JP2009234933A - Skin external preparation - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a sunscreen skin external preparation which is free of a silicone oil or contains the silicone oil, if any, in a controlled slight amount and has no problem of safety to the skin by solving the problems such as a fear of the environmental aspect after use due to nonbiodegradability of the silicone oil and a fear of a feeling of dryness after use and difficulty in washing although the chemically and biologically safe silicone oil has high safety and is widely used in skin external preparations having an SPF effect due to a refreshing feeling of use. <P>SOLUTION: The skin external preparation is a water-in-oil emulsion comprising no silicone oil or a silicone oil, if any, in a controlled slight amount, a nonionic surface active agent which is liquid at normal temperatures and includes, for example, a polyglyceryl fatty acid ester, an animal oil, a vegetable oil, an ester oil or the like, an ultraviolet scattering agent, and an oil absorbable powder other than the ultraviolet scattering agent. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

The present invention relates to a preparation to be applied to the skin of cosmetics, quasi-drugs and the like having an effect of preventing sunburn.

Even in daily life, the sun's ultraviolet rays affect skin aging, and measures against ultraviolet rays are becoming essential for beauty.

There are many UV-resistant products on the market, and their effects have been written by SPF. A product capable of displaying SPF contains an ultraviolet absorber and / or an ultraviolet scattering agent as a component having the function.

In the article of NIKKEI-NET's 2008.2.16, “corals are whitened by sunscreen—I University, confirmed by experiment”, the sunscreen “paraben, cinnamic acid, benzophenone, camphor extract” The substance was found to have the effect of whitening coral in an amount comparable to that which would dissolve into the sea when in use. " Cinnamic acid and benzophenone are constituents of UV absorbers. Furthermore, since there is a problem of safety to the skin when a high amount of the UV absorber is blended, the upper limit of use is determined in Ministry of Health, Labor and Welfare Notification No. 331 such as 2-ethylhexyl paramethoxycinnamate and sodium hydroxymethoxybenzophenone sulfonate.

Also, since it is often used in the summer when the amount of ultraviolet rays increases, a refreshing silicone oil is preferred and is used for most sunscreens. In particular, the ultraviolet scattering agent is mainly titanium oxide or zinc oxide, and in most cases, silicone oil is used as a dispersion medium by hydrophobizing the surface so that it does not flow with sweat. On the other hand, silicone oil is poor in biodegradability, it exists for a long time after use, and environmental concerns are also considered.

There are refreshing ester oils and mineral oils in place of silicone oils, but safety to the skin has become a problem and is not practical.

There has been a demand for an invention of a product having a sunscreen effect comprising a water-in-oil emulsion composition which contains an ultraviolet scattering agent and does not use silicone oil as the main component of the dispersion medium and does not easily flow into water.

Since chemically and biologically stable silicone oil does not decompose, there was an environmental concern after use. The topic is a topical skin preparation that is slightly suppressed even if it does not contain the silicone oil, and is highly safe to the skin by sunscreen using an ultraviolet scattering agent.

In order to achieve the above object, the preparation according to the present invention is prepared by dispersing an ultraviolet scattering agent in ester oil, animal oil, vegetable oil, mineral oil which is liquid oil at room temperature, and containing 1% or less of silicone oil. In an oil of SPF5 or higher, containing 6% by weight or less of a nonionic surfactant that is liquid at room temperature, 10% by weight or more of water, and 1% by weight or more of an oil-absorbing powder other than an ultraviolet scattering agent It is characterized by being a water-type emulsion. The amount of water is not particularly limited as long as it is 10% by weight or more. If it is less than 10% by weight, the oily feeling is strong and the feeling of use is not preferred.

