JP2006008530A - Tooth bleaching set - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a tooth bleaching set that sticks a preparation to the surface of a tooth, keeps it for many hours without being influenced by saliva, thus draws out high whitening effect on a tooth and has excellent usability and stability with time. <P>SOLUTION: The tooth bleaching set is equipped with a nonaqueous composition comprising a polyhydric alcohol, a methyl vinyl ether-maleic anhydride copolymer crosslinked with a crosslinking agent and substantially no water and an application tool that is detachably attached to a tooth in a state of holding the nonaqueous composition. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention is a tooth whitening agent that is capable of maintaining a high adhesion and maintaining a long period of time on a tooth surface without being affected by saliva, exhibiting a high tooth whitening effect, and having excellent usability and stability over time. Regarding the set.

  For the purpose of gradual release of medicinal ingredients, cleaning of the tooth surface, whitening and the like, a patch or patch to be applied to the oral mucosa or tooth surface has been proposed. As a means for applying the agent to the tooth surface, for example, a method of improving the retention on the tooth surface by making the support thin and flexible (using a support having a bending strength of 5 g / cm or less) (Patent Document 1; Table 2002-503990), or a method of physically fixing to a tooth surface by deforming a permanently deformable support (use of a support deformed under a pressure of less than 250,000 Pa) (Patent Document 2; Table 2002-537003) is proposed.

  However, these may not be sufficient for high adhesion to the teeth without being affected by saliva. Especially when a support that is permanently deformed is used, it is retained in the oral cavity between the agent and the tooth surface. In some cases, saliva enters and does not adhere.

  In addition, an oral patch (Patent Document 3; Japanese Patent Laid-Open No. 10-17448) comprising an adhesive layer containing a whitening component such as a water-soluble polymer and kojic acid and a support, and a peroxide as a whitening component, A dry type tooth whitening patch using a hydrophilic glass polymer in the adhesion layer (Patent Document 4; JP 2003-526648 A) is also proposed, but a water-soluble polymer that gels in a non-aqueous composition, etc. In addition to the fact that the adhesive component is very limited, the usability such as stickiness is remarkably lowered when blended in a large amount to ensure the adhesiveness, for example, the agent is applied to the support, and the agent is applied with a facing film. In the case of processing into a three-layered sheet sandwiching the material, there may be a problem that the agent protrudes from the edge of the sheet over time. In addition, the dry-type patch material exhibits adhesiveness by being hydrated with saliva and is not suitable for the purpose of the present invention.

On the other hand, with regard to whitening of teeth, a method of changing the optical properties of the enamel part without chemical reaction such as bleaching has been proposed (Patent Document 5: International Publication No. 03/030851 pamphlet). Polyethylene glycol and the like are disclosed as components. These whitening components exhibit a high whitening effect when applied to the teeth, but if the adhesion to the teeth deteriorates due to the influence of saliva, sufficient effects may not be exhibited.
In addition, the applicant has proposed in Japanese Patent Application No. 2003-426716 and Japanese Patent Application No. 2003-432095, which use polyethylene glycol or the like as a whitening component.

  Therefore, in preparations for whitening teeth, it is desired to improve high adhesion to the teeth, usability and stability.

JP 2002-503990 Gazette Special Table 2002-537003 Japanese Patent Laid-Open No. 10-17448 Special table 2003-526648 gazette International Publication No. 03/030851 Pamphlet

  The present invention has been made in view of the above circumstances, and can highly adhere a non-aqueous composition for whitening teeth to the tooth surface without being affected by saliva, and can be held on the tooth surface for a long time, and is high. An object of the present invention is to provide a tooth whitening set that exhibits a tooth whitening effect and is excellent in usability and stability over time.

  As a result of intensive studies to achieve the above object, the present inventor applied a non-aqueous composition obtained by gelling a polyhydric alcohol with a methyl vinyl ether-maleic anhydride copolymer crosslinked with a crosslinking agent to teeth. Can be kept in close contact with the tooth without being affected by saliva and can be held for a long time. For this reason, the polyhydric alcohol, which is a tooth whitening component, is closely attached to the tooth without being affected by saliva. As a result, the present inventors have found that excellent whitening effects can be obtained, and that excellent whitening effects can be exhibited, and that excellent usability and stability over time can be obtained.

