JP2003201208A - Cosmetic composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new and safe melanin formation inhibitor and a cosmetic composition comprising the same. <P>SOLUTION: This melanin formation inhibitor comprises luteolin or its glycoside or a plant extract consisting essentially of the same, especially an extract from one or more species of plants selected from dyer's rocket, Weld (Reseda luteola), white upright mignonette (Reseda alba L.) and common mignonette (Reseda odorata L.) which are plants of the genus Reseda of the family Resedaceae. The cosmetic composition is obtained by formulating the inhibitor. Thereby, the inhibitor and cosmetic composition have the excellent inhibitory actions on the melanin formation and are capable of ameliorating dermal stains and ephelides, ameliorating and bleaching the skin color and imparting gloss and firmness to the skin. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a melanin production inhibitor containing luteolin or a glycoside thereof and a cosmetic composition containing the same. For more details,
Luteolin or its glycosides, or plant extracts containing these as essential elements, especially Dyer's Rocket (Wel)
d), a melanin production inhibitor containing an extract from at least one or more plants selected from Phellinus linteus, and a cosmetic composition containing the same.

[0002]

2. Description of the Related Art The color of human skin is the amount of melanin in the epidermis,
Although blood flow in capillaries, food-derived pigment (carotene), and thickness of stratum corneum are affected, melanin pigment is reported to be the most important factor. So-called liver spots (spots), freckles (freckles), and sunlight-induced pigmentation are markedly enhanced melanin pigment production due to activation of pigment cells in the skin. It is one of the big worries.

This melanin pigment is produced by melanosomes, which are organelles in pigment cells (melanocytes) existing in the basal layer of the epidermis, the root of hair and the outer root sheath. During the process of melanin pigment production, tyrosinase activates tyrosine in the pigment cell (melanocyte) to oxidize tyrosine,
It is converted to dopa and dopaquinone, further auto-oxidized and polymerized via dopachrome and 5,6-dihydroxyindole to finally become melanin pigment. The melanin thus produced is secreted from the dendrites of pigment cells (melanocytes) to the basal cells, the basal cells divide, become spinous cells and rise to reach the stratum corneum. Further, it has been reported that when the melanin is irradiated with ultraviolet rays, the existing melanin is oxidized to temporarily turn black.

[0004] Many reports have been made as a method for preventing or ameliorating the liver spots (spots) on the skin, the freckles of freckles (freckles) and the color black due to pigmentation. Among them, inhibiting the melanin production process and oxidation It is said that it is effective to prevent the melanin from being blackened or to lighten the already formed melanin. Based on this, various whitening components have been conventionally proposed. For example, arbutin, kojic acid or its derivative, ascorbic acid or its derivative,
Tocopherol or its derivative, glutathione, hydrogen peroxide, zinc peroxide, hydroquinone monobenzyl ether, placenta extract, silk extract and plant extract (Arnica, Althea, Aloe, Scutellariae, Gnatgrass, Chamomile, Licorice, Gardenia, Genus Ginger, Sikon , Ginger, birch, senkyu, genocho, psycho, mountain tea flower, toki, pearl quince, elderberry, safflower, garlic, pearl barley, litchi, logwood)
Are known.

[0005]

However, the above-mentioned whitening ingredients are poor in stability and solubility in the cosmetic formulation system, and have an offensive odor and coloration due to precipitation and decomposition, and also have an effect at the biological level. It is not enough, and there are problems with safety such as skin irritation,
I was not satisfied.

[0006]

Means for Solving the Problems As a result of earnest research on the theme of development of a useful whitening ingredient for cosmetics which does not have such drawbacks, the inventors of the present invention have found that the plant of the genus Mothaceae (particularly Dyer's Rocket, Wel
d), Shinobu Mokusoiso, Mokusoiso) extract has a strong inhibitory effect on melanin production, and they have good stability and solubility in cosmetic prescription system, It was confirmed to be extremely safe.

[0007] In the process of further analyzing the active ingredients from these plant extracts, attention was paid to luteolin or luteolin glycosides, which were found to be commonly present, and as a result of examination of their usefulness, Since a strong melanin production inhibitory effect was observed in these, it was presumed to be the main active ingredient of the plant extract. Furthermore, it was confirmed that the action of luteolin or luteolin glycoside was stronger than that of known whitening components.

[0008] Based on the melanin production inhibitory action found in luteolin, luteolin glycosides, or extracts of the plant of the genus Musetia, which contains these, it was applied to a cosmetic composition and evaluated. The present invention provides a highly safe melanin production inhibitor or cosmetic composition capable of confirming the effects of improving freckles, whitening the skin color, and imparting gloss and tension to the skin. Has been completed.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION The luteolin or luteolin glycoside used in the present invention means a compound having a structure represented by the following formula.

[Chemical 1]

These may be chemically synthesized or produced by microorganisms, or may be extracted from natural products such as plants.

[0011] For example, "luteoline" refers to the family Omodaka (Al
ismataceae) Takusha: Alisma plant
ago-aquatica L., Cactaceae (Cactaceae): Ounta ficus-indica (L.) MI
LL., King Ginkgo of the Caprifoliaceae family,
Honeysuckle: Lonicera japonica THUNB., Asteraceae (Comp
Achillea millefoli: Achillea millefoli
um L., Arnica: Arnica montana L., Taragon: Arte
misia dracunculus L. roman chamomile: Chamaemelu
m nobile (L.) ALL., Centriflorum japonicum, Thistle, Thistle, Hleathistle, Holy Tissle: Cnicus benedictus L.,
Thistle, Artichoke: Cynara scolymu
s L., Echinacea, Lycaenium: Echinacea sp
p, lettuce: Lactuca sativa L., chamomile, German chamomile: Matricaria recutita L., cornflower, Santorina: Santolina chamaecyparissus L.,
Salsify: Tragopogon porrifolius L., Mexican Daisy: Tridax procumbens L., Convolvulaceae (Convo
lvulaceae) .: Cuscuta reflexa ROX
B., Dioscoreaceae (Dioscoreaceae), Potatoes: Dioscorea japonica Thunb., Equisetaceae (Equ
isetaceae) Equisetum arvense L., Flacourtiaceae (Euraceae): Hydnocarpu
s wightiana BLUME, Ginkgoaceae Ginkgo: Ginkgo biloba L., Gramineae lemongrass (West): Cymbopogon citratus (DC. ex NE
ES) STAPF, Caryas: Miscanthus tinctorius Hacke
l., rushes of the family Juncaceae: Juncus effusus
L., Labiatae family oysterfish: Glechoma heder
acea L., English Lavender: Lavandula angus
tifolia MILLER, Hoahound White: Marrubium
vulgare L., Mint, Mint: Mentha arvensis var. p
iperascens MALINV. EX LH BAILEY, Spearmint,
Dutch peppermint: Menthaspicata L., peppermint: Me
ntha x piperita subsp. nothosubsp. piperita, apple mint: Mentha x rotundifolia (L.) HUDSON, basil, burdock: Ocimum basilicum L., oregano, Hana mint: Origanum vulgare L., Perilla: Perilla frute
scens (L.) BRITTON, Perilla: Perilla frutescens va
r. japonica, European Tatsunami: Scutellaria galer
iculata L., Rosemary: Rosmarinus officinalis
L., Yakuyou Salvia, Sage: Salvia officinalis
L., Golden Germander: Teucrium polium
L., Thyme: Thymus vulgaris L., Leguminosae (Leguminosa
e) Wild Indigo, Murasakisen Daihagi: Bap
tisia tinctoria R. BR., bloom, crocodile, crocodile: Cytisus scoparius (L.) LINK., Phaseolus vulgaris subsp.va
r. vulgaris, fenugreek, fenugreek: Trigonella fo
enum-graecum L., Flax (Linaceae) flax: Linum u
sitatissimum L., henna of Lythraceae, elephants: Lawsonia inermis L., water lily (Nym
phaeaceae) lotus: Nelumbo nucifera L., Oleaceae olive: Olea europaeasubsp. europa
ea, Passifloraceae (Passifloraceae), Passionflower: Passiflora incarnata L.,
Devil's claw of the sesame family (Pedaliaceae): Harpagophyt
um procumbens (BURCH.) DC. EX MEISN., plantain of the plantain family (Plantaginaceae): Plantago major L.,
Rutaceae lemons: Citrus limon (L.) BU
RMAN f., Scrophulariaceae digitalis: Digitalis lanata EHRH., Purple digitalis: Digitalis purpurea L., Solanaceae Physalis: Physalis alkekingi L., Potato: Solanum tuberosum L. Sterculiacea
e) Cacao: Theobroma cacao L., Ginkgoaceae (T
hymelaeaceae) 's wisteria: Daphne genkwaSIEB & ZU
CC., Umbelliferae Sumaridge, Wild Celery: Apiumgraveolens L., Cumin: Cuminum cyminu
m L., carrot, carrot: Daucus carota L., Dokuserimodoki, white lace flower: Ammi majus L.,
Ashitaba: Angelica keiskei Koidz., Vitac
eae) European grapes: Vitisvinifera L., Panjiri
-ka Pat: Since it is contained in plants such as Anisochilus carnosus WALL., solvent extracts from these plants may be used.

"Luteolin 7 glucoside" is a ginseng of the Araliaceae family (Panax ginseng).
CA MEYER, Achillea millefolium L. from the Compositae family: Achillea millefolium L., Roman chamomile: Chamaemelum nobile (L.) ALL., Echinacea, Echinacea spp, chamomile, German chamomile: Matricaria recutita L.
hus oleraceus L., Dandelion: Taraxacum offi
cinale WEBER EX FH WIGG., Labiatae family mint, horse mint: Mentha longifolia (L.) H
UDS., Greek sage: Salvia triloba L., Cousui mint, Lemon balm: Melissa officinalis L., Mayonara, Marjoram: Origanum majorana L., Rosemary: Rosmarinus officinalis L., Yakuyou Salvia,
Sage: Salvia officinalis L., English wild time: Thymus serpyllum L., Leguminosae (Legumino)
Acacia tortilis (FO)
RSSK.) HAYNE, Redama: Spartium junceum L., Lotus of Nymphaeaceae: Nelumbo nucifera L.,
Cuminum of the Umbelliferae: Cuminum cyminum
L., Dokzelimodoki, White lace flower: Ammi m
ajus L., Inondo, Dill: Anethum graveolens L.,
Italian carrot of Verbenaceae, Chest tree: Vitex agnus-castus L., Jericho Rose: Anastatica hierochunti
Since it is contained in plants such as ca L., an extract from these with a solvent may be used.

The plant extract containing luteolin or luteolin glycoside as an essential component is particularly a plant of the genus Moxiaceae (Dyer's Rock).
It is preferable to use an extract obtained from et. That is, it is a liquid extracted from a plant or extracted with a solvent. Although luteolin or luteolin glycoside is certainly considered as a melanin production inhibitory component, it is more preferable to use them as a plant extract because the effect of the present invention is high.

Incidentally, "Dyer's Rocket (Dyer's Ro
cket) ”,“ Shinobokusou ”,“ Mokusetsu ”
And the genus Risoedaceae (Resedaceae)
eseda), the scientific name of each is Dyer's Rocket (Weld) "Reseda luteola
L. ", White Upright Mignonet
te) “Reseda alba L.”, and Moseseou (Common Mignonette) “Reseda odorata L.”. In addition, there are about 60 species belonging to the same genus, but any species and any hybrid species thereof can be used.

