IN2013MU02726A - - Google Patents

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Publication number
IN2013MU02726A
IN2013MU02726A IN2726MU2013A IN2013MU02726A IN 2013MU02726 A IN2013MU02726 A IN 2013MU02726A IN 2726MU2013 A IN2726MU2013 A IN 2726MU2013A IN 2013MU02726 A IN2013MU02726 A IN 2013MU02726A
Authority
IN
India
Prior art keywords
purification
parathyroid hormone
steps
rhpth1
teriparatide
Prior art date
Application number
Inventor
Mendiratta Sanjeevkumar
Singh Avanishkumar
Bandyopadhyay Sanjay
Original Assignee
Cadila Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US14/912,984 priority Critical patent/US20160200792A1/en
Priority to NZ716205A priority patent/NZ716205A/en
Priority to JP2016516093A priority patent/JP6046862B2/en
Priority to CA2919604A priority patent/CA2919604A1/en
Priority to AU2014310255A priority patent/AU2014310255B2/en
Priority to CN201480046603.3A priority patent/CN105473610A/en
Priority to PCT/IN2014/000539 priority patent/WO2015025335A1/en
Priority to IN2726MU2013 priority patent/IN2013MU02726A/en
Application filed by Cadila Healthcare Ltd filed Critical Cadila Healthcare Ltd
Priority to EP14793628.0A priority patent/EP3036252A1/en
Priority to MX2016002274A priority patent/MX2016002274A/en
Priority to KR1020167003963A priority patent/KR101687686B1/en
Priority to SG11201600511QA priority patent/SG11201600511QA/en
Priority to EA201690264A priority patent/EA201690264A1/en
Publication of IN2013MU02726A publication Critical patent/IN2013MU02726A/en
Priority to IL243642A priority patent/IL243642A/en
Priority to ZA2016/00424A priority patent/ZA201600424B/en
Priority to HK16111539.7A priority patent/HK1223378A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)

Abstract

ABSTRACT NOVEL PURIFICATION PROCESS FOR PTH The present invention relates to improved method for purification of a recombinant parathyroid hormone (rhPTH1?34 or teriparatide), said process for purification of parathyroid hormone comprising following essential steps: (a) Enzymatic cleavage; (b) anion exchange chromatography, followed by other suitable purification steps; wherein step (a) and (b) can be carried out in any order.
IN2726MU2013 2013-08-21 2014-08-21 IN2013MU02726A (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
EP14793628.0A EP3036252A1 (en) 2013-08-21 2014-08-21 Purification process for pth
NZ716205A NZ716205A (en) 2013-08-21 2014-08-21 Purification process for pth
MX2016002274A MX2016002274A (en) 2013-08-21 2014-08-21 Purification process for pth.
AU2014310255A AU2014310255B2 (en) 2013-08-21 2014-08-21 Purification process for PTH
CN201480046603.3A CN105473610A (en) 2013-08-21 2014-08-21 Purification process for PTH
PCT/IN2014/000539 WO2015025335A1 (en) 2013-08-21 2014-08-21 Purification process for pth
IN2726MU2013 IN2013MU02726A (en) 2013-08-21 2014-08-21
US14/912,984 US20160200792A1 (en) 2013-08-21 2014-08-21 Purification Process for PTH
JP2016516093A JP6046862B2 (en) 2013-08-21 2014-08-21 Purification method of PTH
CA2919604A CA2919604A1 (en) 2013-08-21 2014-08-21 Purification process for pth
KR1020167003963A KR101687686B1 (en) 2013-08-21 2014-08-21 Purification process for PTH
SG11201600511QA SG11201600511QA (en) 2013-08-21 2014-08-21 Purification process for pth
EA201690264A EA201690264A1 (en) 2013-08-21 2014-08-21 PTH CLEANING METHOD
IL243642A IL243642A (en) 2013-08-21 2016-01-17 Purification process for pth
ZA2016/00424A ZA201600424B (en) 2013-08-21 2016-01-19 Purification process for pth
HK16111539.7A HK1223378A1 (en) 2013-08-21 2016-10-04 Purification process for pth pth

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN2726MU2013 IN2013MU02726A (en) 2013-08-21 2014-08-21

Publications (1)

Publication Number Publication Date
IN2013MU02726A true IN2013MU02726A (en) 2015-06-26