  Therefore, the present invention includes a non-aqueous composition containing a polyhydric alcohol and a methyl vinyl ether-maleic anhydride copolymer crosslinked with a crosslinking agent, substantially free of water, and the non-aqueous composition. A tooth whitening set comprising an application tool that is detachably attached to a tooth in a held state.

In this case, it is preferable to use one kind selected from polyethylene glycol having an average molecular weight of 190 to 630, 1,3-butylene glycol and glycerin alone or in combination of two or more kinds as the polyhydric alcohol.
Further, the non-aqueous composition preferably contains an inorganic powder.

  In addition, as a tool to be applied to teeth, a tape, sheet, film, mouth tray, mouthpiece, sponge, impression material, pack material, or tooth cover molded into a dentition is preferably used. Is done.

  According to the present invention, the preparation can be kept in close contact with the tooth surface without being affected by saliva, and can be held for a long time, whereby a high whitening effect of the tooth can be obtained, and the usability It is possible to provide a tooth whitening set having good stability over time.

  Hereinafter, the present invention will be described in more detail. The tooth whitening set of the present invention contains a polyhydric alcohol and a methyl vinyl ether-maleic anhydride copolymer crosslinked with a crosslinking agent, and substantially contains water. A non-aqueous composition that is not contained, and an application tool that is detachably attached to a tooth while holding the non-aqueous composition.

  In the present invention, examples of the polyhydric alcohol include polyethylene glycol having an average molecular weight of 190 to 630, 1,3-butylene glycol, glycerin, diglycerin, propylene glycol, dipropylene glycol, ethylene glycol, and diethylene glycol. One kind can be used alone, or two or more kinds can be used in combination.

  Among these polyhydric alcohols, one kind selected from polyethylene glycol having an average molecular weight of 190 to 630, 1,3-butylene glycol, and glycerin is used singly or in combination of two or more kinds particularly from the viewpoint of whitening effect. In particular, it is preferable to use polyethylene glycol having an average molecular weight of 190 to 630 in combination with 1,3-butylene glycol and / or glycerin. In this case, polyethylene glycol having an average molecular weight of 380 to 630 and 1,3-butylene glycol and / or glycerin are mass ratio of 8: 2 to 4: 6, particularly 7: 3 in terms of taste when applied to teeth. It is more preferable to use it together at a ratio of 5: 5.

  In addition, average molecular weight shows the average molecular weight described in cosmetic raw material standard (2nd edition comment), polyethylene glycol 200 (average molecular weight 190-210), polyethylene glycol 300 (average molecular weight 280-320), polyethylene glycol 400 (average molecular weight 380) To 420) and polyethylene glycol 600 (average molecular weight 570 to 630). Depending on the product, there may be a # between the polyethylene glycol and the numerical value, such as polyethylene glycol # 200.

  The blending amount of the polyhydric alcohol in the non-aqueous composition of the present invention is preferably 40 to 99% (mass%, the same applies hereinafter) of the total amount of the composition from the viewpoint of whitening effect and taste, more preferably 55 to 96. %.

  The methyl vinyl ether-maleic anhydride copolymer crosslinked with the crosslinking agent according to the present invention has a molar ratio of methyl vinyl ether to maleic anhydride of 40:60 to 60:40, What was bridge | crosslinked by applying 9-decadiene, 1,7-octadiene, etc. is used suitably, and it is preferable that the crosslinking degree is 1 to 5%. Furthermore, when the viscosity (25 ° C.) of a 0.5% aqueous solution (neutralized with 10% NaOH) was measured with a BH type viscometer (No. 7 rotor used, rotation speed 10 rpm, 30 sec.), 20,000 to What is 120,000 mPa * s is suitable.

