JP2009203190A - Cell activator and anti-aging skin preparation for external use - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new cell activator and an anti-aging skin preparation for external use. <P>SOLUTION: This cell activator is provided by containing at least one kind of glycerol phosphate derivative, and the anti-aging preparation for external use containing the same is also provided. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a novel cell activator and an anti-aging skin external preparation.

Phospholipids such as soybean phospholipid are widely used as a base for external preparations for skin such as cosmetics. However, the use of a glycerol phosphate derivative obtained by deacylating this has not been well known. Patent Documents 1 and 2 propose use of glycerol phosphate or a derivative thereof as an external preparation for skin. However, these patent documents do not describe the cell activation action of these agents.
Japanese Unexamined Patent Publication No. 64-16890 JP 7-506348

  An object of the present invention is to provide a novel cell activator and an anti-aging skin external preparation.

In order to solve the above-mentioned problems, the present invention provides a cell activator containing at least one glycerol phosphate derivative as an active ingredient, and an anti-aging skin external preparation containing this as an active ingredient.
Among the glycerol phosphate derivatives, glycerol phosphorylethanolamine and glycerol phosphoryl inositol are preferable. Also, the glycerol derivatives, preferably glycerol phosphorylethanolamine and glycerol phosphoryl inositol are preferably deacylated products of soybean phospholipid.

  ADVANTAGE OF THE INVENTION According to this invention, the novel cell activator which shows a favorable cell activation effect | action, and the skin external preparation which shows the favorable anti-aging effect brought about by this cell activator can be provided.

Hereinafter, the present invention will be described in detail. In the present specification, “to” means a range including numerical values before and after.
The present invention relates to a cell activator comprising at least one glycerol phosphate derivative as an active ingredient. The cell activator of the present invention may contain one kind of glycerol phosphate derivative as an active ingredient, or may contain two or more different glycerol phosphate derivatives as an active ingredient. In the present specification, the “glycerol phosphate derivative” refers to a compound in which any of the hydrogen atoms of three hydroxyl groups of glycerin is substituted with a phosphate derivative. Examples thereof include glycerol phosphorylcholine (hereinafter sometimes referred to as “GPC”), glycerol phosphorylethanolamine (hereinafter sometimes referred to as “GPE”), and glycerol phosphorylinositol (hereinafter referred to as “GPI”). Is included). GPC, GPE and GPI are each a compound represented by the following general formula.

These compounds contain acyl groups in the molecule of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylinositol (PI), which are components of soybean phospholipid and egg yolk phospholipid. Each has a deacylated structure.
The method for synthesizing these compounds used in the present invention is not particularly limited. Any of a compound obtained by deacylating a phospholipid and a compound obtained by chemical synthesis without passing through the deacylation step can be used.

  For example, since egg yolk phospholipid and soybean phospholipid contain PC, PE, and PI, the cell activator of the present invention can be prepared by deacylating egg yolk phospholipid or soybean phospholipid. . In addition, after egg yolk phospholipid or soybean phospholipid is deacylated, GPC, GPE and GPI are isolated by chromatogram or the like, and the isolated compounds can be used. Moreover, chemically synthesized GPC, GPE and GPI can also be used for the cell activator of the present invention. Since GPC is commercially available as a reagent (for example, manufactured by Wako Pure Chemical Industries, Ltd.), the cell activator of the present invention can be prepared by mixing the reagent as it is or with GPE or GPI. GPE or GPI is a reagent in which a fatty acid and a corresponding phosphoric acid derivative are bound to glycerol (for example, dipalmitoyl phosphatidylethanolamine (manufactured by Wako Pure Chemical Industries) and dipalmitoyl phosphatidylinositol sodium salt (manufactured by Wako Pure Chemical Industries)) Are commercially available, and can be synthesized by deacylating them.

