IT8020508A0 - 24,24-difluoro-1alfa,25-diidrossicolecalciferolo. - Google Patents

24,24-difluoro-1alfa,25-diidrossicolecalciferolo.

Info

Publication number: IT8020508A0
Authority: IT; Italy
Prior art keywords: 1alfa; dihydroxycholecalciferol; difluoro
Prior art date: 1979-03-28

Application number

IT8020508A

Other languages

English (en)

Other versions

IT1140776B (it

Inventor

Heinrich K Schnoes

Hector F Delluca

Ikekawa Nobuo

Tanaka Yoko

Kobayashi Yoshiro

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-03-28

Filing date

1980-03-11

Publication date

1980-03-11

1980-03-11 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

1980-03-11 Publication of IT8020508A0 publication Critical patent/IT8020508A0/it

1986-10-10 Application granted granted Critical

1986-10-10 Publication of IT1140776B publication Critical patent/IT1140776B/it

Links

GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C35/48—Halogenated derivatives
- C07C35/52—Alcohols with a condensed ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IT20508/80A 1979-03-28 1980-03-11 24,24-difluoro-1, alfa,25-diidrossicolecalciferolo IT1140776B (it)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/024,848 US4201881A (en)	1979-03-28	1979-03-28	24,24-Difluoro-1α,25-dihydroxycholecalciferol

Publications (2)

Publication Number	Publication Date
IT8020508A0 true IT8020508A0 (it)	1980-03-11
IT1140776B IT1140776B (it)	1986-10-10

Family

ID=21822707

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT20508/80A IT1140776B (it)	1979-03-28	1980-03-11	24,24-difluoro-1, alfa,25-diidrossicolecalciferolo

Country Status (15)

Country	Link
US (1)	US4201881A (it)
JP (2)	JPS6342618B2 (it)
AU (1)	AU530015B2 (it)
BE (1)	BE882143A (it)
CH (1)	CH650240A5 (it)
DK (1)	DK147300C (it)
FR (1)	FR2452481A1 (it)
GB (2)	GB2045765B (it)
IE (1)	IE49753B1 (it)
IL (1)	IL58526A (it)
IT (1)	IT1140776B (it)
NL (1)	NL7920190A (it)
NZ (1)	NZ191900A (it)
SE (1)	SE8008339L (it)
WO (1)	WO1980002028A1 (it)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4284577A (en) *	1979-02-16	1981-08-18	Sachiko Yamada	Novel vitamin D3 derivative and process for preparing the same
CA1189537A (en) *	1981-08-28	1985-06-25	John J. Partridge	Cholecalciferol derivatives
US4456689A (en) *	1982-05-17	1984-06-26	Becton Dickinson And Company	Competitive protein binding assay using an organosilane-silica gel separation medium
NZ204223A (en) *	1982-05-17	1986-11-12	Hoffmann La Roche	Veterinary compositions containing 24,24-difluoro-1 alpha,25-dihydroxycholecalciferol
US4428946A (en) *	1982-07-26	1984-01-31	Wisconsin Alumni Research Foundation	Method of preventing milk fever in dairy cattle
EP0205285B1 (en) *	1985-05-30	1989-08-09	Taisho Pharmaceutical Co. Ltd	Vitamin d3 derivatives
US4832875A (en) *	1985-11-21	1989-05-23	Taisho Pharmaceutical Co., Ltd.	Vitamin D3 derivative
US4853378A (en) *	1986-10-20	1989-08-01	Sumitomo Chemical Company, Limited	Fluorine derivatives of vitamin D3 and process for producing the same
WO1990009179A1 (en) *	1989-02-16	1990-08-23	University Of Georgia Research Foundation, Inc.	Treatment of tibial dyschondroplasia
US5316770A (en) *	1989-02-16	1994-05-31	University Of Georgia Research Foundation, Inc.	Vitamin D derivative feed compositions and methods of use
US5366736A (en) *	1989-02-16	1994-11-22	University Of Georgia Research Foundation, Inc.	Vitamin D derivative feed compositions and methods of use
US5063234A (en) *	1990-05-25	1991-11-05	Eli Lilly And Company	Method of inhibiting demineralization of bone
CA2710954C (en) *	2007-12-28	2015-07-21	Wisconsin Alumni Research Foundation	(20s)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin d analogs
JP5504898B2 (ja) *	2010-01-08	2014-05-28	セントラル硝子株式会社	ジフルオロシクロプロパン化合物の製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3741996A (en) *	1971-12-02	1973-06-26	Wisconsin Alumni Res Found	1{60 -hydroxycholecalciferol
FR2267590B1 (it) *	1974-04-10	1977-05-20	Ibm
US3969700A (en) *	1974-04-10	1976-07-13	International Business Machines Corporation	Regional context maximum likelihood error correction for OCR, keyboard, and the like
JPS5729745B2 (it) *	1974-09-25	1982-06-24
US3993675A (en) *	1975-02-24	1976-11-23	Hoffmann-La Roche Inc.	Process for the preparation of 1α,25-dihydroxycholecalciferol
US4069321A (en) *	1975-10-14	1978-01-17	Merck & Co., Inc.	Blocked cholecalciferol and dihydrotachysterol 3 derivatives
US4284577A (en) *	1979-02-16	1981-08-18	Sachiko Yamada	Novel vitamin D3 derivative and process for preparing the same