  As the methyl vinyl ether-maleic anhydride copolymer crosslinked with such a crosslinking agent, STABILEZE QM and STABILEZE 06 which are methyl vinyl ether-maleic anhydride copolymers crosslinked with 1,9-decadiene are commercially available. ISP) and the like.

  The amount of the cross-linked methyl vinyl ether-maleic anhydride copolymer is preferably 1 to 20% of the total composition, more preferably 3 to 10 in terms of adhesion, taste, and stability over time of the sheet. %. If the blending amount is less than 1%, gelation may be insufficient, and saliva erosion may not be achieved due to high adhesion, and if it exceeds 20%, elasticity may be too strong and application to teeth may be difficult.

  Furthermore, it is preferable to mix inorganic powder with the non-aqueous composition of the present invention from the viewpoints of adhesion, whitening effect, and stability over time. As the inorganic powder, those generally used for oral products can be used. Specifically, thickened silica, anhydrous silicic acid, aluminum silicate, zirconium silicate, dicalcium phosphate dihydrate and anhydride Insoluble sodium metaphosphate, calcium carbonate, titanium oxide, alumina, aluminum hydroxide and the like can be mentioned, and one or more of these can be used. Of these, thickened silica, anhydrous silicic acid, dicalcium phosphate dihydrate and anhydride are particularly preferable.

  The blending amount of the inorganic powder is preferably 1 to 20%, more preferably 3 to 10% of the total composition of the thickening silica from the viewpoint of adhesion, whitening effect and stability over time of the sheet. The blending amount of the inorganic powder is preferably 3 to 50%, more preferably 5 to 30% of the entire composition. If the thickening silica is blended in excess of 20%, or other inorganic powders are blended in excess of 50%, the gel may become hard and cannot be closely adhered. If the blending amount of the inorganic powder is less than the above value, a satisfactory blending effect may not be obtained.

  In addition, in a non-aqueous composition containing an inorganic powder generally used as a polishing agent for dentifrice other than the thickening silica, the non-aqueous composition remaining on the tooth surface after applying to the tooth, such as a toothbrush In addition to being able to exhibit the whitening effect by brushing with the cleaning tool, the tooth surface and the oral cavity can be cleaned.

Furthermore, in this invention, the polymer which can be melt | dissolved in a polyhydric alcohol can be mix | blended in order to control the viscoelasticity of a gel. Specifically, hydroxypropylcellulose (weight average molecular weight 10,000 to 400,000), polyvinylpyrrolidone (PVP) (K-30 to K-120), etc. are used in combination as a polymer that can be dissolved in a polyhydric alcohol. Can do.
The blending amount of the polymer that can be dissolved in the polyhydric alcohol is preferably 1 to 20%, particularly preferably 3 to 15% of the whole composition, and if less than 1%, a satisfactory blending effect may not be obtained. If it exceeds 50%, problems may occur in terms of usability such as increased elasticity.

  In the non-aqueous composition of the present invention, other components can be appropriately blended as necessary. Specifically, active ingredients, surfactants, sweeteners, fragrances, preservatives, antioxidants, pH adjusters, and the like can be blended.

  For example, fluoride (such as sodium fluoride) as an active ingredient as an active ingredient, dextranase, mutanase, prevention of hypersensitivity, aluminum lactate, potassium nitrate, piroctone olamine, other potassium pyrophosphate, tripolyphosphate as inhibitory ingredients Water-soluble polyphosphates such as sodium and sodium metaphosphate, ascorbic acid and salts thereof, herbal extracts such as tocopherol acetate, rosemary, clove and thyme can be used alone or in combination of two or more. In addition, the compounding quantity of an active ingredient can be made into an effective quantity in the range which does not inhibit the effect of this invention.

  In addition, for the purpose of solubilizing insoluble components and removing dirt on tooth surfaces, one or more of anionic surfactants, nonionic surfactants, zwitterionic surfactants and the like are added to the entire composition. 0.01 to 10%, especially 0.1 to 5% can be blended from the viewpoint of blending effect.

