IT1271267B - Ammidi di acidi mono e bicarbossilici con amminoalcoli,selettivamente attive sul recettore periferico dei cannabinoidi - Google Patents

Ammidi di acidi mono e bicarbossilici con amminoalcoli,selettivamente attive sul recettore periferico dei cannabinoidi

Info

Publication number
IT1271267B
IT1271267B ITMI942513A ITMI942513A IT1271267B IT 1271267 B IT1271267 B IT 1271267B IT MI942513 A ITMI942513 A IT MI942513A IT MI942513 A ITMI942513 A IT MI942513A IT 1271267 B IT1271267 B IT 1271267B
Authority
IT
Italy
Prior art keywords
search
compounds
cannabinoids
mono
acid amides
Prior art date
Application number
ITMI942513A
Other languages
English (en)
Inventor
Valle Francesco Della
Alberta Leon
Gabriele Marcolongo
Silvana Lorenzi
Original Assignee
Valle Francesco Della
Alberta Leon
Gabriele Marcolongo
Silvana Lorenzi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valle Francesco Della, Alberta Leon, Gabriele Marcolongo, Silvana Lorenzi filed Critical Valle Francesco Della
Publication of ITMI942513A0 publication Critical patent/ITMI942513A0/it
Priority to ITMI942513A priority Critical patent/IT1271267B/it
Priority to JP51826496A priority patent/JP4111349B2/ja
Priority to CA002207804A priority patent/CA2207804C/en
Priority to EP95942141A priority patent/EP0799188B1/en
Priority to PCT/EP1995/004926 priority patent/WO1996018600A1/en
Priority to DE69512273T priority patent/DE69512273T2/de
Priority to AU43441/96A priority patent/AU4344196A/en
Priority to AT95942141T priority patent/ATE184591T1/de
Priority to IL11640195A priority patent/IL116401A0/xx
Publication of ITMI942513A1 publication Critical patent/ITMI942513A1/it
Application granted granted Critical
Publication of IT1271267B publication Critical patent/IT1271267B/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06Fatty acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/20Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/49Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ITMI942513A 1994-12-14 1994-12-14 Ammidi di acidi mono e bicarbossilici con amminoalcoli,selettivamente attive sul recettore periferico dei cannabinoidi IT1271267B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ITMI942513A IT1271267B (it) 1994-12-14 1994-12-14 Ammidi di acidi mono e bicarbossilici con amminoalcoli,selettivamente attive sul recettore periferico dei cannabinoidi
PCT/EP1995/004926 WO1996018600A1 (en) 1994-12-14 1995-12-13 Amides of mono and bicarboxylic acids with amino acids or glycosamines, selectively active on the cannabinoid peripheral receptor
CA002207804A CA2207804C (en) 1994-12-14 1995-12-13 Amides of mono and bicarboxylic acids with amino acids or glycosamines, selectively active on the cannabinoid peripheral receptor
EP95942141A EP0799188B1 (en) 1994-12-14 1995-12-13 Amides of mono and dicarboxylic acids with glycosamines, selectively active on the cannabinoid peripheral receptor
JP51826496A JP4111349B2 (ja) 1994-12-14 1995-12-13 カンナビノイド末梢レセプターに選択的に作用するモノおよびビカルボン酸のアミノ酸あるいはグリコサミンとのアミド類
DE69512273T DE69512273T2 (de) 1994-12-14 1995-12-13 Amide von mono-und dicarbonsäuren mit glycosaminen, mit selektiver wirkung auf den peripheren cannabinoiden rezeptor
AU43441/96A AU4344196A (en) 1994-12-14 1995-12-13 Amides of mono and bicarboxylic acids with amino acids or glycosamines, selectively active on the cannabinoid peripheral receptor
AT95942141T ATE184591T1 (de) 1994-12-14 1995-12-13 Amide von mono-und dicarbonsäuren mit glycosaminen, mit selektiver wirkung auf den peripheren cannabinoiden rezeptor
IL11640195A IL116401A0 (en) 1994-12-14 1995-12-14 Amid s of ono a d dic rboxy ic acids with aminoalcohols selectively active on the cannabinoid peripheral receptor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI942513A IT1271267B (it) 1994-12-14 1994-12-14 Ammidi di acidi mono e bicarbossilici con amminoalcoli,selettivamente attive sul recettore periferico dei cannabinoidi

Publications (3)

Publication Number Publication Date
ITMI942513A0 ITMI942513A0 (it) 1994-12-14
ITMI942513A1 ITMI942513A1 (it) 1996-06-14
IT1271267B true IT1271267B (it) 1997-05-27

Family

ID=11369990

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI942513A IT1271267B (it) 1994-12-14 1994-12-14 Ammidi di acidi mono e bicarbossilici con amminoalcoli,selettivamente attive sul recettore periferico dei cannabinoidi