1979
- 1979-03-28 US US06/024,848 patent/US4201881A/en not_active Expired - Lifetime
- 1979-10-15 JP JP55500243A patent/JPS6342618B2/ja not_active Expired
- 1979-10-15 NL NL7920190A patent/NL7920190A/nl unknown
- 1979-10-15 WO PCT/US1979/000899 patent/WO1980002028A1/en unknown
- 1979-10-15 CH CH8817/80A patent/CH650240A5/de not_active IP Right Cessation
- 1979-10-22 IL IL58526A patent/IL58526A/xx unknown
1980
- 1980-02-08 NZ NZ191900A patent/NZ191900A/xx unknown
- 1980-02-22 AU AU55810/80A patent/AU530015B2/en not_active Ceased
- 1980-03-07 BE BE0/199728A patent/BE882143A/fr not_active IP Right Cessation
- 1980-03-11 IT IT20508/80A patent/IT1140776B/it active
- 1980-03-13 GB GB8008488A patent/GB2045765B/en not_active Expired
- 1980-03-13 GB GB8035585A patent/GB2067567B/en not_active Expired
- 1980-03-17 FR FR8005935A patent/FR2452481A1/fr active Granted
- 1980-03-26 IE IE619/80A patent/IE49753B1/en unknown
- 1980-11-27 SE SE8008339A patent/SE8008339L/xx unknown
- 1980-11-27 DK DK505080A patent/DK147300C/da not_active IP Right Cessation
1987
- 1987-09-16 JP JP62229955A patent/JPS63179855A/ja active Granted

Also Published As

Publication number	Publication date
DK505080A (da)	1980-11-27
AU530015B2 (en)	1983-06-30
CH650240A5 (de)	1985-07-15
IL58526A (en)	1983-05-15
FR2452481A1 (fr)	1980-10-24
GB2067567A (en)	1981-07-30
DK147300C (da)	1984-12-24
US4201881A (en)	1980-05-06
BE882143A (fr)	1980-07-01
NL7920190A (nl)	1981-01-30
JPS56500296A (it)	1981-03-12
IE49753B1 (en)	1985-12-11
SE8008339L (sv)	1980-11-27
JPS6342618B2 (it)	1988-08-24
IT1140776B (it)	1986-10-10
DK147300B (da)	1984-06-12
IE800619L (en)	1980-09-28
JPS63179855A (ja)	1988-07-23
GB2045765B (en)	1983-06-15
WO1980002028A1 (en)	1980-10-02
AU5581080A (en)	1980-10-02
NZ191900A (en)	1984-11-09
FR2452481B1 (it)	1984-10-19
GB2067567B (en)	1983-03-02
IL58526A0 (en)	1980-01-31
JPH0146504B2 (it)	1989-10-09
GB2045765A (en)	1980-11-05

Publication	Publication Date	Title
DK537780A (da)	1980-12-17	1,8-naphthyridin-derivater
IT1193190B (it)	1988-06-02	2,3,4,5-tetraidro-1h-3-benzazepine mercapto-sostituito
NO153847C (no)	1986-06-04	2,4,4-triklor-4-formyl-butyronitril.
IT8119459A0 (it)	1981-02-02	25-idrossi-26,26,26,27,27,27-esaflu orocolecalciferolo.
DK3881A (da)	1981-01-06	Substituerede 9,10-anthracen-bishydrazoner
FI793663A (fi)	1980-05-30	1,2,4,5-tetra-alkyl-4-arylpiperidiner
IT8020508A0 (it)	1980-03-11	24,24-difluoro-1alfa,25-diidrossicolecalciferolo.
SE7803411L (sv)	1979-09-24	2,6-dialkoxibensamider
NL7920160A (nl)	1980-12-31	24,24-difluor-25-hydroxycholecalciferol.
FI803727L (fi)	1981-06-08	2,3-indolidionderivat
IT7823796A0 (it)	1978-05-25	1,2,4-triazolidin-3-oni e-tioni.
NO793494L (no)	1981-05-04	Sylinderlaas i.
FI801473A (fi)	1980-11-22	Framstaellningsfoerfarande foer 5-merkapto-1,2,3-triazoler
IT1196913B (it)	1988-11-25	6,7 secoergoline
NL7901111A (nl)	1979-10-05	2,3-dihydro-4h-1-benzopyran-4-on-0-carbamoyloximen.
DK136379A (da)	1979-10-06	4,6-dihalogensteroider
ATE24476T1 (de)	1987-01-15	1,3-dihalopropan-2-ole.
NO153453C (no)	1986-05-07	Stabilisert 1,1,1-trikloretan.
DE2953611A1 (de)	1981-04-09	24,24-difluoro-1alpha,25-dihydroxycholecalciferol
IT1209140B (it)	1989-07-10	6 alfa-fluoro-prednisolone 17,21-diesteri.
DK430479A (da)	1980-04-14	2,6-dihalogenbensylestere
IT7925626A0 (it)	1979-09-11	2,6-metano-3-benzazocine.
NL7803610A (nl)	1978-10-09	2,4,6-trigesubstitueerde 2,3-dihydrobenzofuranen.
FI860774A0 (fi)	1986-02-21	3,4,5-trihydroxipiperidinderivat.
DK446582A (da)	1982-10-08	24,24-difluor-1alfa,15-dihydro-5,6-transcholecalciferol