  In this case, anionic surfactants include sodium alkyl sulfates such as sodium lauryl sulfate, sodium myristyl sulfate and sodium cetyl sulfate, sodium N-acyl glutamate such as sodium N-lauroyl glutamate, sodium N-palmitoyl glutamate, and N-lauroyl. N-acyl sarcosine sodium, such as sarcosine sodium, N-myristoyl sarcosine sodium, N-methyl-N-acyl taurine sodium, N-methyl-N-acylalanine sodium, such as N-lauroylmethyl taurine sodium, N-myristoyl methyl taurine sodium Sodium laurylbenzene sulfonate, hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, α-o Sodium fins sulfonate, lauryl POE sodium sulfate, sodium lauryl POE acetate, sodium lauryl POE phosphate, stearyl POE sodium phosphate and the like are used.

  Nonionic surfactants include glycerin fatty acid esters such as monoglyceryl stearate and decaglyceryl laurate, sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester and lactose fatty acid ester, maltitol fatty acid ester, and lactitol fatty acid ester. Sugar alcohol fatty acid esters, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monostearate, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, myristic acid mono- or diethanolamide Fatty acid ethanol amide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxy Propylene copolymer, polyoxyethylene polyoxypropylene fatty acid ester or the like is used.

  Zwitterionic surfactants include alkyldimethylaminoacetic acid betaines such as lauryldimethylaminoacetic acid betaine, N-alkyldiaminoethylglycine such as N-lauryldiaminoethylglycine, N-myristyldiaminoethylglycine, and N-alkyl-N-carboxyl. Methyl ammonium betaine, 2-alkyl-1-hydroxyethyl imidazoline betaine sodium and the like are used.

  Moreover, in this invention, alcohol other than the said polyhydric alcohol as a solvent, specifically, lower alcohols, such as ethanol and an isopropalol, can also be mix | blended.

  Further, the non-aqueous composition of the present invention includes perfume ingredients such as l-menthol, anethole, carvone, citral, benzaldehyde, cinnamic aldehyde, octanol, methyl salicylate, peppermint oil, spearmint oil, benzoic acid and its sodium salt, Preservatives such as parabens such as methyl paraben, ethyl paraben, propyl paraben, butyl paraben, red No. 3, red No. 104, yellow No. 4, blue No. 1, green No. 3, mica titanium, petals or coloring agents such as petals, Sweeteners such as xylitol, saccharin and its sodium salt, stevioside, glycyrrhizin and aspartame can be blended.

  The pH of the non-aqueous composition is not particularly limited as long as it is in a range that does not cause safety problems in the oral cavity and the human body, but preferably 25 when the non-aqueous composition is diluted 10 times with purified water. The pH at ° C. is 4.0 to 10.0, more preferably 5.0 to 9.0. When the pH is less than 4.0, there is a concern about decalcification depending on the application time, and when the pH is more than 10.0, there is a concern such as mucosal detachment when touching the gingiva.

  Examples of pH adjusters include hydrochloric acid, citric acid, malic acid, malonic acid, glycolic acid, phosphoric acid, sodium hydroxide, potassium hydroxide, sodium carbonate, sodium citrate, sodium hydrogen citrate, sodium phosphate, phosphorus Sodium oxyhydrogen, triethanolamine, triisopropanolamine, arginine and the like can be blended.

  In addition, shellac, acrylic polymer, and higher fatty acids such as oleic acid, myristic acid, isostearic acid, etc. as a film-forming component on the tooth surface are blended in an amount of about 0.1 to 5% with respect to the entire composition. You can also

  In addition, the tooth whitening effect in this invention is implement | achieved by penetrating polyhydric alcohol to a tooth enamel, and substituting the water | moisture content in an enamel. In the present invention, a non-aqueous composition that does not substantially contain water is applied to the teeth, and the whitening effect is more efficiently expressed. When water is added, the whitening effect decreases.

  The effect of the non-aqueous composition of the present invention is further enhanced by preparing it as a gel or paste form and applying it together with an application tool dedicated to holding and fixing to a tooth.