  Among the glycerol phosphate derivatives, GPE and GPI are preferable because of their high cell activation effect. The cell activator of the present invention preferably contains at least one of GPE and GPI as an active ingredient. More specifically, the cell activator of the present invention preferably contains GPE and / or GPI at a mass ratio of 30% or more. Soy phospholipid contains about 14% by mass and 17% by mass of PE and PI, respectively. Therefore, the cell activator prepared by deacylating soybean phospholipid contains GPE and GPI in a total amount of about 31% by mass, and is considered to exhibit a high cell activation effect.

  The present invention also relates to a skin external preparation containing the cell activator of the present invention, that is, a cell activator containing as an active ingredient at least one selected from glycerol phosphate derivatives. The external preparation for skin of the present invention exhibits an excellent anti-aging effect by the cell activation action of a glycerol phosphate derivative. The content of the cell activator in the external preparation for skin of the present invention is preferably 0.0001 to 20% by mass (hereinafter simply referred to as “%”), more preferably 0.001 to 10%. If it exists in this range, the said extract can be mix | blended stably and the high anti-aging effect can be exhibited.

  The external preparation for skin of the present invention can be prepared by formulating the cell activator by blending it with various forms of bases according to a conventional method. Furthermore, by preparing the above-mentioned cell activator in combination with one or more other medicinal agents, the cell activation effect is further enhanced, or a skin external preparation that exhibits other medicinal effects together with the cell activation effect is prepared. Can do. Examples of other medicinal agents include, but are not limited to, whitening agents, UV protection agents, antibacterial agents, anti-inflammatory agents, other cell activators, active oxygen scavengers, and moisturizers. Absent.

  Examples of whitening agents include ascorbic acid or derivatives thereof, arbutin, ellagic acid, linoleic acid, vitamin E and derivatives thereof, glycyrrhizic acid and derivatives thereof, tranexamic acid, placenta extract, chamomile extract, licorice extract, age extract , Ogon extract, seaweed extract, cucumber extract, caquette extract, gokahi extract, rice bran extract, wheat germ extract, saicin extract, hawthorn extract, sun penz extract, shirayuri extract, peony extract Sempukuka extract, soybean extract, tea extract, molasses extract, sandalwood extract, grape extract, hop extract, micaika extract, mokka extract, yukinoshita extract and the like.

  Examples of the UV protection agent include paramethoxycinnamate-2-ethylhexyl, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5 sodium sulfate, 4-t-butyl-4′- Examples thereof include methoxydibenzoylmethane, 2-phenyl-benzimidazole-5-sulfuric acid, titanium oxide, and zinc oxide.

  Examples of the antibacterial agent include benzoic acid, sodium benzoate, p-hydroxybenzoate ester, benzalkonium chloride, phenoxyethanol, isopropylmethylphenol, and the like.

  Anti-inflammatory agents include, for example, sulfur and its derivatives, glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, artea extract, ashitaba extract, arnica extract, ginseng extract, nettle extract, buckwheat extract, hypericum Examples include extracts, chamomile extracts, goldfish extract, watercress extract, comfrey extract, salvia extract, sicon extract, perilla extract, birch extract, gentian extract and the like.

  Examples of other cell activators include caffeine, chicken crown extract, shell extract, shell extract, royal jelly, silk protein and its degradation product or derivatives thereof, lactoferrin or its degradation product, chondroitin sulfate, hyaluronic acid Mucopolysaccharides or their salts, collagen, yeast extract, lactic acid bacteria extract, bifidobacteria extract, fermentation metabolic extract, ginkgo extract, barley extract, assembly extract, diatom extract, carrot extract, Rosemary extract, glycolic acid, citric acid, lactic acid, malic acid, tartaric acid, succinic acid and the like are included.

