display area 500 blinks when an analysis item corresponding to accuracy management that needs to be performed regularly, such as accuracy management to be performed prior to analysis processing in the automatic analyzer, is registered. . When the Pre-Setting display block 501 blinks and the operator instructs the button 505, analysis items for quality control that need to be regularly performed are displayed in the display area 510, and the displayed analysis items are displayed. Quality control is activated.

  The time-over display block 502 in the display area 500 blinks when the effective time of accuracy management has passed. When the operator designates the button 506 when the time-over display block 502 blinks, the analysis items for accuracy management that need to be performed are displayed in the display area 510, and the accuracy management of the displayed analysis items is performed. It is activated.

  The QC.Failed display block 503 in the display area 500 blinks when accuracy management failure occurs. When the QC.Failed display block 503 blinks and the operator instructs the button 507, the analysis items for the accuracy management that need to be performed are displayed in the display area 510, and the accuracy management of the displayed analysis items is performed. It is activated.

  Next, contents displayed in the display area 410 will be described. In the column of Test 511, analysis items to be subjected to accuracy management are displayed. In the column of A.Unit 512, the name of the analysis unit to be subjected to accuracy management is displayed. In the column of Control 513, the name of the control sample used for accuracy management to be performed is displayed. In the Type 514 column, a type that defines the type of concentration of the control sample used for accuracy management to be performed is displayed. In the Lot 515 column, the production lot number of the control sample used for accuracy control to be performed is displayed. In the column of Time Out 516, the elapsed time of accuracy management to be performed / the interval (effective time) of accuracy management is displayed.

  In FIG. 5, it is necessary to perform the accuracy control of the analysis items AST, ALT, and ALP by using the control sample of lot number X970400 with the name of Ctrl-1 and the type of Ser / Pl in the analysis unit 3D. It is displayed that the time / accuracy management interval is 10/100 for all AST, ALT, and ALP. Moreover, it is necessary to perform accuracy management of the analysis item LDH using the control sample of lot number S668795 in the analysis unit 3E with the name Ctrl-2 and the type Ser / Pl, and the elapsed time / accuracy control interval is , 50/60. Furthermore, it is necessary to perform accuracy management of the analysis item TP using the control sample of lot number S668795 in the analysis unit 3E with the name Ctrl-2 and the type Ser / Pl, and the elapsed time / accuracy management interval is , 50/60. Furthermore, the accuracy management of the analysis item UN needs to be performed in the analysis unit 3F using the control sample having the name Ctrl-U and the type Urin and the lot number V846852, and the elapsed time / accuracy management interval is 10 / 60 is displayed. Furthermore, the accuracy management of the analysis item CRE must be performed in the analysis unit 3F using the control sample of lot number S668795 with the name Ctrl-2 and the type Ser / Pl. The elapsed time / accuracy control interval is , 50/60. Furthermore, the accuracy management of the analysis item CRP must be performed in the analysis unit 3D using the control sample having the name Ctrl-M and the type Ser / Pl and the lot number M970123, and the elapsed time / accuracy control interval is 10/60 is displayed.

  Any one of the buttons 505 to 507 is instructed, and a list of analysis items is displayed in the display area 510. At the same time, information on control samples necessary for accuracy management of each analysis item is associated with each analysis item, The data may be output from the printer 44.

  In addition, when the number of analysis items displayed in the display area 510 is large and not all can be displayed at once, the analysis items can be displayed by scrolling with buttons 551 and 552.

  Next, the buttons displayed on the quality control support screen other than the above will be described. When the Select button 531 is instructed by the operator, the list displayed on the screen can be edited. When the Select button 531 is instructed by the operator, the list displayed on the screen can be edited. When the Save button 532 is instructed by the operator, the list displayed on the screen is saved. When the Help button 533 is instructed by the operator, help information is displayed.

  Next, the operation of the support system will be described. A program that defines the operation of the support system is stored in the storage unit 45, and the operation of the support system is performed by the overall control computer 40 reading and executing the program.

  FIG. 6 is a flowchart showing an outline of the operation of the support system. First, in step 610, the support system calls a calibration presetting processing routine. Next, in step 620, a quality control presetting processing routine is called. Thereafter, in step 630, the analysis monitoring processing routine is called and executed, and the process ends.

  7 and 8 are detailed flowcharts of the calibration presetting process routine started in step 610. FIG. In step 710, the calibration presetting process routine first accepts input of calibration presetting items that are analysis items to be calibrated regularly. The calibration presetting item is input from the operation unit 42 by the operator.

