JP2002003373A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin care preparation for preventing aging of the skin and a skin care preparation for improving roughened skin having excellent effect to prevent. the aging of the skin by the prevention of the sagging of the skin, the loss of gloss, or the like, as well as the prevention of skin roughening and the improvement of roughened skin. SOLUTION: The objective preparation contains a basic amino acid or its salt or tranexamic acid in combination with a 4-6C sugar alcohol such as xylitol or erythritol formulated as active components.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an external preparation for skin,
More specifically, the present invention relates to a skin external preparation having a high effect of preventing skin aging, preventing sagging of the skin, loss of gloss, and the like, in addition to preventing rough skin and improving rough skin.

[0002]

2. Description of the Related Art Conventionally, hyaluronic acid and amino acids have been blended in skin external preparations for imparting a moisturizing effect. However, the anti-aging effect was not yet sufficient and was not enough to expect the effect.

[0003]

SUMMARY OF THE INVENTION The present inventors have intensively studied whether there is a method for preventing skin roughness, improving skin roughness, preventing sagging of the skin, loss of gloss, and the like, and improving the effect of preventing aging. Alternatively, they have found that this object can be achieved by blending a salt thereof or tranexamic acid with a sugar alcohol having 4 to 6 carbon atoms, and completed the present invention.

[0004]

That is, the present invention relates to an external use for improving skin roughness characterized by blending a basic amino acid or a salt thereof or tranexamic acid and a sugar alcohol having 4 to 6 carbon atoms as active ingredients. And an external preparation for preventing aging. Hereinafter, the configuration of the present invention will be described in detail.

The basic amino acids and salts thereof used in the present invention include arginine, lysine, histidine and their alkali metal salts and hydrochlorides.

The amount of the basic amino acid and its salt in the present invention is not particularly limited, but is preferably 0.001 to 10.0% by weight, more preferably 0.01 to 5% by weight, based on the total amount of the external preparation for skin. 0.0% by weight.

The amount of tranexamic acid in the present invention is not particularly limited, but is preferably in the total amount of the external preparation for skin.
0.01 to 10.0% by weight, more preferably 0.1%
~ 5.0% by weight.

The sugar alcohol having 4 to 6 carbon atoms used in the present invention includes xylitol and erythritol.

The amount of the sugar alcohol having 4 to 6 carbon atoms in the present invention is not particularly limited, but is preferably 0.001 to 20.0% by weight, more preferably 0.01 to 20.0% by weight, based on the total amount of the external preparation for skin. １10.0% by weight.

[0010] In addition to the above essential components, the skin external preparation of the present invention also contains other components usually used in skin external preparations such as cosmetics and pharmaceuticals, such as avocado oil, palm oil, peanut oil, rice bran oil, jojoba oil. , Carnauba wax, lanolin,
Oils such as liquid paraffin, oxystearic acid, isostearyl palmitate, and isostearyl alcohol; humectants such as glycerin, sorbitol, polyethylene glycol, pyrrolidone carboxylic acid and its salts, collagen, hyaluronic acid and its salts, chondroitin sulfate and its salts Ultraviolet absorbers such as amyl paradimethylaminobenzoate, urocanic acid and ethyl diisopropylcinnamate; antioxidants such as sodium erythorbate, sage extract and parahydroxyanisole; sodium stearyl sulfate, diethanolamine cetyl sulfate, cetyltrimethylammonium saccharin, Surfactants such as polyethylene glycol isostearate and glyceryl arachiate; preservatives such as ethylparaben and butylparaben;
Extracts such as oak, spinach, loquat, peonies, yellowtail, birch, carrot, aloe, mallow, iris, grape, yokuinin, loofah, lily, saffron, senkyu, ginger, ononis, garlic, etc .; glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives , Salicylic acid derivatives, hinokitiol, zinc oxide, allantoin and other anti-inflammatory agents; placental extracts, glutathione, ascorbic acid derivatives and other whitening agents; royal jelly, photosensitizers, cholesterol derivatives, activators such as various amino acids, etc .; Blood circulation promoters such as sodium sulfate; antiseborrheic agents such as sulfur and thiantole; fragrances; water; alcohols; thickeners such as carboxyvinyl polymers; coloring agents such as titanium yellow, carsamine, and safflower red if necessary. Mix appropriately Door can be.