Liquid oils at room temperature include safflower oil, palm oil, persic oil, meadow foam oil, olive oil, rice germ oil, jojoba oil, sunflower oil, squalane, macadamia nut oil and other animal and vegetable oils, and tri (capryl and capric acid) Triglycerides such as glyceryl, glyceryl triisostearate, glyceryl triethylhexanoate, octyldodecyl palmitate, ethylhexyl palmitate, glyceryl tri (caprylic / capric) glyceryl, trimethylolpropane triisostearate, glyceryl triisostearate, etc. , Liquid paraffin, olefin oligomer, and the like, containing one or more of these oils, and a total of 15 to 70% by weight of this oil is blended. As long as the characteristics of the present invention such as safety are not impaired, a relatively low molecular weight oil having a molecular weight of 290 or less such as dicapryl carbonate, ethylhexyl ethylhexanoate, isopropyl myristate, butyl myristate, and isononanoyl isononanoate is blended. Things are also possible.

The nonionic surfactant is polyglyceryl fatty acid ester or glyceryl fatty acid ester, the polymerization degree of glycerin is 1 to 10, the fatty acid is isostearic acid, oleic acid, linoleic acid, condensed ricinoleic acid, caprylic acid, etc., and HLB is 7 It is the following, and is 1 to 6% by weight. Other surfactants such as cationic surfactants, anionic surfactants, and amphoteric surfactants can be blended within the range where the features of the present invention such as safety are not impaired.

Oil-absorbing powders include silicic anhydride, iron oxide, aluminum hydroxide, talc, kaolin, mica, mica, chromium hydroxide, bentonite, aluminum silicate, montmorillonite, nylon powder, polymethyl methacrylate, cellulose powder, It is a derivative in which a hydrophobic group is combined with polyethylene powder or the like, silicic anhydride, starch, bentonite, cellulose or the like, and is incorporated at 1 to 30% by weight. If it is less than 1% by weight, stickiness of the oil becomes a problem, and the feeling of use is not preferable. If it is 30% by weight or more, the powdery sensation is strong, thick on the skin, and the remaining sensation is not preferred.

The ultraviolet scattering agent is an inorganic powder such as titanium oxide or zinc oxide, and includes those that have been surface-treated with a fatty acid, a metal soap of a fatty acid, silicone, or the like, and is blended in an amount of 1 to 25% by weight. If it is less than 1% by weight, the sun protection effect is weak, and if it exceeds 25% by weight, the whiteness increases during use and the usability deteriorates.

Silicone oils are liquid oils such as cyclomethicone such as decamethylcyclopentasiloxane, methylpolysiloxane, and methylphenylpolysiloxane. These oils do not contain these or are contained in an amount of 1% by weight or less.

Although the skin external preparation of the present invention can be prepared even if the SPF is less than 5, since the product having sunscreen effect has a higher SPF value in the market, the SPF is a water-in-oil type of 5 or more. It was set as the skin external preparation which is an emulsion. Dihydroxydimethoxybenzophenone, dihydroxybenzophenone, sodium hydroxymethoxybenzophenone sulfonate, 4-tert-butyl-4'-methoxydibenzoylmethane, 2-ethylhexyl paramethoxycinnamate, mono-2-ethylhexanoic acid diparamethoxycinnamate An ultraviolet absorber such as glyceryl can also be blended, and a higher SPF can be expected when used in combination with an ultraviolet scattering agent.

As long as the effect of the present invention is not impaired, alcohols such as ethanol, glycerin, sorbitol, butylene glycol, pentylene glycol, glucose, dipropylene glycol, and isomerized sugar, which are usually used for external preparations for skin, and riboflavin phosphate Vitamin and derivatives thereof such as sodium, ascorbic acid, magnesium L-ascorbyl phosphate, ascorbyl tetra-2-hexyldecanoate, tocopherol, amino acids and derivatives thereof such as aspartic acid, cationionine, methionine, lysine, trimethylglycine, polyquaternium-51, chitosan , Sodium carboxymethylcellulose, carboxyvinyl polymer, collagen, elastin, water-soluble polymers such as methylcellulose and sodium hyaluronate, glycyrrhizin And its derivatives, glycyrrhetinic acid and its derivatives, anti-inflammatory agents such as allantoin and its derivatives, lysolecithin, lecithin, ceramide, hydrogenated soybean phospholipid, hydroxylated soybean phospholipid, hydrogenated lysolecithin and other phospholipids, gucholic acid, alginic acid , Salicylic acid, glutamic acid, edetic acid, diethylenetriaminepentaacetic acid, citric acid, lactic acid, malic acid, dehydroacetic acid and its salts, sodium hydroxide, triethanolamine, 2-amino-2-methyl-1,3-propanediol, arginine PH regulators, nylon powder, cross-linked silicone / network-type silicone block copolymers, powders such as iron oxides, pigments such as tar pigments, plant extracts such as sicon extract, Sakuhakuhi extract, flavorings, pearls, preservatives And bactericides, bacterial metabolites, reducing agents, γ -Oryzanol, ceramide, tocotrienol, ubiquinone, etc. can be blended.