  Note that the calibration preset items may be updated once input unless they are changed daily. Further, if there is a change such as increase / decrease for some items, it is possible to input only for those items and update the others.

  Next, in step 720, the input calibration preset item is stored in the storage unit 45. When the calibration preset item is stored in the storage unit 45, the pre-setting display block 401 on the calibration support screen in FIG. Next, in step 740, it is determined whether or not there is an instruction for the button 405 (an instruction to display a calibration preset item) by the operator. If it is determined in step 740 that the operator has not instructed the button 405, input of a display instruction is awaited. If it is determined in step 740 that the operator has instructed the button 405, the process proceeds to step 750, and calibration presetting items are displayed in the display area 410 on the calibration support screen of FIG.

  Next, in step 810, execution of one of the calibration preset items is instructed. In step 820, it is determined whether the calibration (calibration instructed to be executed in step 810) has been successful. If it is determined in step 820 that the calibration has failed, the process proceeds to step 870, the calibration failure processing routine is called and executed, and then the process returns to step 820. If it is determined in step 820 that the calibration is successful, the process proceeds to step 830, and the calibration time stored in the storage unit 45 is reset for the analysis item of the calibration.

  Next, in step 840, the display of the calibration analysis item among the calibration preset items displayed in the display area 410 on the calibration support screen of FIG. 4 is erased. Next, in step 850, the memory for the calibration analysis item among the presetting items stored in the storage unit 45 is erased.

  Next, in step 860, it is determined whether or not calibration has been completed for all analysis items in the calibration presetting items. If it is determined in step 860 that there is an analysis item that has not yet been calibrated among the presetting items, the process returns to step 810. If it is determined in step 860 that calibration has been completed for all analysis items in the presetting items, the process returns.

  Next, FIG. 9 is a detailed flowchart of the calibration failure processing routine started in step 870 in the calibration presetting processing routine. In step 910, the calibration failure processing routine first stores the analysis item for which calibration has failed in the storage unit 45 as a calibration / fail item. Next, in step 920, the Calib.Failed display block 403 on the calibration support screen of FIG. 4 is blinked. Next, in step 930, it is determined whether or not there has been an instruction from the operator for the button 407 (an instruction to display a carib / fail item). If it is determined in step 930 that the operator has not designated the button 407, the display instruction input is awaited. If it is determined in step 930 that the operator has instructed the button 407, the process proceeds to step 940, and the calibrated / failed item is displayed in the display area 410 on the calibration support screen of FIG. Next, in step 950, execution of calibration of the calibrated / failed item is instructed. Thereafter, the process proceeds to step 960, and the analysis item of the calibration in the display of the calibration / fail item displayed in the display area 410 on the calibration support screen of FIG. 4 is deleted. Next, in step 970, the storage of the analysis item of the calibration among the calibrated / failed items stored in the storage unit 45 is deleted, and the process returns.

  FIGS. 10 and 11 are detailed flowcharts of the quality control presetting routine started in step 620 of the flowchart of FIG. 6 showing the outline of the operation of the present support system. In step 1010, the accuracy management presetting routine first receives input of a quality management presetting item, which is an analysis item that should be regularly subjected to accuracy management. The accuracy management presetting item is input from the operation unit 42 by the operator.

  Next, in step 1020, the input quality management preset item is stored in the storage unit 45. When the quality management presetting item is stored in the storage unit 45, the pre-setting display block 501 on the quality management support screen in FIG. Next, in step 1040, it is determined whether or not there has been an instruction from the operator for the button 505 (an instruction to display the accuracy management presetting item). If it is determined in step 1040 that the operator has not instructed the button 505, the display instruction input is awaited. If it is determined in step 1040 that the operator has instructed the button 505, the process proceeds to step 1050, and the quality control presetting item is displayed in the display area 510 on the quality management support screen of FIG.

  Next, in step 1110, execution of one of the quality control presetting items is instructed. In step 1120, it is determined whether the accuracy management (accuracy management instructed to be executed in step 1110) is successful. If it is determined in step 1120 that the accuracy management has failed, the process proceeds to step 1170, the accuracy management failure processing routine is called and executed, and then the process returns to step 1120. If it is determined in step 1120 that the accuracy management is successful, the process proceeds to step 1130, and the accuracy management time stored in the storage unit 45 is reset for the analysis item of the accuracy management. Next, in step 1140, the display of the quality control analysis items in the quality control presetting items displayed in the display area 510 on the quality control support screen of FIG. 5 is erased. Next, in step 1150, the storage of the quality control analysis items in the quality control presetting items stored in the storage unit 45 is erased.

