IT1223313B - BILIARY ACID DERIVATIVES THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

BILIARY ACID DERIVATIVES THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number
IT1223313B
IT1223313B IT22343/87A IT2234387A IT1223313B IT 1223313 B IT1223313 B IT 1223313B IT 22343/87 A IT22343/87 A IT 22343/87A IT 2234387 A IT2234387 A IT 2234387A IT 1223313 B IT1223313 B IT 1223313B
Authority
IT
Italy
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
acid derivatives
biliary acid
Prior art date
Application number
IT22343/87A
Other languages
Italian (it)
Other versions
IT8722343A0 (en
Inventor
Giuliano Frigerio
Roberto Pellicciari
Aldo Roda
Original Assignee
Gipharmex Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gipharmex Spa filed Critical Gipharmex Spa
Publication of IT8722343A0 publication Critical patent/IT8722343A0/en
Priority to IT22343/87A priority Critical patent/IT1223313B/en
Priority to DE198888116747T priority patent/DE312867T1/en
Priority to DE8888116747T priority patent/DE3870801D1/en
Priority to ES198888116747T priority patent/ES2009723T3/en
Priority to EP88116747A priority patent/EP0312867B1/en
Priority to AT88116747T priority patent/ATE75750T1/en
Priority to JP63262672A priority patent/JP2813610B2/en
Priority to US07/259,870 priority patent/US4921848A/en
Priority to GR89300125T priority patent/GR890300125T1/en
Application granted granted Critical
Publication of IT1223313B publication Critical patent/IT1223313B/en
Priority to GR920401315T priority patent/GR3004980T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Nutrition Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compounds of formula I <CHEM> wherein: R1 is hydrogen or hydroxy, and the methyl and hydroxy groups at 6- and 7-positions respectively can be either in alpha or beta configuration, are useful in human therapy. Compounds I are prepared by methylation of the corresponding appropriately protected 7-keto-derivatives.
IT22343/87A 1987-10-20 1987-10-20 BILIARY ACID DERIVATIVES THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM IT1223313B (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IT22343/87A IT1223313B (en) 1987-10-20 1987-10-20 BILIARY ACID DERIVATIVES THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EP88116747A EP0312867B1 (en) 1987-10-20 1988-10-10 Billiary acid derivatives, processes for the preparation thereof and phamaceutical compositions containing them
DE8888116747T DE3870801D1 (en) 1987-10-20 1988-10-10 GALLEN ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS THAT CONTAIN IT.
ES198888116747T ES2009723T3 (en) 1987-10-20 1988-10-10 DERIVATIVES OF BILIAR ACIDS, PROCEDURES FOR THE PREPARATION OF THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
DE198888116747T DE312867T1 (en) 1987-10-20 1988-10-10 GALLEN ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS THAT CONTAIN IT.
AT88116747T ATE75750T1 (en) 1987-10-20 1988-10-10 BIL ACID DERIVATIVES, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.
JP63262672A JP2813610B2 (en) 1987-10-20 1988-10-18 Bile acid derivative, method for producing the same, and pharmaceutical composition containing the same
US07/259,870 US4921848A (en) 1987-10-20 1988-10-19 Biliary acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
GR89300125T GR890300125T1 (en) 1987-10-20 1990-01-31 Billiary acid derivatives, processes for the preparation thereof and phamaceutical compositions containing them
GR920401315T GR3004980T3 (en) 1987-10-20 1992-06-18

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22343/87A IT1223313B (en) 1987-10-20 1987-10-20 BILIARY ACID DERIVATIVES THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (2)

Publication Number Publication Date
IT8722343A0 IT8722343A0 (en) 1987-10-20
IT1223313B true IT1223313B (en) 1990-09-19

Family

ID=11194953

Family Applications (1)

Application Number Title Priority Date Filing Date
IT22343/87A IT1223313B (en) 1987-10-20 1987-10-20 BILIARY ACID DERIVATIVES THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (8)

