JP2004219276A - Filter for sampling/preserving implement for urine specimen - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a filter for a sampling/preserving apparatus for urine specimens hardly causing clogging and capable of smoothly filtering the urine specimen even when various particulate substances are contained in the urine specimens. <P>SOLUTION: The filter comprises a membrane filter with an asymmetric pore size wherein a filter pore size of a urine specimen inflow side 10a is larger than a filter pore size of a urine specimen outflow side 10b. Specifically, the filter pore size of the urine specimen inflow side 10a is 1-50μm, and the filter pore size of the urine specimen outflow side 10b is made 0.05-0.2μm. <P>COPYRIGHT: (C)2004,JPO&NCIPI

Description

[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to a filtration filter used for a urine sample collection / storage instrument used for collecting and storing a urine sample in a urine test in the field of clinical diagnosis.
[0002]
[Prior art]
A urine test can be measured without imposing a burden on a subject at the time of sample collection, and is therefore widely used in a screening test at an outpatient initial examination and a group test, a daily test for follow-up, and the like.
[0003]
A urine sample collected from a subject is denatured in a relatively short time by endogenous or exogenous bacteria, oxygen, light, and the like, and therefore, it is considered preferable to measure the urine sample within 3 to 4 hours after collection. If a urine sample is to be left for 3-4 hours or more after collection, it must be stored in a closed or refrigerated or frozen state. After storage, the urine sample is returned to room temperature at the time of the test and the measurement is performed.
[0004]
If the urine sample is left as it is in the open air due to endogenous or exogenous bacteria, the bacteria may propagate and the components in the urine sample may change. Furthermore, since there is a component unstable to oxygen and light in the urine sample, accurate measurement may not be possible if the urine sample is left in the open air. In particular, when measuring a large amount of urine sample as in a mass examination, the measurer and the measuring device should be resident and allowed to perform the measurement within a short time, or the urine sample should be kept in a refrigerated or frozen state, and sealed. You may need to make inefficient choices, such as sometimes thawing. In addition, urine samples collected in areas or facilities that do not have measurement means must not only be kept refrigerated or frozen, but also preserved when transported to facilities where measurement is possible. Economic transportation is needed.
[0005]
Therefore, even if the collected urine sample is stored at room temperature for several days, accurate measurement can be performed without changing the components in the urine sample, and the collected urine sample is also refrigerated or frozen at the time of mass screening. The present inventors have invented a device for collecting and storing a urine sample that can be easily transported and inspected without performing the above-mentioned treatment.
[0006]
As shown in FIGS. 7 and 8, the urine sample collection and storage device invented by the present inventors includes a filter holder 22 holding a urine sample filtration filter 21 and a urine sample sealed under reduced pressure by a plug 23. And a sample collection container 24. The filter holder 22 has a space S for holding the filtration filter 21, an outer cylinder 22 a is provided on the upper side of the sample delivery side, and an injection needle 25 communicating with the space S is provided in the outer cylinder 22 a. Further, a sample aspirating tube 26 communicating with the space S is provided at the lower part of the sample taking side. In order to communicate the sample aspirating tube 26 with the space S, the sample aspirating tube 26 is communicated with a communication hole 27a of a lid 27 that seals the space S from below. The collection container 24 can be inserted into the outer cylinder 22a of the filter holder 22 from the stopper 23 side.
[0007]
In such a device for collecting and storing urine specimens, the filtration filter 21 is made of cellulose acetate, polysulfone, or polyethersulfone, which has a low adsorptivity for a test component in urine such as a protein, and has a pore size that does not pass bacteria. It is said that the thickness is preferably 0.05 μm to 0.2 μm so that the sample can be filtered smoothly (see Patent Document 1).
[0008]
[Patent Document 1]
JP-A-2002-311021 (page 2 right column to page 3 left column, FIG.
(Fig. 2)
[0009]
[Problems to be solved by the invention]