As a solvent for extraction from plants,
Water, alcohols (for example, lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol, 1,3-butylene glycol and glycerin), ketones such as acetone, ethyl ether, dioxane, acetonitrile, Esters such as ethyl acetate and organic solvents such as xylene, benzene and chloroform can be used alone or in any combination of two or more kinds, and can also be used in a state where each solvent extract is combined. .

The extraction method is not particularly limited, but it is usually within the range of the boiling point of the solvent at room temperature and atmospheric pressure, and after extraction, filtration or ion exchange resin is used for adsorption / adsorption.
It may be decolorized and purified to form a solution, paste, gel or powder. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added within a range that does not affect the effect, and as a purification treatment means such as deodorization and decolorization, An activated carbon column or the like may be used, and any ordinary means generally applied depending on the extraction substance may be arbitrarily selected.

In order to obtain luteolin or luteolin glycoside using plants, flowers, spikes, pericarps, fruits, stems,
Any of leaves, branches, foliage, stems, bark, rhizomes, root bark, roots, seeds or whole plants can be used. Moreover, you may utilize what is available as a crude drug.

The melanin production inhibitor according to the present invention contains luteolin or luteolin glycoside in an amount of 0.001% or more,
It may be in any form such as liquid, paste or solid, and the cosmetic composition is preferably adjusted to contain 0.001% to 5% of luteolin or luteolin glycoside.

As the cosmetic composition, 1) topical or systemic skin cleansing agents or skin cosmetics, 2) medicinal and / or cosmetic preparations applied to the scalp and hair, and 3) throwing in a bath water. Bath agent, 4) deodorant / deodorant for human body, 5) mouthwash, mouthwash, mouthwash, etc., 6) skin patch sheet, cosmetic sheet,
Means cosmetic cotton, sanitary goods, sanitary cotton, wet tissues, etc., including ampoules, capsules, powders, granules, solids, solutions, gels, bubbles, emulsions,
A sheet, a mist, a spray agent or the like can be formed into a suitable form for use.

Specifically, lotions, emulsions, creams, ointments, gels, lotions, oils, packs, mists, basic cosmetics such as facial makeup sheets, shaving agents, facial cleansers, skin cleansing agents, shampoos. , Rinse, hair treatment, hairdressing, perm agent, hairnic, hair dye,
Hair cosmetics such as hair growth and hair nourishing agents, foundations, lipsticks, blushers, eye shadows, eye liners, makeup cosmetics such as mascara, perfumes, deodorants for skin, antiperspirants, bath agents, etc.

The melanin production inhibitor and cosmetic composition of the present invention may optionally contain, in addition to the above-mentioned essential components, the components and additives exemplified below within the range not impairing the effects of the present invention. It can be selected and used in combination.

(1) Various oils and fats Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange lafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed Oil, Persic oil, Castor oil, Cottonseed oil, Peanut oil, Turtle oil, Mink oil, Egg yolk oil, Palm oil, Palm kernel oil, Owl, Palm oil, Beef tallow, Lard, Squalene,
Squalane, pristane or hydrogenated products of these oils (hardened oil, etc.), etc.

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, etc.

(3) Mineral oil Liquid paraffin, petrolatum, paraffin, ozokeride, ceresin, microcrystalline wax, etc.

(4) Fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid,
Docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, natural fatty acids such as lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexane Acids, synthetic fatty acids such as isopentanoic acid.

(5) Alcohols ethanol, isopropyl alcohol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, 2-
Hexyldecanol, isostearyl alcohol, 2-octyldodecanol and other synthetic alcohols.

(6) Polyhydric alcohols ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, etc.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound gum arabic, benzoin gum, dammar gum, guaiac butter, Irish moss, karaya gum, tragacanth gum,
Carob gum, quince seed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) with alkylene (C2-C4) oxide such as ethylene oxide added. )
Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose , Carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylates, polyalkylene oxides such as polyethylene oxide and polypropylene oxide Or its cross-linked polymer, carboxyvinyl polymer, polyethylene N'imin like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), Sulfate ester type amphoteric surfactant, Sulfonic acid type amphoteric surfactant, Phosphate ester type amphoteric surfactant, Nonionic surfactant (ether type nonionic Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, other surfactants (natural surfactants) , Protein hydrolyzate derivatives,
Polymer surfactant, surfactant containing titanium / silicon,
Fluorocarbon type surfactant) etc.

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acid,
Nicotinic acid, Pantothenic acid, Biotin, Choline,
Inositols, vitamin C group: vitamin C acid or its derivative, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxosterol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K)
2), menadione (vitamin K3), menadiol (vitamin K4), other, essential fatty acid (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, etc., and their sulfates, phosphates, nitrates, citrates,
Alternatively, amino acid derivatives such as pyrrolidonecarboxylic acid.

(13) Various additives derived from plant- or animal-based raw materials These are processes (for example, crushing, milling, washing, hydrolysis, etc.) which are conventionally carried out depending on the product type and form to be added. Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, powderization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. are selected and combined), and various materials are selected. You can select it and use it.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, the processing to be performed later, etc., but usually, water, methanol, ethanol, propyl alcohol, isopropyl is used. Alcohol, lower alcohol such as butanol, isobutanol or hydrous lower alcohol, polyhydric alcohol such as propylene glycol, 1,3-butylene glycol, glycerin or hydrous polyhydric alcohol, various organic solvents such as acetone, ethyl acetate, etc. It is desirable to use one or a mixture of two or more of them. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol that is easy to remove after extraction may be used and used alone or in any mixed solution with water, or Exploited extract may be used.

Additives derived from plant or animal raw materials are
When it is applied to external or topical preparations for the whole body or topical, it protects the skin and hair, as well as moisturizes, improves texture and texture,
Giving flexibility, reducing irritation, relieving stress caused by fragrance, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing rough skin and improving it, hair growth, hair growth, hair loss prevention, gloss , Cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as warm bath effect, fragrance, deodorant, thickening,
The effects of antiseptic and buffer can be expected.