Family

ID=51862491

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2726MU2013 IN2013MU02726A (en) 2013-08-21 2014-08-21

Country Status (16)

Country Link
US (1) US20160200792A1 (en)
EP (1) EP3036252A1 (en)
JP (1) JP6046862B2 (en)
KR (1) KR101687686B1 (en)
CN (1) CN105473610A (en)
AU (1) AU2014310255B2 (en)
CA (1) CA2919604A1 (en)
EA (1) EA201690264A1 (en)
HK (1) HK1223378A1 (en)
IL (1) IL243642A (en)
IN (1) IN2013MU02726A (en)
MX (1) MX2016002274A (en)
NZ (1) NZ716205A (en)
SG (1) SG11201600511QA (en)
WO (1) WO2015025335A1 (en)
ZA (1) ZA201600424B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3012952B1 (en) * 2013-11-08 2015-11-06 Essilor Int METHOD FOR DETERMINING AT LEAST ONE OPTICAL DESIGN PARAMETER OF A PROGRESSIVE OPHTHALMIC LENS
WO2019077432A1 (en) * 2017-10-16 2019-04-25 Intas Pharmaceuticals Ltd. Improved purification method of recombinant pth (1-34)
CN107941983B (en) * 2018-01-05 2020-05-15 北京博康健基因科技有限公司 Detection method and purity analysis method of rhPTH protein or rhPTH protein preparation

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116952A (en) * 1986-07-18 1992-05-26 The University Of Melbourne Protein active in humoral hypercalcemia of malignancy-pthrp
US5171670A (en) * 1989-05-12 1992-12-15 The General Hospital Corporation Recombinant dna method for production of parathyroid hormone
DE3935738A1 (en) * 1989-10-27 1991-05-08 Forssmann Wolf Georg DRUGS CONTAINING THE HUMAN PARATHORMONE FRAGMENT (1-37) AS AN ACTIVE AGENT
DE69700561T2 (en) * 1996-06-14 2000-05-04 Takeda Chemical Industries, Ltd. Process for the removal of N-terminal methionine
WO1998054195A1 (en) * 1997-05-30 1998-12-03 Bion, Inc. Large-scale isolation and purification of hif
US7323553B2 (en) 2002-04-26 2008-01-29 Genentech, Inc. Non-affinity purification of proteins
EP1598075A1 (en) * 2004-05-21 2005-11-23 LEK Pharmaceuticals d.d. Process for the isolation and / or purification of proteins
CN1706947A (en) * 2004-06-04 2005-12-14 南京大学生物制药工程研究中心 Construction, expression and purification method of recombinant human parathyroid hormone in colibacillus
JP4897792B2 (en) * 2005-04-20 2012-03-14 ビロメッド カンパニー， リミテッド Compositions and methods for separation of fusion proteins
CN1861790A (en) * 2006-04-25 2006-11-15 华东理工大学 Preparation process of human recombined parathyroid hormone 1 84
EP2173768B1 (en) * 2007-08-09 2014-03-05 USV Limited Novel orthogonal process for purification of recombinant human parathyroid hormone (rhpth) (1-34)
WO2011151714A1 (en) * 2010-06-04 2011-12-08 Lupin Limited Modified sak gene for the production of recombinant proteins
SG189872A1 (en) * 2010-10-11 2013-06-28 Abbvie Inc Processes for purification of proteins

Also Published As

Publication number Publication date
WO2015025335A8 (en) 2016-02-04
WO2015025335A1 (en) 2015-02-26
HK1223378A1 (en) 2017-07-28
AU2014310255A1 (en) 2016-02-25
CN105473610A (en) 2016-04-06
EP3036252A1 (en) 2016-06-29
KR101687686B1 (en) 2016-12-19
JP2016528173A (en) 2016-09-15
ZA201600424B (en) 2017-03-29
JP6046862B2 (en) 2016-12-21
AU2014310255B2 (en) 2017-02-16
IL243642A0 (en) 2016-03-31
NZ716205A (en) 2017-05-26
EA201690264A1 (en) 2016-06-30
IL243642A (en) 2017-05-29
CA2919604A1 (en) 2015-02-26
MX2016002274A (en) 2016-05-31
US20160200792A1 (en) 2016-07-14
KR20160027204A (en) 2016-03-09
SG11201600511QA (en) 2016-02-26

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