JP4137020B2 - Cosmetics - Google Patents
Cosmetics Download PDFInfo
- Publication number
- JP4137020B2 JP4137020B2 JP2004202301A JP2004202301A JP4137020B2 JP 4137020 B2 JP4137020 B2 JP 4137020B2 JP 2004202301 A JP2004202301 A JP 2004202301A JP 2004202301 A JP2004202301 A JP 2004202301A JP 4137020 B2 JP4137020 B2 JP 4137020B2
- Authority
- JP
- Japan
- Prior art keywords
- acid
- gum
- nicotinic acid
- nicotinic
- cosmetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002537 cosmetic Substances 0.000 title claims description 34
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 20
- MVQVNTPHUGQQHK-UHFFFAOYSA-N 3-pyridinemethanol Chemical compound OCC1=CC=CN=C1 MVQVNTPHUGQQHK-UHFFFAOYSA-N 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 8
- 229960003512 nicotinic acid Drugs 0.000 claims description 7
- 235000001968 nicotinic acid Nutrition 0.000 claims description 7
- 239000011664 nicotinic acid Substances 0.000 claims description 7
- 229920002125 Sokalan® Polymers 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 235000017788 Cydonia oblonga Nutrition 0.000 claims description 4
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 241000894007 species Species 0.000 claims description 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 235000010418 carrageenan Nutrition 0.000 claims description 3
- 229920001525 carrageenan Polymers 0.000 claims description 3
- 239000000679 carrageenan Substances 0.000 claims description 3
- 229940113118 carrageenan Drugs 0.000 claims description 3
- 229920002674 hyaluronan Polymers 0.000 claims description 3
- 229960003160 hyaluronic acid Drugs 0.000 claims description 3
- 229920000609 methyl cellulose Polymers 0.000 claims description 3
- 239000001923 methylcellulose Substances 0.000 claims description 3
- 235000010981 methylcellulose Nutrition 0.000 claims description 3
- 229920001285 xanthan gum Polymers 0.000 claims description 3
- 235000010493 xanthan gum Nutrition 0.000 claims description 3
- 239000000230 xanthan gum Substances 0.000 claims description 3
- 229940082509 xanthan gum Drugs 0.000 claims description 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 2
- NZAKDNQAIWGNOG-UHFFFAOYSA-N 2-benzylpyridine-3-carboxylic acid Chemical compound OC(=O)C1=CC=CN=C1CC1=CC=CC=C1 NZAKDNQAIWGNOG-UHFFFAOYSA-N 0.000 claims description 2
- RESGCFMULOVHHB-UHFFFAOYSA-N 2-ethylpyridine-3-carboxylic acid Chemical compound CCC1=NC=CC=C1C(O)=O RESGCFMULOVHHB-UHFFFAOYSA-N 0.000 claims description 2
- HNTZKNJGAFJMHQ-UHFFFAOYSA-N 2-methylpyridine-3-carboxylic acid Chemical compound CC1=NC=CC=C1C(O)=O HNTZKNJGAFJMHQ-UHFFFAOYSA-N 0.000 claims description 2
- 244000215068 Acacia senegal Species 0.000 claims description 2
- 229920001817 Agar Polymers 0.000 claims description 2
- GUBGYTABKSRVRQ-DCSYEGIMSA-N Beta-Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-DCSYEGIMSA-N 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- 229920001661 Chitosan Polymers 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 229920002307 Dextran Polymers 0.000 claims description 2
- 229920001353 Dextrin Polymers 0.000 claims description 2
- 239000004375 Dextrin Substances 0.000 claims description 2
- 239000001856 Ethyl cellulose Substances 0.000 claims description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 2
- 229920002148 Gellan gum Polymers 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- 229920002907 Guar gum Polymers 0.000 claims description 2
- 229920000084 Gum arabic Polymers 0.000 claims description 2
- 229920000569 Gum karaya Polymers 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- 229920000161 Locust bean gum Polymers 0.000 claims description 2
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 claims description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- 239000004373 Pullulan Substances 0.000 claims description 2
- 229920001218 Pullulan Polymers 0.000 claims description 2
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 241000934878 Sterculia Species 0.000 claims description 2
- 240000004584 Tamarindus indica Species 0.000 claims description 2
- 235000004298 Tamarindus indica Nutrition 0.000 claims description 2