As a concrete plant (crude drug) used as a raw material,
For example, almonds, ai, blue vines
(Seifufuji), Aoki (Aoki), Aogiri or Kenashiaogiri
(Goji paulownia), Aotsutsurafuji (Kibo), Aotenma, Acacia, Red capsicum (Akasoma), Redcurrant `` fruit '', Red clover, Red grapes, Red amber (Logwood), Red algae (Red bud), Red pine or Red madder or Red madder (Akane) (Grassroots), Akagia jiou or jiou (ground yellow),
Agi (A Wei), Aki Larch, Akinire (Resin), Aguay Gua Su, Aguahe (Omi Tenguyashi), Akebei
(Ki-dori), Asa (Asakojin), Malva Morning Glory or Morning Glory
(Dagushi), Hydrangea (hydrangea), Ashitaba (tomorrow leaf), Azuki (red azuki bean), Asunaro, Acerola, Asenyak (Asenyaku), Athira (Sakuyoukanna), anise, abiu, abiulana, canola, abemaki "fruit" ,Avocado,
Ama, Amacha (sweet tea), Amachatsuru, Amadokoro (Tamatake), Amana (Kokoji), Amaranthus (Hiyu, Hagatetow, Himegateto, Senninkoku, Sugimorigateto,
Hosoaogatetou, Aogatetou, Haribiyu, Aozulan, Amaranthus hippocondriacus), Amigasa lily or Fritillaria (shellfish), Aristromelia (Yurizuisen), Arcana (Arcanna), Algarrobo (Cabbage), Artea, Arnica, Alpinia or Katsumadai
(Souzuku), aloe (蘆 薆), aloe vera, angelica, apricot or hon apricot (apricot kernel), ansokkou (benzoin), yellow sapote, igakoukousrina (geijutsu), sardine or chinensis (indian cabbage), rush
(Wicked grass), Japanese knotweed (Kojo root), yew (first place), strawberry,
Fig (flowerless "fruits and leaves"), figs (first), hibiscus (winter aoi), Ichiyakuso (one medicinal herb), ginkgo (ginkgo biloba "seed, leaves"), Itohimehagi (distant), locust bean, Inunazuna (Taylexi) , Inubiyu (Honagainubiyu), rice "seed, seed coat", inondo "seed", Echinochloa japonica, nettle, ylang-ylang, iwatobacco (Iwabaki),
Iwahiba or Iwamatsu (wind roll), common bean, oolong tea, fennel (incense), wheat (Chibana), ukiyagara (Sanryo), Uguisukagura "fruit", Himeyokiou, turmeric (Yukin), duckweed (Ukiwa), Usubasaishin Or Keirin saishin or Sengoku saishin (spicy), mussels mallow, mung bean mallow, medusa orchid, nemophilus (summer hay), udo or shishido (invigoration, independence, indonesia), unyadegat (unkalia, cat's claw),
Uba Tea, Ume (Ume "seed, fruit pulp"), Vladimir Ogashira, Argentine (Rawberry), Unshu Mikan (Chenhide), Umboku, Estragon, Ezo-kogi (Ezo Goka), Ezo Suzuran, Echinashi (Hosobamurasakibareniku, Echinashi), Enishi Mushrooms), Ebisugusa or Cassia tora (Keiko), El Campre, Elderberry "fruit",
Elemi, Eryngii or Pre-Lotus erynge, Enju (Sophorae, Sophorae rice), Pea, Ougi or Kibanana
(Yellow radish), Naruco lily or Kagi Kurumabanaruko Yuri (Yellow), Ohihisasanoyuki or Sasanoyuki, Ouren (Yellow), Ogata Houken, Ookarasuri (Calocon),
Plantain (Civil engineering incense), Giant tsuboji (Self-defense), Plantain
(Carmaco, Carophyllum), Milk thistle (Yuzhou Leopard, Bald Ear), Toucan Hazel (Haruko), Toucan Cactus, Obana Ochera or Ochera (White Sprout), Obana Sarsberg (Banaba), Ooba Yashaboshi "Fruit", "Fruit" Grains), Oomiacatetsu, Omihawthorn or Hawthorn
(Yamashiko), Omiyashi, Barley (barley), Oka, Okazeri (Heiwako), Okra "fruit", Oguruma (overturning), Oklurihigotai (Banzhou Leopard, Indigo Spin), Panax ginseng or Panax ginseng (carrot) , Hypericum perforatum or Hypericum perforatum or Hypericum perforatum (younger brother cut grass), Odorikosou (intermittent), Onami (blue ears), Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninogagara
(Tianma), Oniyuri or Sasayuri or Hakatayuri (yuri),
Onoelan, Ononis, halibut, Ominaeshi
(Soy sauce), Oyuco, Dutch mustard (cresson), Dutch jelly, Dutch millet, Dutch honeywort, olive "fruit, seed, leaf", oregano, orange "fruit, peel",
Kaikaizou (ripe ground yellow), cacao "fruit, peel, seed", oyster (persimmon "leaf"), oyster vine (fishing hook), oyster or citrus root (rensenzo), oyster, hydrangea, cassia, casino ki ( (Fruit `` fruit ''), banyan tree (pepper), oak (camellia tree, camellia leaf), cascarilla, cascara sagrada, gypsophila, kasenso, cypress (Kinshato), kaniwa, carnation, valerian root, hippo,
Birch or weeping birch (white birch), gerbera, pumpkin, kapok cypress `` seed '', kahokusansho (shusho),
Cattail, chamomile or Roman chamomile, chamomile
(Grazing), cam cam (duck), karagwa or yamawawa
(Mulberry), color, calyx salmon, crow cucumber or cinnamon cucumber (royal gourd), crow bishaku (half summer), oats, guarana "seed", callahoo (bamboo), karaya, garyu, karin (wood melon), garcinia, kawamidori, kawarasaiko (Koryo greens, white grass), kawajisha, kawaratake, kawaranadeshiko (ishitake) or ezokawaranadeshiko (green oats, barley barley), kawaran carrots (blue lacquer), kawara mugwort (茵 蒿), kansui (sweet potato), kanzo (kanzo). Licorice), cantara, candelilla, canto, canna, kanran, raspberry (ezo strawberry, dutch strawberry, shrimp strawberry, nawashiro strawberry, maple strawberry, european raspberry), kiwi `` fruit, leaves '', citrus cucumber (melon root), kyokyo (kikyo, bellflower) Root), chrysanthemum (chrysanthemum, chrysanthemum, chrysanthemum), chrysanthemum, cowpea (Azusa), chrysanthemum Kishi (Yotei), Kizitsu (Kurimi), Kizuta, Kidachi Aloe, Kidachi mint, Kina, Kinaki (Shincona, Red quinine), Quinoa (Quinoa), Kihada (Yellow Hashi), Kimame, Gymnema sylvesta, Kimenkaku, cabbage, cabbage ",
Caraway, cucumber, gyoryu (Nishikawayanagi, Teiyanagi), Kiraja Saponaria, Kiraya, Kiransu (Kenshi small grass), kumquat "fruit", kinkju, ginsekkai,
Kinbusen, betel, agrimony (Sentsurukusa), Brocade, Ginran, cymbidium floribundum, Guapeba-Vermelha, guava "fruit", Guayure, Kuerukusu-Infekutoria (Gallic), kukui nut, Kugenumaran, wolfberry (wolfberry Kukoko wolfberry leaves, ground (Bone skin), Xanthus chinensis (Tenmon winter), Kudzu (Kudzu root), Camphor tree, Gooseberry "fruit", Xing carrot (yellow flower), Kutiti river,
Gardenia (Yamashiko), Kunugi (Kusou), Kupuasu, Kubeba, Kumazasa, Bear vine (Clown grass), Clara (Buffalo), Cranberry "fruit", chestnut "seed, fruit, astringent skin", Curculigo latifolia "fruit", Grapefruit "Fruits / Leaves", buckthorn, black hemlock (necessity of rescue), turtle-buckthorn or black-buckthorn broom or bunch
(Enmeisou), cloves (cloves, cloves), gumbai nazuna (sekimei, sekimeishi), keikai (mature stalks, sage ears), keito (cow flowers, cob crows), geckavidin, bay leaves
(Laurel), Kenashisarutoriibara (Tori 苯 苓, mountain return), Gentiana, Gennoshoko (Old bird grass), Kemponashi (Kygushi), Koukisekekoku, Kishikankan (Koji, Tachibana, Obenimikan, Fukulemican, Sagamisanta, Ponkan) ), Kousimbara (Monthly flower), Kousui mint, Kozo `` fruit '', Kocha (black tea), Kouhone (river bone), Kouhon (Straw book, Karamoto book), Kouryan, Koryokyo (Takagura), Koendro `` fruit '', Coptis chinensis (huhuangren), Scutellaria (yellow gon), cowberry (Koshitachi)
Coconut “fruit”, goshuyu (gome mushrooms), gosho strawberry
(Okubonko), pepper (pepper), cosmos, copaiba balsam, coffee `` seed, leaves '', kobushi or magnolia (spicy), burdock (burdock, burdock root), kobotsudura, sesame (sesame), sesame noha (genus), Garlic (Gomiza), rapeseed or vine, or wheatgrass, wheat (wheat), rice or rice bran "Aka bran, Shiranuka", rice oil, cola acuminata "seed", cola vera "seed", colonyella, fenugreek "fruit", Colombo, Conzurango, kelp, konjac, konfuri (final grass), sisal (sisal),
Rhinoceros orchid, Sakaneran (Ezosakaneran), Saxima button crane or Shina button crane or Cinnamon vine
(Gaisen), Sakura (Oshima Sakura, Yama Sakura, Oyama Sakura, Ed Higashi, Mame Sakura, Miyama Sakura,
Somei Yoshino, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura "leaf, flower, fruit, bark (cherry bark)"), cherry, pomegranate, sasa, sasabaginran,
Sasanqua, Sageomodaka (Sawataki), Sweet potato, Sugar cane, Sugar beet, Sanebuta jujube (Natsumejin), Saffron (Banffi, West safflower), Sapodilla, Zapotea mario, Pomelo "fruits", Saponsau, Salmon berry "fruits", Saladina Hemp), salancito (sand indigo stab), salvia (sage), scallion (mountain spinach), sour walnut (mountain walnut), sanctum cactus, sangre de grad (croton), anemone camphorum, anemone carrot (three seven carrots) , Sanshuyu (Yamatake), Sansho (Yamasho), Sandscon (Yamame root), Shea (Karite), Cyanoki "fruit", Shiitake (Shiitake), Zion (Shien), Shikakumame, Dixalis,
Shikunshi (Koshikuniko), Perilla or Aojiso or Chirimendiso or Catamendiso (Shiso leaf, Shisoko), Rosewood, linden, Shina honoki, Shinarengyo (Long-termed), Shimeji (Hinjimeji, Shakashimeji, Hatakeshimeji, Bushimejita, Bushimejita, Bushimejita, Bushimejita, Bushimejita, Beechashita ), Magnolia (spicy), spirea, potato, peony
(Peony root), Shajin (Shasan), Jasmine (Matsuryuka), Janohige (Mugimon winter), Juroku cowpea, Syringa paniculata, Shukshamitsu (Sandhi, Crushed sand), Juzdama, Shiro "fruits", Shunran, Dauca palm ,Ginger
(Ginger), hydrangea (tsuneyama), shobu (iris,
Iris root), shozuku "fruit", white oak "seed", silane (butterfly), white-breasted butterfly "seed", white clover (clover), white azuki (chicken bone grass), white squirrel (smell iris), white clover "flowers", white lupine, Shirominanten (Nami Tenmi), Shinkona Sakushibura, Jinchoge (Mizuka, Zuihika, Shichohana), Cinnamon, Cinnamomum cassia (cinnamon), Watermelon (watermelon),
Honeysuckle (gold and silver flower, Shinobi winter), sorrel (acidic), swimberry “fruit”, star apple, stevia, strawberry “fruit”, Suzuko (Lord Xu), horsetail (question), purslane (horse toothpaste, horse toothbrush). ), Plum "fruit", Surugaran (Oran), Pinus sylvestris "cone", Japanese larch, European Ivy, gulmi, hawthorn, hazelnut, dandelion, horse chestnut (marronii), pear "fruit", natsukiyu Kisou, Sambucus nigra (Elder), Nezu (Juniper, Juniper), Achillea millefolium (Milfoil), Rose of rose, Steller's fowl,
Mistletoe, European Mint or Western Mint, Horseradish, Sekisho (Ishikon), Ginkgo
(Sakura Sekkoku, Kouki Sekkoku, Oobanashi Sekkoku, Okinawa Sekkoku, Hong Sekkoku, Kocho Sekokoku, Shikaku Sekkoku, Kibanano Sekokoku) (Dendrobium, Ishibana), Cedron (Boushuubokku), Zeniaoi,
Hiroha Senega, Senega, Celery, Celery, Senkyu (River Kyu), Senshinren (Shinren), Sendan, Sennin Cactus, Senna "Fruits, Leaves", Senninsou (Taiso),
Senburi (this drug), Senboku, Souka (grass fruit), Elephants, soybean rootweed, buckwheat "seed seed", some potatoes, broad bean, rhubarb (daikon), radish, soybean, daidai (orange peel, currant fruit), takasago rorihigotai (south indigo) (Stab), Takasaburo (Lotus lotus), Takatodai (Ojaku), Takawarabi
(Inui), dark sweet cherry "fruit", hollyhock, pearl oyster (thyme, Hyorika), tachidokoro
(Haikai), Tachiyanagi, Tamarind "seed", onion, tamshiba (spicy), Taranoki "fruit, leaf, root bark", Tarayou (Obayu winter blue, single-leaf tea, chincho tea, dacha tea), dahlia
(Tenjiku Button), Tarwi, Tankirimame, Tanchiuchiwa, Tanjin (Ginseng), Dandelion (Ganko Hide) or Shirobana Dandelion or Moco Dandelion, Danmal, Cherry "fruit", Chigaya "fruit, root, sprout", Chixetsu ginseng (Bamboo ginseng) , Chicory, chanka piedra (traditional citrus), tulip, choconostay, artichoke (artichoke), ginseng (large yellow), ginseng (garden), ginseng (spiny leaves), choreimaitake (boiled boar), chologi. , Tsukisou, Tsukushimakaneran, Tsukuritake (mushroom), Tsuchiakebi, camellia, Centella asiatica, Clover (lacquer grass), Tsuyukusa (duckweed grass), Tsuzuki Azuki (red adzuki bean), Tsurutsuchia vine, Tsukudami (Japanese sardine), Apricot (Apricot), Tsuruna, Tsuna (Yoshiba ginseng),
Glycine soja, Tsuwabuki, Deiko, Walnut, Duberry "Fruit", Amaranthus, Tencha (green tea), Tendaiyaku (crow), Pepper (winter gourd), Pine vine, Capsicum (Pancho), Pepper (attributable), Pimples (spotted) Marigold), Gleditsia sinensis, Touna Bena (river cutting), corn or corn hair (nanban hair), squirrel mochi (sadako), gentian or gentian (dragon gall), horsetail (tree bandit), dokudami (ten drug), turmeric (conger) Roots), Toshishi or Mamedaoshi or Nenshikazura, Eucommia (Dunaka "bark, leaves, roots"), Ash (Hata peel), tomatoes, tragacanth, Triacanthus "seed", Eustoma grandiflorum, Tormentilla, Dronoki, Torohoaoi, Tonro beans, Nigeria berry "Fruit", Chinese yam or yam (mountain pot),
Nagiikada (Butcher Bloom), Naginata Koju,
Nazuna, rapeseed, peanut or mane (sword bean), natsumikan, jujube (Oju), Naniwaibara (Kinsakurako), navena
(Interruption), nameko, peanut (peanut), nanten (southern nut), nanbankaramushi (chima), iooi violet, nigaki (sorrow), nigga wormwood (bitterness), nutmeg, kei or nikkei or ceylon nikkei or yab nikkei ( Cinnamon) or Keishi (Keishi), Nyoko-duck, Chinese chive (Nishi), elderberry
(Grafting tree `` fruit, flower, stem, leaf ''), garlic (large garlic), nullde (quintet), leek, alveolum or nebu or nebi or nemlinoki or digobana (enjoyment), thistle (daikon), noira (no fruit), Nostoc vine (Ryohaku), Nogate, Yarrow, Nodake (Phuket), Novara, Nomomo, Pineapple "fruit", Hibiscus (Bussouge, Fuurin Bussouge, Roselle), Hyelindo, Hachiwa, Pau
Doce, Hakamaurabosi (Bone fracture), Hakukayutomu, Chinese cabbage, Chinese cabbage (Ringworm skin), Hakuruberry "fruit", Hakobe (Historical), Hazel (Haruko), Hasiridokoro
(Roth root), basil, lotus (lotus, lotus meat, lotus root), parsley
(Netherlands jelly), hadakamugi, batata, bee weed, or bamboo shoots (boiled bamboo), patchouli, mint (light load, light load leaf), hassho beans, pearl barley (Yokuinin), hanasuge (knowledge mother), banana, hanahakka, hanabishi (shitsuri, shitsuri) , Vanilla vins, papayas, yellow squirrels (mouse koji), pahalobobo, hub "whole grass, stems, leaves", paprika, stilts,
Hamago or Mitsuba Hamago (vine vine), Hamasuge (Kafuzi), Hamabishi (Shitsuriko), Hamanasu (maikai flower), Hamaboufu (hama windbreak), Hamamelis, palm, rose (rose), balata, balata, aratake mushroom,
White-bellied agaric, Usukimorinokasa), Haran, Pariurus (Rhododendron japonicum), Parietaria, Harkanran, Balsamina (Tsurureishi, Nigauri), Harunire
(Insect skin, Elm skin, Insect leaf), Barbasco, Harlindo, Handaikai (Katsu Omi), Panoki, Hyogi (Hikari), Pea nuts, Carrots
(Gypsum, Liu Singh), Higulmadaria, Higotai, Hishi
(Hishimi), pistachio, beet, tsutsumi (Ishidashi), hibiscus edulis, daisies (daisies), Hinako no Kozuchi
(Cow knee), Hydrangea cypress, cypress, hiba, castor, sunflower, bell pepper, Himeuzu (Aoi), himemagama (garlic), Himematsutake (Kawariharatake, Hiromatsutake), Himemuyoran, Pimenta "fruits", juniper, Japanese juniper, Japanese juniper "Fruit", chickpeas, lentils, biloba mallow,
Broadbrush (Bald-headed), loquat "fruit, leaf, stem", betel nut (daiskin skin, calyx), Pu'er tea (Fu-cha), Futokazura (nantan), butterbur, butterbur dandelion (submarine winter flower, subordinate winter leaf), Wisteria mackerel (Orchid grass), Wisteria bean (Foliar beans), Wisteria
(Chrysanthemum cherry, Fuyuhana), grape "fruit, peel, seed,
Leaves, Beech, Fuyusuminatsutake (Coleoptera: Cordyceps), Brazilian licorice, Brazilian carrot, Brazilian palm, Brazilian elephant palm, Black currant "Fruits", Blackberries, Branjen, Plums "Fruits", Frucellaria, Blueberries Cypress), prune, floral blanka, blond psyllium, bundou (mung bean), hazelnut, loofah, hetkaran, safflower
(Safflower), Henneken, Belladonna, Berry “fruit”, Persear, Perbianberg, Pereschia grandifolia, Benchisou or Duckweed (Keiten), Boysenberry “fruit”, Broomwood or Eldera or Nendou or Hakidoki kokia (ground silkworm) ), Hosairan, Haoutenga
(Fengxian, acute child, skeleton grass), Pouteria sapota, Pouteria lucuma, honoki, spinach, physalis (Torone), honoki (Japanese thicket, magnolia), bokeh (wood melon), hollyhock (Bokuyoku), hosoba Ogura, Hosobana okera
(Sosou), Rhododendron japonicum (Keiten Sanchi), Rhododendron japonicum, Bodaiju (Bodhi tree), Button (peony `` flower, leaf,
Stem, bark "), button pie (peony skin), hop, jojoba, bourgei (Ruricha), Bordeaux, white berry" fruit ", Hongonik (Meat Juyo, Daiei), Hongsekoku (Sekiseki Suzu, Suzuyama Ishihasu) , Maizuru Tennan Show (Tiannansei), Maitake (Maitake), Maou (Mako), Maca, Macadamia nuts, Margaret (Mokshungiku), Makuri (Seagrass), Magwa (Mulberry bark "bark, leaf"), Magnolia・ Sprengheri, Masarunzuba, Masalanzuuba de Ceara, Masheira de Boi, Mashua (Tamanouzenhallen, Kyukonkinrenka), Matatabi (Matsukasa), Matsukasa, pine "leaf, bark, root", Matta Orho, Matsuhodo (boiled peony), Matico (Cordon sillo), Mayoram (Hanajaca), Marvanojazin (Ginseng), Mulberry "fruit", quince, Malein (Bilroadmou) Zuica), mango, mangosteen, mansagna (Andes chamomile), manshugurumi, mandarin "fruit",
Ganoderma lucidum (Ganoderma lucidum), Pheasant (Gourmet `` Fruit ''), Mishima Psycho (Saiko), Water plantain or Water morning glory (Rhinoglossus),
Mizokukushi (Half-sided lotus), Misohagi (Senkyaku), Michiyanagi or Niwayanagi (Henji), Mitsugashiwa, Mitsuba, Midori Zapote, Midorihakka, Mimosa, Myoga, Miracle Fruit "fruits", Myrrh, Myrobalan, Mugiwaragiku, Mukuge , Mukunoki, Mukuroji (prolonged skin), Munya, purple (purple root), purple syrup or purple syrup
(Purple), purple corn, purple fuji (Kunmei chicken blood wisteria), megakansa opuntica, swordfish (prosperous herb), mebourgi, evening primrose (evening primrose), melaloca, melissa, melilote, melon "fruit", sorghum, moss worm, mokurin. , Moje (pepper), holly, mokko (wood incense), maple,
Peach (peaches "leaves, seeds, flowers, fruits"), bean sprouts, morelo cherry "fruits", Moroheiya (burlap), Yakuwamurasaki yam, Yakuchi (Machi), cornflower (cornflower), cornflower, yakon, yashabushi ( Yarrow) or Himeyashabushi or Oyabayashabushi "fruit, fruit skin, fruit ear", willow willow, stinking (octagonal metal plate), mistletoe (willow parasite), willow (cow willow, weeping willow, willowia unagi, willow unagi, willow unagi, willow tree, willow tree, willow tree, willow tree, willow , Miyayanagi, palm, yamayanagi, willow, willow, willow, willow), willow tree "leaves, stems", yabs, yabukoji (purple gold beef), yab tobacco (crane, Tenmeisei),
Pokeweed (Shokuryoku), Yamanoki (Yamaharu), bayberry (Yangume skin), wormwood, eucalyptus, Yukinoshita (tiger ear grass),
Yucca or flavifolia, yuzu "fruit", lily, yellow dragonfly, mugwort (mage leaf), rygan (thunder circle), lime "fruit", rye, lakanka "fruit", raspberry "leaf,"
`` Fruits '', Latania (Clameria), Rakkyo or Shallot (white meat), Lavender, Longan (dragon eye meat), Agave (Aonoguretsuran, Fukurin agave), Ryoccha (green tea), Apple "fruit, seeds,"
Leaves, roots ", gentian, rubus or Suabisimus,
Ruritama thistle (Vladivostigo, Shinji indigo stab), litchi (lichi, lichi kernel), lettuce (chisha), red currant `` fruit '', red pitaya, lemon `` fruit '', lemongrass, forsythia or chinese forsythia (consecutive), Astragalus, Rhizoma, Rumeshi, Locon (Reed, Rhizome),
Logan berry "fruit", rosemary (mannen wax), rose hips (novara), wasabi, cotton wisteria
(Dimenghua), Waremoko (earthen worm), etc.