The dosage form is not limited, such as cream, emulsion, lotion, aerosol, foundation.

A skin external preparation that is a water-in-oil emulsion that is safe and has an SPF effect can be obtained even when a silicone, which is considered to have poor biodegradability, is not blended or even in a small amount.

As the nonionic surfactant that is liquid at room temperature, a polyglyceryl fatty acid ester or a glyceryl fatty acid ester that can be produced from plants or animals with both hydrophilic groups and lipophilic groups is suitable. Made of natural substances, it is environmentally friendly. The degree of polymerization of glycerin is 1 to 10, and the fatty acid is an activator obtained by esterifying a considerable number of moles of isoleic acid with HLB of 7 or less, and 1 to 6% by weight is blended. Preferably 1-3 weight% is mix | blended.

Many of the external preparations for skin which are water-in-oil emulsions having an SPF effect are blended with silicone oil and are not sticky and have good usability. If silicone oil is replaced with liquid oil at room temperature, the oily feeling is strong and the usability deteriorates. Replacing with a relatively low molecular weight oil having a molecular weight of 290 or less provides a relatively close feeling of use, but it tends to irritate the skin. Animal and vegetable oils such as safflower oil, palm oil, persic oil, meadow foam oil, olive oil, rice germ oil, jojoba oil, sunflower oil, squalane, macadamia nut oil, tri (caprylic / capric) glyceryl, glyceryl triisostearate, triethyl Combinations of triglycerides such as glyceryl hexanoate and octyldodecyl palmitate, ethylhexyl palmitate, glyceryl tri (capryl / capric) glyceryl, triisostearate trimethylolpropane, glyceryl triisostearate, liquid paraffin, olefin oligomer, etc. Alternatively, it is blended solely or mainly as an ester oil such as dicapryl carbonate, ethylhexyl ethylhexanoate, isopropyl myristate, butyl myristate, isononyl isononanoate. In particular, octyldodecyl myristate and isotridecyl isononanoate have good usability and safety, and the combination of one or both is 25 to 50% by weight, and the other oil is most preferably 10% by weight or less.

Silicone oil (liquid oil having a polysiloxane chain such as cyclomethicone such as decamethylcyclopentasiloxane, methylpolysiloxane, and methylphenylpolysiloxane) is not contained. It is desirable that the surface treatment of the fine particle zinc oxide and fine particle titanium oxide of the ultraviolet scattering agent is not subjected to silicone treatment such as methicone or dimethicone. For example, an ultraviolet scattering agent obtained by surface-treating fine zinc oxide or fine titanium oxide with a metal salt of a fatty acid such as stearic acid or lauric acid, such as iron, magnesium, calcium, or iron to make the surface hydrophobic is preferable.

Higher SPF is preferable, but when the amount of the ultraviolet scattering agent is increased, the transparency is lowered and the usability is deteriorated. An organic compound UV absorber may be used in combination. When the ultraviolet absorber is not included, SPF 15 or higher is possible, and when the ultraviolet absorber is included, SPF 25 or higher is possible.

Silicone is chemically and biologically inert and stable, so in the case of a skin external preparation that is a water-in-oil emulsion using silicone oil, if it is washed away, a special cleansing agent will not be used on the skin. Often left. By chemical synthesis, such as silicone and Teflon (registered trademark), oil that is chemically and biologically inert and stable can be easily washed out without using a special cleaning agent.