In the filtration filter 21 used for the above-mentioned conventional urine sample collection / preservation instrument, the pore size is preferably 0.05 μm to 0.2 μm so that the sample can be filtered smoothly without passing bacteria. Since the filter has the same pore size in the thickness direction of the filter (the direction from the urine sample inflow side to the urine sample outflow side), depending on the type of the urine sample, for example, various patients such as diabetic diseases and the elderly The urine sample and the like contain various particulate substances, and have a problem that clogging is likely to occur and the urine sample cannot be filtered smoothly.
[0010]
Therefore, an object of the present invention is to solve the above-described conventional problems, and even when various particulate substances are contained in a urine sample, it is possible to smoothly filter the urine sample without causing clogging. An object of the present invention is to provide a filtration filter for a device for collecting and storing urine samples which can be obtained.
[0011]
[Means for Solving the Problems]
For this reason, the filtration filter for a urine sample collection / preservation instrument of the present invention comprises a membrane filter having an asymmetric pore size in which the filter pore size on the urine sample inflow side 10a is larger than the filter pore size on the urine sample outflow side 10b.
[0012]
That is, the filtration filter for a urine sample collection / preservation instrument of the present invention has a filter pore size of 1 to 50 μm on the urine sample inflow side 10a and a filter pore size of 0.05 to 0.2 μm on the urine sample outflow side 10b. I have.
[0013]
The urine sample collection / preservation instrument filtration filter according to the present invention includes a urine sample collection / preservation instrument, wherein the urine sample collection / preservation instrument includes a urine sample collection holder 3 having a cover body 2 connected below a container holder 1; A urine sample container 5 sealed under reduced pressure by a stopper 4 is provided. An injection needle 11 communicating with the space S is provided in a cylinder 6 of the container holder 1, and a base 8 of the cover 2 is provided. Is provided below the sample suction pipe 12 communicating with the space S.
[0014]
BEST MODE FOR CARRYING OUT THE INVENTION
Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.
[0015]
First, FIGS. 1 to 3 show a urine sample collecting and preserving instrument using the filtration filter of the present invention, which enables a urine sample to be stored for a long time without denaturation. It comprises a urine sample collection holder 3 to which a filter holder 2 is connected below, and a urine sample collection container 5 hermetically sealed by a plug 4 under reduced pressure.
[0016]
The collection container holder 1 is provided with a cylindrical portion 7 below the cylindrical body 6, and the filter holder 2 is provided with a cylindrical portion 9 above the base 8. The collection container 5 can be inserted into the body 6 from the stopper 4 side.
[0017]
The cylindrical portion 7 and the cylindrical portion 9 are fitted to each other, and the outer periphery of the filter 10 is pressed into the space S formed therein by the force acting by the fitting. It is assumed that the filter 10 is held. That is, in order to fit the tubular portion 7 and the tubular portion 9, the tubular portion 9 is attached to the tubular portion 9 so that the outer peripheral surface of the tubular portion 9 contacts the inner peripheral surface of the tubular portion 7. Is forcibly fitted. Thereby, the cylindrical end 9a of the cylindrical portion 9 presses the outer peripheral portion of the filtration filter 10 so that the filtration filter 10 is held in the space S in a sealed state. Further, an injection needle 11 communicating with the space S is provided in the cylindrical body 6 of the collection container holder 1, and a sample suction tube 12 communicating with the space S is provided below the base 8 of the filter holder 2. It has been provided.
[0018]
Then, as shown in FIG. 4, the filtration filter 10 of the present invention used in the urine sample collection / preservation instrument has a filter pore diameter on the urine sample inflow side 10a (sample suction tube 12 side) and the urine sample outflow side 10b. The membrane filter has an asymmetric pore diameter larger than the filter pore diameter of the (needle 11 side). That is, the filter hole diameter on the urine sample inflow side 10a (sample suction tube 12 side) is 1 to 50 μm, and the filter hole diameter on the urine sample outflow side 10b (injection needle 11 side) is 0.05 to 0.2 μm. The material of the filtration filter 10 is cellulose acetate, polysulfone, polyethersulfone, or the like, which has a low adsorptivity for urine test components such as proteins. Specific examples of such a filter 10 include “Millipore Express Membrane Filter” manufactured by Millipore. The “Millipore Express Membrane Filter” manufactured by Millipore has a material of polyethersulfone and a thickness of 150 to 200 μm.
[0019]