As the seaweeds, there are seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, aonori (usubaaonori, sujiaonori, hiraaonori, bouaonori, hosoedaonori), anaosaa (sea algae), Kind: kelp (Macombus, liquorice, Hosomekonbu, Mitsuishikonbu), wakame, hirome, aowakame, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitrus ruetokeana), hijiki, hibamata, sea uchiwa, usubaumiu Kirebanoumiuchi, Akabatumiuchi, Konaumiuchiwa, Okuchiuchiwa, Usuyukiuchiwa, Echiukiumiuchiwa], Seaweed [Red algae: Hijirimen, Hakusa, Hirakusa, Onik , Obakusa, Kataobakusa,
Yatabegusa, Yukigiri, Amanita, Tosakanori, Togekirinsai, Amaxakirinsai, Giraffe, Jakushinkirinsai, Tsunomata, Obatatsunomata, Tochaka (Nyakuzuna-no-Tomashita), Ezotsunomatsuta, Togenomata, Hirasakonotoma, Kotobuki, Kotobuki, Kotobushi
[Yaleus Banori, Kagious Banori, Suzius Banori, Haius Banori, Akamomijinori] and the like.

Further, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Qualmomim: Quanonimo, Volvox: Ohigewawari, Volbox, Palmera, Yotsumeu, Genus Aomizu: Hizaori, Ao midori, Genus Tsurugimido, Genus Himidoro: Hibimidoro, Genus Aosa: Anaaosa, Amiosa, Nagaaosa, Kawanori: Kawanori,
Fruicula genus, Shiogusa genus: Oenothera genus, Asamidoriushigusa, Kawashiogusa, Marimo, Baronia genus: Tamagobalonia, Tamabaronia, Magatagum genus: Magata, Iwachia genus: Fusaiwaduta, Black squirrel, Mildewer, Black millet, Nematoda, Hagemonia, Nematoda. Sakibutimir, Nagamir, Hiramiru, and Kasanori:
Casanori, genus genus: Futozuzumo, Tamazuzumo,
(Mizujuzumo, Mikadzuki genus, Colecaete genus, Tsudumimo genus, Kikkokusa genus: Kikkokusa, Astragalus genus: Hitogusa, Hirohanohitohegusa, Usutoegusa, Motukihitoe, Sayamidoro, etc.

Cyanobacteria (genus Suizenjinori: genus Suizenjinori, genus Water-bloom, genus Nostoc: Kawatake, Nostoc commune,
Hassai, genus Yuremo, racenmo (spirulina) genus: spirulina, trichodesmium (aiacacio), etc.).

Brown algae (Pyraera: Pyraela, Shiomidoro: Nagamisio Midoro, Isogrape: Isogrape,
Genus Isogawara: Isogawara, Kurogashira: Gunsen Kurogashira, Kasakizaki: Kazakizaki, Muchimo: Muchimo, Hiramuchimo, Keperigusa, Astragalus: Astragalus, Sakibirohajiza, Sanyuhajihadosa, Azagusa saga: Common sage: Common clover, Common clover Prickly squirrel, Ulaboshihaha, Symphalida: Symphologus, Cyperus genus: Cyperus cypress, Konaumi uchiwa, Akabayumi uchiwa, Namikura genus: Prunus chinensis, Somexaceae genus: Somenaceae
Pinus genus: Matsumo, Nagamatsu genus: Nagamatsu moth, Okinawa mozuku genus: Okinawa mozuku, Niceft mozuku genus: Physcomit genus, Physmozuku genus: Physcomitum genus: Genus mosquito: Genus mosquito: Genus moss, Genus moss Isige, Iroro, Ichimegasa: Ichimegasa, Calligraphy: Calli, Umibosu: Umibosu, Urushigusa: Urushigusa,
Black cypress, Tobacco bug, Genus: Haemorium, Haberdoki: Haberodoki, Havanori: Havanori, Habernori: Hazelnut, Common genus: Common butterbur, Ezoburo genus: Nematode: Nephila, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Pleurotus vulgaris Genus Kagomenori: genus Kagomenori, genus Muralis: murachidori, genus Phalaenopsis: shark
Sardine: Sardine, Asclepias: Asclepias, Kayamonori: Kayamonori, Fennel genus: Fennel, Tsurumo: Tsurumo, Anata: Squirrel, Susume: Aedes albopictus, Missus konjac, Miscanthus, Aedes radisculent, konjac beetle, konjac beetle, scutella conserved , Onikonbu, Goheikonbu, Nagakombu, Pea kombi, Otojijimokubu, Tororokonbu genus: Tororocombu, Antocume: Antokume, Kajime: Kajime, Tsuruarame, Kurume, Chrysanthemum genus: Chrysanthemum genus: Necrochamus genus, Black konjac genus, Black locust, Black civet, : Catfish,
Genus Alame: Alame, Ainu Wakame, Ainu Wakame, Chigaiso, Oniwaka Ezo Ishige: Ezo Ishige, Yabanemoku: Yabanemoku, Rappamok: Rappamok, Jolomok: Ugananomoku, Jolomok, Hiemoku, Honduramaku, Isamanidae, Tamanashira Akamoku, Shidamok, Hondawara, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yasumatamok, Umitranano, Obamamok, Fushizushimok, Hahamok, Togemoku, Yoremoku, Sugimurakoku, Sugimurakoku, Sugimurakoku, Sugimoku, Sugimoku, Sugimoku
Burukkimo, genus Kayamonori: Kayamonori, etc.).