  The active oxygen scavenger has an action such as suppression of lipid peroxide production. For example, superoxide dismutase, mannitol, quercetin, catechin and derivatives thereof, rutin and derivatives thereof, button pi extract, yashajitsu extract, melissa extract , Lanahan fruit extract, retinol and its derivatives, vitamin A such as carotenoid, thiamine and its derivative, riboflavin and its derivative, pyridoxine and its derivative, vitamin B such as nicotinic acid and its derivative, tocopherol and its derivative, etc. Vitamin E, dibutylhydroxytoluene, butylhydroxyanisole, etc. are mentioned.

  Examples of the humectant include proteins such as elastin and keratin or derivatives thereof, hydrolysates and salts thereof, amino acids such as glycine, serine, aspartic acid, glutamic acid, arginine and theanine and derivatives thereof, sorbitol, erythritol, Trehalose, inositol, glucose, sucrose and derivatives thereof, dextrin and derivatives thereof, saccharides such as honey, D-panthenol and derivatives thereof, urea, phospholipid, ceramide, auren extract, ginger extract, diautum extract, sensyu extract Product, mallow extract, gypsophila extract, dokudami extract, hamamelis extract, bodaige extract, maronier extract, quince extract and the like.

  Moreover, arbitrary components other than the cell activator of this invention can be mix | blended with the skin external preparation of this invention. Examples of such components include, but are not limited to, physiologically active substances such as amino acids, lipids, sugars, hormones, enzymes, and nucleic acids. In addition, components that are usually used in the production of cosmetics, quasi-drugs, skin external preparations and the like, for example, water (purified water, hot spring water, deep water, etc.), oil agents, Surfactant, metal soap, gelling agent, powder, alcohol, water-soluble polymer, film-forming agent, resin, inclusion compound, fragrance, deodorant, salt, pH adjuster, refreshing agent, plant / animal -Extracts derived from microorganisms, blood circulation promoters, astringents, antiseborrheic agents, chelating agents, keratolytic agents, enzymes, hormones, other vitamins and the like can be used as necessary.

  The external preparation for skin of the present invention has various forms such as powders such as powder and powder foundation; solids such as soap and lipstick; emulsions such as cream, emulsion and cream foundation; It is preferable that it is a cosmetic composition. However, it is not limited to these.

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples. However, the scope of the present invention is not limited to the following examples.
[Example 1: Preparation of cell activator]
A reagent manufactured by Wako Pure Chemical Industries was used as GPC.
GPE and GPI were produced by subjecting commercially available dipalmitoyl phosphadylethanolamine (manufactured by Wako Pure Chemical Industries) and dipalmitoyl phosphatidylinositol sodium salt (manufactured by Wako Pure Chemical Industries) to deacylation treatment, respectively. Deacylation proceeded by the action of metal sodium or sodium alcoholate in alcohol. In addition, a product obtained by subjecting soybean phospholipid to a deacylation process (hereinafter sometimes referred to as GSP) by a similar method was also produced.

[Example 2: Cell activation test by cell culture]
About GPE and GPI, the cell activation test was done by the following method.
Specifically, GPE and GPI were respectively added to 1% fetal bovine serum (FBS) -added medium at the concentrations shown in the following table, and the cell growth rate was determined by a conventional method.
Based on the cell growth rate in the 1% FBS medium to which the sample is not added, when the cell growth rate is higher than that, there is a cell activation effect, and when it is lower, it can be evaluated that there is no cell activation effect.
A medium supplemented with 10% FBS was used as a positive control.
The results are shown in the following table. The results shown in the following table are the cell growth rates of the respective samples calculated with the cell growth rate of the 1% FBS medium not added with the sample as 100%.

  From the results shown in the above table, it can be understood that GPE and GPI, which are glycerol phosphate derivatives, show a high cell activation effect. In addition, although the test was done similarly about GPC, although the cell activation effect was recognized, the cell activation effect was low compared with GPE and GPI.