  Next, in step 1160, it is determined whether or not accuracy management for all analysis items in the accuracy management presetting items has been completed. If it is determined in step 1160 that there is an analysis item for which accuracy management has not been completed among the accuracy management presetting items, the process returns to step 1110. If it is determined in step 1160 that accuracy management has been completed for all analysis items among the accuracy management presetting items, the process returns.

  Next, FIG. 12 is a detailed flowchart of the quality control failure processing routine started at step 1170 in the quality control presetting process routine. In step 1210, the accuracy management failure processing routine first stores, in the storage unit 45, an analysis item for which accuracy management has failed as a QC failure item. Next, in step 1220, the QCFailed display block 503 on the quality control support screen in FIG. 5 is blinked. Next, in step 1230, it is determined whether or not there has been an instruction from the operator on the button 507 (an instruction to display a QC field item). If it is determined in step 1230 that the operator has not instructed the button 507, input of a display instruction is awaited. If it is determined in step 1230 that the operator has instructed the button 507, the process proceeds to step 1240, and the QC failure item is displayed in the display area 510 on the quality control support screen in FIG.

  Next, in step 1250, execution of quality control of the QC failure item is instructed. Thereafter, the process proceeds to step 1260, and the analysis item for the quality control in the display of the QC failure item displayed in the display area 510 on the quality control support screen of FIG. 5 is deleted. Next, in step 1270, the storage of the quality control analysis item in the QC failure items stored in the storage unit 45 is deleted, and the process returns.

  FIG. 13 is a detailed flowchart of the analysis monitoring processing routine started in step 630 in the flowchart of FIG. 6 showing the outline of the operation of the present support system. In step 13010, the analysis monitoring process routine first instructs each analysis unit of the automatic analyzer to execute the analysis process. Next, in step 13020, it is determined whether or not there is an analysis item for which the accuracy management effective time has elapsed. If it is determined in step 13020 that there is an analysis item for which the accuracy management valid time has elapsed, the process proceeds to step 13060 to call and execute the accuracy management valid time overprocessing routine.

  Next, in Step 13070, it is determined whether or not the accuracy management executed in the accuracy management effective time over processing routine is successful. If it is determined in step 13070 that the accuracy management executed in the accuracy management effective time over processing routine is successful, the process proceeds to step 13090, and the analysis items of the accuracy management stored in the storage unit 45 are Reset the quality control time. Thereafter, the process returns to Step 13010. If it is determined in step 13070 that the accuracy management executed in the accuracy management valid time over processing routine has failed, the process proceeds to step 13080 to call and execute the above-described accuracy management failure processing routine. Return to. If it is determined in step 13020 that there is no analysis item for which the accuracy management effective time has passed, the process proceeds to step 13030.

  In step 13030, it is determined whether there is an analysis item for which the effective time of calibration has elapsed. If it is determined in step 13030 that there is an analysis item for which the calibration valid time has elapsed, the process proceeds to step 13100, and the calibration valid time over processing routine is called to calibrate the analysis item.

  Next, in step 13110, it is determined whether or not the calibration executed in the calibration valid time over process routine has been successful. If it is determined in step 13110 that the calibration executed in the calibration valid time over processing routine has been successful, the process proceeds to step 13130, and the analysis item of the calibration stored in the storage unit 45 is updated. Reset the calibration time. Thereafter, the process returns to Step 13010. If it is determined in step 13110 that the calibration executed in the calibration valid time over process routine has failed, the process proceeds to step 13120, and the above-described calibration failure process routine is called and executed. Return to. If it is determined in step 13030 that there is no analysis item for which the calibration valid time has passed, the process proceeds to step 13040 to determine whether or not a reagent shortage has occurred and it is necessary to add a reagent bottle.

  If it is determined in step 13040 that it is not necessary to add a reagent bottle, the process proceeds to step 13050, where it is determined whether all analysis processes have been completed. If it is determined in step 13050 that there is still an analysis process to be executed, the process returns to step 13020. If it is determined in step 13050 that all analysis processes have been completed, the process returns. If it is determined in step 13040 that a reagent bottle needs to be added, the process proceeds to step 13140, and a display screen on the CRT 43 displays that a reagent bottle needs to be added.

