JP2006254969A - Radiation image acquisition apparatus and radiation image acquisition method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a radiation image acquisition apparatus and a radiation image acquisition method capable of improving diagnostic ability and reducing an exposure dose in a radiation diagnosis. <P>SOLUTION: This radiation image acquisition apparatus comprises: first image acquisition means 1 and 9 for irradiating an object M with radiation and obtaining a projection image; and second image acquisition means 11, 12 and 13 for detecting light emitted from the subject in response to the radiation and imaging it. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a radiographic image acquisition apparatus and radiographic image acquisition method for acquiring internal information of a subject, and more particularly to a radiographic image acquisition apparatus and radiographic image acquisition method for acquiring medical images.

  Radiation images such as X-ray images are often used in fields such as disease diagnosis. The X-ray image is obtained by irradiating the phosphor layer (phosphor screen) with X-rays that have passed through the subject, thereby generating visible light, and then using this visible light as when taking a normal photograph. Thus, a so-called radiographic method is widely used in which a silver halide photographic light-sensitive material (hereinafter also simply referred to as “photosensitive material”) is irradiated and then subjected to development processing to obtain a visible silver image.

  However, in recent years, a new method for taking out an image directly from a phosphor layer has begun to spread in place of an image forming method using a photosensitive material having a silver halide salt. This method uses a radiation image conversion plate (hereinafter, also simply referred to as “plate”) containing a stimulable phosphor, and the radiation transmitted through the subject is applied to the stimulable phosphor layer of this plate. Then, the radiation energy corresponding to the radiation transmission density of each part of the subject is accumulated, and then the stimulable phosphor is raster-scanned with excitation light such as laser light in the visible to near-infrared region, thereby stimulating the fluorescence. Radiation energy accumulated in the body is released as stimulated luminescence. The signal resulting from the intensity of this stimulating light is converted into an electrical signal by a photoelectric conversion element such as a CCD or photomultiplier tube, then sampled and converted into a digital signal, and this signal is recorded on a silver halide photographic material or the like. It is reproduced as a visible image on a display device such as a material or CRT.

  This system using a photostimulable phosphor plate is called a computed radiography (hereinafter referred to as “CR”) and is widely used today. This radiographic image reading apparatus using CR is roughly divided into two types: a dedicated type with a built-in plate and a cassette type in which a cassette in which the plate is stored is loaded into the apparatus and the cassette is pulled out from the plate within the apparatus for reading. Is done. These are widely used in the medical field today because of the economy that can be used repeatedly and the convenience of handling images as digital data.

  In recent years, a flat panel detector (hereinafter referred to as “CR”) that obtains a radiographic image by reading light emitted from a phosphor layer by a two-dimensional sensor array or two-dimensionally reading charges generated in a scintillator such as amorphous selenium with respect to CR. "FPD") is also in practical use. These generally have high sharpness and are regarded as high-quality detectors.

  On the other hand, since these X-ray images are obtained by irradiating the subject with ionizing radiation at the time of acquisition, it is not non-invasive to the human body, and it is necessary to always consider the balance between the risk of exposure and the benefit of the examination. Furthermore, since these X-ray images are formed by the difference in X-ray absorption by the tissue, it is easy to obtain morphological information such as bones, but in order to distinguish between lesions in soft tissues and normal tissues A sufficient difference in absorption could not be obtained, and it was not always the optimum method for obtaining functional information of the living body.

  Therefore, in recent years, attempts to obtain in-vivo information using near-infrared light (650-1500 nm) or the like that penetrates the living body relatively well and light diagnosis have been proposed (Non-Patent Document 1 below). , 2). Near-infrared light is easily absorbed by hemoglobin in blood, and the absorption varies depending on the oxidation state of hemoglobin, so that it is suitable for obtaining functional information of a living body. However, near-infrared light is strongly scattered in the living body unlike X-rays, so that the light spreads and there is a problem that the resolving power is insufficient to obtain information inside the living body.