The dosage form of the external preparation for skin of the present invention is arbitrary,
Any dosage form, such as a solution system, a solubilizing system, an emulsifying system, a powder dispersion system, a water-oil two-layer system, a water-oil-powder three-layer system, may be used. In addition, the use of the external preparation for skin of the present invention is also optional, and may be used for facial cosmetics such as lotions, emulsions, creams, packs and the like, makeup cosmetics such as foundations, lipsticks, eye shadows and the like, body cosmetics, ointments and the like. Can be.

[0012]

EXAMPLES Next, the present invention will be specifically described with reference to examples and comparative examples. The present invention is not limited by this. The amount is% by weight

Test Examples 1-4 In a cream having the following formulation, xylitol was 0% by weight, 5.0% by weight, L-arginine was 0% by weight, 0.5% by weight.
The cream, which was changed to the weight%, was subjected to a skin roughness prevention and skin roughness improvement effect test on a human body panel. That is, the replica of the skin surface of a healthy female person (face) was sampled using a replica method using myristin resin, and a microscope (17) was used.
X).

Table 1 shows the state of the skin pattern and the peeled state of the stratum corneum.
Using 40 persons (skin rough panel) judged to have skin roughness evaluations 1 and 2 based on the criteria shown in the above, L-
One cream containing arginine and xylitol (Test Example 1), one cream not containing L-arginine (Test Example 2), one cream not containing xylitol (Test Example 3), and one cream not containing both (Test Example 4) It was applied twice a day. Two weeks later, a replica was again taken to observe the condition of the skin, and evaluated according to the criteria shown in Table 1. Evaluation of sagging of the skin and beam was performed by five specialized panels before and after use according to the criteria in Table 2. Table 3 shows the results. A. Cetanol 0.5% by weight Vaseline 2.0 Squalane 7.0 Self-emulsifying glyceryl monostearate 2.5 Polyoxyethylene sorbitan monostearate (20EO) 1.5 Pantothenyl ethyl ether 0.5 Jojoba oil 5.0 B. Propylene glycol 5.0 Glycerin 5.0 Vegum (montmorillonite) 5.0 Xylitol 5.0 or 0 Potassium hydroxide 0.3 L-Arginine 0.5 or 0 Water Residue (Production method) A (oil phase) and B (water Phase) are each heated to 70 ° C. and completely dissolved. Add A to B and emulsify with an emulsifier. The emulsion was cooled using a heat exchanger to obtain a cream.

[0015]

[Table 1] 評 Evaluation score ─────────────────── １ 1 Skin sulcus, skin hills disappear, and widespread stratum corneum. 2 Skin sulcus and skin hills are unclear and horny layer is turned up. 3 Skin sulcus and skin ridge are observed but flat. 4 Skin sulcus and skin hills are clear. 5 Skin sulcus and skin hills are clear and well-organized. ─────────────────────────

[0016]

[Table 2] ───────────────────────── Visual evaluation ────────────────── ─────── ◎ The skin is very sticky and there is no sagging. ○ There is still skin and no sagging. △ Skin does not have much swelling and feels sagging. × There is no skin on the skin and it is sagging. ─────────────────────────

[0017]

[Table 3] Replica Test Example 1 Test Example 2 Test Example 3 Test Example 4 Evaluation Cream No L-arginine No xylitol No both ────────────────────────────────── 10 6 5 people 10 people 20 people 6 people 6 people 7 people 3 2 people 7 people 8 people 3 people 4 7 people 1 person 1 people 0 people 5 11 people 0 people 0 people 0 people ────────── ──────────────────────── Visual evaluation Before use ◎ 0 people 0 people 0 people 0 people ○ 1 person 1 person 0 people 1 person △ 2 people 2 people 3 people 3 people × 2 people 2 people 2 people 1 person After use ◎ 3 people 0 people 0 people 0 people ○ 2 people 3 people 2 people 0 people △ 0 people 1 person 2 people 2 people × 0 people 1 person 1 First three people ─────────────────────────── ──────

From these results, it was confirmed that the face part using the cosmetic containing L-arginine and xylitol had a remarkable effect of preventing and improving the rough skin as compared with the face part using the other cosmetics. In addition, there was no slack on the skin.

Example 1 Cream A. Stearic acid 10.0% by weight Stearyl alcohol 4.0 Butyl stearate 8.0 Monoglycerin stearate 2.0 Vitamin E acetate 0.5 Macadamia nut oil 1.0 Fragrance 0.4 Preservative Suitable amount B. Glycerin 4.0 1,2-pentanediol 3.0 potassium hydroxide 0.4 magnesium ascorbate 0.1 L-arginine hydrochloride 0.01 erythritol 1.0 trisodium edetate 0.05 purified water residue A Are heated to 70 ° C. and completely dissolved. Add phase A to phase B and emulsify with an emulsifier. The emulsion was cooled using a heat exchanger to obtain a cream.