- 229920001615 Tragacanth Polymers 0.000 claims description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 2
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 claims description 2
- 235000010489 acacia gum Nutrition 0.000 claims description 2
- 239000000205 acacia gum Substances 0.000 claims description 2
- 239000008272 agar Substances 0.000 claims description 2
- 229940023476 agar Drugs 0.000 claims description 2
- 235000010419 agar Nutrition 0.000 claims description 2
- 235000010443 alginic acid Nutrition 0.000 claims description 2
- 239000000783 alginic acid Substances 0.000 claims description 2
- 229920000615 alginic acid Polymers 0.000 claims description 2
- 229960001126 alginic acid Drugs 0.000 claims description 2
- 150000004781 alginic acids Chemical class 0.000 claims description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 2
- 239000000305 astragalus gummifer gum Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 235000015165 citric acid Nutrition 0.000 claims description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 2
- 235000019425 dextrin Nutrition 0.000 claims description 2
- MPFLRYZEEAQMLQ-UHFFFAOYSA-N dinicotinic acid Chemical compound OC(=O)C1=CN=CC(C(O)=O)=C1 MPFLRYZEEAQMLQ-UHFFFAOYSA-N 0.000 claims description 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 2
- 229920001249 ethyl cellulose Polymers 0.000 claims description 2
- 235000010492 gellan gum Nutrition 0.000 claims description 2
- 239000000216 gellan gum Substances 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 235000010417 guar gum Nutrition 0.000 claims description 2
- 239000000665 guar gum Substances 0.000 claims description 2
- 229960002154 guar gum Drugs 0.000 claims description 2
- 229920000591 gum Polymers 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 2
- 235000010494 karaya gum Nutrition 0.000 claims description 2
- 239000000231 karaya gum Substances 0.000 claims description 2
- 229940039371 karaya gum Drugs 0.000 claims description 2
- 235000010420 locust bean gum Nutrition 0.000 claims description 2
- 239000000711 locust bean gum Substances 0.000 claims description 2
- 235000010449 maltitol Nutrition 0.000 claims description 2
- 239000000845 maltitol Substances 0.000 claims description 2
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 2
- 229940035436 maltitol Drugs 0.000 claims description 2
- 229950006238 nadide Drugs 0.000 claims description 2
- 235000005152 nicotinamide Nutrition 0.000 claims description 2
- 239000011570 nicotinamide Substances 0.000 claims description 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims description 2
- 235000010987 pectin Nutrition 0.000 claims description 2
- 239000001814 pectin Substances 0.000 claims description 2
- 229920001277 pectin Polymers 0.000 claims description 2
- 239000011574 phosphorus Substances 0.000 claims description 2
- 229910052698 phosphorus Inorganic materials 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
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- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 235000019423 pullulan Nutrition 0.000 claims description 2
- GJAWHXHKYYXBSV-UHFFFAOYSA-N quinolinic acid Chemical compound OC(=O)C1=CC=CN=C1C(O)=O GJAWHXHKYYXBSV-UHFFFAOYSA-N 0.000 claims description 2
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 claims description 2
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- HSHXDCVZWHOWCS-UHFFFAOYSA-N N'-hexadecylthiophene-2-carbohydrazide Chemical compound CCCCCCCCCCCCCCCCNNC(=O)c1cccs1 HSHXDCVZWHOWCS-UHFFFAOYSA-N 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
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- JOUIQRNQJGXQDC-ZYUZMQFOSA-L nicotinate D-ribonucleotide(2-) Chemical compound O1[C@H](COP([O-])([O-])=O)[C@@H](O)[C@@H](O)[C@@H]1[N+]1=CC=CC(C([O-])=O)=C1 JOUIQRNQJGXQDC-ZYUZMQFOSA-L 0.000 claims 1
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Landscapes
- Cosmetics (AREA)
Description
本発明は、化粧料に関し、更に詳しくは、荒れ肌改善性に優れ、しかも刺激性の低い化粧料に関する。 The present invention relates to a cosmetic, and more particularly to a cosmetic that is excellent in rough skin improvement and has low irritation.