In order to solve this problem, various attempts have been made such as development of an algorithm that takes light scattering into consideration (for example, see Patent Document 1 below). However, at present, other than the method called OCT (0ptical Coherence Tomography), which acquires information on the very surface of the living body, is used for fundus examinations, the actual situation is that diagnosis inside the living body using light is not widespread. is there.
Japanese Patent Publication No. 7-81948 "Light and Bio, Light and Medical" Proceedings, held on September 25 and 26, 2003, Japan Optical Society, Optoelectronics Technology Promotion Association) “Diagnosis with light: Lung cancer” (https://www3.ocn.ne.jp/~doraran/c_3_1.htm)

  The present invention has been made in view of the above-described problems of the prior art, and an object of the present invention is to provide a radiological image acquisition apparatus and a radiological image acquisition method capable of improving diagnostic performance in radiation diagnosis and reducing the amount of exposure.

  In order to achieve the above object, a radiological image acquisition apparatus according to the present invention detects a light emitted from a subject by receiving the radiation and detecting a light emitted from the subject by first irradiating the subject with radiation and obtaining a projection image. And second image acquisition means for converting to a second image acquisition means.

  According to this radiographic image acquisition device, the projection image of the subject by radiation and the image by the light emitted from the subject upon receiving radiation can be combined and corresponded. realizable. Moreover, even if the amount of exposure is reduced by reducing the amount of X-ray irradiation, it is possible to obtain a diagnostic ability equivalent to or better than the diagnosis based on the conventional X-ray image obtained with the amount of exposure.

  In the radiological image acquisition apparatus, it is preferable that the first image acquisition unit includes a radiation detector that detects the radiation, and the second image acquisition unit includes a photodetector that detects the light.

  The second image acquisition means preferably includes a mirror disposed for bending the optical path between the subject and the radiation detector. In this case, it is preferable that the second image acquisition unit includes an imaging lens disposed between the mirror and the photodetector.

  The first image acquisition unit and the second image acquisition unit preferably include a unit for positioning the subject so that information from the subject in substantially the same arrangement can be acquired.

  Moreover, it is preferable that the image by the first image acquisition unit and the image by the second image acquisition unit are acquired substantially simultaneously. Thereby, since the time for image acquisition by the second image acquisition means is not required, the burden on the subject (patient) is small.

  Further, by constructing an image inside the subject based on the image information by the projection image of the subject by the radiation and the image information by the second image acquisition means, the functional 3 in the subject with higher accuracy and higher resolution can be obtained. A dimensional image can be obtained.

  Another radiological image acquisition apparatus according to the present invention includes a first image acquisition unit that irradiates a subject with radiation and obtains a projected image, light emitted from the subject by irradiating the subject with light such as near infrared light, and the And second image acquisition means for detecting and imaging at least one of the light transmitted through the subject.

  According to this radiographic image acquisition device, it is possible to cope with a combination of a projected image of a subject by radiation and an image of light emitted from the subject by light irradiation such as near infrared light or light transmitted through the subject. Therefore, the judgment materials for diagnosis increase and the diagnostic ability can be improved. Moreover, even if the amount of exposure is reduced by reducing the amount of X-ray irradiation, it is possible to obtain a diagnostic ability equivalent to or better than the diagnosis based on the conventional X-ray image obtained with the amount of exposure.

  In the radiological image acquisition apparatus, it is preferable that the first image acquisition unit includes a radiation detector that detects the radiation, and the second image acquisition unit includes a photodetector that detects the light.

  The second image acquisition means preferably includes a mirror disposed for bending the optical path between the subject and the radiation detector. In this case, it is preferable that the second image acquisition unit includes an imaging lens disposed between the mirror and the photodetector.

  Further, it is preferable that the photodetector is disposed between the subject and the radiation detector and is detachable. As a result, the photodetector can be disposed in the vicinity of the subject, and the mirror and the imaging lens can be omitted, resulting in a simple configuration.

  The first image acquisition unit and the second image acquisition unit preferably include a unit that fixes the subject so that information from the subject in substantially the same arrangement can be acquired.

  Moreover, it is preferable that the image by the first image acquisition unit and the image by the second image acquisition unit are acquired substantially simultaneously. Thereby, since the time for image acquisition by the second image acquisition means is not required, the burden on the subject (patient) is small.

  Further, by constructing an image inside the subject based on the image information by the projection image of the subject by the radiation and the image information by the second image acquisition means, the functional 3 in the subject with higher accuracy and higher resolution can be obtained. A dimensional image can be obtained.