[Example 3: lotion]
A lotion was prepared by the following production method.
(Manufacturing method)
A. The following components (1) to (11) are mixed and dissolved.
B. The following components (12) to (18) are mixed and dissolved.
C. B was added to A and mixed uniformly to obtain a skin lotion.
(Ingredient) (%)
(1) Glycerol 3.0
(2) 1,3-butylene glycol 2.0
(3) Propylene glycol 4.0
(4) Oleyl alcohol 0.1
(5) Polyoxyethylene monolaurate (20E.O.)
Sorbitan 1.5
(6) Polyoxyethylene (20E.O.) lauryl ether 0.5
(7) Squalane 0.5
(8) Ethyl alcohol 20.0
(9) Methyl paraoxybenzoate 0.1
(10) dl-α-tocopherol acetate * 1 0.5
(11) Perfume appropriate amount (12) Dipotassium glycyrrhizinate * 2 0.5
(13) Rosemary extract * 3 0.5
(14) Sodium dl-pyrrolidonecarboxylate * 4 0.2
(15) Locust bean gum 1.0
(16) Yokuinin extract * 5 0.5
(17) GPE * 6 0.5
(18) Purified water remaining * 1 Eisai * 2 Maruzen Pharmaceutical * 3 Maruzen Pharmaceutical * 4 Ajinomoto * 5 Maruzen * 6 Prepared in Example 1

  The prepared lotion was a lotion that had a fresh and refreshing feeling of use, and was able to provide beautiful skin without rough skin or dull skin.

[Example 4: Cream]
Claims were prepared by the following method.
(Manufacturing method)
A. The following components (1) to (10) are heated and mixed and maintained at 70 ° C.
B. The following components (11) to (21) are heated and mixed and maintained at 70 ° C.
C. B is added to A and emulsified.
D. After cooling C, the following component (22) was added and mixed to obtain a cream.
(Ingredient) (%)
(1) Squalane 20.0
(2) Beeswax 5.0
(3) Jojoba oil 5.0
(4) Glyceryl monostearate 2.0
(5) Polyoxyethylene monostearate (20E.O.)
Sorbitan 2.0
(6) Sorbitan monostearate 2.0
(7) Phytosterol * 1 0.5
(8) Candelilla wax 1.0
(9) Glycerin 5.0
(10) Methyl paraoxybenzoate 0.1
(11) Lily extract * 2 1.0
(12) Carrot extract * 3 1.0
(13) Ginkgo biloba extract * 4 1.0
(14) Isolate extract * 5 1.0
(15) Clara extract * 6 1.0
(16) Hydrolyzed rice extract * 7 1.0
(17) Licorice extract * 8 1.0
(18) Toki extract * 9 1.0
(19) GPI * 10 0.1
(20) GPE * 11 0.1
(21) Purified water Remaining amount (22) Fragrance Appropriate amount * 1 Eisai * 2 Maruzen Pharmaceutical * 3 Maruzen Pharmaceutical * 4 Joban Plant Chemical Research * 5 Maruzen * 6 Maruzen * 7 Made by Technoble * 8 Made by Maruzen Pharmaceutical Co., Ltd. * 9 Made by Nippon Powder Chemical Co., Ltd. * 10 Prepared by Example 1 * 11 Prepared by Example 1

  The prepared cream had a smooth and rich feeling of use, and was a cream that can be made into beautiful skin without rough skin or dull skin.

[Example 5: Cleansing cream]
A cleansing cream was prepared by the following method.
(Manufacturing method)
A. The following components (1) to (9) are heated and mixed and maintained at 70 ° C.
B. The following components (10) to (14) are heated and mixed and maintained at 70 ° C.
C. B is added to A and emulsified.
D. After cooling C, the following component (15) was added and mixed to obtain a cleansing cream.
(Ingredient) (%)
(1) Paraffin wax 10.0
(2) Beeswax 3.0
(3) Vaseline 15.0
(4) Liquid paraffin 41.0
(5) Sorbitan sesquioleate 4.2
(6) Polyoxyethylene monooleate (20E.O.)
Sorbitan 0.8
(7) Hydrogenated soybean phospholipid 0.5
(8) Medu home oil * 1 1.0
(9) Methyl paraoxybenzoate 0.1
(10) Quince seed extract * 2 1.0
(11) Soybean extract * 3 1.0
(12) Mallow extract * 4 1.0
(13) GSP * 5 1.0
(14) Purified water Remaining amount (15) Perfume appropriate amount * 1 Made by Nippon Surfactant * 2 Made by Koei Kogyo * 3 Made by Maruzen Pharmaceutical * 4 Made by Maruzen Pharmaceutical * 5 Prepared in Example 1