  As described above, the non-aqueous composition is applied together with an application tool dedicated to holding / fixing a tooth, but is dedicated to holding / fixing a tooth used in combination with the non-aqueous composition of the present invention. In addition to assisting in the reliable application and fixation of non-aqueous compositions to teeth, this device also prevents elution of non-aqueous compositions during use into the gums, tongue, and oral mucosa, unpleasant feeling of use and saliva. It is used for the purpose of preventing induction, and further preventing the invasion, occlusion, mastication, and other non-aqueous composition of the non-aqueous composition due to physical stimulation and removal from the teeth. The material and shape of the tool are not particularly limited as long as the above object can be achieved, but a tape, sheet, film, mouth tray, mouthpiece, sponge, impression material made of a water-insoluble material. A tooth cover molded into a pack material or a dentition is preferably used. Other examples include a chewing brush having a large number of protrusions on a tooth contact surface molded into a dentition.

  The thickness of the application tool is preferably 0.01 to 5 mm, which does not give a sense of incongruity when applied to a tooth, and is preferably 0.01 to 2 mm for films and sheets.

The material of the application tool is not particularly limited as long as it is excellent in safety applicable to the oral cavity, but polyethylene, polypropylene, polyester, polyurethane, rayon, pulp, cotton, silk, paper, acetic acid It is preferable to use one or more of vinyl resin, acrylic resin, silicone rubber, natural rubber and metal foil. From the viewpoint of good fit and suppression of saliva secretion, it is preferable to use a plastic film or a woven or non-woven fabric made of synthetic or natural fibers. When used as a woven fabric or non-woven fabric, those composed of one or more of polyethylene, polypropylene, polyester, rayon, nylon, cotton, pulp, paper, silk are preferred because of the good feel when worn. The thing of 300 (g / m < ² >) is preferable.

  In addition, by adhering a water-impermeable film such as polyethylene, polypropylene, or polyester to one side or both sides of a woven fabric or non-woven fabric or between two woven or non-woven fabrics, the formulation can be adsorbed excessively or the non-woven fabric It is possible to prevent permeation and elution into the oral cavity, or conversely, saliva permeates through the nonwoven fabric or the like and enters the preparation. In addition, in the mouth tray, mouthpiece, and tooth cover, plastic resins such as silicone rubber and natural rubber, and thermoplastic resins such as vinyl acetate resin and acrylic resin are also easily deformed according to the dentition. It is suitable because of excellent fit.

  In addition, although the frequency | count of application and time of the set for tooth whitening of this invention are selected suitably, it is 1-6 times a day normally, Especially it is 1-3 times. The application time is 1 minute to 6 hours, particularly 1 minute to 2 hours, but it can also be applied while sleeping.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, the blending amount is mass%.

[Examples 1 to 11 and Comparative Examples 1 to 3]
About the non-aqueous composition of the composition shown in Tables 1-3, the preparation is prepared by the following method to prepare a sheet, the adhesion to the tooth, the taste at the time of use, the whitening effect, the temporal stability of the sheet by the following method Evaluated. The results are shown in Tables 1-3.

<Preparation of formulation>
All the raw materials (excluding fragrance) were weighed, mixed at about 80 ° C. under reduced pressure (about −700 mmHg), added with fragrance at 40 ° C. to 20 ° C., and mixed under reduced pressure to prepare a preparation. The pH was adjusted so that the pH at 25 ° C. when diluted 10-fold with purified water was 4.0 to 10.0.

<Production of sheet>
Between a non-woven sheet consisting of 3 layers of polypropylene (PP) / polyethylene (PE) film / rayon + polypropylene (PP) (7/3) having a thickness of about 0.5 mm and a facing film coated with silicone on the surface, The preparation was applied so that the total thickness was 1 mm.
Then, a sheet coated with the preparation can be cut into the same shape using a tooth mold designed to cover the lip and tongue surfaces of the left and right third to third teeth of the upper and lower jaws and can be applied to the upper and lower jaws A simple sheet was produced.