Country Status (9)

Country Link
EP (1) EP0799188B1 (it)
JP (1) JP4111349B2 (it)
AT (1) ATE184591T1 (it)
AU (1) AU4344196A (it)
CA (1) CA2207804C (it)
DE (1) DE69512273T2 (it)
IL (1) IL116401A0 (it)
IT (1) IT1271267B (it)
WO (1) WO1996018600A1 (it)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19706903A1 (de) 1997-02-21 1998-08-27 Bayer Ag Verwendung von bekannten Agonisten des zentralen Cannabinoid-Rezeptors CB 1
EP1071419B1 (en) 1998-04-21 2007-07-25 THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Cannabinoids as antioxidants and neuroprotectants
DE60042004D1 (de) 1999-04-28 2009-05-28 Toray Industries Stoffe zur enternung von cannabinoiden und säulen mit diesen stoffen zur entfernung von cannabinoiden
ES2368199T3 (es) 1999-07-07 2011-11-15 Innovet Italia S.R.L. Derivados covalentes de alcanolamidas de ácidos monocarboxílicos y dicarboxílicos funcionalmente activos en el receptor cannabinoide cb2.
WO2002029001A2 (en) * 2000-10-03 2002-04-11 University Of Virginian Patent Foundation Novel lysophosphatidic acid receptor agonists and antagonists
US8449908B2 (en) 2000-12-22 2013-05-28 Alltranz, Llc Transdermal delivery of cannabidiol
WO2002064616A2 (en) 2001-01-30 2002-08-22 University Of Virgina Patent Foundation Agonists and antagonists of sphingosine-1-phosphate receptors
ITMI20011483A1 (it) * 2001-07-11 2003-01-11 Res & Innovation Soc Coop A R Uso di composti come antagonisti funzionali ai recettori centrali deicannabinoidi
US20050101590A1 (en) 2002-02-19 2005-05-12 Kiyoshi Yasui Antipruritics
AU2003217961B2 (en) 2002-03-08 2008-02-28 Signal Pharmaceuticals, Llc Combination therapy for treating, preventing or managing proliferative disorders and cancers
ES2284807T3 (es) * 2002-06-26 2007-11-16 Innovet Italia S.R.L. Composicion farmaceutica para prevenir el desarrollo y la progresion de enfermedades cutaneas superficiales.
EP1917956A3 (en) * 2002-07-25 2008-12-31 Lion Corporation External preparation composition
WO2004082673A1 (ja) * 2003-03-20 2004-09-30 Menicon Co. Ltd. 眼科用液剤組成物
EP1750722A4 (en) 2004-05-06 2010-03-10 Univ Virginia NEW LYSOPHOSPHIC ACID RECEPTORSELECTIVE ANTAGONISTS
ITMI20041567A1 (it) * 2004-07-30 2004-10-30 Maycos Italiana Di Comini Miro "derivati n-acilati di acidi bicarbossilici con amminoacidi e con idrolizzati proteici vegetali e loro applicazione in prodotti cosmetici, dermofarmaceutici e farmaceutici"
EP2176208B1 (en) 2007-07-30 2015-01-21 Zynerba Pharmaceuticals, Inc. Prodrugs of cannabidiol, compositions comprising prodrugs of cannabidiol and methods of using the same
WO2009125409A2 (en) * 2008-04-09 2009-10-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Fatty acid amides and uses thereof
MY144409A (en) * 2009-04-09 2011-09-15 Malaysian Palm Oil Board A method of producing derivatives of azelaic acid
AU2012210179C1 (en) * 2011-01-24 2016-11-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Nanoparticles based for dermal and systemic delivery of drugs
CN106232577B (zh) 2014-04-25 2019-02-22 味之素株式会社 免疫刺激剂
EP3368508A1 (en) 2015-10-28 2018-09-05 Ajinomoto Co., Inc. Immunostimulating agent
IT201800000728A1 (it) * 2018-01-11 2019-07-11 Univ Degli Studi Di Milano Bicocca Nuovi antagonisti del tlr4 umano
IT201800003912A1 (it) * 2018-03-26 2019-09-26 Innovet Italia Srl N-palmitoil-d-glucosamina in forma micronizzata
EP3574899A1 (en) * 2018-05-28 2019-12-04 Université de Bourgogne Oleic acid derivatives, pharmaceutical composition or food composition comprising said oleic acid derivatives, and their uses
CN112341354B (zh) * 2020-09-24 2022-06-10 湖北泓肽生物科技有限公司 一种pms的合成方法
CN113502153B (zh) * 2021-07-07 2023-02-14 哈尔滨工程大学 一种非芳香性发光小分子/SiO2杂化的荧光纳米材料及其制备方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5117535B2 (it) * 1973-04-23 1976-06-03
JPS5117534B2 (it) * 1973-04-23 1976-06-03
JPS5850961B2 (ja) * 1976-11-05 1983-11-14 カネボウ株式会社 安定化された毛髪染色用組成物
US4933363A (en) * 1988-08-16 1990-06-12 Elsohly Mahmoud A Method for effecting systemic delivery of delta-9-tetrahydrocannabinol
US4999417A (en) * 1989-03-30 1991-03-12 Nova Pharmaceutical Corporation Biodegradable polymer compositions
JP3202777B2 (ja) * 1992-01-24 2001-08-27 リンテック株式会社 経皮吸収促進剤及びテープ製剤
IL101708A (en) * 1992-04-28 1996-08-04 Senyorina Ltd Anti-fattening drugs comprising amino acid derivatives
JP3435195B2 (ja) * 1992-10-30 2003-08-11 花王株式会社 皮脂分泌抑制剤
IL103932A (en) * 1992-11-30 1997-02-18 Yissum Res & Dev Fatty acid and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0799188A2 (en) 1997-10-08
JPH11501615A (ja) 1999-02-09
ATE184591T1 (de) 1999-10-15
ITMI942513A0 (it) 1994-12-14
ITMI942513A1 (it) 1996-06-14
EP0799188B1 (en) 1999-09-15
CA2207804C (en) 2007-08-07
IL116401A0 (en) 1996-03-31
DE69512273T2 (de) 2000-05-11
DE69512273D1 (de) 1999-10-21
AU4344196A (en) 1996-07-03
WO1996018600A1 (en) 1996-06-20
JP4111349B2 (ja) 2008-07-02
CA2207804A1 (en) 1996-06-20