  The radiological image acquisition method according to the present invention includes a first image acquisition step of irradiating a subject with radiation and obtaining a projection image, and a second image acquisition step of detecting and imaging light emitted from the subject upon receiving the radiation. It is characterized by including these.

  According to this radiological image acquisition method, the projection image of the subject by radiation and the image by the light emitted from the subject upon receiving radiation can be combined and corresponded, so that the judgment materials in diagnosis increase and the diagnostic ability is improved. realizable. Moreover, even if the amount of exposure is reduced by reducing the amount of X-ray irradiation, it is possible to obtain a diagnostic ability equivalent to or better than the diagnosis based on the conventional X-ray image obtained with the amount of exposure.

  In the radiological image acquisition method, it is preferable that the first image acquisition step and the second image acquisition step are performed substantially the same. Thereby, since the time for a 2nd image acquisition step is not required, the burden of a to-be-photographed object (patient) is also small.

  Another radiological image acquisition method according to the present invention includes a first image acquisition step of irradiating a subject with radiation and obtaining a projected image, and transmitting light emitted from the subject or passing through the subject by irradiating the subject with light. And a second image acquisition step of detecting and imaging at least one of the light.

  According to this radiological image acquisition method, a projection image of a subject by radiation and a light emitted from the subject by irradiation with light such as near-infrared light or an image by light transmitted through the subject can be combined and supported. Therefore, the judgment materials for diagnosis increase and the diagnostic ability can be improved. Moreover, even if the amount of exposure is reduced by reducing the amount of X-ray irradiation, it is possible to obtain a diagnostic ability equivalent to or better than the diagnosis based on the conventional X-ray image obtained with the amount of exposure.

  In the radiological image acquisition method, it is preferable that the first image acquisition step and the second image acquisition step are performed substantially the same. Thereby, since the time for a 2nd image acquisition step is not required, the burden of a to-be-photographed object (patient) is also small.

  Still another radiological image acquisition method according to the present invention uses a transmission image of a subject by radiation to construct an image inside the living body based on information transmitted through the subject or light generated from within the subject. And Thereby, a functional three-dimensional image in the subject with higher accuracy and higher resolution can be obtained.

  According to the radiographic image acquisition apparatus and radiographic image acquisition method of the present invention, it is possible to improve the diagnostic ability in radiation diagnosis and reduce the exposure dose.

  The best mode for carrying out the present invention will be described below with reference to the drawings.

  <First Embodiment>

  FIG. 1 is a side view showing a schematic configuration of a radiological image acquisition apparatus according to the first embodiment. The radiological image acquisition apparatus 10 of FIG. 1 is configured to be able to use both mammography (mammography with X-rays) and optical diagnosis.

  As shown in FIG. 1, the radiological image acquisition apparatus 10 includes a base 2 installed at a predetermined position, a vertical member 3 fixed to the base 2, an upper member 4 fixed to the vertical member 3, The X-ray source 1 disposed in the member 4, the subject table 5 for positioning the subject (breast) M with the X-rays from the X-ray source 1, and the X-rays from the X-ray source 1 are the subject M And an X-ray detector 9 disposed on an extension line of the subject M so as to detect a transmission line that has passed through. The X-ray detector 9 may be a radiation image conversion plate or FPD containing a stimulable phosphor, but is not limited thereto.

  The radiological image acquisition apparatus 10 further includes a folding mirror 11 disposed between the subject M and the X-ray detector 9, an imaging lens 12 disposed on the optical path from the folding mirror 11, and an imaging lens. And a light detector 13 for detecting light imaged on the detection surface by the lens 12. The photodetector 13 may be a CCD or the like, but is not limited to this.

  The photodetector 13 can detect, for example, fluorescence generated from the subject M during X-ray irradiation. The human body originally contains a very small amount of fluorescent material (see Non-Patent Document 2 and Non-Patent Document 1 “Application of optical diagnostic technology to endoscopes”, Akihiro Horii). Even emits fluorescence. As described above, in the radiological image acquisition apparatus 10, light for obtaining an image by light uses fluorescence slightly emitted from a living body when X-rays are irradiated. However, in order to obtain stronger light, X-ray irradiation is performed. A contrast agent that emits light may be used.

  Since the bending mirror 11 only needs to reflect light, it is possible to use a thin flat plate made of resin having a good X-ray transmittance and having a reflecting surface formed by aluminum vapor deposition or the like. The subject table 5 is made of a transparent material having a good light transmittance.