荒れ肌を予防あるいは改善するためにニコチン酸、ニコチン酸誘導体、ニコチニックアルコール、ニコチニックアルコール塩等の角質細胞間脂質の合成促進剤が配合されてきた（例えば、特許文献１参照）。
しかしながら、例えばアトピー性皮膚炎等の感受性の高い皮膚に対しては、ニコチン酸、ニコチン酸誘導体、ニコチニックアルコール、ニコチニックアルコール塩等は刺激を与える場合があり、そのような肌に使用される化粧料には配合できないか、あるいは低濃度っでしか配合できなかった。
However, for sensitive skin such as atopic dermatitis, nicotinic acid, nicotinic acid derivatives, nicotinic alcohol, nicotinic alcohol salts, etc. may irritate and are used for such skin It could not be added to cosmetics, or could only be added at low concentrations.
本発明者等は上記の事情に鑑み、鋭意研究した結果本発明を完成したものであって、その目的とするところは、荒れ肌の予防もしくは改善効果に優れ、なおかつ皮膚への刺激性の少ない化粧料を提供するにある。 The present inventors have completed the present invention as a result of diligent research in view of the above circumstances, and the object of the present invention is makeup that is excellent in preventing or improving rough skin and has little irritation to the skin. In providing a fee.
上述の目的は、（Ａ）ニコチン酸、ニコチン酸誘導体、ニコチニックアルコール、ニコチニックアルコール塩から選ばれる少なくとも１種以上と、Ｂ）特定の単糖及びオリゴ糖からなる群から選択される少なくとも１種以上と、（Ｃ）水溶性の皮膜形成性高分子から
なる群より選択される１種以上とを含有することを特徴とする化粧料によって達成される。
The above-mentioned object is at least one selected from the group consisting of (A) at least one selected from nicotinic acid, nicotinic acid derivatives, nicotinic alcohol and nicotinic alcohol salt, and B) a specific monosaccharide and oligosaccharide. It is achieved by a cosmetic comprising at least one species and at least one species selected from the group consisting of (C) a water-soluble film-forming polymer.
本発明の化粧料は、荒れ肌の予防もしくは改善効果に優れ、しかも皮膚への刺激性の少ない化粧料である。 The cosmetic of the present invention is a cosmetic that is excellent in preventing or improving rough skin and has little irritation to the skin.
以下、本発明の実施の形態について詳述する。 Hereinafter, embodiments of the present invention will be described in detail.
本発明で（Ａ）成分として用いられるニコチン酸アミド、ニコチン酸誘導体、ニコチニックアルコール、ニコチニックアルコール塩は、化粧品原料として公知の物質である。 The nicotinamide, nicotinic acid derivative, nicotinic alcohol, and nicotinic alcohol salt used as the component (A) in the present invention are substances known as cosmetic raw materials.
ニコチン酸誘導体の具体例としては、メチルニコチン酸、エチルニコチン酸、ベンジルニコチン酸、ニコチン酸アミド、クエン酸ニカメタート、ニコチン酸トコフェロール、キノリン酸、ピリジン３，５−ジカルボン酸、ニコチンアミドアデニンジヌクレオチドリン酸、ニコチン酸モノヌクレオチド等が挙げられる。 Specific examples of nicotinic acid derivatives include methyl nicotinic acid, ethyl nicotinic acid, benzyl nicotinic acid, nicotinic acid amide, citric acid nicamethate, nicotinic acid tocopherol, quinolinic acid, pyridine 3,5-dicarboxylic acid, nicotinamide adenine dinucleotide phosphorus Examples include acids and nicotinic acid mononucleotides.