Similar Documents

Publication Publication Date Title
IT1271267B (it) Ammidi di acidi mono e bicarbossilici con amminoalcoli,selettivamente attive sul recettore periferico dei cannabinoidi
CA2200707A1 (en) Novel prostaglandin synthase inhibitors
CA2304713A1 (en) Biphenyl-5-alkanoic acid derivatives and use thereof
KR970704864A (ko) 세정제 조성물
EA200200510A1 (ru) 4-карбоксиамино-2-этил-1,2,3,4-тетрагидрохинолин в кристаллической форме как ингибитор сетр
RU94033486A (ru) Способ получения 3-арил-бензофуранонов
HK1075660A1 (en) Polycyclic compounds as potent alpha2-adrenoceptorantagonists
AU6570186A (en) Novel pyrrolidinylamide ester derivative having anti-prolyl endopeptidase activity and synthesis and use thereof
CA2133885A1 (en) Crystalline inclusion complex of diclofenac with beta-cyclodextrin
DE59902779D1 (de) Kristallmodifikation der liponsäure
ID30511A (id) Proses polimerisasi radikal bebas dengan penghentian segera
FI955498A0 (fi) Nipekotiinihappojohdannaisia hyytymistä estävinä aineina
KR950008497A (ko) 락톨 유도체, 이의 제법 및 용도
FR2854629B1 (fr) Procede de synthese de la 4-hydroxyisoleucine et de ses derives
MX9603348A (es) Derivados de disulfuro de amida indano-2-mercaptoacetilica novedosos utiles como inhibidores de encefalinasa.
EA200101001A1 (ru) Декурсинол или его производное в качестве аналгезирующего средства
ES2128031T3 (es) Forma cristalina y polimorfica de (s,s,s)-n-(1-(2-carboxi-3-(n2-mesilisilamino)propil)-1-ciclopentilcarbonil)tirosina.
AU563426B2 (en) 3-alkoxy-2(n-pyrrolidino)-n-pyridyl-n-furyl (or thienyl) methyl propylamines
BR0013094A (pt) Processo para a preparação de compostos 1,3-dicarbonìlicos acilados
CA2183320A1 (en) Novel Mercaptoacetylamide Disulfide Derivatives Useful as Inhibitors of Enkephalinase and Ace
BR9405186A (pt) Processo para a preparação de 2,4,5-tribromopirrol-3-carbonitrila
ATE93260T1 (de) Fluessigkristallzusammensetzung und vorrichtung, die diese verwendet.
FI960588A0 (fi) Mikrobisideina käytettäviä tiokarbamoyyliyhdisteitä
CA2276320A1 (en) L-tartrate of trans-(-)-4-(4-fluorophenyl)-3-hydroxymethylpiperidine compound and process for preparing the same
KR960037049A (ko) 케노데옥시콜린산의 유도체를 함유하는 혈관형성 억제제

Legal Events

Date Code Title Description
0001 Granted