Oil-absorbing powders other than ultraviolet scattering agents are preferably silicic anhydride, talc, kaolin and nylon powder, and one or more of these powders are desirably 3 to 15% by weight in total. However, powder having an average particle diameter of 1 μm or less is good at 1 to 3% by weight. These shapes are not particularly limited, such as a plate shape, a spherical shape, and an indeterminate shape. Silica anhydride and nylon powder are preferably spherical.

The amount of water is not particularly limited as long as it is 10% by weight or more. If it is less than 10% by weight, the oily feeling is strong and the feeling of use is not preferred.

In the composition described above, alcohols such as ethanol, glycerin, sorbitol, glucose, isomerized sugar, riboflavin sodium phosphate, ascorbic acid, L-ascorbyl magnesium phosphate, as long as the effects of the present invention are not impaired. Vitamins such as ascorbyl tetra-2-hexyldecanoate and derivatives thereof, amino acids such as aspartic acid, cationion, methionine, lysine, trimethylglycine and derivatives thereof, polyquaternium-51, chitosan, sodium carboxymethylcellulose, carboxyvinyl polymer, methylcellulose and sodium hyaluronate Water-soluble polymers such as glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, allantoin and its derivatives, anti-inflammatory agents, nylon powder and bridges Type silicone / reticulated type silicone block copolymer, powders such as talc and iron oxide, pigments such as tar pigments, plant extracts such as sicon extract and suhakuhi extract, fragrances, pearls, antiseptics and fungicides, bacterial metabolite , A reducing agent, γ-oryzanol, ceramide, sodium pyrrolidonecarboxylate and the like are also possible.

[Prescription example]
As examples, SPF10 serum, SPF25 cream, SPF25 cream, SPF35 cream, and SPF25 are shown below with respect to five points of emulsion used.

Table 5 shows the formulations of Example 1, Example 2, Comparative Example 1, Comparative Example 2, and Comparative Example 3 of the SPF 25 emulsion of the present invention. Table 6 shows the results of the usability evaluation and the patch test, which were applied to the skin and examined in the same manner as normal sunscreen products for 15 panelists. The oily feeling at the time of application of the feeling of use was evaluated as 1 to 5 on a scale of 1 to 5, although there was no oily feeling, 1 was moderate, 3 was strong, and the average value was recorded. Similarly, the moisturizing feeling after 3 hours of use was set to 1, although the moist feeling was strong, 3 was moderate, and 5 was dry. Detergency with the fatty acid soap after 3 hours of use has fallen even without washing, but 1 is moderate, and 5 remains after washing. The isostearyl palmitate of Example 1 has a molecular weight of 508.9, the cetyl ethylhexanoate of Example 2 has a molecular weight of 368.9, and the isopropyl myristate of Comparative Example 1 has a molecular weight of 270.5. Although the usability of Comparative Example 1 is not much different, the result of the patch test is bad. Comparative Example 2 is an example using silicone oil, the patch test is good, and the touch at the time of application is refreshingly good, but after 3 hours it is dried and it is removed with fatty acid soap which is a general cleaning agent. hard. Comparative Example 3 is a prescription from which nylon powder which is an oil-absorbing powder other than titanium oxide and kaolin are omitted, but the result of the patch test is bad and irritation.

Claims (4)

1 to 6% by weight of a nonionic surfactant that is liquid at room temperature, 15 to 70% by weight of oil that is liquid at room temperature, 1 to 25% by weight of an ultraviolet scattering agent, 10 to 60% by weight of water, and silicone oil A skin external preparation, which is a composition that does not contain or contains 1% by weight or less, and is a water-in-oil emulsion having an SPF (Sun Protection Factor) of 5 or more. The skin external preparation according to claim 1, wherein the nonionic surfactant is polyglyceryl fatty acid ester or glyceryl fatty acid ester, the degree of polymerization of glycerin is 1 to 10, the fatty acid is isostearic acid, and HLB is 7 or less. 2. The skin external preparation according to claim 1, wherein the liquid oil is one or more of squalane, liquid paraffin, jojoba oil, olive oil, sunflower oil, a branched ester oil having a weight average molecular weight of 290 or more. The skin external preparation according to claim 1, wherein at least one oil-absorbing powder is blended in addition to the ultraviolet light scattering agent, and the total is 1 to 30% by weight.