JP2009107988A - Dentifrice composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a dentifrice composition which produces a high feeling of tightness of gingiva, leaves almost no sweet after-taste in the mouse when used, has such excellent low-temperature storage stability as not to deteriorate in its surface appearance when squeezed even after low-temperature storage, and being useful as a dentifrice composition for preventing gingivitis. <P>SOLUTION: The dentifrice composition comprises (A) dipotassium glycyrrhizinate, (B) sodium chloride, and (C) trimethylglycine, wherein the amount of component (B) added is 1-15 mass% based on the entire composition, and the mass ratio [(C)/(A)] between components (C) and (A) is 50-500. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention is excellent in the feeling of tightening gums, has no lingering sweetness derived from dipotassium glycyrrhizinate, has a good feeling of use, has excellent low-temperature storage stability, and prevents periodontal diseases such as gingivitis or It relates to a dentifrice composition useful for treatment.

  Conventionally, various active ingredients are blended in dentifrice compositions for the purpose of preventing problems in the oral cavity. For the purpose of preventing gingivitis, various active ingredients having inflammation suppressing effect, blood circulation promoting effect, tissue activating effect, etc. are used. Among them, dipotassium glycyrrhizinate is a natural product-derived active ingredient and has a high anti-inflammatory effect. It is widely used because of having it.

  On the other hand, it is desirable that the dentifrice for preventing gingivitis can be continuously used by the user for the full manifestation of the effect. For this reason, the user's sense of use and satisfaction with brushing his teeth are increased. Is preferably promoted. Therefore, a technique for preventing or treating periodontal diseases such as alveolar pyorrhea has been conventionally proposed by adding denaturing sodium chloride to the dentifrice, providing a feeling of tightening the gums by the astringent action. This reduces the uncomfortable feeling of gums due to gingivitis and allows the user to feel a refreshing feeling in the oral cavity after brushing his teeth, giving a satisfactory feeling of use. Patent Document 1 (JP-A-7-17838) proposes a dentifrice composition in which the salty taste derived from sodium chloride is reduced by using polyoxyethylene lauryl ether in combination with sodium chloride. Furthermore, Patent Document 1 discloses a dentifrice containing sodium chloride and dipotassium glycyrrhizinate in Example 5.

  However, as a result of studies by the present inventors, if sodium chloride having an astringent action is used in combination with dipotassium glycyrrhizinate having an anti-inflammatory action as described above, it is used for both prevention of gingivitis and a feeling of tightening gums. However, when sodium chloride is used in combination with dipotassium glycyrrhizinate, the sweetness that draws the unique aftertaste derived from dipotassium glycyrrhizinate is emphasized by the combined use of sodium chloride. Even if you gargle after use, this unique sweetness remains in the mouth, and there is a disadvantage that it is inferior to the feeling of use. Furthermore, the coexistence of dipotassium glycyrrhizinate and sodium chloride causes the problem that the dentifrice of the dentifrice composition deteriorates after low-temperature storage, and the aging stability during low-temperature storage also decreases, and a solution to these problems is desired. .

  Therefore, it is required to provide a dentifrice composition that has an inflammation suppressing effect such as gingivitis and an astringent action, has an excellent gum tightening effect, and has an excellent feeling of use and low-temperature storage stability.

Japanese Unexamined Patent Publication No. 7-17838 Japanese Patent Laid-Open No. 9-25221 JP 2001-508423 A JP 2002-80336 A JP 2006-117598 A JP 2004-217614 A Acta Odontol Scan (2002), 60 (5), p306-310 J Contemp Dent Pract (2003), 4 (2), p11-23

  The present invention was made in view of the above circumstances, has a high feeling of tightening gums, has an excellent feeling of use without a unique aftertaste after dipotassium glycyrrhizinate in the mouth after use, and deteriorates kneaded skin after low-temperature storage An object of the present invention is to provide a dentifrice composition having no storage stability and excellent storage stability.

