JO3300B1 - مركبات وتركيبات لتعديل نشاط egfr - Google Patents

مركبات وتركيبات لتعديل نشاط egfr

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Publication number
JO3300B1
JO3300B1 JOP/2013/0171A JOP20130171A JO3300B1 JO 3300 B1 JO3300 B1 JO 3300B1 JO P20130171 A JOP20130171 A JO P20130171A JO 3300 B1 JO3300 B1 JO 3300B1
Authority
JO
Jordan
Prior art keywords
compounds
egfr activity
compositions
modulating egfr
modulating
Prior art date
Application number
JOP/2013/0171A
Other languages
English (en)
Inventor
Bursulaya Badry
Chen Bei
Michellys Pierre-Yves
H Marsilje Thomas Iii
Lelais Gerald
Epple Robert
Jiang Songchun
Mcneill Matthew
Lu Wenshuo
Long Yun
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54193706&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3300(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of JO3300B1 publication Critical patent/JO3300B1/ar

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

يقدم الإختراع المركبات والتركيبات الصيدلانية منه، والتي تكون مفيدة في تعديل نشاط EGFR، بالإضافة إلى طرق إستخدام تلك المركبات في علاج، تخفيف، أو منع الحالة المرتبطة بنشاط EGFR الغير طبيعي أو الغير منتظم.
JOP/2013/0171A 2012-06-06 2013-06-04 مركبات وتركيبات لتعديل نشاط egfr JO3300B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1741DE2012 2012-06-06
US201361770752P 2013-02-28 2013-02-28

Publications (1)

Publication Number Publication Date
JO3300B1 true JO3300B1 (ar) 2018-09-16

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JOP/2013/0171A JO3300B1 (ar) 2012-06-06 2013-06-04 مركبات وتركيبات لتعديل نشاط egfr

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US (1) US9440957B2 (ar)
EP (2) EP3257848A1 (ar)
JP (1) JP6039800B2 (ar)
KR (1) KR101817829B1 (ar)
CN (1) CN104379575B (ar)
AP (1) AP3909A (ar)
AR (1) AR091368A1 (ar)
AU (1) AU2013271733B2 (ar)
BR (1) BR112014030386B1 (ar)
CA (1) CA2875966C (ar)
CL (1) CL2014003227A1 (ar)
CO (1) CO7160047A2 (ar)
CR (1) CR20140563A (ar)
CU (1) CU20140139A7 (ar)
CY (1) CY1119531T1 (ar)
DK (1) DK2773635T3 (ar)
DO (1) DOP2014000277A (ar)
EA (1) EA026269B1 (ar)
ES (1) ES2645973T3 (ar)
GE (1) GEP201606555B (ar)
GT (1) GT201400282A (ar)
HR (1) HRP20171670T1 (ar)
HU (1) HUE034759T2 (ar)
IL (1) IL235974A (ar)
JO (1) JO3300B1 (ar)
LT (1) LT2773635T (ar)
MA (1) MA37739B1 (ar)
MX (1) MX345630B (ar)
MY (1) MY165036A (ar)
NZ (1) NZ627661A (ar)
PE (1) PE20150726A1 (ar)
PH (1) PH12014502704B1 (ar)
PL (1) PL2773635T3 (ar)
PT (1) PT2773635T (ar)
RS (1) RS56396B1 (ar)
SG (1) SG11201407793TA (ar)
SI (1) SI2773635T1 (ar)
TN (1) TN2014000487A1 (ar)
TW (1) TWI650319B (ar)
UA (1) UA113543C2 (ar)
UY (1) UY34849A (ar)
WO (1) WO2013184757A1 (ar)

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