Red algae (genus: Kensuke Nori, Funori Nousuke, genus Noriophyra: Asakusanori, Susabinori,
Upruinori, Onia manori, Tasa, Fuiritha, Benitasa, Rhodocorton: Milnobeni, Akebono Mozuku: Akebono Mozuku, Konahada genus: Hikonahada, Yogorekonahazukuni Azukuniboku, Azusa konjac, Azusa konjac, Azurus chinensis, Azurus chinensis, Azulina serrata, Azurus serrata, Scorpionaceae. : Pine pine, Fusanori genus: Fusanori, False genus: False genus,
Genus Sodegari: Sodegarami, Rattle Genus: Rattle, Rattle, Hilotatamaidae: Hirohatamai Taki, Tamai Taki: Tamai Tadaki, Kagenokiri: Kagaminori, Kaburi, Hibachi, Hibachi, Hibachi, Hibachi, Hitenagao, Hitengusa, Hitenagasa, Hitenagasa, Hitenagai Genus: Hihibiroud, Hibihibiroud,
Pteridophytes: Pleurotus, Pleurotus: Pleurotus: Rumex, Ryumonsou: Ryumonsou, Hera Ryumon, Nymphalaceae: Nisekarekigusa: Okitsubara genus: Psyllium syllabus: Acacia
Naminohana, Coral Spodoptera: Rattlefish, Shiogusagoromo: Shiogusagoromo, Ivanoka genus: Etsukiiwanokawa, Kainokawa: Kainokawa, Kanitonote: Kaninote, Corydalis, Dendrobium, Scutellaria, Dioscorea, Rhizophorus, Scutellaria, Saccharomyces , Tambanori, slippery,
Fudaraku, Maruba Hudarak, Isonohana: Nurakusa,
Black knuckle, Ginkgo biloba, Japanese quince: Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese pine tree, Japanese pine tree Nagaobane genus: Nagaobane,
Genus: Hanafunori, Fukurofunori, Mafunori, Kaligukisa: Pachydermia japonicum, Podocarpus genus: Hosobanotokaomodoki, Hirohanotosakadoki, Yatsudegatatokadoki, Kurotosakatodoki, Katodoki, Katodoki, Katodoki, Katodoki Doki,
Himetosakadoki, Kinuhada genus: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honoo: Honoo, Hichinagenasu, Nihonbunio, Nihonburonoo Pleurotus cornucopia, Okamuragusa:
Yamadagusa, Mirin: Mirin, Hosobamirin, Tosakanori: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomokka, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kadikio Nori, Phytophthora alba Spodoptera litura, genus Astragalus: Astragalus,
Genus Ogonori: Ogonori, Cranegrass, Shiramo, Ozonori, Mizookonori, Cabana Nori, Beniogonori, Fukuroshinonori, Muranosakinogoonori, Scorpionaceae, Scutellariae, Scorpionoris , Amanita genus: Nectaria vulgaris, Fushiklenori genus: Fushiklenori, Namibia genus: Pleurotus cornucopiae, Cyprinidae: Pleurotus genus, Periwinkle genus: Periwinkle, Prunus genus: Pleurotus genus: Simi, Hedgehog, Lotus japonicus
Lotus japonicus, Scutellaria: squid reeds,
Novonori, Black-headed genus: Black-headed ginsou, Red-headed genus: Red-headed ginsou, Rhizoma genus: Hishibukuro, Madaragusa: Scutellaria, Etsukimadara, Taogo-nagien: Taogosou, Hanasakura, Haduna, sugi , Hiratao goat genus: Hiratao goat, dalus genus: dalus, scorpionfish, anadalus, weebagsa genus: weebagsa, benifukuronori genus: benifukuronori, fushuna genus: fushunagi, himefusutsunagi,
Broadbill, Salix genus: Spodoptera cinerea, Usbawa vulgaris, squid genus: squid, caygis, squid squid, haneigis, axusa, egonori:
Egonori, Futogigis, Saeda: Saeda, Chirimomimushi: Chirimomiji, Konohanori family: Hatabenoori, Konohanori, Suzuronori, Usubini: Usbeni, Hasugiginu: Hasujiginu, Nagausaginohagi, Hausaginohagi, Hausaginohaji, Niusakonohaji, sugi-nosagi, sugi, sugi Yaleus Banori, Suzius Banori, Haius Banori, Usbanorimodoki: Usbanorimodoki, Ayanishiki: Ayanishiki, Agianu:
Ayaginu, Dasia genus: Enashidasia, Shimadsia genus: Isohagi, Shimadaia, Dagimodi: Dagimodoki, Itogusa: Moroitogusa, Futoigusa, Makuri: Makuri, Yanaginori genus: Hana-yanagia, sagiyunayunayunayunayunayunayunayunabenyi, benna : Crosozo, Cobosozo, Hanesoso, Sozonohana, Amaranthus: Ranunculaceae, Raponica, Cozanemo: Cozanemo, Imurasaki, Hosocozanemo, Genus: Mesothraceae, Black-spotted dragonfly, Anemoneaceae, Anemoneaceae, Anemoneaceae, Anemoneaceae, Angustiaceae, Angustiaceae, Angustiformes Astragalus, Rhizophora: Rhizopus, Fujimatsumo: Fujimatsumo, Sawtooth genus: Toothbrush Mushrooms, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome genus: Ideyukogome, Ochiimozuku genus: Ochiimozuku, Otomogusa, Chichinorimo: Chinorimo, Chisujinori: Chisujinori and the like).

Algae (genus Chara, genus Citra,
The genus Rhizopus: Rhizophyllum, the genus Lichnotamnus, the genus Flamus: Himaflamus, Chaboflamus, Tripera, etc.), the yellow algae (Genus Hikarimo: Hikarimo, etc.), etc.

Materials derived from animal-derived materials include poultry extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or decomposed product thereof, cow or pig. Brain tissue extract, hydrolyzed collagen hydrolyzate (acid, alkali, enzyme, etc.) of cattle, pigs or fish, collagen derivative such as water-soluble collagen or acylated collagen, elastin of cattle or pigs or elastin hydrolyzate (acid , Alkali, enzyme, etc.) or water-soluble elastin derivative, keratin and its degradation product or their derivatives, silk protein and its degradation product or their derivatives, pig or bovine blood cell protein degradation product (globin peptide), to cow or pig Degradation products of hemoglobin (hemin, hematin, heme, protoheme, heme iron, etc.),
Milk, casein and its degradation products or their derivatives, skim milk powder and its degradation products or their derivatives, lactoferrin or its degradation products, chicken egg components, fish meat degradation products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid), etc.

As a material derived from a plant or animal material, any site derived from a gene recombinant or a cell fusion,
Cells, tissues, organs, metabolites, etc. can also be used.
Furthermore, for example, an undifferentiated cell group, a cell group in the process of differentiation, or the like obtained by culturing an arbitrary site, cell, tissue, organ or the like can be used.

(14) Marine components Seawater such as deep water, for example, seawater salt, seawater dried matter, inorganic salts (sodium chloride, magnesium chloride, potassium chloride, etc.) obtained from the Dead Sea or the Atlantic Ocean or the Pacific Ocean, sea mud Or mud (fango), for example, sea mud or mud of various places such as Italian fango, German fango, Eifelfango, and Freiburgfango (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, Potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), Seitoku stone, Kurodaite, etc.

(15) Microorganism culture metabolite Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, Fermented rice extract,
Fermented rice bran (red bran, white bran) extract, euglena extract or its decomposition product or water-soluble derivative thereof, trehalose or its derivative, lactic acid fermented product of raw milk or skim milk powder, fermented product of lactic acid bacterium of legumes, lactic acid bacterium of coconut plant Fermented material, etc.

(16) α-hydroxy acids Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.

(17) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, Gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(18) Ultraviolet absorbing / blocking agent Benzophenone derivative (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), para-aminobenzoic acid derivative ( Paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc., methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate,
Octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, mono-2-diparamethoxycinnamate
Glyceryl ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate,
Ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline Derivative, pyrimidine derivative,
Dioxane derivative, camphor derivative, furan derivative,
Pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative, umbelliferone, esculin, benzyl cinnamate, cinoxate, oxybenzone, dioxybenzone, octabenzone, thrisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, Baicalein, berberine, neoheliopan, escarol, zinc oxide,
Talc, kaolin, etc.

(19) Whitening agent Para-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, pyrone derivative,
Nucleic acid derivative, allantoin derivative, nicotinic acid derivative,
Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract. , Ellagic acid, lucinol, etc.

(20) Tyrosinase activity inhibitor Vitamin C or its derivative (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or its derivative (hydroquinone benzyl ether, etc.), kojic acid or its derivative, vitamin E or Derivatives thereof, N-acetyltyrosine or a derivative thereof, glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, gardenia, touki, waremokou,
Clara, mugwort, honeysuckle, yellowfin, duckweed, matsuhod, pearl barley, syringa, hops, hawthorn, eucalyptus, yarrow, altea, keihi, mankeishi, hamarisu, karaguawa or yamgua, enryakushi, bellflower, toshishi, zaiko, ejaculate Mahuang, senkyu,
Dokatsu, Psycho, Bow-fu, Hama-bo-fu, Oogon, Peony skin, Peonies, Geno-shoko, Kakkon, Licorice, Quintuple, Aloe, Shouma, Safflower, Green tea, Black tea, Asakuyaku) etc.

(21) Melanin dye reducing / decomposing substance Phenyl mercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide solution, zinc peroxide, hydroquinone or its derivative (hydroquinone benzyl ether)
etc.

(22) Turnover promoting action / cell activating substance Hydroquinone, lactic acid bacterium extract, placenta extract, ganoderma lucidum extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, dragonfly, horsetail, gentian, burdock,
Sikon, carrot, hamamelis, hop, yokinin,
Odori Koso, Assemblies, Touki, Daffodil, Amacha, Hypericum, Cucumber, Prickly Pear,
Mannenrou, parsley) etc.

(23) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compound), etc. .

(24) Active oxygen scavenger SOD, catalase, glutathione peroxidase, etc.

(25) Antioxidant Vitamin C or salt thereof, stearic acid ester, vitamin E or derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamorin, Gossypol, Propolis etc.

(26) Lipid peroxide production inhibitor β-carotene, plant extract (sesame cultured cells, armature,
Hypericum, Hamamelis, Clove, Melissa, Crassulaceae, Birch, Salvia, Mannenrow, Nantenmi, Ages, Ginkgo, green tea) etc.