  As a result of intensive studies to achieve the above object, the inventors of the present invention incorporated 1-15% by mass of sodium chloride into a dentifrice composition containing dipotassium glycyrrhizinate and also used trimethylglycine in combination. / By making the mass ratio of dipotassium glycyrrhizinate in the range of 50 to 500, the inflammation suppressing effect and astringent action of gingiva etc. are satisfactorily exhibited, and it is excellent in the gum tightening effect. A dentifrice composition that has almost no residual after its unique sweetness, is excellent in low-temperature storage stability without deterioration of kneaded skin even when stored at low temperatures, and is effective in the prevention or treatment of periodontal diseases such as gingivitis Has been found to yield the present invention.

  Trimethylglycine is also known as glycine betaine or betaine, and is a known ingredient widely used in skin cosmetics, hair cosmetics and the like as an amino acid-based moisturizing agent. As an application example of application to the oral cavity, Patent Document 2 (Japanese Patent Application Laid-Open No. 9-25221) reports the effect of removing tongue coating by using various enzymes together. Furthermore, trimethylglycine is known to relieve the irritation of anionic surfactants such as sodium lauryl sulfate, and in Non-Patent Document 1 (Acta Odontol Scan (2002), 60 (5), p306-310). In addition, it has been reported that trimethylglycine suppresses the stimulation of a surfactant on the oral mucosa. Patent Document 3 (Japanese Patent Publication No. 2001-508423) and Non-Patent Document 2 (J Contemp Dent Pract (2003), 4 (2), p11-23) reported the moisturizing effect of the oral mucosa, and trimethylglycine. Toothpaste and the like are described. Patent Document 4 (Japanese Patent Laid-Open No. 2002-80336) is a body odor suppressor and its use. Patent Document 5 (Japanese Patent Laid-Open No. 2006-117598) is a dentifrice composition. Examples include dipotassium glycyrrhizinate and trimethylglycine. In JP-A-2004-217614, there is disclosed a detergent composition in which dipotassium glycyrrhizinate and trimethylglycine are used in combination. Outside the scope of the invention, no combination with sodium chloride is shown.

  Thus, trimethylglycine has a moisturizing effect on the skin and oral mucosa and is known as a compounding ingredient in various cosmetics and oral compositions. According to the present invention, dipotassium glycyrrhizinate, sodium chloride And trimethylglycine in combination with the above specific ratio, surprisingly, it was found that sweetness derived from dipotassium glycyrrhizinate enhanced by the combined use of sodium chloride can be improved, and the low-temperature storage stability can also be improved. It is a thing.

  Therefore, the present invention contains (A) dipotassium glycyrrhizinate, (B) sodium chloride, and (C) trimethylglycine, and the blending amount of component (B) is 1 to 15% by mass of the entire composition. The dentifrice composition is characterized in that the mass ratio [(C) / (A)] of the components (A) and (C) is 50 to 500.

  The dentifrice composition of the present invention has a high feeling of tightening gums, has little after-sweetness in the mouth after use, and has excellent low-temperature storage stability without deterioration of kneaded skin even when stored at low temperatures. It is useful as a dentifrice composition for preventing gingivitis.

  Hereinafter, the present invention will be described in more detail. The dentifrice composition according to the present invention contains (A) dipotassium glycyrrhizinate, (B) sodium chloride and (C) trimethylglycine.

  Component (A), dipotassium glycyrrhizinate, is a component extracted from plant raw materials such as roots and stems of legume licorice, and is used as an active ingredient of anti-inflammatory agents. As dipotassium glycyrrhizinate, commercially available products available from cosmetics and pharmaceuticals, such as those available from Alps Pharmaceutical Co., Ltd. and Maruzen Pharmaceutical Co., Ltd. can be used.

  In the present invention, the blending amount of (A) dipotassium glycyrrhizinate is 0.01 to 0.3% (mass%, the same applies hereinafter), particularly 0.03 to 0.1%, based on the whole dentifrice composition. Preferably, if it is less than 0.01%, a sufficient anti-inflammatory effect may not be obtained, and if it exceeds 0.3%, the remaining after a bite sweetness after use of a dentifrice may not be improved.

  (B) The compounding quantity of sodium chloride of a component is 1-15% with respect to the whole dentifrice composition from the point of the good feeling of tightening gum, Preferably it is 4-12%. If it is less than 1%, a sufficient feeling of tightening gums cannot be obtained, and if it exceeds 15%, deterioration of the kneaded skin after low-temperature storage cannot be improved.