Country Link
US (1) US4921848A (en)
EP (1) EP0312867B1 (en)
JP (1) JP2813610B2 (en)
AT (1) ATE75750T1 (en)
DE (2) DE3870801D1 (en)
ES (1) ES2009723T3 (en)
GR (2) GR890300125T1 (en)
IT (1) IT1223313B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1229569B (en) * 1989-04-17 1991-09-04 Giuliani Spa BILIARY ACID DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
US5650967A (en) * 1995-07-06 1997-07-22 Micron Technology, Inc. Method and apparatus for writing and erasing flash memory
US6592593B1 (en) * 1998-09-18 2003-07-15 United States Surgical Corporation Endovascular fastener applicator
EP1392714B1 (en) 2001-03-12 2005-08-31 Intercept Pharmaceuticals, Inc. Steroids as agonists for fxr
ITMI20021532A1 (en) * 2002-07-12 2004-01-12 Roberto Pellicciari CHEMICAL COMPOUNDS
EP1562915A1 (en) 2002-11-22 2005-08-17 SmithKline Beecham Corporation Farnesoid x receptor agonists
EP1568706A1 (en) * 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Novel steroid agonist for FXR
US10987362B2 (en) 2004-03-12 2021-04-27 Intercept Pharmaceuticals, Inc. Treatment of fibrosis using FXR ligands
US9498484B2 (en) 2004-03-12 2016-11-22 Intercept Pharmaceuticals, Inc. Treatment of fibrosis using FXR ligands
ITMI20050912A1 (en) * 2005-05-19 2006-11-20 Erregierre Spa PROCESS OF PREPARATION OF ACIDS 3-A-YA (B) -DIDROSSI-6-A (B) -ALCHIL-5B-COLANICI
MX2009007728A (en) 2007-01-19 2009-12-15 Intercept Pharmaceuticals Inc 23-substituted bile acids as tgr5 modulators and methods of use thereof.
CA2732323C (en) 2008-07-30 2017-06-27 Intercept Pharmaceuticals, Inc. Tgr5 modulators and methods of use thereof
JP5535233B2 (en) 2008-11-19 2014-07-02 インターセプト ファーマシューティカルズ， インコーポレイテッド TGR5 modulator and method of using the same
AU2013277429B2 (en) 2012-06-19 2016-01-14 Intercept Pharmaceuticals, Inc. Preparation, uses and solid forms of obeticholic acid
US9982008B2 (en) 2012-06-19 2018-05-29 Intercept Pharmaceuticals, Inc. Preparation and uses of obeticholic acid
EP3006557A1 (en) 2014-10-07 2016-04-13 Heinrich-Heine-Universität Düsseldorf Bile acids for inducing hepatic differentiation
EP3359160B1 (en) 2015-10-07 2021-08-25 Intercept Pharmaceuticals, Inc. Farnesoid x receptor modulators
CN106589039B (en) * 2015-10-15 2019-12-17 苏州朗科生物技术股份有限公司 preparation method of obeticholic acid and related compound
CN107021994B (en) * 2017-04-07 2020-12-22 华东师范大学 Synthetic method of intermediate 3 alpha-hydroxy-7-ketone-5 beta-cholestane-24-acid of obeticholic acid
CN106995478A (en) * 2017-04-07 2017-08-01 华东师范大学 A kind of synthetic method of the keto lithcholic acid of intermediate 7 of urso
CN107033208A (en) * 2017-04-07 2017-08-11 华东师范大学 A kind of synthetic method of 7 keto lithcholic acid
CN106939030A (en) * 2017-04-07 2017-07-11 华东师范大学 A kind of synthetic method of the keto lithcholic acid of intermediate 7 of shellfish cholic acid difficult to understand

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2615902A (en) * 1950-10-24 1952-10-28 Merck & Co Inc Chemical compounds and processes for preparing the same
US2966499A (en) * 1958-04-09 1960-12-27 Merck & Co Inc Oxidation of cholic acid with chlorine
US2938031A (en) * 1958-12-11 1960-05-24 Searle & Co 17-carboxyalkylated 3-oxygenated 6-methylandrosten-17-ol lactones and intermediates
US3591687A (en) * 1968-03-13 1971-07-06 George A Bray Bile acids and derivatives thereof as anorectic agents
US4172076A (en) * 1977-04-04 1979-10-23 Diamond Shamrock Corporation Process for preparing steroidal acids and their intermediate derivatives
US4460509A (en) 1981-08-19 1984-07-17 Beth Israel Medical Center Chemical synthesis
US4545938A (en) 1983-11-02 1985-10-08 Beth Israel Medical Center Chemical synthesis
US4648995A (en) 1983-11-02 1987-03-10 Beth Israel Medical Center Chemical synthesis

Also Published As

Publication number Publication date
DE312867T1 (en) 1989-10-05
EP0312867B1 (en) 1992-05-06
ATE75750T1 (en) 1992-05-15
JPH01135795A (en) 1989-05-29
GR3004980T3 (en) 1993-04-28
IT8722343A0 (en) 1987-10-20
DE3870801D1 (en) 1992-06-11
EP0312867A1 (en) 1989-04-26
US4921848A (en) 1990-05-01
ES2009723A4 (en) 1989-10-16
GR890300125T1 (en) 1990-01-31
JP2813610B2 (en) 1998-10-22
ES2009723T3 (en) 1993-02-16

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