<Evaluation of adhesion to teeth, taste during use, and whitening effect>
The sheet produced by the above method was attached to the upper and lower tooth rows and allowed to stand for 30 minutes, and then the sheet was peeled off to remove the preparation remaining on the tooth surface. And the adhesiveness to the tooth which is mounting | wearing a sheet | seat, the taste, and the whitening effect of the tooth after removing a sheet | seat were evaluated based on the following reference | standard. It was conducted by 10 panelists.
-Adhesiveness 5 points: It is fixed perfectly.
4 points: It is fixed and does not shift or move.
3 points: Slightly off, but not worried.
2 points: I'm worried about moving.
1 point: Cannot be fixed.
・ Taste 5 points: I do not feel any bitterness.
4 points: tastes a little bit but not bitter.
3 points: I feel a bit bitter.
2 points: I feel bitterness.
1 point: I feel strongly bitter.
・ Whitening effect 5 points: I feel that it is clearly whitened.
4 points: Whitening effect is felt.
3 points: Slight whitening is felt.
2 points: Almost no whitening is felt.
1 point: No whitening is felt at all.

Each evaluation item was evaluated by each panel, and a final evaluation was performed based on the average score based on the following criteria.
◎: 4.5 or more ○: 3.5 or more and less than 4.5 △: 2.5 or more and less than 3.5 × ×: less than 2.5

<Stability over time>
The processed sheet was subjected to acceleration conditions, and the state of the sheet after being stored in a thermostat at 50 ° C. for 1 week was observed and evaluated.
A: No change from the initial stage.
○: Almost the same as the initial stage.
Δ: Slightly protruding from the sheet.
X: The state where the preparation protrudes from the sheet.

  From the above results, a non-aqueous preparation containing a methyl vinyl ether-maleic anhydride copolymer cross-linked with a polyhydric alcohol and a cross-linking agent, and a non-aqueous preparation containing an inorganic powder are highly adhered to the teeth and have high whiteness. It has been found that it has a aging effect and has excellent temporal stability.

Example 12
A non-aqueous preparation (following composition 1) prepared by the same production method as in the above Examples was applied to a polyethylene film (thickness 25 μm) so that the total thickness was about 1 mm, and was used for single teeth (one tooth This was cut and affixed to a dental mold. Evaluation was performed according to the above-described evaluation method. As a result, the adhesiveness, taste, whitening effect, and change with time of the sheet were all excellent.

<Composition 1>
Polyethylene glycol # 400 62.4%
1,3-butylene glycol 26.7
Methyl vinyl ether-maleic anhydride copolymer crosslinked with 1,9-decadiene (manufactured by ISP, STABILEZE QM) 5
Shellac (manufactured by Nippon Shellac Industry, dry transparent white rack) 2
Xylitol 3
Sodium fluoride 0.2
Sodium hydroxide 0.4
Fragrance 0.1
Tocopherol acetate 0.2
Total 100.0%

Example 13
A non-aqueous preparation (following composition 2) prepared by the above-mentioned manufacturing method is applied to a polypropylene film (thickness of about 0.1 mm) so that the total thickness is about 1 mm, and teeth for left and right first to third teeth A sheet cut into a mold was prepared and affixed, and evaluated by the evaluation method described above. As a result, the adhesiveness, taste, whitening effect, and change with time of the sheet were all excellent.

<Composition 2>
Polyethylene glycol # 600 32.85%
1,3-butylene glycol 32.8
Methyl vinyl ether-maleic anhydride copolymer cross-linked with 1,9-decadiene (manufactured by ISP, STABILEZE QM) 3
Hydroxypropylcellulose-L (Nippon Soda, HPC-L) 5
Silica 20
Sodium lauryl sulfate 0.1
Aminoalkyl methacrylate polymer 0.8
(Rohm, EUDRAGIT RSPO)
Ethanol 5
Sodium hydroxide 0.05
Fragrance 0.1
Ascorbic acid 0.2
Tocopherol acetate 0.1
Total 100.0%

Example 14
The non-aqueous preparation (following composition 3) prepared by the above-mentioned production method was applied to a two-layer nonwoven fabric (thickness: about 0.2 mm) of polypropylene / polyethylene film so that the total thickness was about 1 mm. A sheet cut into a No. 3 tooth mold was prepared and evaluated according to the evaluation method described above. As a result, the adhesion, taste, whitening effect, and change with time of the sheet were all ◎.

