IN2014MN02436A - - Google Patents

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Publication number
IN2014MN02436A
IN2014MN02436A IN2436MUN2014A IN2014MN02436A IN 2014MN02436 A IN2014MN02436 A IN 2014MN02436A IN 2436MUN2014 A IN2436MUN2014 A IN 2436MUN2014A IN 2014MN02436 A IN2014MN02436 A IN 2014MN02436A
Authority
IN
India
Prior art keywords
gas
subject
petx
inspired
target
Prior art date
Application number
Inventor
Michael Klein
Joseph Fisher
James Duffin
Marat Slessarev
Cathie Kessler
Shoji Ito
Olivia Sobczyk
Charbonney Anne Battisti
David Mikulis
Daniel Michael Mandell
Original Assignee
Michael Klein
Joseph Fisher
James Duffin
Marat Slessarev
Cathie Kessler
Shoji Ito
Olivia Sobczyk
Charbonney Anne Battisti
David Mikulis
Daniel Michael Mandell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Michael Klein, Joseph Fisher, James Duffin, Marat Slessarev, Cathie Kessler, Shoji Ito, Olivia Sobczyk, Charbonney Anne Battisti, David Mikulis, Daniel Michael Mandell filed Critical Michael Klein
Publication of IN2014MN02436A publication Critical patent/IN2014MN02436A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0057—Pumps therefor
    • A61M16/0066—Blowers or centrifugal pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0045—Means for re-breathing exhaled gases, e.g. for hyperventilation treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/021—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes operated by electrical means
    • A61M16/022—Control means therefor
    • A61M16/024—Control means therefor including calculation means, e.g. using a processor
    • A61M16/026—Control means therefor including calculation means, e.g. using a processor specially adapted for predicting, e.g. for determining an information representative of a flow limitation during a ventilation cycle by using a root square technique or a regression analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
    • A61M16/122—Preparation of respiratory gases or vapours by mixing different gases with dilution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/091—Measuring volume of inspired or expired gases, e.g. to determine lung capacity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0027—Accessories therefor, e.g. sensors, vibrators, negative pressure pressure meter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
    • A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
    • A61M2016/0036—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the breathing tube and used in both inspiratory and expiratory phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
    • A61M2016/102—Measuring a parameter of the content of the delivered gas
    • A61M2016/1025—Measuring a parameter of the content of the delivered gas the O2 concentration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
    • A61M2016/102—Measuring a parameter of the content of the delivered gas
    • A61M2016/103—Measuring a parameter of the content of the delivered gas the CO2 concentration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0208—Oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0225—Carbon oxides, e.g. Carbon dioxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3303—Using a biosensor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502—User interfaces, e.g. screens or keyboards
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/04—Heartbeat characteristics, e.g. ECG, blood pressure modulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/202—Blood composition characteristics partial carbon oxide pressure, e.g. partial dioxide pressure (P-CO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/205—Blood composition characteristics partial oxygen pressure (P-O2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/208—Blood composition characteristics pH-value
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/40—Respiratory characteristics
    • A61M2230/43—Composition of exhalation
    • A61M2230/432—Composition of exhalation partial CO2 pressure (P-CO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/40—Respiratory characteristics
    • A61M2230/43—Composition of exhalation
    • A61M2230/435—Composition of exhalation partial O2 pressure (P-O2)

Landscapes

  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

An apparatus and method for controlling the end tidal partial pressure of a gas X in a subject s lung and to the use of such an apparatus and method for research diagnostic and therapeutic purposes wherein the method consists of: obtaining input of a series of logistically attainable PetX values for a series of respective breaths: determining an amount of gas X required to be inspired by the subject in an inspired gas to target the PetX for each of said respective breaths: and controlling a gas delivery device to deliver the amount of gas in a volume of gas delivered to the subject in each of said respective breaths to target the respective PetX for that breath.
IN2436MUN2014 2012-04-30 2013-04-30 IN2014MN02436A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261640570P 2012-04-30 2012-04-30
PCT/CA2013/000427 WO2013163735A1 (en) 2012-04-30 2013-04-30 A new method and apparatus to attain and maintain target arterial blood gas concentrations using ramp sequences

Publications (1)

Publication Number Publication Date
IN2014MN02436A true IN2014MN02436A (en) 2015-10-09

Family

ID=49514138

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2436MUN2014 IN2014MN02436A (en) 2012-04-30 2013-04-30

Country Status (7)

Country Link
US (3) US20150114394A1 (en)
EP (1) EP2844324B1 (en)
JP (1) JP2015521059A (en)
KR (1) KR20150050526A (en)
CA (1) CA2872055A1 (en)
IN (1) IN2014MN02436A (en)
WO (1) WO2013163735A1 (en)