本発明で用いられる（Ａ）成分の含有量は、化粧料の総量を基準として、０．０１〜１０．０質量％（以下、％と略記する）が好ましく、特に好ましくは０．１〜８．０％である。０．０１％以上で肌荒れ改善及び予防効果が特に優れており、また１０．０％以下であれば、他の（Ｂ），（Ｃ）成分との相乗効果による皮膚刺激性の低減効果が特に顕著であり、またコスト的にも有利だからである。 The content of the component (A) used in the present invention is preferably from 0.01 to 10.0% by mass (hereinafter abbreviated as%), particularly preferably from 0.1 to 8 based on the total amount of the cosmetic. 0.0%. If it is 0.01% or more, the rough skin improvement and prevention effect is particularly excellent, and if it is 10.0% or less, the skin irritation reducing effect due to the synergistic effect with other components (B) and (C) is particularly high This is remarkable and is advantageous in terms of cost.
本発明で（Ｂ）成分として用いられる単糖又はオリゴ糖も、化粧品原料として公知の物質である。 The monosaccharide or oligosaccharide used as the component (B) in the present invention is also a known substance as a cosmetic raw material.
（Ｂ）成分は、ラフィノース、マルチトール、ソルビトール、トレハロース、β−ラクトース、ブドウ糖から選択される。 (B) Ingredients are raffinose, maltitol, sorbitol, trehalose, beta-lactose, is selected from glucose.
本発明で用いられる（Ｂ）成分全体の含有量は、化粧料の総量を基準として、０．０１〜２０．０％が好ましく、さらに好ましくは０．１〜１０．０％、特に好ましくは０．１〜５．０％である。０．０１％以上で、肌荒れ改善及び予防効果、及び（Ａ）成分に起因する刺激性の低減効果が特に優れており、また２０．０％以下が、コスト的にも有利だからである。 The content of the entire component (B) used in the present invention is preferably 0.01 to 20.0%, more preferably 0.1 to 10.0%, particularly preferably 0, based on the total amount of the cosmetic. .1 to 5.0%. When the content is 0.01% or more, the effect of improving and preventing rough skin and the effect of reducing irritation caused by the component (A) are particularly excellent, and 20.0% or less is advantageous in terms of cost.
本発明で（Ｃ）成分として用いられる水溶性の皮膜形成性高分子も、化粧品原料として公知の物質である。 The water-soluble film-forming polymer used as the component (C) in the present invention is also a known substance as a cosmetic raw material.
（Ｃ）成分の具体例としては、カルボキシビニルポリマー、アルキル変性カルボキシビニルポリマー、アラビアガム、アルギン酸またはその塩、カラギーナン、寒天、グアーガム、クインスシード、タマリンドガム、デキストリン、デキストラン、デンプン、ローカストビーンガム、カラヤガム、トラガカントガム、ペクチン、マルメロ、キトサン、キサンタンガム、ジェランガム、ヒアルロン酸またはその塩、プルラン、メチルセルロース、エチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、ヒドロキシプロピルメチルセルロース、カルボキシメチルセルロース、カチオン化セルロース、ポリアクリル酸アミド、ポリビニルアルコール、ポリビニルピロリドン等を挙げることができ、１種以上を組み合わせて用いることができる。 Specific examples of the component (C) include carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, gum arabic, alginic acid or a salt thereof, carrageenan, agar, guar gum, quince seed, tamarind gum, dextrin, dextran, starch, locust bean gum, Karaya gum, tragacanth gum, pectin, quince, chitosan, xanthan gum, gellan gum, hyaluronic acid or salts thereof, pullulan, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, cationized cellulose, polyacrylamide, polyvinyl Alcohol, polyvinyl pyrrolidone, etc. can be mentioned, combining one or more It can be used.
中でも、カルボキシビニルポリマー、アルキル変性カルボキシビニルポリマー、カラギーナン、キサンタンガム、ヒアルロン酸またはその塩、メチルセルロース、ポリアクリル酸アミドからなる群より選択される１種以上を組み合わせて用いることが好ましい。 Among these, it is preferable to use a combination of one or more selected from the group consisting of carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, carrageenan, xanthan gum, hyaluronic acid or a salt thereof, methylcellulose, and polyacrylamide.
