IT1252567B - DERIVATIVES OF 5-ISOKINOLINSULPHONAMIDS INHIBITORS OF PROTEIN-KINASES - Google Patents

DERIVATIVES OF 5-ISOKINOLINSULPHONAMIDS INHIBITORS OF PROTEIN-KINASES

Info

Publication number
IT1252567B
IT1252567B ITMI913431A ITMI913431A IT1252567B IT 1252567 B IT1252567 B IT 1252567B IT MI913431 A ITMI913431 A IT MI913431A IT MI913431 A ITMI913431 A IT MI913431A IT 1252567 B IT1252567 B IT 1252567B
Authority
IT
Italy
Prior art keywords
isokinolinsulphonamids
kinases
inhibitors
protein
derivatives
Prior art date
Application number
ITMI913431A
Other languages
Italian (it)
Inventor
Silvio Levi
Gianni Gromo
Tiziana Maoret
Alberto Sala
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Priority to ITMI913431A priority Critical patent/IT1252567B/en
Publication of ITMI913431A0 publication Critical patent/ITMI913431A0/en
Priority to PCT/EP1992/002869 priority patent/WO1993013072A1/en
Priority to AU32561/93A priority patent/AU3256193A/en
Priority to ZA929768A priority patent/ZA929768B/en
Publication of ITMI913431A1 publication Critical patent/ITMI913431A1/en
Application granted granted Critical
Publication of IT1252567B publication Critical patent/IT1252567B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ITMI913431A 1991-12-20 1991-12-20 DERIVATIVES OF 5-ISOKINOLINSULPHONAMIDS INHIBITORS OF PROTEIN-KINASES IT1252567B (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ITMI913431A IT1252567B (en) 1991-12-20 1991-12-20 DERIVATIVES OF 5-ISOKINOLINSULPHONAMIDS INHIBITORS OF PROTEIN-KINASES
PCT/EP1992/002869 WO1993013072A1 (en) 1991-12-20 1992-12-11 5-isoquinolinesulfonamide derivatives as protein kinase inhibiting agents
AU32561/93A AU3256193A (en) 1991-12-20 1992-12-11 5-isoquinolinesulfonamide derivatives as protein kinase inhibiting agents
ZA929768A ZA929768B (en) 1991-12-20 1992-12-17 5-isoquinolinesulfonamide derivatives as protein kinase inhibiting agents.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI913431A IT1252567B (en) 1991-12-20 1991-12-20 DERIVATIVES OF 5-ISOKINOLINSULPHONAMIDS INHIBITORS OF PROTEIN-KINASES

Publications (3)

Publication Number Publication Date
ITMI913431A0 ITMI913431A0 (en) 1991-12-20
ITMI913431A1 ITMI913431A1 (en) 1993-06-20
IT1252567B true IT1252567B (en) 1995-06-19

Family

ID=11361396

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI913431A IT1252567B (en) 1991-12-20 1991-12-20 DERIVATIVES OF 5-ISOKINOLINSULPHONAMIDS INHIBITORS OF PROTEIN-KINASES

Country Status (4)

Country Link
AU (1) AU3256193A (en)
IT (1) IT1252567B (en)
WO (1) WO1993013072A1 (en)
ZA (1) ZA929768B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5707985A (en) * 1995-06-07 1998-01-13 Tanabe Seiyaku Co. Ltd. Naphthyl-, quinolyl- and isoquinolyl- sulfonamide derivatives as cell adhesion modulators
TW402591B (en) * 1997-07-11 2000-08-21 Janssen Pharmaceutica Nv Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
WO1999027921A2 (en) * 1997-12-03 1999-06-10 Eisai Co., Ltd. Compositions and methods for modulating the activity of fibroblast growth factor
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
UY29177A1 (en) 2004-10-25 2006-05-31 Astex Therapeutics Ltd SUBSTITUTED DERIVATIVES OF PURINA, PURINONA AND DEAZAPURINA, COMPOSITIONS THAT CONTAIN METHODS FOR THEIR PREPARATION AND ITS USES
DK3421471T3 (en) 2006-04-25 2021-06-14 Astex Therapeutics Ltd PURIN AND DEAZAPURIN DERIVATIVES AS PHARMACEUTICAL COMPOUNDS
CA3041868C (en) 2008-10-09 2023-03-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bis sulfonamide piperazinyl and piperidinyl activators of human pyruvatekinase
CA2758071C (en) 2009-04-06 2018-01-09 Agios Pharmaceuticals, Inc. Pyruvate kinase m2 modulators, therapeutic compositions and related methods of use
WO2010129596A1 (en) 2009-05-04 2010-11-11 Agios Pharmaceuticals, Inc. Pmk2 modulators for use in the treatment of cancer
AR077292A1 (en) 2009-06-29 2011-08-17 Agios Pharmaceuticals Inc DERIVATIVES OF PIPERAZIN - QUINOLIN SULFONAMIDS AND PHARMACEUTICAL COMPOSITIONS
ES2618630T3 (en) 2009-06-29 2017-06-21 Agios Pharmaceuticals, Inc. Therapeutic compositions and related methods of use
CN102199122A (en) * 2010-03-23 2011-09-28 范扶民 Homopiperazine derivative and preparation method thereof
JP2013525438A (en) 2010-04-29 2013-06-20 アメリカ合衆国 Human pyruvate kinase activator
CA2821975A1 (en) 2010-12-17 2012-06-21 Shunqi Yan N-(4-(azetidine-1-carbonyl)phenyl)-(hetero-) arylsulfonamide derivatives as pyruvate kinase m2 pkm2 modulators
EP2655350B1 (en) 2010-12-21 2016-03-09 Agios Pharmaceuticals, Inc. Bicyclic pkm2 activators
TWI549947B (en) 2010-12-29 2016-09-21 阿吉歐斯製藥公司 Therapeutic compounds and compositions
PL3406251T3 (en) 2011-05-03 2024-04-29 Agios Pharmaceuticals, Inc. Pyruvate kinase activators for use in therapy
EP4344703A1 (en) 2015-06-11 2024-04-03 Agios Pharmaceuticals, Inc. Methods of using pyruvate kinase activators

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4456757A (en) * 1981-03-20 1984-06-26 Asahi Kasei Kogyo Kabushiki Kaisha Isoquinolinesulfonyl derivatives and process for the preparation thereof
JPH0667926B2 (en) * 1985-11-12 1994-08-31 旭化成工業株式会社 Cyclic isoquinoline sulfonamide derivative

Also Published As

Publication number Publication date
ITMI913431A1 (en) 1993-06-20
AU3256193A (en) 1993-07-28
WO1993013072A1 (en) 1993-07-08
ITMI913431A0 (en) 1991-12-20
ZA929768B (en) 1993-06-14

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19951206