(27) Anti-inflammatory agent Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, chamazulen, chlorpheniramine maleate, glycyrrhizic acid or its salt, glycyrrhetinic acid or its salt, licorice extract, shikon extract, agets extract, propolis and the like.

(28) Antibacterial / bactericidal / disinfectant acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercury chrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, porridge powder, iodine compound,
Iodoform, sorbic acid or its salt, propionic acid or its salt, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p- Chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565,
Halocarbane, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant Agents (polyoxyethylene lauryl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactants (odor Trimethylammonium chloride, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, yellowtail Ant Green, Malachite Green, Crystal Violet, Jermal, Photosensitizer No. 101, Photosensitizer No. 201, Photosensitizer No. 401, N-long chain acyl basic amino acid derivative and its acid addition salt, zinc oxide, hinokitiol, kujin, propolis, etc. .

(29) Moisturizer Glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, glycerin tricaprylcaprate, glycolic acid (α-hydroxy acid),
Hyaluronic acid or its salt, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative, pyrrolidonecarboxylic acid or its salt, sodium lactate, urea, sorbitol, amino acid or its derivative (valine, leucine, isoleucine, threonine, methionine). , Phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine,
Cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine, their sulfates, phosphates, nitrates, citrates or pyrrolidonecarboxylic acid), oils and fats " Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange lafer oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, quince seed oil, kukui nut oil, safflower oil, shea Fat, liquid shea fat, soybean oil, camellia oil, corn oil,
Rapeseed oil, jojoba oil, persic oil, castor oil, sunflower oil, cottonseed oil, peanut oil, turtle oil, tea tree oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mokurou, palm oil, eucalyptus oil, beef tallow, pork Fats, squalene, squalane, pristane or hydrogenated products of these oils (hardened oil) ", waxes (beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax,
Rice wax), mineral oil (liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcristan wax), Bacillus natto metabolite, natto extract,
Silk fiber extract, plant extract (red pine sap, aloe, kudzu root,
Chamomile, licorice, cucumber, licorice, rice or rice bran, purple root,
White birch or white birch sap, assembly, mulberry bark, biwa leaf, loofah, peony bark, peony) etc.

(30) Elastase activity inhibitor diisopropyl fluorophosphate, plant extract (salmon, hypericum, clara, mulberry leaf, cinnamon, ginger ginger, comfrey, salvia, elderberry, bodige, button pie), seaweed extract and the like.

(31) Hair agent Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thiantol, castari tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid, etc.

(32) Antiandrogens Estrogen (estron, estradiol, ethinyl estradiol, etc.), isoflavone, oxendron, etc.

(33) Peripheral vascular blood flow enhancer Vitamin E or its derivative, assembly extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(34) Stimulant capsicum tincture, nonyl acid vanilamide, cantharis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(35) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid or its derivatives, allantoin, placenta extract, biotin, pentadecanoic acid glyceride, etc.

(36) Antiseborrheic agent pyridoxine or its derivative, sulfur, vitamin B6
etc.

(37) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea, etc.

(38) Oxidizing agent Hydrogen peroxide water, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium peroxytripolyphosphate, sodium bromate, potassium bromate, pyroline peroxide Sodium acid salt, sodium peroxide orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution,
Mushroom extract, etc.

(39) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide, thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(40) Hair swelling agent Ethanolamine, urea, guanidine, etc.

(41) Dyeing agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
-5-Nitro-2 ', 4'-diaminoazobenzene-5'-sodium sulfonate, hematein, etc.

(42) Fragrances Natural animal fragrances such as musk, civet, castorium, and ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayak Wood Essential Oil, Cumin Essential Oil, Black Letter Essential Oil, Cayenne Essential Oil, Cinnamon Essential Oil, Geranium Essential Oil, Copaiba Balsam Essential Oil, Coriandel Essential Oil, Perilla Essential Oil, Cedarwood Essential Oil, Citronella Essential Oil, Jasmine Essential Oil, Gingergrass Essential Oil, Cedar Essential Oil, Spearmint Essential Oil, Western Mint essential oil, large scented essential oil, tuberose essential oil, Choji essential oil, orange essential oil, winter green essential oil, true balsam essential oil, butchery essential oil, rose essential oil, palmarosa essential oil, cypress essential oil, hiba essential oil,
Sandalwood Essential Oil, Petit Glen Essential Oil, Bay Essential Oil, Vetiver Essential Oil, Bergamot Essential Oil, Peruvian Balsam Essential Oil, Boad Rose Essential Oil, Homou Essential Oil, Mandarin Essential Oil, Eucalyptus Essential Oil, Lime Essential Oil, Lavender Essential Oil, Linaloe Essential Oil, Lemongrass Essential Oil, Lemon Essential Oil, Rosemary Essential Oil (Mannen wax) Essential oils, vegetable flavors such as Japanese peppermint essential oil, and other synthetic flavors.

(43) Dye / Coloring Agent Red cabbage dye, red rice dye, madder dye, annatto dye, squid dye, turmeric dye, endu dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, whole buckwheat pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

(44) Other hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antifungal agents, cooling agents, stabilizers, emulsifiers, kinetics
Vegetable protein and its degradation products, animal / vegetable polysaccharides and its degradation products, animal / vegetable glycoprotein and its degradation products, blood flow promoters, anti-inflammatory / anti-inflammatory / anti-allergic agents, wound healing agents, Examples include foaming agents, thickening agents, enzymes, purified water (including electronic water, small clusters, etc.), deodorants and deodorants.

When used in combination with these components and additives, additive or synergistic improvement of the effects of the present invention or other cosmetic effects can be expected. Examples of production examples, evaluation tests, prescription examples and the like will be shown below for further detailed explanation, but the present invention is not limited thereto.

[0078]

[Examples] Production Example 1 100 g of each dried product of Dyer's Rocket, Weld, Shinobu Mokuso, and Mokusoso was heated and extracted with purified water (about 80 ° C) for about 5 hours, and filtered to extract ( Dry solid content: about 0.1-3.0%) to obtain about 1.0-3.0 kg.

[0079]

Example 2 Production Example 2 100 g of each dried product of Dyer's Rocket, Weld, Shinobu moth soup, and moth soup was soaked in a 50% ethanol solution, extracted at room temperature for 5 days, and then filtered to extract ( Dry solids: approx. 0.3-3.5%) approx. 1.0-
I get 3.0 kg.

[0080]

Example 3 Production Example 3 100 g of each dried product of Dyer's Rocket, Weld, Shinobu Mokusoiso, and Mokuseiso 50 was mixed in an equal volume mixture of a 30% propylene glycol solution and a 30% 1,3-butylene glycol solution. The mixture is gently heated at 6 ° C for 6 hours for extraction, and suction-filtered to obtain an extract (dry solid content: 0.2 to 2.5%) of about 1.0 to 3.0 kg.

[0081]

Example 4 Production Example 4 100 g of each dried product of Dyer's Rocket, Weld, Shinobu moth, and Moth wort are 70% ethanol solution or 30% 1,3-butylene glycol solution, or 60% propylene glycol solution, or Purified water (about 30
C.) and extracted at room temperature for 5 days and night, and then filtered to obtain an extract (dry solid content: about 0.3 to 2.5%) of about 1.0 to 3.0 kg.

[0082]

[Examples] Melanin production inhibitory activity evaluation test "Test method and evaluation method" B16 melanoma cells were cultured for 24 hours, and this culture solution was replaced with a culture solution containing a sample. At this time, only the solvent used for dissolving the sample was added to the blank. After culturing for 3 days, the cells were treated with trypsin, heated and dissolved in a 1N-NaOH solution containing 10% DMSO, and the absorbance at 420 nm was measured. At the same time, the MTT reduction method (Tim Mosmann; Journal of Immunologi
Cal methods 65, P55-63 (1983)) were used to measure the number of cells, and after confirming that there was no difference in the number of viable cells between the blank group and the sample-added group, the inhibition rate of the blank cells against the amount of melanin production (%) Was calculated by the equation 1. The results are shown in Table 1.

"Sample" A sample was prepared by using a reagent and the extract obtained in the Production Example, adjusting the solid content concentration in the culture solution to be constant, and used for the test. As a sample for comparison, arbutin manufactured by Sigma was prepared under the same conditions and subjected to the test.

[0084]

[Equation 1]

(Test Results) As shown in Table 1, luteolin or luteolin glycosides, and each extract of Dyer's Rocket, Weld containing these compounds, Synophoraceae, and Moxiacea extract were compared with arbutin. A strong or almost equivalent melanin production inhibitory effect was observed, and it was confirmed to be useful as a whitening agent. In addition, although the effectiveness of luteolin and luteolin glycosides is considered to be certain, it is thought that the high effect as a plant extract is the mixing effect of plant-derived components other than luteolin and luteolin glycosides. .

[Table 1]

[0086]

[Examples] Safety test (1) Primary skin irritation test An aqueous solution of luteolin, luteolin glycoside, and the plant extracts obtained in Production Examples 1 to 4 was prepared to a solid content concentration of about 1.0%. 2 x the skin of Hartley guinea pigs (female, 3 animals per group, weighing about 340 g) with a shaved back.
Each animal was applied with 0.03 mL per 2 cm ² . Judgment was performed 24, 48, and 72 hours after application by the primary irritation scoring method using erythema and edema as indexes. As a result, in all animals, no erythema or edema was observed, and it was determined to be negative.

(2) Skin cumulative irritation test An aqueous solution was prepared from luteolin, luteolin glycoside, and the plant extracts obtained in Production Examples 1 to 4 so that the solid content concentration was about 2.0%. Hartley guinea pig with shaved flank (2 × 2 cm ² ) (female, 3 per group, weight 320 g)
Before and after) 2 x 2 cm ² of skin, once a day, 5 times a week, 0.0
3 mL was applied to each animal. Application for 2 weeks,
Shears were timely performed. Judgment was performed on the day after each application day and the day after the last application day, using erythema and edema as indexes by the primary irritation scoring method. As a result, in all animals, 2 after application
Neither erythema nor edema was observed over the week and the result was negative.

(3) Single-dose toxicity test An aqueous solution was prepared from luteolin, luteolin glycoside, and the plant extracts obtained in Production Examples 1 to 4 so that the solid content concentration was about 1.0%. 16 mL / kg per
Ddy mouse (male and female, 1 group 5)
Orally administered to a mouse (5 weeks old) with a sonde, and the onset and degree of toxicity symptoms were observed over time. As a result, no abnormality was observed in all mice for 14 days, and the results of autopsy were also abnormal. Therefore, the LD ₅₀ was 2,000 mg / kg or more, and it was determined to be a safe substance.