  Next, in step 13150, it is determined whether a reagent bottle has been added. If it is determined in step 13150 that no reagent bottle has been added, the process returns to step 13140. If it is determined in step 13150 that a reagent bottle has been added, the process proceeds to step 13160, and information stored in the storage unit 45 indicates whether or not there is a need to execute calibration accompanying the addition of the reagent bottle. Determine based on. If it is determined in step 13160 that there is no need to execute calibration associated with the addition of the reagent bottle, the process returns to step 13010. If it is determined in step 13160 that there is a need to execute calibration associated with the addition of the reagent bottle, the process proceeds to step 13170, a change-over process routine is called and executed, and then the process proceeds to step 13110.

  Next, FIG. 14 is a detailed flowchart of an accuracy management valid time over processing routine called at step 13060 in the analysis monitoring processing routine. In step 1410, the accuracy management valid time over processing routine first stores, in the storage unit 45, an analysis item for which the accuracy management valid time has elapsed as a time over item. Next, in step 1420, the time-over display block 502 on the quality control support screen in FIG. 5 is blinked. Next, in step 1430, it is determined whether or not there has been an instruction from the operator on the button 506 (time over item display instruction). If it is determined in step 1430 that the operator has not instructed the button 506, input of a display instruction is awaited. If it is determined in step 1430 that the operator has instructed the button 506, the process proceeds to step 1440, and the time-over item is displayed in the display area 510 on the quality control support screen in FIG. Next, in step 1450, execution of accuracy management for the time-over item is instructed. Thereafter, the process proceeds to step 1460, and the analysis item for the accuracy management in the display of the time-over item displayed in the display area 510 on the accuracy management support screen of FIG. 5 is deleted. Next, in step 1470, the storage of the analysis item of the quality control among the time-over items stored in the storage unit 45 is deleted, and the process returns.

  Next, FIG. 15 is a detailed flowchart of a calibration valid time over process routine started in step 13100 in the analysis monitoring process routine. In step 1510, the calibration effective time over processing routine first stores the analysis item for which the calibration effective time has elapsed in the storage unit 45 as a calib now item. Next, in step 1520, the Calib.Now display block 402 on the calibration support screen of FIG. 4 is blinked. Next, in step 1530, it is determined whether or not there is an instruction for the button 406 (an instruction to display a calib / now item) by the operator. If it is determined in step 1530 that the operator has not instructed the button 406, input of a display instruction is awaited.

  If it is determined in step 1530 that the operator has instructed the button 406, the process proceeds to step 1540, and a calib now item is displayed in the display area 410 on the calibration support screen of FIG. 4. Next, in step 1550, execution of calibration of the current and now items is instructed. Thereafter, the process proceeds to step 1560, and the analysis item of the calibration in the display of the calibration / now item displayed in the display area 410 on the calibration support screen of FIG. 4 is deleted. Next, in step 1570, the storage of the calibration analysis item in the calibration / now items stored in the storage unit 45 is deleted, and the process returns.

  FIG. 16 is a detailed flowchart of a change-over process routine started at step 13170 in the analysis monitoring process routine. In the change-over process routine, first, in step 1610, an analysis item that needs to be calibrated with the addition or update of the reagent bottle is stored in the storage unit 45 as a change-over item. Next, in Step 1620, the Change Over display block 404 on the calibration support screen in FIG. 4 is blinked. Next, in step 1630, it is determined whether or not there has been an instruction from the operator on the button 408 (instruction to display a change-over item). If it is determined in step 1630 that the operator has not instructed the button 408, input of a display instruction is awaited. If it is determined in step 1630 that the operator has instructed the button 408, the process proceeds to step 1640, and a change-over item is displayed in the display area 410 on the calibration support screen of FIG. Next, in step 1650, execution of calibration of the change-over item is instructed. Thereafter, the process proceeds to step 1660, and the analysis item of the calibration in the display of the change-over item displayed in the display area 410 on the calibration support screen in FIG. 4 is deleted. Next, in step 1670, the storage of the analysis item of the calibration among the change-over items stored in the storage unit 45 is deleted, and the process returns.

  FIG. 17 is a flowchart showing details of calibration execution processing in step 810 of FIG. 8, step 950 of FIG. 9, step 1550 of FIG. 15, and step 1650 of FIG.