  The prepared cleansing cream was a cleansing cream that had a light and smooth feeling of use, was well-familiar with makeup stains, was excellent in removing stains, and had beautiful skin with no rough skin or dull skin.

[Example 6: Latex]
An emulsion was prepared by the following method.
(Manufacturing method)
A. The following components (14) to (23) are heated and mixed and maintained at 70 ° C.
B. The following components (1) to (13) are heated and mixed and maintained at 70 ° C.
C. B is added to A and emulsified.
D. After cooling C, the following components (24), (25), and (26) were added and mixed to obtain an emulsion.
(Ingredient) (%)
(1) Sorbitan monostearate 0.3
(2) Polyoxyethylene monooleate (20E.O.)
Sorbitan 0.1
(3) Lipophilic glyceryl monostearate 0.2
(4) Stearic acid 0.5
(5) Cetanol 0.5
(6) Squalane 3.0
(7) Liquid paraffin 4.0
(8) Plant squalane * 1 0.2
(9) Glyceryl tri-2-ethylhexanoate 2.0
(10) Dimethylpolysiloxane 1.0
(11) Hydrogenated soybean phospholipid 0.1
(12) nicotinic acid dl-α-tocopherol * 2 0.05
(13) Methyl paraoxybenzoate 0.1
(14) Carboxyvinyl polymer 0.1
(15) Sodium hydroxide 0.05
(16) Glycerin 5.0
(17) 1,3-butylene glycol 7.0
(18) Purified water remaining amount (19) GPE * 3 0.5
(20) GPI * 4 0.5
(21) Reishi extract * 5 2.0
(22) Sodium hyaluronate 1% aqueous solution * 6 5.0
(23) Acetylglutamic acid * 7 0.3
(24) Ethyl alcohol 5.0
(25) Porous silica 3.0
(26) Perfume appropriate amount * 1 Nikko Chemicals * 2 Eisai * 3 Prepared in Example 1 * 4 Prepared in Example 1 * 5 Maruzen Pharmaceutical * 6 Nikko Chemicals * 7 Kyowa Hakko

[Example 7: Latex]
(Manufacturing method)
A. The following components (13) to (22) are heated and mixed and maintained at 70 ° C.
B. The following components (1) to (12) are heated and mixed and maintained at 70 ° C.
C. Add B to A and emulsify uniformly.
D. After cooling C, the following components (23), (24) and (25) were added and mixed to obtain an emulsion.
(Ingredient) (%)
(1) Sorbitan monostearate 0.3
(2) Polyoxyethylene monooleate (20E.O.)
Sorbitan 0.1
(3) Lipophilic glyceryl monostearate 0.2
(4) Stearic acid 0.5
(5) Cetanol 0.5
(6) Squalane 3.0
(7) Liquid paraffin 4.0
(8) Glyceryl tri-2-ethylhexanoate 2.0
(9) Dimethylpolysiloxane 1.0
(10) Hydrogenated soybean phospholipid 0.1
(11) Rutin * 1 0.2
(12) Methyl paraoxybenzoate 0.1
(13) Carboxyvinyl polymer 0.1
(14) Sodium hydroxide 0.05
(15) Glycerin 5.0
(16) 1,3-butylene glycol 7.0
(17) GPI * 2 5.0
(18) Purified water remaining amount (19) Yeast extract * 3 0.5
(20) Ashitaba extract * 4 0.5
(21) Hop extract * 5 0.5
(22) Peach extract * 6 0.5
(23) Ethyl alcohol 5.0
(24) Porous silica 3.0
(25) Fragrance Appropriate amount * 1 Made by Sigma * 2 Made in Example 1 * 3 Made by BIO-DELL * 4 Made by Maruzen Pharmaceutical * 5 Made by Maruzen Pharmaceutical * 6 Made by Maruzen Pharmaceutical