本発明で用いられる（Ｃ）成分全体の含有量は、化粧料の総量を基準として、０．００１〜１０．０％が好ましく、さらに好ましくは０．１〜５．０％、特に好ましくは０．１〜１．０％である。０．００１％以上で、肌荒れ改善及び予防効果、及び（Ａ）成分に起因する刺激性の低減効果が特に優れており、また１０．０％以下が、コスト的にも有利だからである。 The content of the entire component (C) used in the present invention is preferably 0.001 to 10.0%, more preferably 0.1 to 5.0%, particularly preferably 0, based on the total amount of the cosmetic. 0.1-1.0%. It is because the effect of improving and preventing rough skin and the effect of reducing irritation caused by the component (A) are particularly excellent at 0.001% or more, and 10.0% or less is advantageous in terms of cost.
（Ａ）成分と（Ｂ）成分の含有比率は、閉塞性の複合皮膜を形成し易く、（Ａ）成分の荒れ肌の予防あるいは改善効果を十分に発揮でき、しかも（Ａ）成分に起因する刺激性の低減効果に優れているという点で、（Ａ）：（Ｂ）＝３：１〜１：１０が好ましく、さらに好ましくは、２：１〜１：８である。 The content ratio of the component (A) and the component (B) is easy to form an occlusive composite film, can sufficiently exert the effect of preventing or improving the rough skin of the component (A), and the stimulation caused by the component (A) (A) :( B) = 3: 1 to 1:10 is preferable and 2: 1 to 1: 8 is more preferable in that the effect of reducing the property is excellent.
また（Ｂ）成分と（Ｃ）成分を合わせた含有量は、化粧料の総量を基準として、１．０〜５．０％が好ましい。 The total content of the component (B) and the component (C) is preferably 1.0 to 5.0% based on the total amount of the cosmetic.
本発明の化粧料は、上述した成分を必須の構成成分とするが、当該組成物には本発明の目的を損なわない範囲で、他の成分、例えば、陰イオン性界面活性剤、両性界面活性剤、非イオン性界面活性剤、粘剤、油剤、粉体（色素、樹脂、顔料）、防腐剤、香料、保湿剤、生理活性成分、塩類、溶媒、酸化防止剤、キレート剤、パール化剤、中和剤、ｐＨ調整剤、昆虫忌避剤、酵素等の成分を適宜配合することができる。 The cosmetic of the present invention has the above-described components as essential components, but other components such as an anionic surfactant and an amphoteric surfactant are included in the composition as long as the object of the present invention is not impaired. Agent, nonionic surfactant, sticky agent, oil agent, powder (dye, resin, pigment), preservative, fragrance, moisturizer, physiologically active ingredient, salt, solvent, antioxidant, chelating agent, pearlizing agent Ingredients such as a neutralizer, a pH adjuster, an insect repellent, and an enzyme can be appropriately mixed.
以下に他の配合成分の具体例を示すが、これらに限られるものではない。 Specific examples of other blending components are shown below, but are not limited thereto.
陰イオン性界面活性剤としては、直鎖あるいは分岐鎖脂肪酸塩、α−アシルスルホン酸塩、アルキルスルホン酸塩、アルキルアリルスルホン酸塩、アルキルナフタレンスルホン酸塩、アルキル硫酸塩、アルキルエーテル硫酸塩、アルキルアミド硫酸塩、ポリオキシエチレンアルキルエーテル硫酸塩、ポリオキシエチレンアルキルアミドエーテル硫酸塩、アルキルリン酸塩、アルキルアミドリン酸塩、アルキロイルアルキルタウリン塩、Ｎ−アシルアミノ酸塩、スルホコハク酸塩、パーフルオロアルキルリン酸エステル等が挙げられる。 Examples of the anionic surfactant include linear or branched fatty acid salts, α-acyl sulfonates, alkyl sulfonates, alkyl allyl sulfonates, alkyl naphthalene sulfonates, alkyl sulfates, alkyl ether sulfates, Alkylamide sulfate, polyoxyethylene alkyl ether sulfate, polyoxyethylene alkylamide ether sulfate, alkyl phosphate, alkylamide phosphate, alkyloylalkyl taurine salt, N-acyl amino acid salt, sulfosuccinate, Examples thereof include fluoroalkyl phosphate esters.