  In the calibration execution process, first, in step 1710, the activation of the automatic analyzer is instructed. Next, in step 1720, analysis items to be executed from the data stored in the storage unit 45 corresponding to each analysis item and information about the standard solution necessary for calibration of the analysis item are stored. The standard solution rack 74 necessary for the calibration is specified. Moreover, it is necessary for calibration of the analysis item to be executed from the data stored in the storage unit 45 corresponding to each standard solution rack and the position (address) on the rotor 76 of the standard solution rack. The address on the rotor 76 of the standard solution rack 74 is obtained.

  Next, in step 1730, the rotor 76 is rotated by the driving means 73 while detecting the position by the sensor 72, and the standard liquid rack 74 at the address is stopped before the inlet to the main transport line 20. Next, in step 1740, an instruction is given to put the standard solution rack 74 onto the main transport line 20. Next, in step 1750, it is determined based on the data stored in the storage unit 45 which analysis unit to execute the calibration of the analysis item to be executed.

  Next, in step 1760, the main transport line 20 is controlled so that the standard solution rack 74 is transported to the analyzer determined to be calibrated. When the standard solution rack 74 is transferred to the analysis unit determined to be calibrated, the calibration is executed using the standard solution on the standard solution rack 74 for the corresponding analysis unit in step 1770. To instruct. When receiving this instruction, the analysis unit performs calibration of the analysis item to be executed.

  FIG. 18 is a flowchart showing details of the accuracy management execution process in step 1110 in FIG. 11, step 1250 in FIG. 12, and step 1450 in FIG. In the accuracy management execution process, first, in step 1810, the activation of the automatic analyzer is instructed. Next, in step 1820, the analysis item to be executed from the data stored in the storage unit 45 in correspondence with each analysis item and information about the control sample necessary for accuracy management of the analysis item. The control sample rack 77 necessary for the accuracy control of is specified. Moreover, it is necessary for the accuracy management of the analysis item to be executed from the data stored in the storage unit 45 corresponding to each control sample rack and the position (address) on the rotor 76 of the control sample rack. An address on the rotor 76 of the control specimen rack 77 is obtained.

  Next, at step 1830, the rotor 76 is rotated by the driving means 73 while detecting the position by the sensor 72, and the control sample rack 77 at the address is stopped before the inlet to the main transport line 20. Next, in step 1840, the control sample rack 77 is instructed to be loaded onto the main transport line 20. Next, in step 1850, it is determined based on the data stored in the storage unit 45 which analysis unit is to execute the accuracy management of the analysis item to be executed. Next, in step 1860, the main transport line 20 is controlled so that the control sample rack 77 is transported to the analysis unit determined to perform accuracy management. When the control sample rack 77 is transported to the analysis unit determined to perform the accuracy management, in step 1870, the analysis unit is configured to execute the accuracy management using the control sample on the control sample rack 77. Instruct. Upon receiving this instruction, the analysis unit executes the accuracy management of the analysis item to be executed.

  The display blocks 401 to 404 in FIG. 4 and the display blocks 501 to 503 in FIG. 5 are classification headings corresponding to the necessity of calibration or accuracy management. Among the display blocks 401 to 404 in FIG. 4 and the display blocks 501 to 503 in FIG. 5, the display block positioned above the screen is set to have higher priority than the display block positioned below. Yes.

  When a classification state requiring two or more calibrations or quality control occurs with respect to the same analysis item, the corresponding two or more display blocks blink. When execution of calibration or accuracy management is instructed from the reception button corresponding to one display block having high priority among the blinking display blocks, the automatic analyzer executes the instruction. This eliminates the need for calibration or accuracy control corresponding to display blocks with low priority, so the remaining display blocks that did not receive instructions also disappear, and stored information about the occurrence of necessity is stored. Erased.

  In the explanation of the operation of the support system, the analysis items to be set as presetting items, calib / now items, calib / fail items, change / over items, time / over items, and QC / fail items are stored in the storage unit 45. If you have memorized the analysis item that has been memorized, the preset item, the carib-now item, the carib-fail item, the change-over item, the time-over item, and the QC-fail item will be used. Also good.