  Each of the prepared emulsions of Examples 6 and 7 was an emulsion that had a smooth and mild use feeling and made beautiful skin without rough skin or dull skin.

[Example 8: Pack]
(Manufacturing method)
A. The following components (1) to (7) are mixed and heated to 70 ° C. to dissolve.
B. The following components (8) to (13) are mixed and dissolved.
C. The following components (14) to (16) are mixed and dissolved.
D. B was added to A, mixed and then cooled, and further C was mixed to obtain a pack.
(Ingredient) (%)
(1) Polyvinyl alcohol 13.0
(2) Silicic anhydride 0.5
(3) Polyethylene glycol 0.5
(4) Medu home oil * 1 0.2
(5) Polyoxypropylene (10 PO)
Methyl glucoside 5.0
(6) Glycerin 5.0
(7) Purified water remaining amount (8) Tea extract * 2 1.0
(9) Hermanus extract * 3 1.0
(10) Anhydrous caffeine * 4 1.0
(11) GPE * 5 5.0
(12) Phosphoric acid-L-ascorbyl magnesium * 6 3.0
(13) Purified water 10.0
(14) Ethyl paraoxybenzoate 0.1
(15) Ethyl alcohol 13.0
(16) Fragrance Appropriate amount * 1 Made by Nippon Surfactant Co., Ltd. * 2 Made by Maruzen Pharmaceutical Co., Ltd. * 3 Made by Maruzen Pharmaceutical Co., Ltd. * 4 Made by Pure Chemical Industries, Ltd. * 5 Prepared in Example 1 * 6 Made by Nikko Chemicals

  The prepared pack had an appropriate refreshing feeling and tension, and the skin after packing had a feeling of elasticity on the skin, and it was a beautiful skin with no rough skin or dull skin.

[Example 9: Cream foundation]
(Manufacturing method)
A. The following components (1) to (11) are heated and mixed and maintained at 70 ° C.
B. The following components (12) to (17) are heated and mixed and maintained at 70 ° C.
C. B is added to A and emulsified.
D. After cooling C, the following component (18) was added and mixed to obtain a cream foundation.
(Ingredient) (%)
(1) Sorbitan sesquioleate 3.0
(2) Self-emulsifying glyceryl monostearate 2.0
(3) Aluminum stearate 0.5
(4) Ceresin wax 5.0
(5) Squalane 10.0
(6) Liquid paraffin 15.0
(7) Vaseline 5.0
(8) Titanium oxide 8.0
(9) Talc 4.0
(10) Coloring pigment appropriate amount (11) Methyl paraoxybenzoate 0.05
(12) Propylene glycol 5.0
(13) Kinginga extract * 1 1.0
(14) Birch extract * 2 1.0
(15) GPI * 3 0.1
(16) GPE * 4 0.1
(17) Purified water Remaining amount (18) Fragrance Appropriate amount * 1 Nagaoka Fragrance Co., Ltd. * 2 Maruzen Pharmaceutical Co., Ltd. * 3 Prepared in Example 1 * 4 Prepared in Example 1