  Component (C), trimethylglycine, is a quaternary ammonium compound represented by the following formula, which is also called another name such as glycine betaine or betaine.

  As trimethylglycine, for example, those sold under the trade name AQUADU from Ajinomoto Co., Inc. and Amino Coat from Asahi Kasei Chemicals Corporation can be used.

  The blending amount of trimethylglycine is preferably 0.5 to 25%, particularly 3 to 20% of the whole dentifrice composition. If the blending amount is less than 0.5%, it may not be possible to improve the remaining after a bite sweetness after using the toothpaste, or the deterioration of the kneaded skin after low-temperature storage may not be improved. If it exceeds 25%, the kneaded skin after low-temperature storage may not be improved. May get worse.

  In the present invention, (A) dipotassium glycyrrhizinate and (C) trimethylglycine have a mass ratio of [(C) / (A)] of 50 to 500, preferably 70 to 400, more preferably 70 to 200. Mix in the range. If the blending ratio is less than 50, the remaining after sweetening cannot be improved after using the toothpaste, and if it exceeds 500, the effect of improving deterioration of the kneaded skin over time in low-temperature storage is not sufficiently exhibited.

  The dentifrice composition of the present invention can be prepared by a conventional method as a dentifrice such as a toothpaste, liquid dentifrice, liquid dentifrice, and moisturized dentifrice, and in particular, a toothpaste, and does not impair the effects of the present invention depending on its dosage form. In addition to the above essential components, other additives can be blended as optional components. For example, in the case of toothpaste, abrasives, thickeners, binders, surfactants, sweeteners, preservatives, active ingredients other than dipotassium glycyrrhizinate, pigments, fragrances, and the like can be added. Can be mixed and manufactured.

As abrasives, silica-based abrasives such as precipitated silica, silica gel, aluminosilicate, zirconosilicate, dibasic calcium phosphate dihydrate, dibasic calcium phosphate anhydrate, phosphoric acid abrasives such as calcium pyrophosphate, water Aluminum oxide, alumina, titanium dioxide, crystalline zirconium silicate, polymethyl methacrylate, insoluble calcium metaphosphate, light calcium carbonate, heavy calcium carbonate, magnesium carbonate, tribasic magnesium phosphate, zeolite, zirconium silicate, tribasic calcium phosphate, Examples thereof include hydroxyapatite, fluoroapatite, calcium deficient apatite, tricalcium phosphate, quaternary calcium phosphate, eighth calcium phosphate, and synthetic resin-based abrasives. One of these may be used alone or two or more thereof. In combination it can be used. Of these, silica-based abrasives, calcium carbonate-based, phosphoric acid-based abrasives, and heavy calcium carbonate are preferably used from the viewpoint of feeling of use such as a feeling of brushing.
The blending amount of the abrasive is usually 7 to 60% with respect to the total amount of the composition, generally 7 to 30% for the silica-based abrasive, and 15 to 50% for the phosphate-based abrasive and heavy calcium carbonate. Used in

  As a thickener, one or more of glycerin, sorbit, propylene glycol, polyethylene glycol having a molecular weight of 200 to 6000, ethylene glycol, 1,3-butylene glycol, polyhydric alcohol such as reduced starch saccharified product, etc. can do. A compounding quantity is 5 to 70% normally with respect to the composition whole quantity.

  As the binder, cellulose-based binders such as sodium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxymethyl ethyl cellulose, methyl cellulose, xanthan gum, carrageenan, guar gum, sodium alginate, cationized cellulose, montmorillonite, gelatin , Sodium polyacrylate, and the like, and one or more of these can be blended. A compounding quantity is 0.1 to 5% normally with respect to the composition whole quantity.