  According to the radiological image acquisition apparatus 10 of FIG. 1, as shown by a solid line from the X-ray source 1, the X-ray detector 9 generates transmission lines transmitted through the subject M by irradiating the subject M on the subject table 5 with X-rays. The projection image of the subject M is acquired by the X-ray detector 9 and, at the same time, the fluorescence generated from the subject M when the subject M is irradiated with X-rays passes through the bending mirror 11 and the imaging lens 12 as indicated by the broken line. Then, an image by fluorescence is acquired by forming an image on the detection surface of the photodetector 13.

  Since the projection image of the subject M obtained by the X-ray obtained as described above and the image obtained by receiving the X-ray and the light emitted from the subject M can be combined and corresponded to each other, the judgment material in diagnosis is increased and the diagnostic ability is increased. Improvements can be realized.

  In contrast to conventional X-ray transmission images, a lesion can only be diagnosed from a very small difference in absorption, whereas the radiological image acquisition apparatus 10 in FIG. It is possible to more reliably determine whether the light shadow is benign or malignant by making it correspond to an image having. Alternatively, even if the amount of exposure is reduced by reducing the amount of X-ray irradiation, it is possible to obtain a diagnostic ability equivalent to or better than the diagnosis based on the conventional X-ray image obtained with the amount of exposure.

  In addition, even when it is difficult to make a diagnosis alone because the resolution of the light transmitted through the living body of the light is low, complementing the X-ray image together with the conventional X-ray image as described above can provide sufficient resolution. An effect can be obtained. Of course, if the resolution of the light-transmitted biological image is improved, the diagnostic ability can be further improved.

  In FIG. 1, since light generated in the subject M by X-ray irradiation is used, an X-ray image and a light image can be obtained almost simultaneously, so the burden on the subject, that is, the patient is small.

  <Second Embodiment>

  FIG. 2 is a side view showing a schematic configuration of a radiation image acquisition apparatus according to the second embodiment. The radiological image acquisition apparatus 20 in FIG. 2 is configured to be able to use both mammography (mammography with X-rays) and optical diagnosis, and has basically the same configuration as that in FIG. The point of irradiation is different.

  As shown in FIG. 2, the radiological image acquisition apparatus 20 includes a near-infrared light source 15 disposed in the vicinity of the X-ray source 1 in the upper member 4. The near-infrared light source 15 can be composed of, for example, a semiconductor laser that generates near-infrared light. Light such as scattered light generated from the subject M by irradiating the subject M with near-infrared light from the near-infrared light source 15 is detected by the photodetector 13 as in FIG. In this case, light of a wavelength of 650 to 1500 nm, for example, is generated from the subject M by irradiating near infrared light, and the photodetector 13 is configured so that the generated light can be detected efficiently.

  2, the projection image of the subject M by X-rays obtained in the same manner as in FIG. 1 and the image by light such as scattered light emitted from the subject M upon receiving near-infrared light. Therefore, it is possible to increase the diagnostic ability and increase the diagnostic ability.

  Further, if near-infrared light is irradiated simultaneously with X-ray irradiation or with a very slight time difference, an X-ray image and an optical image can be obtained almost simultaneously, so the burden on the subject, that is, the patient is small.

  A preferred method of irradiating near infrared light from the near infrared light source 15 will be described with reference to FIG. FIG. 4 is a schematic plan view of the subject M on the subject table 5 shown in FIG.

  The near-infrared light from the near-infrared light source 15 may be uniformly irradiated on the entire surface of the subject M. However, as shown in FIG. Two-dimensional scanning is performed so that scanning is performed in the sub-scanning direction Y, and light corresponding to each position is detected by, for example, a planar photodetector 16 disposed below the subject M as shown in FIG. By acquiring the transmission image, more detailed three-dimensional information about the subject M can be obtained, so that the diagnostic ability can be further improved.

  <Third Embodiment>

  FIG. 3 is a side view showing a schematic configuration of a radiological image acquisition apparatus according to the third embodiment. The radiological image acquisition apparatus 30 in FIG. 3 is configured to be able to use both mammography (mammography with X-rays) and optical diagnosis, and has basically the same configuration as that in FIG. The difference is in the configuration.