<Composition 3>
Polyethylene glycol # 400 36.4%
Glycerin 36.4
Methyl vinyl ether-maleic anhydride copolymer crosslinked with 1,9-decadiene (manufactured by ISP, STABILEZE QM) 5
Calcium phosphate dihydrate 20
Sodium lauryl sulfate 0.1
Isostearic acid 1
Saccharin sodium 0.2
Sodium hydroxide 0.4
Fragrance 0.2
Methylparaben 0.2
Tocopherol acetate 0.1
Total 100.0%

Example 15
Thermoplastic mouthpiece A mouthpiece made of ethylene vinyl acetate resin was warmed and softened with hot water, chewed to prepare a mouthpiece fitted to the tooth shape, filled with about 3 g of a non-aqueous preparation (composition 4 below), and attached. When the mouthpiece was used, it was difficult to determine the adhesion, so the whitening effect and taste were evaluated according to the evaluation method described above. As a result, both the whitening effect and the taste were ◎.

<Composition 4>
Polyethylene glycol # 400 61%
1,3-butylene glycol 25.8
Methyl vinyl ether-maleic anhydride copolymer cross-linked with 1,9-decadiene (manufactured by ISP, STABILEZE QM) 10
Shellac (manufactured by Nippon Shellac Industry, dry transparent white rack) 1.8
Saccharin sodium 0.1
Sodium hydroxide 0.6
L-Arginine 0.5
Fragrance 0.1
Tocopherol acetate 0.1
Total 100.0%

Example 16
Non-woven mouse tray PP + rayon (8/2) / PE film / PP + rayon (3/7) 3-layer non-woven mouse tray made of non-woven preparation (following composition 5) about 5g Filled and fitted. When a mouse tray was used, it was difficult to determine the adhesion, and thus the whitening effect and taste were evaluated according to the evaluation method described above. As a result, both the whitening effect and the taste were ◎.

<Composition 5>
Polyethylene glycol # 600 52%
1,3-butylene glycol 17.4
Glycerin 17.4
Methyl vinyl ether-maleic anhydride copolymer cross-linked with 1,9-decadiene (manufactured by ISP, STABILEZE QM) 10
Polyvinylpyrrolidone K90 (manufactured by BASF) 2
Sodium hydroxide 0.8
Fragrance 0.1
BHT 0.2
Tocopherol acetate 0.1
Total 100.0%

Example 17
About 5 g of a non-aqueous preparation (composition 6 below) was filled in a silicone rubber mouth tray, chewed and applied to the tooth surface. When a mouse tray was used, it was difficult to determine the adhesion, so the whitening effect and taste were evaluated according to the method described above. As a result, the whitening effect was good and the taste was good.

<Composition 6>
1,3-butylene glycol 60%
Glycerin 25.6
Methyl vinyl ether-maleic anhydride copolymer cross-linked with 1,9-decadiene (manufactured by ISP, STABILEZE QM) 10
Oleic acid 0.5
Xylitol 3
Sodium hydroxide 0.8
Fragrance 0.1
Total 100.0%

Claims (4)

  A non-aqueous composition containing a polyhydric alcohol and a methyl vinyl ether-maleic anhydride copolymer cross-linked by a cross-linking agent, substantially free of water, and a tooth in a state of holding this non-aqueous composition A tooth whitening set comprising an application tool that is detachably mounted.   The tooth whitening set according to claim 1, wherein the non-aqueous composition further contains an inorganic powder.   The tooth whitening set according to claim 1 or 2, wherein the polyhydric alcohol contains one kind selected from polyethylene glycol having an average molecular weight of 190 to 630, 1,3-butylene glycol and glycerin alone or two or more kinds. The application tool is a tape, a sheet, a film, a mouth tray, a mouthpiece, a sponge, an impression material, a pack material, or a tooth cover molded into a dentition made of a water-insoluble material. Tooth whitening set described.