  Next, the structure of data stored in the storage unit 45 in order to realize the operation of the support system will be described. FIG. 19 shows the structure of this data. As shown in FIG. 19, calibration information 1900 and quality management information 1910 are stored in the storage unit 45. The calibration information 1900 includes, for each analysis item, a calibration time interval, an elapsed time from the calibration of the analysis item executed last time (or a time of calibration of the analysis item executed last time), and a calibration execution format. (Standard solution name used in calibration, calibration method, etc.), calibration parameters (information on calibration curve formulas), calibration execution conditions (information on when calibration is executed), etc. Storing. The accuracy management information 1910 includes, for each analysis item, an accuracy management time interval, an elapsed time from the accuracy management of the analysis item executed last time (or a time of accuracy management of the analysis item executed last time), accuracy management, An execution format (control sample name used in accuracy management, accuracy management method, etc.), accuracy management execution conditions (information on when to execute accuracy management), and the like are stored. The overall control computer 40 performs calibration and accuracy management while referring to the calibration information 1900 and the accuracy management information 1910 as necessary.

  Further, FIG. 20 shows the correlation of data regarding calibration, which is generated in accordance with the operation of the support system and stored in the storage unit 45.

  First, the 1st example about the mutual relationship of the said data is shown.

  As the calibration item pre-setting data 2020, an analysis item for regularly executing calibration is set in advance by the operator. As the calibration item valid expiration data 2030, an analysis item for re-execution of calibration when the calibration time interval has elapsed is set in advance by the operator. As the calibration failure data 2040, an analysis item for re-execution of calibration when the calibration fails is set in advance by the operator. As the calibration execution data 2050 associated with the reagent shortage, an analysis item for re-execution of calibration when a reagent bottle is added is set in advance by the operator.

  When the automatic analyzer enters a state in which calibration is executed regularly, the support system reads the calibration item preset data 2020 and sets it as the calibration item preset data 2020. The calibration execution item list 2010 storing the analysis items to be calibrated and the standard solutions in association with each other is generated with reference to the calibration information 1900 (see FIG. 19) relating to the analysis items being performed, and the calibration is executed. Calibration is performed based on the item list 2010.

  When a calibration occurs after the time interval as the valid time has elapsed, the support system determines whether or not the analysis item of the calibration is set as the valid item expiration data 2030 of the calibration item. To do. When it is determined that the calibration analysis item is set as the calibration item valid expiration data 2030, the calibration is referred to the calibration information 1900 (see FIG. 19) related to the analysis item. A calibration execution item list 2010 in which the analysis items to be performed and the standard solution are stored in association with each other is generated, and calibration is executed based on the calibration execution item list 2010. When it is determined that the calibration analysis item is not set as the calibration item valid time-out data 2030, the calibration execution item list 2010 is not generated.

  When the calibration fails, the support system determines whether the calibration analysis item is set as the calibration failure data 2040. If it is determined that the calibration analysis item is set as the calibration failure data 2040, the calibration information 1900 (see FIG. 19) regarding the analysis item is referred to, and the analysis to be calibrated is performed. A calibration execution item list 2010 in which items and standard solutions are stored in association with each other is generated, and calibration is executed based on the calibration execution item list 2010. If it is determined that the calibration analysis item is not set as the calibration failure data 2040, the calibration execution item list 2010 is not generated.

  When a reagent bottle is added or replaced, the support system determines whether or not the analysis item of the calibration is set as calibration execution data 2050 associated with a reagent shortage. When it is determined that the calibration analysis item is set as the calibration execution data 2050 associated with the reagent shortage, the calibration information 1900 (see FIG. 19) regarding the analysis item is referred to, and calibration is performed. A calibration execution item list 2010 in which the analysis items to be performed and the standard solution are stored in association with each other is generated, and calibration is executed based on the calibration execution item list 2010. If it is determined that the analysis item of the calibration is not set as the calibration execution data 2050 associated with the reagent shortage, the calibration execution item list 2010 is not generated.

  Next, a second example of the correlation of data regarding calibration will be shown.

  As the calibration item preset data 2020, the preset items received in step 710 of the calibration preset process shown in FIG. 7 are stored. The calibration item valid time-out data 2030 is the calib-now item stored in step 1510 of the calibration valid time-over process shown in FIG. The calibration failure data 2040 is a calibration failure item stored in step 910 of the calibration failure process shown in FIG. The calibration execution data 2050 accompanying the reagent shortage is the change-over item stored in step 1610 of the change-over process shown in FIG. When these calibration item pre-setting data 2020, calibration item valid time-out data 2030, calibration failure data 2040, and calibration execution data 2050 due to lack of reagents are generated, the overall control computer 40 performs calibration. With reference to information 1900, a calibration execution item list 2010 in which the analysis items to be calibrated and standard solutions are stored in association with each other is generated, and calibration is executed based on the calibration execution item list 2010.