  As the surfactant, an anionic surfactant, a nonionic surfactant, an amphoteric surfactant, a cationic surfactant and the like can be blended. Anionic surfactants include sodium alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-acyl sarcosine such as sodium N-lauroyl sarcosine, sodium N-myristoyl sarcosine, sodium dodecylbenzenesulfonate, hydrogenated coconut fatty acid N-acyl glutamate such as sodium monoglyceride monosulfate, sodium lauryl sulfoacetate, sodium N-palmitoyl glutamate, sodium N-methyl-N-acyl taurate, sodium N-methyl-N-acylalanine, sodium α-olefin sulfonate Is mentioned. Nonionic surfactants include, for example, polyoxyethylene hydrogenated castor oil, sucrose fatty acid ester, alkylol amide, polyoxyethylene sorbitan monostearate, polyoxyethylene polyoxypropylene glycol, alkyl glucoside, decaglyceryl laurate, etc. Used. Examples of amphoteric surfactants include lauryl dimethylaminoacetic acid betaine, N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, coconut oil fatty acid amidopropyl dimethylaminoacetic acid betaine, and coconut oil fatty acid amidopropyl. Betaine or the like is used, but is not limited thereto. Among these, sodium lauryl sulfate, sodium N-lauroyl sarcosine, coconut oil fatty acid amidopropyl betaine and the like are preferably used in terms of foaming. The compounding quantity of the said surfactant is 0.1 to 2% of the whole composition normally.

As various active ingredients, in addition to the above-mentioned dipotassium glycyrrhizinate, other effective ingredients can be blended in an effective amount as long as the effects of the present invention are not hindered. Specifically, fluorine compounds such as sodium fluoride, sodium monofluorophosphate and tin fluoride, water-soluble phosphate compounds such as potassium salt and sodium salt of orthophosphoric acid, tranexamic acid, epsilon-aminocaproic acid, and allantochlor Hydroxyaluminum, hinokitiol, ascorbic acid, dl-tocopherol acetate, dihydrocholesterol, α-bisabolol, chlorhexidine salts, azulene, glycyrrhetin, glycyrrhetinic acid, copper chlorophyllin sodium, chlorophyll, glycerophosphate, copper gluconate, etc. Copper compounds, aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid and its derivatives, sodium tripolyphosphate, zeolite, methoxyethyl , Maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterin, cetylpyridinium chloride, benzethonium chloride, dihydrocholesterol, trichlorocarbanilide, zinc citrate, sweet cherry extract, buckwheat extract, chamomile, clove, rosemary, Examples thereof include extracts such as ougon and safflower.

  Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, Iris concrete, absolute Natural fragrances such as peppermint, absolute rose and orange flower, and fragrances processed by these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder fragrance, etc.) Menthol, carvone, anethole, cineol, salicylic acid , Cinnamic aldehyde, eugenol, 3-l-menthoxypropane-1.2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-paramentane-3-carboxamide, pinene, octyl Aldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, hexanal, propyl alcohol, butanol, Isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethyl pyrazine, ethyl lactate, methyl lactate, ethyl thioacetate Toothpaste compositions such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. The well-known perfume material used for can be used, and it is not limited to the perfume of an Example.

  Moreover, although the compounding quantity of a fragrance | flavor is not specifically limited, It is preferable to use said fragrance | flavor raw material 0.000001 to 1% in a formulation composition. Moreover, as a fragrance | flavor for fragrance | flavor which uses the said fragrance | flavor raw material, it is preferable to use 0.1 to 2.0% in a formulation composition.

As sweeteners, saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perilartine and the like, as preservatives, parabens such as butylparaben and ethylparaben, paraoxybenzoate, Examples thereof include sodium benzoate.
Examples of the colorant include Blue No. 1, Yellow No. 4, Green No. 3, and the like.

  In addition, the compounding quantity of these arbitrary components can be made into a normal quantity in the range which does not prevent the effect of this invention.

  The material in particular of the container which accommodates the dentifrice composition of this invention is not restrict | limited, Usually, the container used for a dentifrice composition can be used. Specifically, plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, and nylon can be used.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, the blending amount is mass%.

Examples and comparative examples
Dentifrice compositions (toothpaste) having the compositions shown in Tables 1 and 2 were prepared by the following production methods and evaluated by the following methods.
Manufacturing method:
(1) A phase was prepared by mixing and dissolving water-soluble components (excluding binder and propylene glycol) in purified water at room temperature.
(2) A phase B in which a binder was dispersed at room temperature in propylene glycol was prepared.
B phase was added and mixed in the stirring A phase to prepare C phase.
(3) In phase C, ingredients other than water-soluble ingredients such as fragrances and abrasives are mixed at room temperature using a 1.5 L kneader (manufactured by Ishiyama Kogyo), defoamed under reduced pressure (2666 Pa), and dentifrice 1.2 kg of composition was obtained.

