JOP20190143A1 - Small molecule inhibitors of the jak family of kinases - Google Patents

Small molecule inhibitors of the jak family of kinases

Info

Publication number
JOP20190143A1
JOP20190143A1 JOP/2019/0143A JOP20190143A JOP20190143A1 JO P20190143 A1 JOP20190143 A1 JO P20190143A1 JO P20190143 A JOP20190143 A JO P20190143A JO P20190143 A1 JOP20190143 A1 JO P20190143A1
Authority
JO
Jordan
Prior art keywords
kinases
small molecule
molecule inhibitors
jak family
methods
Prior art date
Application number
JOP/2019/0143A
Other languages
Arabic (ar)
Inventor
Russell C Smith
Tatiana Koudriakova
Michele C Rizzolio
Mark S Tichenor
Aihua Wang
Kevin D Kreutter
Kristi Leonard
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of JOP20190143A1 publication Critical patent/JOP20190143A1/en
Application granted granted Critical
Publication of JOP20190143B1 publication Critical patent/JOP20190143B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions mediated by JAK, such as inflammatory bowel disease. FIG.1
JOP/2019/0143A 2016-12-16 2017-12-15 Small molecule inhibitors of the jak family of kinases JOP20190143B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662435609P 2016-12-16 2016-12-16
US201762592680P 2017-11-30 2017-11-30
US201762596607P 2017-12-08 2017-12-08
PCT/US2017/066744 WO2018112379A1 (en) 2016-12-16 2017-12-15 Small molecule inhibitors of the jak family of kinases

Publications (2)

Publication Number Publication Date
JOP20190143A1 true JOP20190143A1 (en) 2019-06-13
JOP20190143B1 JOP20190143B1 (en) 2023-09-17

Family

ID=61692222

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2019/0143A JOP20190143B1 (en) 2016-12-16 2017-12-15 Small molecule inhibitors of the jak family of kinases

Country Status (34)

Country Link
US (5) US10294226B2 (en)
EP (2) EP3555097B1 (en)
JP (2) JP7291077B2 (en)
KR (1) KR102352462B1 (en)
CN (1) CN110088105B (en)
AU (3) AU2017377069B2 (en)
BR (1) BR112019011968A2 (en)
CA (1) CA3046965A1 (en)
CL (1) CL2019001626A1 (en)
CO (1) CO2019006200A2 (en)
CR (1) CR20190282A (en)
DK (1) DK3555097T3 (en)
EC (1) ECSP19042688A (en)
ES (1) ES2922379T3 (en)
HR (1) HRP20220885T1 (en)
HU (1) HUE059274T2 (en)
IL (1) IL267275B (en)
JO (1) JOP20190143B1 (en)
LT (1) LT3555097T (en)
MD (1) MD3555097T2 (en)
MX (2) MX2022004474A (en)
MY (1) MY196260A (en)
NI (1) NI201900060A (en)
PE (1) PE20191105A1 (en)
PH (1) PH12019501254A1 (en)
PL (1) PL3555097T3 (en)
PT (1) PT3555097T (en)
RS (1) RS63500B1 (en)
SA (1) SA519402216B1 (en)
SI (1) SI3555097T1 (en)
TW (1) TWI777997B (en)
UA (1) UA125042C2 (en)
WO (1) WO2018112379A1 (en)
ZA (1) ZA201904615B (en)