  FIG. 21 shows the interrelationship of data regarding quality control, which is generated along with the operation of the support system and stored in the storage unit 45.

  First, the 1st example about the mutual relationship of the said data is shown.

  As the accuracy management item pre-setting data 2120, an analysis item for regularly performing accuracy management is set in advance by the operator. As the expiration date data 2130 of the accuracy management item, an analysis item for re-execution of accuracy management is set in advance by the operator when the accuracy management effective time has elapsed. As the accuracy management failure data 2140, an analysis item for re-execution of accuracy management when accuracy management fails is set in advance by the operator.

  When the automatic analyzer is in a state of executing the accuracy management that is regularly executed, the support system reads the accuracy management item preset data 2120 and sets it as the accuracy management item preset data 2120. Referring to the accuracy management information 1910 (see FIG. 19) relating to the analysis item being processed, an accuracy management execution item list 2110 storing the analysis items to be subjected to accuracy management and the control samples in correspondence with each other is generated, and the accuracy management is executed Quality control is executed based on the item list 2110.

  In the case where the accuracy management for which the valid time has elapsed occurs, the support system determines whether or not the analysis item of the accuracy management is set as the expiration date data 2130 of the accuracy management item. When it is determined that the analysis item of the quality control is set as the valid time-out data 2130 of the quality management item, the quality management information 1910 (see FIG. 19) related to the analysis item is referred to, and the quality management is performed. A quality management execution item list 2110 in which the analysis items to be performed and the control sample are stored in association with each other is generated, and quality management is executed based on the quality management execution item list 2110. If it is determined that the quality control analysis item is not set as the quality control item valid time-out data 2130, the quality control execution item list 2110 is not generated.

  When the accuracy management fails, the support system determines whether or not the accuracy management analysis item is set as the accuracy management failure data 2140. If it is determined that the analysis item for the quality control is set as the quality management failure data 2140, the quality management information 1910 (see FIG. 19) relating to the analysis item is referred to, and the analysis for which quality management is to be performed A quality management execution item list 2110 in which items and control samples are stored in association with each other is generated, and quality management is executed based on the quality management execution item list 2110. If it is determined that the quality management analysis item is not set as the quality management failure data 2140, the quality management execution item list 2110 is not generated.

  Next, a second example of the interrelationship of data regarding accuracy management is shown.

  As the precision management item preset data 2120, the preset item received in step 1010 of the precision management presetting process shown in FIG. 10 is stored. The quality management item valid time-out data 2130 is the time-over item stored in step 1410 of the quality management valid time-over process shown in FIG. The quality control failure data 2140 is a QC failure item stored in step 1210 of the quality control failure process shown in FIG. When the quality control item pre-set data 2120, the quality control item valid time-out data 2130, and the quality management failure data 2140 are generated, the overall control computer 40 refers to the quality management information 1910 and performs quality management. A quality management execution item list 2110 in which analysis items to be performed and control samples are stored in association with each other is generated, and quality management is executed based on the quality management execution item list 2110.

  Furthermore, the standard solution name, the standard solution rack number, the position of the standard solution container in the standard solution rack, the standard solution identification information (ID), and the lot number of the standard solution are stored in association with each other. When calibration to be executed occurs, the standard solution name, standard solution rack number, position of the standard solution container in the standard solution rack, standard solution identification information (ID), standard solution required for the calibration The lot number may be displayed on the display screen of the CRT 43. Similarly, the control sample name, the control sample rack number, the position of the control sample container in the control sample rack, the control sample identification information (ID), and the lot number of the control sample are stored in association with each other. When accuracy control to be performed occurs, the control sample name, control sample rack number, control sample container position in the control sample rack, control sample identification information (ID), control sample required for the accuracy control The lot number may be displayed on the display screen of the CRT 43.

  An example of such a display screen of the CRT 43 is shown in FIG. In FIG. 22, for example, when the Pre-Setting button 2201 is touched by the operator, the name of the standard solution required for executing the calibration of the calibration item pre-setting data 2020 in FIG. The standard solution rack number is in the Rack 2212 column, the position of the standard solution container in the standard solution rack is in the Pos 2213 column, the standard solution identification information (ID) is in the ID 2214 column, and the lot number of the standard solution is LOT2215. The reason for executing calibration is displayed in the column of “REASON” 2216 in the column of “2”. At the same time, the control sample name necessary for execution of the accuracy management of the accuracy management item preset data 2120 in FIG. 21 is the Name 2217 column, the control sample rack number is the Rack 2218 column, and the control sample containers in the control sample rack Is displayed in the Pos 2219 column, the control sample identification information (ID) is displayed in the ID 2220 column, the control sample lot number is displayed in the LOT 2221 column, and the reason for executing the quality control is displayed in the REASON 2222 column. When the number of standard solutions and the number of control samples to display information are large, the display screen can be scrolled with the button 2241, button 2242, button 2243, and button 2244.