[0089]

Examples Production of Cosmetic Composition Various cosmetic compositions were produced using the melanin production inhibitor according to the present invention. A prescription example is shown below. (Formulation Example 1) Emulsion weight% 1. Squalane 8.0 2. Jojoba oil 7.0 3. Cetyl alcohol 1.5 4. Glycerin monostearate 2.0 5. Polyoxyethylene (20) cetyl ether 3.0 6. Polyoxyethylene (20) sorbitan mono Olate 2.0 7.1,3-Butylene glycol 1.0 8. Glycerin 2.0 9. A: Diamonds rocket extract of Production Example 2 B: Sinus botanic Extract of Production Example 2 C: Mokusou Extract of Production Example 2 * A to C Any one extract 5.0 10. Preservative (paraoxybenzoic acid ester) Appropriate amount 11. Perfume Appropriate amount 12. Purified water 100 Residue

[0090] (Prescription example 2) Emulsion                                                               weight%     1. Squalane 8.0     2. Jojoba oil 7.0     3. Glyceryl p-aminobenzoate 1.0     4. Ethyl urocanate 1.0     5. Vitamin C phosphate magnesium salt 1.0     6. Cetyl alcohol 1.5     7. Glycerin monostearate 2.0     8. Polyoxyethylene (20) cetyl ether 3.0     9. Polyoxyethylene (20) soorbitan monooleate 2.0    10.1,3-butylene glycol 1.0    11. Glycerin 2.0    12. Production Example 3 Dyers Rocket Extract 3.0    13. Shinanobusumiso extract of Production Example 3 3.0    14. Preservative (paraoxybenzoate) Suitable amount    15. Residue to make purified water 100

[0091] (Prescription example 3) Cosmetic oil                                                               weight%     1. Liquid paraffin 30.0     2. Squalane 20.0     3. Olive oil 20.0     4. Isopropyl palmitate 10.0     5. Grapefruit fruit or leaf hot water extract 3.0     6. Mokuseiso extract 3.0 of Production Example 1     7. Production Example 1 Dyers Rocket Extract 3.0     8. Olive oil 1.0     9. Shea butter 1.0    10.Butyl hydroxyanisole 0.1    11. Vitamin E derivative 0.1    12. Preservative (benzalkonium chloride) Suitable amount    13. Perfume (musk water) proper amount    14. Purified water 100 residue

[0092] (Prescription example 4) Flexible lotion                                                               weight%     1. Glycerin 5.0     2.1,3-butylene glycol 5.0     3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0     4. Ethanol 15.0     5. 30% ethanol extract solution     6. 30% ethanol extract of Mokusoiso 1.0     7. Grapefruit fruit or leaf 50% ethanol extract 1.0     8. Kiwi fruit 50% ethanol extract 1.0     9. Antibacterial and antiseptic (lactoferrin solution)    10. Fragrance (Western light water) Suitable amount    11. Residue to make purified water 100

[0093] (Prescription example 5) Astringent lotion                                                               weight%     1. Sorbit 2.0     2.POE (20) oleyl alcohol 1.0     3. Ethanol 15.0     4. Dyers rocket 50% 1,3-butylene glycol extract 2.0     5. Shinobu Mokusoso 50% 1,3-butylene glycol extract 2.0     6. Gentian whole plant 50% ethanol extract 1.0     7. Sage whole plant 50% ethanol extract 1.0     8. Allantoin 0.2     9. Astringent (zinc sulfocarbonate) 0.2    10. Antibacterial / antiseptic agent (thiamin lauryl sulfate)    11. Perfume (Lavender water) Suitable amount    12. Residue to make purified water 100

[0094] (Prescription example 6) Two-layer lotion (liquid-liquid type)                                                               weight%     1. Squalane 8.0     2. POE sorbitan tetraoleate 0.3     3. Solbit 1.0     4. Ethanol 15.0     5. Mokuso 30% ethanol extract 2.0     6. Dyers Rocket 30% ethanol extract 2.0     7. Shinanobu Mokuso 30% ethanol extract 2.0     8. Higotai 30% ethanol extract 2.0     9. Peony 30% glycerin extract 1.0    10. Whole hawthorn grass 30% glycerin extract 1.0    11. Ascorbic acid 0.2    12. Astringent (calamine) 0.1    13. Preservative (phenoxyethanol) Appropriate amount    14. Perfume (lemon water) Suitable amount    15. Residue to make purified water 100

[0095] (Prescription example 7) Carmine lotion (liquid-solid type)                                                               weight%     1. Glycerin 3.0     2.1,3-butylene glycol 5.0     3. Ethanol 15.0     4. Iron oxide (red iron oxide) 0.2     5. Zinc oxide 0.5     6. Kaolin 2.0     7. Mokusoso 50% propylene glycol extract 2.0     8. Dyers Rocket 50% Propylene Glycol Extract 2.0     9. Panax ginseng root 50% propylene glycol extract 1.0    10. Placenta extract 1.0    11. Camphor 0.2    12. Phenol 0.03    13. Preservative (photosensitive element 201 & 401) Suitable amount    14. Perfume (bodhi water) Suitable amount    15. Residue to make purified water 100

[0096] (Prescription example 8) Pack                                                               weight%     1. Polyvinyl alcohol 15.0     2. Carboxymethyl cellulose sodium 5.0     3. Propylene glycol 3.0     4. Ethanol 10.0     5. Shinanobu Mokuso 50% ethanol extract 1.0     6. Mokuseiso 50% ethanol extract 1.0     7. Thyme whole plant 50% ethanol extract 1.0     8. Melissa leaf or stem 50% ethanol extract 1.0     9. Preservative (paraoxybenzoate) Suitable amount    10. Perfume (tokimizu) Appropriate amount    11. Residue to make purified water 100

[0097] (Prescription example 9) Peel off pack                                                               weight%     1. Glycerin 5.0     2. Propylene glycol 4.0     3. Polyvinyl alcohol 15.0     4. Ethanol 8.0     5. Polyoxyethylene glycol 1.0     6. Pantothenyl ethyl ether 1.0     7. Dyers Rocket 50% Ethanol Extract 2.0     8. 30% ethanol extract solution     9. Mokusoso 30% ethanol extract 2.0    10. Safflower whole plant 50% ethanol extract 2.0    11. Yuzu fruit 50% ethanol extract 2.0    12. Preservative (paraoxybenzoate) Suitable amount    13. Perfume (cypress leaf water)    14. Purified water 100 residue

[0098] (Prescription example 10) Cold cream                                                               weight%     1. White beeswax 11.0     2. Liquid paraffin 22.0     3. Lanolin 10.0     4. Olive oil 5.0     5. Chamomile oil 5.0     6. Palm oil 5.0     7. Borax 0.5     8. Dyers Rocket Extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)     9. Shinanobu Mokuso extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    10. White birch bark extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    11. Liquid shea butter 1.0    12. Preservative (acrinol) 0.1    13. Perfume (sage water) appropriate amount    14. Purified water 100 residue

[0099] (Prescription example 11) Emollient cream                                                               weight%     1. Stearic acid 2.0     2. Stearyl alcohol 7.0     3. Reduced lanolin 2.0     4. Squalane 5.0     5. Octyldodecanol 6.0     6. Polyoxyethylene cetyl ether (25E.O.) 3.0     7. Lipophilic glyceryl monostearate 2.0     8. Propylene glycol 5.0     9. Mokusoiso hot water extract 3.0    10. Dyers rocket 10% 1,3-butylene glycol extract 3.0    11. Shinobu Mokusoso 30% 1,3-butylene glycol extract 3.0    12. Rosemary leaf or flower 50% 1,3-butylene glycol extract 2.0    13. Preservative (paraben) Suitable amount    14. Perfume (clove water) appropriate amount    15. Residue to make purified water 100

[0100] (Prescription example 12) Face wash cream                                                               weight%     1. Myristic acid 25.0     2. Stearic acid 5.0     3. Beef tallow fatty acid 5.0     4. Propylene glycol 10.0     5. Potassium hydroxide 6.0     6. Coconut oil fatty acid diethanolamide 6.0     7. Dyers Rocket Extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 2 extraction solvent)     8. Hot water extract 2.0     9. Mokusoiso 10% 1,3-butylene glycol extract 2.0    10. Loofah fruit or stem 50% 1,3-butylene glycol extract 2.0    11. Dipotassium glycyrrhetinate 1.0    12. Preservative (salicylic acid) 0.1    13. Perfume (sage water) appropriate amount    14. Purified water 100 residue

[0101] (Prescription example 13) Face wash cream                                                               weight%     1. Stearic acid 10.0     2. Palmitic acid 10.0     3. Myristic acid 12.0     4. Lauric acid 4.0     5. Oleyl alcohol 1.5     6. Lanolin derivative (EO adduct) 1.0     7. Glycerin 18.0     8. Potassium hydroxide 6.0     9.A: Diamonds rocket extract of Production Example 2       B: Cinnamomum radix extract of Production Example 2       C: Mokuseiso extract of Production Example 2       * Any one of A to C extract 5.0    10. Royal Jelly Extract 1.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    11. Glycyrrhetinic acid 1.0    12. Preservative (salicylic acid) 0.1    13. Perfume (tokimizu) Appropriate amount    14. Purified water 100 residue

[0102] (Prescription example 14) Body soap                                                               weight%     1. Potassium laurate 15.0     2. Potassium myristate 5.0     3. Propylene glycol 5.0     4. Whey 1.5     5. Dyers Rocket 70% 1,3-butylene glycol extract 1.0     6. Shinobokusou 70% 1,3-butylene glycol extract 1.0     7. Mokuso 70% 1,3-butylene glycol extract 0.5     8. Army cucumber leaf or stem 70% 1,3-butylene glycol extract 0.5     9. Polyethylene powder 0.5    10.Hydroxypropyl chitosan solution 0.5    11. Amino acids (glycine, glutamine, etc.) 0.5    12. Preservatives (undecylenic acid, phenol) Suitable amount    13. pH adjusting agent    14. Perfume (Lavender water) Suitable amount    15. Residue to make purified water 100

[0103] (Prescription example 15) Sunscreen cosmetics (O / W type)                                                               weight%     1. Oxybenzone 2.0     2. Octyl para methoxycinnamate 5.0     3. Squalane 10.0     4. Vaseline 5.0     5. Stearyl alcohol 3.0     6. Stearic acid 3.0     7. Glyceryl monostearate 2.0     8. Polyethyl acrylate 1.0     9.1,3-butylene glycol 6.0    10. Disodium edetate 0.1    11. Triethanolamine 1.0    12. Titanium dioxide 5.0    13. Dyers rocket 50% dipropylene glycol extract 0.5    14. Shinobokusei 50% dipropylene glycol extract 0.5    15. Mokuso 50% dipropylene glycol extract 0.5    16. Mulberry peel 50% dipropylene glycol extract 0.5    17. Purple root 50% dipropylene glycol extract 0.5    18. Preservative (paraben) Suitable amount    19. Perfume (apple water) Appropriate amount    20. Residue of purified water 100

[0104] (Prescription example 16) Sunscreen cosmetics (oil type)                                                               weight%     1. Liquid paraffin 70.0     2. Ethyl paraaminobenzoate 1.0     3. Tetrahydroxybenzophenone 1.0     4. Cetyl octanoate 25.0     5. Dyers Rocket 30% 1,3-butylene glycol extract 1.0     6. Shinobokusouiso 10% 1,3-butylene glycol extract 1.0     7. Mokuso 50% 1,3-butylene glycol extract 0.5     8. Yukinoshita whole plant 30% 1,3-butylene glycol extract 0.5     9. Whole pearl barley 50% 1,3-butylene glycol extract 0.5    10. Incense fruit 30% 1,3-butylene glycol extract 2.0    11. Antioxidant (Butyl hydroxytoluene) Suitable amount    12. Perfume (Bodaiju water) Suitable amount

[0105] (Prescription example 17) Cream foundation (O / W type)                                                               weight%     1. Stearic acid 4.0     2. Glycerin monostearate 3.0     3. Cetanol 1.5     4.Isopropyl myristate 7.0     5. Liquid paraffin 10.0     6. White beeswax 3.0     7. Triethanolamine 1.5     8. Glycerin 3.0     9. Bentonite 1.0    10.Titanium oxide 8.0    11.2,4-Dihydroxybenzophenone 8.0    12. Kaolin 3.0    13. Talc 3.0    14. Coloring pigment (yellow iron oxide) 1.0    15. Dyers rocket hot water extraction dry powder 0.2    16. Shinanobu Mokusou hot water extraction dry powder 0.2    17. Preservative (paraben) proper amount    18. Perfume (rose water)    19. Residue to make purified water 100