[Example 10: Liquid foundation]
(Manufacturing method)
A. The following components (1) to (9) are mixed and dissolved.
B. The following components (20) to (25) are added to A, mixed uniformly, and kept at 70 ° C.
C. The following components (10) to (19) are uniformly dissolved and maintained at 70 ° C.
D. B is added to C and emulsified.
E. After cooling D, the following component (26) was added and mixed to obtain a liquid foundation.
(Ingredient) (%)
(1) Liquid lanolin 2.0
(2) Liquid paraffin 5.0
(3) Stearic acid 2.0
(4) Cetanol 1.0
(5) Self-emulsifying glyceryl monostearate 1.0
(6) Paramethoxycinnamic acid-2-ethylhexyl 8.0
(7) 4-tert-butyl-4′-methoxy dibenzoylmethane 2.0
(8) Retinol palmitate * 1 0.2
(9) Methyl paraoxybenzoate 0.1
(10) Glycerin 5.0
(11) Triethanolamine 1.0
(12) Carboxymethylcellulose 0.2
(13) Bentonite 0.5
(14) Birch extract * 2 5.0
(15) Purified water remaining amount (16) Mannitol * 3 0.1
(17) GSP * 4 1.0
(18) Asparagus extract * 5 0.5
(19) Licorice extract * 6 0.5
(20) Titanium oxide 6.0
(21) Fine particle titanium oxide 2.0
(22) Fine zinc oxide 5.0
(23) Mica 2.0
(24) Talc 4.0
(25) Color pigment 4.0
(26) Perfume appropriate amount * 1 Nippon Roche * 2 Maruzen Pharmaceutical * 3 Sigma * 4 Prepared in Example 1 * 5 Maruzen Pharmaceutical * 6 Maruzen Pharmaceutical

  The prepared Examples 9 and 10 were cream foundations and liquid foundations having a smooth and smooth feeling of use, a uniform and beautiful finish, and a beautiful skin without rough skin and dull skin.

[Example 11: Sunscreen emulsion]
(Manufacturing method)
A. The following components (1) to (10) are mixed and maintained at 70 ° C.
B. The following components (11) to (15) are mixed and maintained at 70 ° C.
C. Add B to A and emulsify uniformly.
D. After cooling C, the following components (16) to (19) were added and mixed to obtain a sunscreen emulsion.
(Ingredient) (%)
(1) Polyoxyalkylene-modified organopolysiloxane 1.0
(2) Dimethylpolysiloxane 5.0
(3) Octamethylcyclotetrasiloxane 20.0
(4) Isotridecyl isononanoate 5.0
(5) Paramethoxycinnamic acid-2-ethylhexyl 5.0
(6) Methyl paraoxybenzoate 0.1
(7) Silicone-treated fine particle titanium oxide 10.0
(8) Silicone-treated fine particle zinc oxide 10.0
(9) Polystyrene powder 3.0
(10) Trimethylsiloxysilicate 0.5
(11) Dipropylene glycol 3.0
(12) Ethyl alcohol 10.0
(13) GPE * 1 1.0
(14) Salt 0.2
(15) Purified water remaining amount (16) β-carotene * 2 0.01
(17) Chamomile extract * 3 1.0
(18) Warmoko extract * 4 1.0
(19) Perfume Appropriate amount * 1 Prepared in Example 1 * 2 Sigma Co., Ltd. * 3 Maruzen Pharmaceutical Co., Ltd. * 4 Maruzen Pharmaceutical Co., Ltd.

  The sunscreen emulsion of Example 11 was a sunscreen emulsion that had a smooth use feeling without stickiness, protected the skin from ultraviolet rays, and made beautiful skin free from rough skin and dull skin.

  ADVANTAGE OF THE INVENTION According to this invention, the novel cell activator and the skin external preparation for anti-aging can be provided.

Claims (5)

A cell activator comprising at least one glycerol phosphate derivative as an active ingredient. The cell activator according to claim 1, comprising at least glycerol phosphorylethanolamine as an active ingredient. The cell activator according to claim 1 or 2, comprising at least glycerol phosphorylinositol as an active ingredient. The cell activator according to any one of claims 1 to 3, wherein the glycerol phosphate derivative is a deacylated product of soybean phospholipid. The skin external preparation for anti-aging which contains the cell activator of any one of Claims 1-4 as an active ingredient.