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JP6744489B2 (en) 2016-10-24 2020-08-19 アストラゼネカ・アクチエボラーグAstrazeneca Aktiebolag 6,7,8,9-Tetrahydro-3H-pyrazolo[4,3-f]isoquinoline derivatives useful in the treatment of cancer
JOP20190144A1 (en) 2016-12-16 2019-06-16 Janssen Pharmaceutica Nv Imidazopyrrolopyridine as inhibitors of the jak family of kinases
US10294226B2 (en) 2016-12-16 2019-05-21 Janssen Pharmaceutica Nv Small molecule inhibitors of the JAK family of kinases
TWI831738B (en) 2016-12-16 2024-02-11 美商瑞塔醫藥有限責任公司 PYRIMIDINE TRICYCLIC ENONE DERIVATIVES FOR INHIBITION OF RORγ AND OTHER USES
PT3494116T (en) 2017-01-30 2020-01-28 Astrazeneca Ab Estrogen receptor modulators
BR112020025605A2 (en) 2018-06-15 2021-03-23 Reata Pharmaceuticals, Inc. pyrazole and imidazole compounds for inhibition of il-17 and rorgama
TW202016110A (en) * 2018-06-15 2020-05-01 比利時商健生藥品公司 Small molecule inhibitors of the jak family of kinases
WO2019246461A1 (en) 2018-06-20 2019-12-26 Reata Pharmaceuticals, Inc. Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith
WO2020216936A1 (en) 2019-04-24 2020-10-29 Janssen Pharmaceutica Nv Non-clinical liquid formulations of pan-jak inhibitor
JP7320628B2 (en) * 2019-06-06 2023-08-03 ハンチョウ ハイライトゥル ファーマシューティカル カンパニー リミテッド Method for synthesizing furoimidazopyridine compound, crystalline form of furoimidazopyridine compound and crystalline form of salt thereof
CN110483514B (en) * 2019-09-16 2022-06-14 启元生物(杭州)有限公司 Cyano-substituted cyclic hydrazine derivative and application thereof
CA3166743A1 (en) * 2020-02-21 2021-08-26 Weiwei Mao Crystalline forms of jak inhibitor and uses thereof
CN116925077A (en) * 2020-09-08 2023-10-24 一又生物(上海)有限公司 Pyrido ring compound, and preparation method, intermediate, composition and application thereof
KR20230156752A (en) 2021-03-11 2023-11-14 얀센 파마슈티카 엔브이 Lorfucitinib for use in the treatment of JAK-mediated disorders
CN113292561A (en) * 2021-05-22 2021-08-24 中国药科大学 Compound with dipyrrolopyridine structure, preparation method and medical application
CN114432317A (en) * 2021-05-31 2022-05-06 广州嘉越医药科技有限公司 Application of pyrrolopyrimidine compounds
CN113861194B (en) * 2021-11-10 2022-07-05 英维沃化工科技(广州)有限公司 Pyrrolopyridine-containing bisamide imidazole compound and preparation method and application thereof

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US6080747A (en) 1999-03-05 2000-06-27 Hughes Institute JAK-3 inhibitors for treating allergic disorders
EP1910358A2 (en) * 2005-07-14 2008-04-16 Astellas Pharma Inc. Heterocyclic janus kinase 3 inhibitors
CN102127078A (en) * 2005-07-14 2011-07-20 安斯泰来制药株式会社 Heterocyclic janus kinase 3 inhibitors
AU2009257602B2 (en) 2008-06-10 2015-10-08 Abbvie Inc. Novel tricyclic compounds
JP2011066747A (en) * 2009-09-18 2011-03-31 Panasonic Corp Surface acoustic wave filter
PE20130005A1 (en) 2009-12-01 2013-02-16 Abbvie Inc NEW TRICYCLIC COMPOUNDS
PL2506716T3 (en) 2009-12-01 2017-10-31 Abbvie Inc Novel tricyclic compounds
MX2012008049A (en) 2010-01-12 2012-08-01 Hoffmann La Roche Tricyclic heterocyclic compounds, compositions and methods of use thereof.
CA2789186A1 (en) 2010-02-10 2011-08-18 Genon Biotechnologies Oy Dual activity kinase domains and uses thereof
WO2013007765A1 (en) * 2011-07-13 2013-01-17 F. Hoffmann-La Roche Ag Fused tricyclic compounds for use as inhibitors of janus kinases
EP2924026A1 (en) * 2014-03-28 2015-09-30 Novartis Tiergesundheit AG Aminosulfonylmethylcyclohexanes as JAK inhibitors
CN111362975B (en) 2015-05-28 2022-04-05 施万生物制药研发Ip有限责任公司 Naphthyridine compounds as JAK kinase inhibitors
WO2017079639A1 (en) 2015-11-04 2017-05-11 Mayo Foundation For Medical Education And Research Methods and materials for treating autoimmune conditions
JP6744489B2 (en) 2016-10-24 2020-08-19 アストラゼネカ・アクチエボラーグAstrazeneca Aktiebolag 6,7,8,9-Tetrahydro-3H-pyrazolo[4,3-f]isoquinoline derivatives useful in the treatment of cancer
EP3528645A1 (en) 2016-12-16 2019-08-28 Société des Produits Nestlé S.A. Oligosaccharides for flavour generation
AU2017378060B2 (en) 2016-12-16 2020-09-03 Eli Lilly And Company 7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors
AU2017374992A1 (en) 2016-12-16 2019-06-20 Basf Se Pesticidal compounds
JOP20190144A1 (en) 2016-12-16 2019-06-16 Janssen Pharmaceutica Nv Imidazopyrrolopyridine as inhibitors of the jak family of kinases
US10294226B2 (en) 2016-12-16 2019-05-21 Janssen Pharmaceutica Nv Small molecule inhibitors of the JAK family of kinases
KR102466418B1 (en) 2016-12-16 2022-11-14 화이자 인코포레이티드 Glp-1 receptor agonists and uses thereof
PT3494116T (en) 2017-01-30 2020-01-28 Astrazeneca Ab Estrogen receptor modulators
AU2018256459B2 (en) 2017-04-21 2023-12-07 Ikena Oncology, Inc. Indole AHR inhibitors and uses thereof
TW202016110A (en) 2018-06-15 2020-05-01 比利時商健生藥品公司 Small molecule inhibitors of the jak family of kinases
WO2020216936A1 (en) 2019-04-24 2020-10-29 Janssen Pharmaceutica Nv Non-clinical liquid formulations of pan-jak inhibitor