両性界面活性剤としては、グリシン型、アミノプロピオン酸型、カルボキシベタイン型、スルホベタイン型、スルホン酸型、硫酸型、リン酸型等が挙げられる。 Examples of amphoteric surfactants include glycine type, aminopropionic acid type, carboxybetaine type, sulfobetaine type, sulfonic acid type, sulfuric acid type, and phosphoric acid type.
非イオン性界面活性剤としては、脂肪酸アルカノールアミド、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレンアルキルエーテル、ポリオキシエチレンアルキルエステル、ショ糖脂肪酸エステル、ポリグリセリン脂肪酸エステル、アルキルアミンオキシド等が挙げられる。 Nonionic surfactants include fatty acid alkanolamide, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene alkyl ester, sucrose fatty acid ester, polyglycerin fatty acid ester, alkyl An amine oxide etc. are mentioned.
油剤としては、通常化粧料に用いられる揮発性及び不揮発性の油剤、溶剤及び樹脂が挙げられ、常温で液体、ペースト、固体のいずれの形態であっても構わない。油剤の例としては、例えばセチルアルコール、イソステアリルアルコール、ラウリルアルコール、ヘキサデシルアルコール、オクチルドデカノール等の高級アルコール、イソステアリン酸、ウンデシレン酸、オレイン酸等の脂肪酸、ミリスチン酸ミリスチル、ラウリン酸ヘキシル、ミリスチン酸オクチルドデシル、オレイン酸デシル、ミリスチン酸イソプロピル、ジメチルオクタン酸へキシルデシル、モノステアリン酸グリセリン、トリオクタン酸グリセリン、フタル酸ジエチル、モノステアリン酸エチレングリコール、オキシステアリン酸オクチル等のエステル類、ステアリン酸コレステリル、オレイン酸コレステリル、分岐脂肪酸コレステリル等のコレステロールエステル、流動パラフィン、ワセリン、スクワラン等の炭化水素、ラノリン、還元ラノリン、カルナバロウ等のロウ、ミンク油、カカオ脂、ヤシ油、パーム核油、ツバキ油、ゴマ油、ヒマシ油、オリーブ油等の油脂、ジメチルポリシロキサン、環状ジメチルポリシロキサン、メチルフェニルポリシロキサン等のシリコーン油等が挙げられる。 Examples of the oil agent include volatile and non-volatile oil agents, solvents, and resins that are usually used in cosmetics, and may be in the form of liquid, paste, or solid at room temperature. Examples of oils include higher alcohols such as cetyl alcohol, isostearyl alcohol, lauryl alcohol, hexadecyl alcohol, octyldodecanol, fatty acids such as isostearic acid, undecylenic acid, oleic acid, myristyl myristate, hexyl laurate, myristine Octyldodecyl acid, decyl oleate, isopropyl myristate, hexyl decyl dimethyloctanoate, glyceryl monostearate, glyceryl trioctanoate, diethyl phthalate, ethylene glycol monostearate, octyl oxystearate, cholesteryl stearate, Cholesterol esters such as cholesteryl oleate and branched fatty acid cholesteryl, hydrocarbons such as liquid paraffin, petroleum jelly and squalane, lanoli , Waxes such as reduced lanolin, carnauba wax, mink oil, cacao butter, palm oil, palm kernel oil, camellia oil, sesame oil, castor oil, olive oil and other oils, dimethylpolysiloxane, cyclic dimethylpolysiloxane, methylphenylpolysiloxane, etc. Silicone oil etc. are mentioned.