Example 2 Cream A. Cetanol 4.0% by weight Vaseline 7.0 Isopropyl myristate 8.0 Squalane 15.0 Monoglycerin stearate 2.2 POE (20) Sorbitan monostearate 2.8 Vitamin E nicotinate 2.0 Fragrance 0.3 Oxidation Appropriate amount of inhibitor Preservative appropriate amount B. Glycerin 10.0 Dipropylene glycol 4.0 Sodium pyrrolidone carboxylate 1.0 Xylitol 10.0 Tranexamic acid 3.0 Disodium edetate 0.01 Purified water Residue A cream was obtained according to Example 1.

Example 3 Emulsion A. Squalane 5.0% by weight Oleyl oleate 3.0 Vaseline 2.0 Sorbitan sesquioleate 0.8 Polyoxyethylene oleyl ether 1.2 (20EO) Evening primrose oil 0.5 Perfume 0.3 Preservative Appropriate amount 1,3-butylene glycol 4.5 Melissa extract 1.5 ethanol 3.0 carboxyvinyl polymer 0.2 potassium hydroxide 0.1 L-arginine L-aspartate 0.01 erythritol 0.5 sodium hexametaphosphate 0 .05 Arbutin 1.5 Purified water Residue Emulsion was obtained according to Example 1.

Example 4 Foundation A. Cetanol 3.5% by weight Deodorized lanolin 4.0 Jojoba oil 5.0 Vaseline 2.0 Squalane 6.0 Monoglycerin stearate 2.5 POE (60) Hardened castor oil 1.5 POE (20) Cetyl ether 1. 0 pyridoxine tripalmitate 0.1 preservative appropriate amount perfume 0.3 B. Propylene glycol 10.0 Compound powder 12.0 L-arginine 5.0 Xylitol 3.0 Kojic acid 1.0 Trisodium edetate 0.2 Purified water Residue A foundation was obtained according to Example 1.

Example 5 Lotion A. Ethanol 5.0% by weight POE oleyl alcohol ether 2.0 oleyl alcohol 0.1 2-ethylhexyl-p-dimethylaminobenzoate 0.18 fragrance 0.05 B. 1,3-butylene glycol 9.5 glycerin 2.0 sodium pyrrolidone carboxylate 0.5 tranexamic acid 0.5 nicotinamide 0.3 β-cyclodextrin 1.0 erythritol 0.05 purified water residue The alcohol phase of A B was added to the aqueous phase and solubilized to obtain a lotion.

[0024]

As described above, the external preparation for skin of the present invention comprises a basic amino acid or a salt thereof, or tranexamic acid, and a sugar alcohol having 4 to 6 carbon atoms, thereby improving skin roughness and improving skin roughness. This has the advantage that the effect of preventing aging by preventing sagging and loss of gloss can be significantly increased without side effects.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 31/047 A61K 31/047 31/196 31/196 A61P 17/00 A61P 17/00 F-term (reference) 4C083 AA122 AB032 AB282 AC012 AC022 AC072 AC082 AC102 AC112 AC122 AC131 AC132 AC182 AC242 AC352 AC422 AC442 AC532 AC552 AC581 AC582 AC612 AC621 AC622 AC842 AC852 AD042 AD092 AD252 AD392 AD632 AD642 AD662 CC04 CC05 CC12 EE12 4C206 AA01 FAA02MA02 MA09

Claims (4)

[Claims] 1. A skin external preparation for improving rough skin, comprising a basic amino acid or a salt thereof or tranexamic acid and a sugar alcohol having 4 to 6 carbon atoms as active ingredients. 2. An external preparation for preventing aging, comprising a basic amino acid or a salt thereof or tranexamic acid and a sugar alcohol having 4 to 6 carbon atoms as active ingredients. 3. The external preparation for skin according to claim 1, wherein the sugar alcohol is xylitol or erythritol. 4. The compounding amount of a basic amino acid or a salt thereof or tranexamic acid is 0.001 to 10.0% by weight, and the compounding amount of a sugar alcohol having 4 to 6 carbon atoms is 0.001%.
3. The external preparation for skin according to claim 1, wherein the amount is 10.0 to 20.0% by weight.