[0106] (Prescription example 18) Shampoo                                                               weight%     1. Lauryl sulfate triethanolamine 5.0     2. Sodium polyoxyethylene lauryl ether sulfate 12.0     3.1,3-butylene glycol 4.0     4. Lauric acid diethanolamide 2.0     5. Disodium edetate 0.1     6. Dyers Rocket 20% 2,3-butylene glycol extract 2.0     7. Shinanobu Mokuso 10% 1,4-butylene glycol extract 2.0     8. Mokusoso 30% 1,4-butylene glycol extract 2.0     9. Aloe 30% 1,3-butylene glycol extract 1.0    10. Hydroxypropyl chitosan solution 2.0    11. Mucopolysaccharide solution 1.0    12. Antibacterial / antiseptic (photosensitive element 101)    13. pH adjusting agent    14. Perfume (sandalwood water)    15. Residue to make purified water 100

[0107] (Prescription example 19) Rinse                                                               weight%     1. Stearyl trimethyl ammonium chloride 2.0     2. cetostearyl alcohol 2.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5. Dyers rocket 50% 1,2-butylene glycol extract 1.0     6. Shinanobu Mokusoso 50% 1,2-butylene glycol extract 1.0     7. Novara 50% 1,2-butylene glycol extract 1.0     8. Coltsfoot 50% 1,3-butylene glycol extract 1.0     9. Hydroxyethyl chitosan solution 1.0    10. Trehalose solution 1.0    11. Hydrolyzed silk solution 1.0    12. Antibacterial / antiseptic (benzalkonium chloride)    13. Perfume (Lavender water) Suitable amount    14. Purified water 100 residue

[0108] (Prescription example 20) Hair liquid                                                               weight%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5. Dyers Rocket Hot Water Extract 2.0     6. Shinanobu Mokuso 50% ethanol extract 2.0     7. Mokuseiso 50% ethanol extract 1.0     8. Melissa whole plant 50% ethanol extract 1.0     9. Panax ginseng root 50% ethanol extract 1.0    10. Carpronium chloride 0.3    11. Hinokitiol 0.5    12. Keratin decomposition solution 1.0    13. Antibacterial / antiseptic (paraben, benzalkonium chloride) appropriate amount    14. Perfume (senkyu water) Suitable amount    15. Residue to make purified water 100

[0109] (Prescription example 21) Heartonic                                                               weight%     1.Ethanol 40.0     2. Ethyl oleate 1.0     3. Polyoxyethylene (40) hydrogenated castor oil 2.0     4.A: Diamonds rocket extract of Production Example 2       B: Cinnamomum radix extract of Production Example 2       C: Mokuseiso extract of Production Example 2       * Any one of A to C extract 5.0     5. Peony skin 50% ethanol extract 3.0     6. Yuzu leaf or fruit 50% ethanol extract 3.0     7. Preservative (paraben) proper amount     8. Residue to make purified water 100

[0110] (Prescription example 22) Heartonic                                                               weight%     1.l-menthol 0.2     2. Ethanol 32.5     3. Polyoxyethylene hydrogenated castor oil 0.5     4. Propylene glycol 5.0     5. Diphenhydramine hydrochloride 0.3     6. Dyers Rocket Hot Water Extract 2.0     7. Hot water extract of Cinnabarium 1.0     8. Mokuseiso 50% ethanol extract 1.0     9. Ougon 50% ethanol extract solution 1.0    10. Carboxymethyl chitin solution 1.0    11. Vitamin E derivative 0.5    12. Antibacterial and antiseptic (paraben) 0.1    13. Perfume (sage water) appropriate amount    14. Purified water 100 residue

[0111] (Prescription example 23) Hair growth and hair nourishing agent                                                               weight%     1.Ethanol 60.0     2. Mokuso 50% propylene glycol extract 5.0     3. Panax ginseng root 50% propylene glycol extract 2.0     4. Artemisia leaf or stem 50% 1,3-butylene glycol extract 1.0     5. Yarrow's Fruit 50% 1,3-Butylene Glycol Extract 1.0     6. Vitamin E derivative 0.5     7. Capsicum tincture 0.5     8. Resorcin 0.5     9. Dipotassium glycyrrhizinate 0.5    10.Carboxymethyl chitin solution 0.5    11. Bovine hematin solution 0.5    12. Mucin solution 0.5    13. Amino acids (glycine, glutamine, etc.) 0.5    14. Antibacterial and antiseptic (paraben) 0.1    15. Perfume (rosemary water)    16. Residue to make purified water 100

[0112] (Prescription example 24) Hair growth and hair nourishing agent                                                               weight%     1.Ethanol 60.0     2. Dyers Rocket 50% 1,3-butylene glycol extract 1.0     3. Shinobu Mokusoso 50% 1,3-butylene glycol extract 1.0     4. Mokuseiso 60% ethanol extract 1.0     5. Cantharis tincture 0.5     6. Pantothenic acid derivative 0.5     7. Glycyrrhizic acid 0.5     8. Resorcin 0.5     9. Salicylic acid 0.5    10.Hydroxyethyl chitosan solution 0.5    11. Elastin hydrolyzate 0.5    12. Antibacterial and antiseptic (paraben) 0.1    13. Perfume (Lavender water) Suitable amount    14. Purified water 100 residue

[0113] (Prescription example 25) Granule bath agent A                                                               weight%     1. Sodium hydrogen carbonate 58.0     2. Anhydrous sodium sulfate 30.0     3. Borax 2.0     4. Dyers Rocket Hot Water Extraction Dry Powder 5.0     5. Eucalyptus whole plant hot water extract dry powder 5.0     6. Dye (Gunjo green) Suitable amount

[0114] (Formulation Example 26) Granule bath agent B                                                               weight%     1. Sodium hydrogen carbonate 58.0     2. Anhydrous sodium sulfate 30.0     3. Borax 4.0     4. Shinanobu Mokuso hot water extraction dry powder 2.0     5. Magnolia hot water extract dry powder 1.0     6. Unshu mandarin orange 50% ethanol extract dry powder 1.0     7. Peach leaf 70% ethanol extract dry powder 1.0     8. Iris leaf or root 70% ethanol extract dry powder 1.0     9. Apple juice powder 1.0    10. Dye (Gunjou, chromium hydroxide)    11. Perfume (grape water) Suitable amount

(Formulation Example 27) A coating solution in which a protective agent for gauze or liniment cloth is mixed with an appropriate amount of the melanin production inhibitor of the present invention, an antibiotic, an anti-inflammatory agent and the like is attached to the wound. Alternatively, the formulation liquid may be directly applied locally and covered with gauze or the like.

[0116]

[Examples] Use test 1 A use test of the cosmetic compositions of the above examples was conducted. That is, people who suffer from stains, freckles, and darkness.
The names were panelists, and each group was divided into 4 groups of 10 people, each day twice in the morning and at night, and after washing the face, an appropriate amount of the emulsion of Formulation Example 1 was applied to the face for 3 months. As the control product, a product prepared by replacing the melanin production inhibitor of the present invention with purified water from the emulsion and using the same method was used. The experiment was conducted without notifying the panelist of the content of the emulsion. The evaluation method was performed based on the following criteria, and the results are shown in Table 2 and the numerical values in the table represent the number of people.

"Blemish freckles & skin color improving effect" Effective: The spots, freckles and the skin color are improved to be white. Slightly effective: The spots, freckles, and skin color were improved to be white. Ineffective: No change from before use.

(Test Results) As shown in Table 2, the emulsion containing the luteolin or the luteolin glycoside-containing plant extract of the present invention significantly improves the spots and freckles, and the skin color is also improved. Was confirmed.

[Table 2]

[0119]

[Example] Use test 2 A use test of the cosmetic composition of the above example was conducted. That is, 5 people aged 30 to 50 years old who suffer from glossy and non-skinned skin are panelists, and apply an appropriate amount of the emulsion of Prescription Example 2 to the face for 3 months after washing twice daily in the morning and at night. went. As the control product, a product prepared by replacing the melanin production inhibitor of the present invention with purified water from the emulsion and using the same method was used. The experiment was conducted without notifying the panelist of the content of the emulsion. The evaluation method was performed based on the following criteria, and the results are shown in Table 3 and the numerical values in the table represent the number of people.

[Effect of improving skin feel] Effective: The gloss and tension of the skin increased. Somewhat effective: The gloss and tension of the skin slightly increased. Ineffective: No change from before use.

(Test Results) As shown in Table 3, it was confirmed that the emulsion containing the luteolin or the luteolin glycoside-containing plant extract of the present invention increased the luster and tension of the skin.

[Table 3]

[0122]

[Effects of the Invention] Luteolin or its glycoside, or a plant extract essentially containing them, especially a plant of the genus Mokuseisou (Dyer's Rock
et., Weld), Shinobokuseiso, Mokuseiso)), a melanin production inhibitor or cosmetic composition containing at least one plant extract selected from the group consisting of at least one plant extract has a whitening effect. It also improves the dark spots and freckles on the skin and whitens the skin. In addition, it is possible to give gloss and tension to the skin, which is safe for humans and animals.

Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 7/00 A61K 7/00 N Q UX 7/02 7/02 A 7/021 7/021 7/06 7 / 06 7/075 7/075 7/08 7/08 7/42 7/42 7/50 7/50 35/78 35/78 C X A61P 17/00 A61P 17/00 43/00 111 43/00 111 F term (reference) 4C083 AA072 AA082 AA111 AA112 AA122 AB032 AB152 AB212 AB232 AB242 AB312 AB352 AB432 AB442 AC012 AC022 AC072 AC082 AC102 AC122 AC132 AC172 AC182 AC212 AC242 AC342 AC352 AC422 AC432 AC442 AC472 AC482 AC532 AC542 AC552 AC582 AC642 AC682 AC692 AC782 AC841 AC842 AC852 AC862 AC902 AC932 AD042 AD092 AD112 AD212 AD272 AD312 AD322 AD391 AD392 AD412 AD442 AD452 AD512 AD532 AD552 AD642 AD662 BB51 CC04 CC05 CC06 CC07 CC19 CC23 CC33 CC37 CC38 CC39 DD05 DD22 DD23 DD27 DD31 DD33 EE09 BA09 EE09 FF08 EE01 FF08 EE88 EE22 FF08 EE22 BA23 BA32 CA05 CA06 CA07 CA08 CA09 CA14 CA17 MA02 MA08 MA17 MA22 MA28 MA63 NA14 ZA89 ZC20 ZC75

Claims (5)

[Claims] 1. A melanin production inhibitor containing luteolin or a glycoside thereof. 2. The melanin production inhibitor according to claim 1, wherein luteolin or a glycoside thereof is a plant extract essentially containing them. 3. The melanin production inhibitor according to claim 2, wherein the plant extract essentially containing luteolin or a glycoside thereof is an extract from at least one plant selected from plants belonging to the genus Mokusou genus. 4. At least one plant selected from the group belonging to the genus Mokusou, belonging to the genus Mokusou, is selected from Dyer's Rocket, Weld
The melanin production inhibitor according to claim 2, which is a plant of one species or more. 5. A cosmetic composition containing the melanin production inhibitor according to any one of claims 1 to 4, which contains luteolin or a glycoside thereof.