Also Published As

Publication number Publication date
NI201900060A (en) 2020-03-16
IL267275B (en) 2021-07-29
KR102352462B1 (en) 2022-01-17
MD3555097T2 (en) 2022-12-31
AU2017377069A1 (en) 2019-06-20
CO2019006200A2 (en) 2019-06-28
US10364246B2 (en) 2019-07-30
CA3046965A1 (en) 2018-06-21
HUE059274T2 (en) 2022-11-28
LT3555097T (en) 2022-08-25
EP3555097A1 (en) 2019-10-23
PL3555097T3 (en) 2022-10-17
TW201831180A (en) 2018-09-01
EP4086256A1 (en) 2022-11-09
RS63500B1 (en) 2022-09-30
JP2023071709A (en) 2023-05-23
US20210340143A1 (en) 2021-11-04
AU2022204240A1 (en) 2022-07-07
PT3555097T (en) 2022-09-22
US10294226B2 (en) 2019-05-21
ZA201904615B (en) 2021-05-26
US20180170931A1 (en) 2018-06-21
IL267275A (en) 2019-08-29
HRP20220885T1 (en) 2022-12-09
CN110088105A (en) 2019-08-02
CN110088105B (en) 2022-03-18
UA125042C2 (en) 2021-12-29
SA519402216B1 (en) 2022-10-02
BR112019011968A2 (en) 2019-11-05
PE20191105A1 (en) 2019-08-23
AU2022204240B2 (en) 2023-10-05
SI3555097T1 (en) 2022-09-30
US11059823B2 (en) 2021-07-13
EP3555097B1 (en) 2022-06-15
MX2019007073A (en) 2019-10-15
KR20190086779A (en) 2019-07-23
MY196260A (en) 2023-03-24
ECSP19042688A (en) 2019-06-30
ES2922379T3 (en) 2022-09-14
MX2022004474A (en) 2023-08-15
JP7493068B2 (en) 2024-05-30
WO2018112379A1 (en) 2018-06-21
JOP20190143B1 (en) 2023-09-17
JP7291077B2 (en) 2023-06-14
AU2017377069B2 (en) 2020-07-23
CR20190282A (en) 2019-08-21
CL2019001626A1 (en) 2019-10-04
TWI777997B (en) 2022-09-21
PH12019501254A1 (en) 2020-01-20
AU2020257068A1 (en) 2020-11-19
DK3555097T3 (en) 2022-07-25
US20190177322A1 (en) 2019-06-13
JP2020502113A (en) 2020-01-23
US10487083B2 (en) 2019-11-26
US20190177321A1 (en) 2019-06-13
US20190185474A1 (en) 2019-06-20

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