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EP2827932B1 (en) 2012-03-19 2020-06-03 Thornhill Scientific Inc. Virtual respiratory gas delivery systems and circuits
SE536642C2 (en) * 2012-09-24 2014-04-22 Innotek Ab System for optimal mechanical ventilation
US10449311B2 (en) * 2013-06-05 2019-10-22 Thornhill Scientific Inc. Controlling arterial blood gas concentration
WO2014194401A1 (en) * 2013-06-05 2014-12-11 Michael Klein Controlling arterial blood gas concentration
US11880989B2 (en) * 2014-04-25 2024-01-23 Thornhill Scientific Inc. Imaging abnormalities in vascular response
US11839717B2 (en) * 2014-12-30 2023-12-12 General Electric Company Minute volume and carbon dioxide clearance as surrogates for EtCO2 in automatic ventilation
CN105457135B (en) * 2015-12-28 2018-12-28 湖南明康中锦医疗科技发展有限公司 Ventilator pressure method of adjustment, device and ventilator
AU2018248113A1 (en) 2017-04-05 2019-10-31 Fisher & Paykel Healthcare Limited Flow therapy system and method
SG11202001113SA (en) * 2017-08-08 2020-03-30 Rostrum Medical Innovations Inc Method and system for estimating the efficiency of the lungs of a patient
JP7091621B2 (en) * 2017-08-29 2022-06-28 コニカミノルタ株式会社 Fixing device and image forming device
EP3833254B1 (en) * 2018-08-07 2024-10-02 Rostrum Medical Innovations Inc. System and method for monitoring a blood flow that does not interact with ventilated lungs of a patient
CN113825441B (en) * 2019-02-26 2024-08-13 迪基特布朗有限公司 System for non-invasive examination of blood environmental parameters
US20220401676A1 (en) * 2019-10-08 2022-12-22 Fisher & Paykel Healthcare Limited Flow therapy system and method
DE102021000313A1 (en) * 2020-02-06 2021-08-12 Löwenstein Medical Technology S.A. Method for operating a ventilator for artificial ventilation of a patient and such a ventilator
WO2022178381A1 (en) * 2021-02-22 2022-08-25 The Trustees Of The University Of Pennsylvania Systems and methods for assessing cerebrovascular reactivity
WO2024189570A1 (en) * 2023-03-14 2024-09-19 Thornhill Scientific Inc. Device and method for measuring metabolic rate using sequential gas delivery

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US4463764A (en) * 1981-09-29 1984-08-07 Medical Graphics Corporation Cardiopulmonary exercise system
US4986268A (en) * 1988-04-06 1991-01-22 Tehrani Fleur T Method and apparatus for controlling an artificial respirator
US6306098B1 (en) * 1996-12-19 2001-10-23 Novametrix Medical Systems Inc. Apparatus and method for non-invasively measuring cardiac output
US6217524B1 (en) * 1998-09-09 2001-04-17 Ntc Technology Inc. Method of continuously, non-invasively monitoring pulmonary capillary blood flow and cardiac output
AU4998600A (en) * 1999-05-10 2000-11-21 James R. Mault Airway-based cardiac output monitor and methods for using same
DE60020842T2 (en) * 1999-06-30 2006-05-18 University of Florida Research Foundation, Inc., Gainesville MONITORING SYSTEM FOR VENTILATOR
US7699788B2 (en) * 2000-02-22 2010-04-20 Ric Investments, Llc. Noninvasive effective lung volume estimation
CA2346517A1 (en) 2001-05-04 2002-11-04 Joseph Fisher Improved method of maintaining constant arterial pco2 during increased minute ventilation and measurement of anatomic and alveolar dead space
CA2379353C (en) * 2002-03-28 2012-07-31 Joseph Fisher A new method for continuous measurement of flux of gases in the lungs during breathing
EP1610852B1 (en) 2003-02-18 2018-12-05 Joseph Fisher Breathing circuit to facilitate the measurement of cardiac output during controlled and spontaneous ventilation
JP5415070B2 (en) * 2005-07-28 2014-02-12 スレッサレブ、マラト Method and apparatus for achieving and maintaining target end-tidal concentrations
US20080230061A1 (en) * 2007-03-23 2008-09-25 General Electric Company Setting expiratory time in mandatory mechanical ventilation based on a deviation from a stable condition of end tidal gas concentrations
KR100868808B1 (en) * 2008-03-04 2008-11-17 한국과학기술원 Method and display apparatus for noninvasively determining the pulmonary characteristics by measuring breath gas and blood gas
WO2011143751A1 (en) 2010-05-18 2011-11-24 Joseph Fisher Non-invasive cardiac output determination
US20120215124A1 (en) * 2011-02-04 2012-08-23 Joseph Fisher Non-invasive arterial blood gas determination
EP3981459B1 (en) * 2011-04-13 2024-10-30 Thornhill Scientific Inc. Gas delivery apparatus
US20140311491A1 (en) * 2011-12-05 2014-10-23 Michael Klein Apparatus to attain and maintain target end tidal partial pressure of a gas
EP2827932B1 (en) * 2012-03-19 2020-06-03 Thornhill Scientific Inc. Virtual respiratory gas delivery systems and circuits

Also Published As

Publication number Publication date
WO2013163735A1 (en) 2013-11-07
JP2015521059A (en) 2015-07-27
US20150114394A1 (en) 2015-04-30
KR20150050526A (en) 2015-05-08
US11077266B2 (en) 2021-08-03
CA2872055A1 (en) 2013-11-07
EP2844324B1 (en) 2022-04-06
US20180311454A1 (en) 2018-11-01
EP2844324A4 (en) 2015-12-30
EP2844324A1 (en) 2015-03-11
US20220016368A1 (en) 2022-01-20

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