  The radiological image acquisition apparatus 30 of FIG. 3 includes a planar photodetector 16 and an adapter unit 17 that is configured so that the photodetector 16 can be attached and detached and also serves as a subject table. By attaching the photodetector 16 to the adapter unit 17, the photodetector 16 is positioned immediately behind the subject M.

  In the radiological image acquisition apparatus 30 of FIG. 3, first, an X-ray image is acquired by X-ray irradiation in a state where the photodetector 16 is removed from the adapter unit 17 as indicated by a broken line in FIG. After being attached to the adapter unit 17, the subject M is irradiated with near-infrared light, and the light generated from the subject M is detected by the photodetector 16, and an optical image is acquired.

  According to the radiological image acquisition apparatus 30 of FIG. 3, the projection image of the subject M by X-rays obtained in the same manner as in FIG. 1, and the image by light such as scattered light emitted from the subject M upon receiving near-infrared light Therefore, it is possible to increase the diagnostic ability and increase the diagnostic ability.

  Further, the bending mirror 11 and the imaging lens 12 in FIG. 2 can be omitted, and the configuration is simple. Moreover, since the time difference between both irradiations can be shortened by attaching the photodetector 16 and irradiating near infrared light immediately after X-ray irradiation, the burden on the subject, that is, the patient is small.

  3, a planar photodetector 16 is configured as shown in FIG. 5, and the subject M is scanned in the main scanning direction X by the narrowed irradiation beam b as shown in FIG. Two-dimensional scanning is performed so as to perform sub-scanning, and a light transmission image corresponding to each position can be acquired by the photodetector 16 in FIG.

  In FIG. 3, the X-ray detector 9 may be disposed in the vicinity of the adapter unit 17 as indicated by a broken line in the figure. Further, both the X-ray detector 9 and the photodetector 16 may be configured to be detachable in the adapter unit 17 so that the X-ray detector 9 and the photodetector 16 can be exchanged.

  According to each of the radiological image acquisition devices of FIGS. 1 to 3, in consideration of the fundamental difficulty in conventional optical diagnosis, X-rays or the like that have been performed in the past are used instead of diagnosing the inside of a living body with light alone. The combined use of radiation diagnosis and optical diagnosis can reduce the amount of exposure and improve the ability to diagnose lesions.

  Also, when constructing the structure inside a subject as a three-dimensional image from the information of the transmitted light and generated light from the subject, which internal structure is generally used to form an image obtained from the transmitted light and generated light It is necessary to solve the inverse problem of whether it should be. At this time, since the transmitted X-ray image includes structural projection information inside the subject, it can be used as an initial value when solving the inverse problem, thereby providing a more accurate and high-resolution in-vivo image. A functional three-dimensional image can be obtained.

  As described above, the best mode for carrying out the present invention has been described. However, the present invention is not limited to these, and various modifications are possible within the scope of the technical idea of the present invention. For example, in this embodiment, the subject is a breast and mammography, but the present invention is not limited to this, and can be applied to general imaging of other parts, and can also be used for animals. . Further, even if it is not a living body, any object that transmits light to some extent can be used for nondestructive inspection.

  In the case of the above general imaging, the morphological information of the subject can be obtained while irradiating the X-ray containing many high energy components with good subject transparency while reducing the influence of the ionizing exposure. Specifically, X-rays having a strong peak of 50 keV or more (excluding characteristic X-rays) may be used. Such X-rays can be obtained by using an aluminum filter, for example.

  2 and 3, the generated light such as scattered light when the subject is irradiated with near-infrared light is detected. However, the present invention is not limited to this, and the transmitted light transmitted through the subject is detected. This transmitted light may be used, and both generated light and transmitted light may be used. Moreover, in order to identify a lesion more reliably, a contrast agent that reacts to near-infrared light may be used. Furthermore, you may comprise so that the light of wavelengths other than near-infrared light may be irradiated.

  In FIG. 1, the photodetector may be configured to be detachable in the vicinity of the subject table as in FIG. 3, and the bending mirror 11 and the imaging lens 12 may be omitted.

It is a side view showing a schematic structure of a radiographic image acquisition device by a 1st embodiment. It is a side view which shows schematic structure of the radiographic image acquisition apparatus by 2nd Embodiment. It is a side view which shows schematic structure of the radiographic image acquisition apparatus by 3rd Embodiment. FIG. 3 is a schematic plan view of a subject M on the subject table 5 in FIG. 2 as viewed from above. FIG. 5 is a side sectional view showing a configuration example of the photodetector in FIGS. 3 and 4.