粉体の例としては、赤色２０１号、黄色４号、青色１号、黒色４０１号等の色素、黄色４号Ａｌレーキ、黄色２０３号Ｂａレーキ等のレーキ色素、ナイロンパウダー、シルクパウダー、シリコーンパウダー、セルロースパウダー、シリコーンエラストマー球状粉体、ポリエチレン末等の樹脂、黄酸化鉄、赤色酸化鉄、酸化クロム、カーボンブラック、群青、紺青等の有色顔料、酸化亜鉛、酸化チタン等の白色顔料、タルク、マイカ、セリサイト、カオリン等の体質顔料、雲母チタン等のパール顔料等の顔料、硫酸バリウム、炭酸カルシウム、炭酸マグネシウム、珪酸マグネシウム等の金属塩、シリカ、アルミナ等の無機粉体、ベントナイト、スメクタイト、窒化ホウ素等が挙げられる。これらの粉体の形状（球状、棒状、針状、板状、不定形状、燐片状、紡錘状等）に特に制限はない。 Examples of powders include red No. 201, yellow No. 4, blue No. 1 and black No. 401 pigments, yellow No. 4 Al lake, yellow No. 203 Ba lake and other lake pigments, nylon powder, silk powder and silicone powder. , Cellulose powder, silicone elastomer spherical powder, resin such as polyethylene powder, yellow iron oxide, red iron oxide, chromium oxide, carbon black, colored pigments such as ultramarine and bitumen, white pigments such as zinc oxide and titanium oxide, talc, Body pigments such as mica, sericite and kaolin, pigments such as pearl pigments such as titanium mica, metal salts such as barium sulfate, calcium carbonate, magnesium carbonate and magnesium silicate, inorganic powders such as silica and alumina, bentonite, smectite, Examples thereof include boron nitride. There are no particular restrictions on the shape of these powders (spherical, rod-like, needle-like, plate-like, indeterminate, flake-like, spindle-like, etc.).
生理活性成分としては、皮膚に塗布した場合に皮膚に何らかの生理活性を与える物質が挙げられる。例えば、老化防止剤、紫外線防御剤、ひきしめ剤、抗酸化剤、保湿剤、血行促進剤、抗菌剤、殺菌剤、乾燥剤、冷感剤、温感剤、ビタミン類、アミノ酸、創傷治癒促進剤、刺激緩和剤、鎮痛剤、細胞賦活剤、酵素成分等が挙げられる。 Examples of the physiologically active ingredient include substances that impart some physiological activity to the skin when applied to the skin. For example, anti-aging agent, UV protection agent, tanning agent, antioxidant, moisturizing agent, blood circulation promoter, antibacterial agent, bactericidal agent, desiccant, cooling agent, warming agent, vitamins, amino acids, wound healing promoter , Stimulation mitigating agents, analgesics, cell activators, enzyme components and the like.
本発明の化粧料は、常法に従って製造することができる。また、本発明の化粧料としては、基礎化粧料、メイクアップ化粧料、ボディ化粧料等が挙げられる。剤形も目的に応じて任意に選択することができる。すなわち、液状、クリーム状、ジェル状、乳液状、シー
ト状、エアゾール状等のものが挙げられる。本発明の化粧料は、一般の化粧料に限定されるものではなく、医薬部外品、指定医薬部外品、外用医薬品等を包含するものである。
The cosmetic of the present invention can be produced according to a conventional method. The cosmetics of the present invention include basic cosmetics, makeup cosmetics, body cosmetics and the like. The dosage form can also be arbitrarily selected according to the purpose. That is, liquid, cream, gel, emulsion, sheet, aerosol and the like can be mentioned. The cosmetics of the present invention are not limited to general cosmetics, and include quasi drugs, designated quasi drugs, topical drugs and the like.
