JOP20160198B1 - مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك - Google Patents

مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك

Info

Publication number
JOP20160198B1
JOP20160198B1 JOP/2016/0198A JOP20160198A JOP20160198B1 JO P20160198 B1 JOP20160198 B1 JO P20160198B1 JO P20160198 A JOP20160198 A JO P20160198A JO P20160198 B1 JOP20160198 B1 JO P20160198B1
Authority
JO
Jordan
Prior art keywords
dengue viral
mono
compounds
substituted indole
viral replication
Prior art date
Application number
JOP/2016/0198A
Other languages
English (en)
Inventor
Bart Rudolf Romanie Kesteleyn
Jean-François Bonfanti
Dorothée Alice Marie-Eve Bardiot
Arnaud Didier M Marchand
Tim Hugo Maria Jonckers
Pierre Jean-Marie Bernard Raboisson
Original Assignee
Janssen Pharmaceuticals Inc
Katholieke Univ Leuven Ku Leuven Research And Development
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc, Katholieke Univ Leuven Ku Leuven Research And Development filed Critical Janssen Pharmaceuticals Inc
Application granted granted Critical
Publication of JOP20160198B1 publication Critical patent/JOP20160198B1/ar

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

يتعلق الاختراع الحالي بمركبات اندول مستبدلة احاديا أو ثنائيا وبطرق لمنع او معالجة الاصابات الفيروسية باستخدام المركبات المذكورة. وكما يتعلق بالمركبات المذكورة بخصوص استخدامها كدواء والافضل لاستخدامها كعلاج لمنع أو معالجة الاصابات الفيروسية لحمى الفنك. كما يتعلق الاختراع الحالي بتركيبات صيدلانية أو مستحضرات متحدة من المركبات، وبالتركيبات أو المستحضرات لاستخدامها كدواء، والافضل لمنع أو معالجة الاصابات الفيروسية لحمى الفنك. كما يتعلق الاخراع بعمليات و طرق لتحضير هذه المركبات.
JOP/2016/0198A 2015-09-16 2016-09-06 مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك JOP20160198B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15185523 2015-09-16
EP16163472 2016-04-01

Publications (1)

Publication Number Publication Date
JOP20160198B1 true JOP20160198B1 (ar) 2022-03-14

Family

ID=56926217

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2016/0198A JOP20160198B1 (ar) 2015-09-16 2016-09-06 مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك

Country Status (30)

Country Link
US (1) US10765662B2 (ar)
EP (1) EP3350162B1 (ar)
JP (2) JP7050666B2 (ar)
KR (1) KR102646174B1 (ar)
CN (1) CN108473422B (ar)
AU (1) AU2016324982B2 (ar)
CA (1) CA2996979C (ar)
CL (1) CL2018000696A1 (ar)
CO (1) CO2018003471A2 (ar)
CR (1) CR20180213A (ar)
DK (1) DK3350162T3 (ar)
EA (1) EA035663B1 (ar)
EC (1) ECSP18020055A (ar)
ES (1) ES2893298T3 (ar)
HK (1) HK1257842A1 (ar)
HR (1) HRP20211352T1 (ar)
HU (1) HUE055870T2 (ar)
IL (1) IL258043B (ar)
JO (1) JOP20160198B1 (ar)
LT (1) LT3350162T (ar)
MA (1) MA42810A (ar)
MX (1) MX2018003255A (ar)
NI (1) NI201800039A (ar)
PE (1) PE20181165A1 (ar)
PH (1) PH12018500576A1 (ar)
SI (1) SI3350162T1 (ar)
TW (1) TWI758255B (ar)
UA (1) UA122973C2 (ar)
UY (1) UY36903A (ar)
WO (1) WO2017046255A1 (ar)

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Also Published As

Publication number Publication date
LT3350162T (lt) 2021-09-27
TWI758255B (zh) 2022-03-21
CA2996979A1 (en) 2017-03-23
UA122973C2 (uk) 2021-01-27
US20180256545A1 (en) 2018-09-13
EP3350162B1 (en) 2021-07-14
CN108473422B (zh) 2021-06-15
CO2018003471A2 (es) 2018-07-10
TW201722913A (zh) 2017-07-01
HUE055870T2 (hu) 2021-12-28
NI201800039A (es) 2018-07-24
PE20181165A1 (es) 2018-07-19
HK1257842A1 (zh) 2019-11-01
DK3350162T3 (da) 2021-10-04
EA201890722A1 (ru) 2018-09-28
AU2016324982A1 (en) 2018-03-15
WO2017046255A1 (en) 2017-03-23
ES2893298T3 (es) 2022-02-08
HRP20211352T1 (hr) 2022-02-04
ECSP18020055A (es) 2018-04-30
CR20180213A (es) 2018-06-27
UY36903A (es) 2017-03-31
PH12018500576A1 (en) 2018-10-15
MA42810A (fr) 2018-07-25
MX2018003255A (es) 2018-11-09
IL258043B (en) 2021-08-31
EP3350162A1 (en) 2018-07-25
CL2018000696A1 (es) 2018-07-06
EA035663B1 (ru) 2020-07-23
AU2016324982B2 (en) 2021-04-15
JP7050666B2 (ja) 2022-04-08
US10765662B2 (en) 2020-09-08
JP2021181485A (ja) 2021-11-25
SI3350162T1 (sl) 2021-11-30
JP2018528220A (ja) 2018-09-27
KR102646174B1 (ko) 2024-03-08
IL258043A (en) 2018-05-31
CA2996979C (en) 2024-01-30
KR20180052672A (ko) 2018-05-18
CN108473422A (zh) 2018-08-31

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