Explanation of symbols

1 X-ray source (first image acquisition means)
5 Subject table 9 X-ray detector (first image acquisition means)
DESCRIPTION OF SYMBOLS 10 Radiation image acquisition apparatus 11 Bending mirror (2nd image acquisition means)
12 Imaging lens (second image acquisition means)
13 Photodetector (second image acquisition means)
15 Near-infrared light source (second image acquisition means)
16 Photodetector (second image acquisition means)
17 Adapter unit 20, 30 Radiation image acquisition device M Subject

Claims (20)

  A first image acquisition unit that irradiates a subject with radiation and obtains a projected image, and a second image acquisition unit that detects and images light emitted from the subject upon receiving the radiation. Radiation image acquisition device. The first image acquisition means comprises a radiation detector for detecting the radiation;
The radiographic image acquisition apparatus according to claim 1, wherein the second image acquisition unit includes a photodetector that detects the light.   The radiographic image acquisition apparatus according to claim 2, wherein the second image acquisition unit includes a mirror disposed for bending an optical path between the subject and the radiation detector.   The radiographic image acquisition apparatus according to claim 3, wherein the second image acquisition unit includes an imaging lens disposed between the mirror and the photodetector.   5. The apparatus according to claim 1, further comprising means for positioning the subject so that the first image obtaining unit and the second image obtaining unit can obtain information from the subject in substantially the same arrangement. The radiographic image acquisition apparatus of any one of Claims.   The radiographic image acquisition apparatus according to any one of claims 1 to 5, wherein an image obtained by the first image acquisition unit and an image obtained by the second image acquisition unit are acquired substantially simultaneously.   7. The image inside the subject is configured based on image information based on a projection image of the subject by the radiation and image information obtained by the second image acquisition unit. 7. Radiation image acquisition device.   A first image acquisition means for irradiating the subject with radiation and obtaining a projection image; and second for detecting and imaging at least one of light emitted from the subject and light transmitted through the subject by irradiating the subject with light. And a radiological image acquisition device. The first image acquisition means comprises a radiation detector for detecting the radiation;
The radiographic image acquisition apparatus according to claim 8, wherein the second image acquisition unit includes a photodetector that detects the light.   The radiographic image acquisition apparatus according to claim 9, wherein the second image acquisition unit includes a mirror disposed for bending an optical path between the subject and the radiation detector.   The radiographic image acquisition apparatus according to claim 10, wherein the second image acquisition unit includes an imaging lens disposed between the mirror and the photodetector.   The radiological image acquisition apparatus according to claim 11, wherein the photodetector is disposed between the subject and the radiation detector and is detachable.   13. The apparatus according to claim 8, further comprising means for positioning the subject so that the first image acquisition unit and the second image acquisition unit can acquire information from the subject in substantially the same arrangement. The radiographic image acquisition apparatus of any one of Claims.   The radiographic image acquisition apparatus according to claim 8, wherein an image obtained by the first image acquisition unit and an image obtained by the second image acquisition unit are acquired substantially simultaneously.   The image inside the subject is configured based on image information obtained by projecting an image of the subject by the radiation and image information obtained by the second image acquisition unit, according to any one of claims 8 to 14. Radiation image acquisition device. A first image acquisition step of irradiating a subject with radiation to obtain a projected image;
A radiation image acquisition method, comprising: a second image acquisition step of detecting and imaging light emitted from the subject in response to the radiation.   The radiographic image acquisition method according to claim 16, wherein the first image acquisition step and the second image acquisition step are performed substantially the same. A first image acquisition step of irradiating a subject with radiation to obtain a projected image;
A radiation image acquisition method comprising: a second image acquisition step of detecting and imaging at least one of light emitted from the subject or light transmitted through the subject by irradiating the subject with light. .   The radiographic image acquisition method according to claim 18, wherein the first image acquisition step and the second image acquisition step are performed substantially the same. A radiographic image acquisition method comprising: forming an image inside a subject based on information of at least one of light transmitted through the subject and light generated from the subject using a transmission image of the subject by radiation.

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