It is a figure which shows schematic structure of the automatic analyzer of one Example of this invention. It is a figure for demonstrating the example of the analyzer of a dispenser type in the Example of FIG. It is a figure for demonstrating the example of the analyzer of a pipetter system in the Example of FIG. It is a figure for demonstrating the calibration assistance screen of this invention. It is a figure for demonstrating the quality control assistance screen of this invention. It is a flowchart which shows the outline | summary of operation | movement of the assistance system of this invention. It is a flowchart which shows the calibration presetting process of the assistance system of this invention. It is a flowchart which shows the calibration presetting process of the assistance system of this invention. It is a flowchart which shows the calibration failure process of the assistance system of this invention. It is a flowchart which shows the quality control presetting process of the assistance system of this invention. It is a flowchart which shows the quality control presetting process of the assistance system of this invention. It is a flowchart which shows the quality control failure process of the assistance system of this invention. It is a flowchart which shows the analysis monitoring process of the assistance system of this invention. It is a flowchart which shows the precision management effective time over process of the assistance system of this invention. It is a flowchart which shows the calibration effective time over process of the assistance system of this invention. It is a flowchart which shows the change over process of the assistance system of this invention. It is a flowchart which shows the calibration execution instruction | indication process of the assistance system of this invention. It is a flowchart which shows the quality control execution instruction | indication process of the assistance system of this invention. It is a figure for demonstrating the structure of the data which the assistance system of this invention memorize | stores. It is a figure for demonstrating the mutual relationship of the data which the assistance system of this invention memorize | stores. It is a figure for demonstrating the mutual relationship of the data which the assistance system of this invention memorize | stores. It is a figure for demonstrating the example of the display screen which the assistance system of this invention displays.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 ... Patient sample rack, 2 ... Patient sample container, 3A-3G ... Analysis unit, 4A-4G ... Sampling line, 5A-5G ... Reaction part, 12, 12A, 12B ... Reagent bottle, 15a, 15b ... Multiwavelength photometer , 17 ... Rack delivery unit, 18 ... Rack collection unit, 20 ... Main transfer line, 26A, 26B ... Reagent disk, 26-29, 32-34 ... Reagent supply unit, 40 ... Computer for control, 50-58 ... Identification Information reading device, 70 ... standby unit, 72 ... sensor, 73 ... drive device, 74 ... standard solution rack, 75 ... standard solution rack / control sample rack inlet, 76 ... rotor, 77 ... control sample rack.

Claims (4)

An automatic analyzer configured such that a plurality of analysis units are arranged along a transport line for transporting a sample, and the sample is stopped via the transport line to an analysis unit selected according to an analysis item. In
A specific sample rack for holding a specific sample measured repeatedly at a predetermined interval;
To wait for the specific sample rack transported and supplied from the rack insertion port and send out the specific sample rack to the transport line as calibration or accuracy management is executed. A rack standby unit with a rotor of
A sampling line for drawing the rack for the specific sample taken out from the rack standby unit from the transport line to the dispensing position of each analysis unit;
The operation of the transfer line is stopped via the transfer line and the sampling line to an analysis unit that requires calibration or accuracy control, and then the specific sample rack is returned to the predetermined position on the rack standby unit. Control means for controlling
An automatic analyzer characterized by comprising. The automatic analyzer according to claim 1, wherein
An automatic analyzer characterized by comprising a display means for displaying a plurality of category headings corresponding to a state requiring calibration and displaying the analysis item names in the corresponding state for one or more category headings. The automatic analyzer according to claim 2,
The automatic analysis apparatus characterized in that the plurality of classification headings include a heading indicating a state in which there is an analysis item whose elapsed time from the previous calibration execution exceeds a predetermined time interval. The automatic analyzer according to claim 1, wherein
An automatic analyzer characterized by comprising a display means for displaying a plurality of classification headings corresponding to a state requiring accuracy management and displaying the analysis item names that need to be performed for one or more classification headings.

Images