実施例１〜６、比較例１〜６［化粧水］
以下、実施例及び比較例によって、本発明を具体的に説明する。また、実施例及び比較例で得られた化粧料についての、荒れ肌改善効果及び刺激性低減効果の評価方法を以下に示す。尚、含有量は全て質量％である。また、本発明はこれら実施例に限定されるものではない。
［荒れ肌改善効果］
表１に示す各組成の化粧料を常法により調製した。下肢外側部に荒れ肌を実感している敏感肌パネラー１０名を対象として、コントロールを片方の足の下肢外側部に、各実施例・比較例の化粧料をもう片方の足の下肢外側部に、１日２回塗布し、１週間連用を行った。コントロール塗布側の荒れ肌改善度に比べたときの各実施例・比較例の荒れ肌改善度を、表２に示す評価基準に従って、パネラー自身が評価し、全パネラーの合計点数を以って評価結果とした。したがって、点数が高いほどコントロールに対する荒れ肌改善効果に優れていることを示す。結果を表３に示す。
［敏感肌パネラーによる刺激感評価］
尚、実施例での刺激感の評価は、上述の試験において、同じ敏感肌パネラー２０名のアンケート回答によって評価した。
Examples 1-6, Comparative Examples 1-6 [lotion]
Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples. Moreover, the evaluation method of the rough skin improvement effect and irritation | stimulation reduction effect about the cosmetics obtained by the Example and the comparative example is shown below. In addition, all content is mass%. The present invention is not limited to these examples.
[Rough skin improvement effect]
Cosmetics of each composition shown in Table 1 were prepared by a conventional method. Targeting 10 sensitive skin panelists who feel rough skin on the outer side of the lower limbs, control is applied to the lower limbs of one leg, and the cosmetics of each of the examples and comparative examples are applied to the lower limbs of the other leg. It was applied twice a day and used continuously for one week. According to the evaluation criteria shown in Table 2, the paneler itself evaluates the rough skin improvement degree of each Example / Comparative Example when compared to the rough skin improvement degree of the control application side, and the evaluation result is obtained with the total score of all the panelists. did. Therefore, it shows that it is excellent in the rough skin improvement effect with respect to control, so that a score is high. The results are shown in Table 3.
[Irritation evaluation by sensitive skin panelists]
In addition, the irritation | stimulation evaluation in an Example was evaluated by the questionnaire response of 20 same sensitive skin panelers in the above-mentioned test.
その評価基準は次の通りである。
評価は２０名の評点の合計点で評価し、結果を表３に記載する。
［刺激感］
＋＋＋ ： かなりの刺激感を感じる（評点３）
＋＋ ： 刺激感を感じる （評点２）
＋ ： わずかに刺激感を感じる（評点１）
− ： 刺激感を感じない （評点０）
The evaluation criteria are as follows.
Evaluation is based on the total score of 20 people, and the results are shown in Table 3.
[Irritation]
++++: I feel a lot of irritation (3)
++: I feel a sense of irritation (Score 2)
+: Slightly irritating (score 1)
-: I do not feel irritation (rating 0)
実施例７〜９
以下、表４〜６に示す各組成の化粧料（実施例７：化粧水、実施例８：乳液、実施例９：クリーム）を常法により調製した。
Examples 7-9
Hereinafter, cosmetics (Example 7: lotion, Example 8: emulsion, Example 9: cream) having respective compositions shown in Tables 4 to 6 were prepared by a conventional method.
実施例１〜６と同様に評価したところ、いずれの化粧料も、荒れ肌の予防もしくは改善効果に優れ、しかも皮膚への刺激性の少ない化粧料であった。
実施例７［化粧水］
When evaluated in the same manner as in Examples 1 to 6, all of the cosmetics were cosmetics that were excellent in preventing or improving rough skin and having little irritation to the skin.
Example 7 [skin lotion]
実施例８［乳液］ Example 8 [Emulsion]
実施例９［クリーム］ Example 9 [Cream]
尚、上記実施例における香料は、下記香料処方のものを用いた。 In addition, the fragrance | flavor of the following fragrance | flavor prescription was used for the said Example.
本発明の化粧料は、荒れ肌の予防もしくは改善効果に優れ、しかも皮膚への刺激性の少ない化粧料である。 The cosmetic of the present invention is a cosmetic that is excellent in preventing or improving rough skin and has little irritation to the skin.
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