JOP20190263A1 - عوامل RNAi لتثبيط التعبير عن Alpha- EnaC وطرق استخدامها - Google Patents

عوامل RNAi لتثبيط التعبير عن Alpha- EnaC وطرق استخدامها

Info

Publication number
JOP20190263A1
JOP20190263A1 JOP/2019/0263A JOP20190263A JOP20190263A1 JO P20190263 A1 JOP20190263 A1 JO P20190263A1 JO P20190263 A JOP20190263 A JO P20190263A JO P20190263 A1 JOP20190263 A1 JO P20190263A1
Authority
JO
Jordan
Prior art keywords
enac
alpha
rnai agents
methods
inhibiting expression
Prior art date
Application number
JOP/2019/0263A
Other languages
English (en)
Inventor
Zhen Li
Erik W Bush
Tao Pei
Rui Zhu
Anthony Nicholas
Original Assignee
Arrowhead Pharmaceuticals Inc
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Publication date
Application filed by Arrowhead Pharmaceuticals Inc filed Critical Arrowhead Pharmaceuticals Inc
Publication of JOP20190263A1 publication Critical patent/JOP20190263A1/ar

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/33Chemical structure of the base
    • C12N2310/333Modified A
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/33Chemical structure of the base
    • C12N2310/335Modified T or U
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/343Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/346Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
    • C12N2310/351Conjugate
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    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications
    • C12N2320/32Special delivery means, e.g. tissue-specific

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
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  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

غير متوفر
JOP/2019/0263A 2017-07-06 2019-01-06 عوامل RNAi لتثبيط التعبير عن Alpha- EnaC وطرق استخدامها JOP20190263A1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762529132P 2017-07-06 2017-07-06
US201862631683P 2018-02-17 2018-02-17
US201862679549P 2018-06-01 2018-06-01

Publications (1)

Publication Number Publication Date
JOP20190263A1 true JOP20190263A1 (ar) 2019-11-12

Family

ID=64904123

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2019/0263A JOP20190263A1 (ar) 2017-07-06 2019-01-06 عوامل RNAi لتثبيط التعبير عن Alpha- EnaC وطرق استخدامها

Country Status (22)

Country Link
US (3) US10590416B2 (ar)
EP (1) EP3649240A4 (ar)
JP (2) JP2020526192A (ar)
KR (1) KR20200024793A (ar)
CN (1) CN110832077A (ar)
AU (1) AU2018297262A1 (ar)
BR (1) BR112019023650A2 (ar)
CA (1) CA3061752A1 (ar)
CL (1) CL2020000019A1 (ar)
CO (1) CO2019014671A2 (ar)
CR (1) CR20190572A (ar)
EC (1) ECSP20000655A (ar)
IL (1) IL271843A (ar)
JO (1) JOP20190263A1 (ar)
MX (1) MX2019014800A (ar)
PE (1) PE20200746A1 (ar)
PH (1) PH12019502660A1 (ar)
TN (1) TN2019000308A1 (ar)
TW (1) TW201919654A (ar)
UY (1) UY37800A (ar)
WO (1) WO2019010274A1 (ar)
ZA (1) ZA202100643B (ar)

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WO2024023254A1 (en) * 2022-07-27 2024-02-01 E-Therapeutics Plc Nucleic acid compounds

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BR112019023650A2 (pt) 2020-06-02
CO2019014671A2 (es) 2020-01-17
KR20200024793A (ko) 2020-03-09
JP2023158192A (ja) 2023-10-26
EP3649240A1 (en) 2020-05-13
JP2020526192A (ja) 2020-08-31
CN110832077A (zh) 2020-02-21
MX2019014800A (es) 2020-02-10
ZA202100643B (en) 2023-03-29
IL271843A (en) 2020-02-27
ECSP20000655A (es) 2020-05-29
US20220090077A1 (en) 2022-03-24
WO2019010274A1 (en) 2019-01-10
CR20190572A (es) 2020-05-23
PH12019502660A1 (en) 2020-06-08
AU2018297262A1 (en) 2020-02-27
CL2020000019A1 (es) 2020-06-12
TN2019000308A1 (en) 2021-05-07
EP3649240A4 (en) 2021-07-07
TW201919654A (zh) 2019-06-01
US20190010494A1 (en) 2019-01-10
UY37800A (es) 2019-01-02
US10590416B2 (en) 2020-03-17
US11214802B2 (en) 2022-01-04
US20200299691A1 (en) 2020-09-24
PE20200746A1 (es) 2020-07-24
CA3061752A1 (en) 2019-01-10

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