As shown in FIGS. 1 and 3, the urine sample collecting / storing device using the filtration filter of the present invention configured as described above includes a collection container 5 in a cylindrical body 6 of a collection container holder 1 and a plug 4. It is in a state of being inserted from the side to just before the injection needle 11. Then, as shown in FIG. 5, the sample suction tube 12 is immersed in a urine sample collected in a urine collection cup U or the like, and the collection container 5 is further inserted into the cylindrical body 6 of the collection container holder 1, and the plug 4 The injection needle 11 is pierced. Then, the urine sample collected in the urine collection cup U or the like flows into the collection container 5 from the sample suction tube 12 through the filtration filter 10 and is collected by the reduced pressure of the collection container 5 that is sealed under reduced pressure.
[0020]
In this case, the urine sample passes through the filter hole on the urine sample outflow side 10b (the injection needle 11 side) from the filter hole on the urine sample inflow side 10a (the sample suction tube 12 side). Since the diameter of the filter hole on the inflow side 10a is larger than the diameter of the filter hole on the urine sample outflow side 10b, even if various particulate substances contained in the urine sample are captured on the urine sample inflow side 10a, the urine sample inflow side 10a Is hardly closed, a flow path from the urine sample inflow side 10a to the urine sample outflow side 10b is secured, and clogging hardly occurs. Therefore, the urine sample passes through the filtration filter 10 smoothly, and various particulate matter and bacteria contained in the urine sample are removed.
[0021]
Further, as shown in FIG. 6, by removing the collection container 5 from the collection container holder 1 and pulling out the injection needle 11 pierced into the stopper 4, the urine sample is collected and stored in the collection container 5. State.
[0022]
【The invention's effect】
The filtration filter for a urine sample collection / preservation instrument of the present invention is configured as described above, and even if various particle substances are contained in the urine sample, the urine sample is hardly clogged and the urine sample is hardly clogged. It can be filtered smoothly.
[Brief description of the drawings]
FIG. 1 is a perspective view of an instrument for collecting and storing a urine sample using the filtration filter of the present invention.
FIG. 2 is an exploded perspective view of a collection holder of the device for collecting and storing a urine sample using the filtration filter of the present invention shown in FIG.
FIG. 3 is a cross-sectional view of a urine sample collection / preservation instrument using the filtration filter of the present invention shown in FIG.
FIG. 4 is a schematic diagram showing the filter pore size of the filtration filter of the present invention.
FIG. 5 is a perspective view showing a use state of the urine sample collection / preservation instrument using the filtration filter of the present invention shown in FIG. 1;
FIG. 6 is a perspective view showing a use state of the urine sample collecting / preserving instrument using the filtration filter of the present invention shown in FIG. 1;
FIG. 7 is a perspective view of a conventional urine sample collection and storage device using a filtration filter.
FIG. 8 is a cross-sectional view of a conventional urine sample collection and storage device using a filtration filter.
[Explanation of symbols]
DESCRIPTION OF SYMBOLS 1 Container holder 2 Cover body 3 Sampling holder 4 Plug body 5 Container 6 Tube part 8 Base 10 Filtration filter 10a Urine sample inflow side 10b Urine sample outflow side 11 Injection needle 12 Sample suction tube S space

Claims (3)

A filter for collecting and storing urine specimens, comprising a membrane filter having an asymmetric pore diameter in which the filter pore diameter on the urine specimen inflow side (10a) is larger than the filter pore diameter on the urine specimen outflow side (10b). 2. The urine sample collecting / collecting method according to claim 1, wherein the filter pore size on the urine sample inflow side (10a) is 1 to 50 [mu] m, and the filter pore size on the urine sample outflow side (10b) is 0.05 to 0.2 [mu] m. Filtration filter for storage equipment. The urine sample collection and storage device comprises a urine sample collection holder (3) formed by connecting a cover body (2) below a container holder (1), and urine sealed under reduced pressure by a plug (4). A container (5) for the specimen, an injection needle (11) communicating with the space (S) is provided in a cylinder (6) of the container holder (1), and a cover (2). 2. A filtration filter for a urine sample collection and storage device according to claim 1, wherein a sample suction tube (12) communicating with the space (S) is provided below the base (8). .

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