The remaining ratings after sweetness:
Ten subjects brushed an appropriate amount of the dentifrice composition for the toothbrush for about 3 minutes, and after 5 minutes of water rinsing, the remaining sweetness in the mouth was subjected to sensory evaluation based on the following criteria. The average value was calculated and evaluated according to the following criteria.

The rest after sweetness (rating)
4 points: No feeling of the rest after sweetness 3 points: Almost no residue after the sweetness, no problem level 2 points: Feeling the rest after sweetness 1 point: Feeling the remainder after sweetness very strongly ( Evaluation criteria)
◎: Average score of remaining scores after sweetness 3.5 points to 4.0 points ○: Average score of remaining scores after sweetness 3.0 points to less than 3.5 points △: Average of remaining scores after sweetness Points 2.0 points to less than 3.0 points ×: Average score of remaining scores after sweetness Less than 2.0 points

Evaluation of the feeling of tightening gums:
After 10 subjects brushed an appropriate amount of the dentifrice composition for a toothbrush for about 3 minutes, each subject performed a sensory evaluation on the degree of actual tightening feeling in the oral cavity according to the following criteria. The average value was calculated and evaluated according to the following criteria.

Feeling of tightening gums (score)
4 points: Feeling the feeling of tightening the gums very strongly 3 points: Feeling the feeling of tightening the gums 2 points: Feeling the feeling of tightening the gums slightly 1 point: No feeling of tightening the gums (evaluation criteria)
◎: Average score of tightening feeling of gums 3.5 points to 4.0 points ○: Average score of tightening feelings of gums 3.0 points to less than 3.5 points △: Average of tightening feeling scores of gums Point 2.0 points or more and less than 3.0 points ×: Average score of gum tightening actual feeling scores Less than 2.0 points

Evaluation of kneaded skin after low-temperature storage:
The storage stability with respect to the kneaded skin was evaluated by the appearance of kneading when the dentifrice composition was filled in a laminated tube having a diameter of 8 mm, stored in a thermostatic bath at −5 ° C. for 3 months, returned to room temperature, and extruded from the tube. The test dentifrice composition was simultaneously stored at room temperature for 3 months and evaluated as a control product.

(Evaluation criteria for kneaded skin)
◎: No change in the kneaded surface compared to the control product ○: No wrinkle on the kneaded surface compared to the control product, but slight deterioration of the surface gloss △: Compared to the control product The surface of the kneaded surface is slightly wrinkled and the surface gloss is inferior. X: The surface of the kneaded surface is wrinkled as compared with the control product, and the surface is not glossy.

The raw materials used are as follows.
Ingredient Name; Manufacturer Product Name Dipotassium Glycyrrhizinate; Maruzen Pharmaceutical Co., Ltd. Dipotassium Glycyrrhizinate Sodium Chloride; Tomita Pharmaceutical Co., Ltd. Sodium Chloride Trimethylglycine; Ajinomoto Co., Inc. Aqua Duo AN-100

  From the results of Tables 1 and 2, the dentifrice composition lacking any of the essential requirements of the present invention (Comparative Examples 1 to 6) is either a feeling of tightening gums, remaining after sweetness, or any of the kneaded skin in low-temperature storage In contrast to the poor evaluation results, the dentifrice compositions (Examples 1 to 11) containing trimethylglycine are excellent in the feeling of tightening gums, and the remaining sweetness residue derived from dipotassium glycyrrhizinate remains in the mouth. No deterioration of the kneaded skin during low-temperature storage was observed, and it was confirmed that it had good storage stability.

Claims (1)

  (A) dipotassium glycyrrhizinate, (B) sodium chloride, and (C) trimethylglycine, the blending amount of component (B) is 1 to 15% by mass of the total composition, (C) Dentifrice composition, wherein mass ratio [(C) / (A)] of component is 50-500.