IL60086A - Pyrimidine compounds,their preparation and pharmaceutical compositions containing them - Google Patents
Pyrimidine compounds,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL60086A IL60086A IL60086A IL6008680A IL60086A IL 60086 A IL60086 A IL 60086A IL 60086 A IL60086 A IL 60086A IL 6008680 A IL6008680 A IL 6008680A IL 60086 A IL60086 A IL 60086A
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- pyrimidine compounds
- pyrimidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH466979 | 1979-05-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL60086A0 IL60086A0 (en) | 1980-07-31 |
IL60086A true IL60086A (en) | 1984-03-30 |
Family
ID=4280399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL60086A IL60086A (en) | 1979-05-18 | 1980-05-15 | Pyrimidine compounds,their preparation and pharmaceutical compositions containing them |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0019811A1 (en) |
JP (1) | JPS55154971A (en) |
KR (1) | KR830002757A (en) |
AR (1) | AR228256A1 (en) |
AU (1) | AU5848480A (en) |
DD (1) | DD150609A5 (en) |
DK (1) | DK214480A (en) |
ES (1) | ES491514A0 (en) |
FI (1) | FI801600A (en) |
GB (1) | GB2052487B (en) |
GR (1) | GR68453B (en) |
IE (1) | IE49803B1 (en) |
IL (1) | IL60086A (en) |
MA (1) | MA18829A1 (en) |
NO (1) | NO801469L (en) |
NZ (1) | NZ193730A (en) |
OA (1) | OA06533A (en) |
PL (1) | PL224313A1 (en) |
PT (1) | PT71251A (en) |
ZA (1) | ZA802909B (en) |
ZW (1) | ZW11880A1 (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4507146A (en) * | 1982-12-28 | 1985-03-26 | Ciba-Geigy Corporation | 2,4-Diamino-6-halo-5-trifluoromethylpyrimidines having herbicidal activity |
DE3829469A1 (en) * | 1988-08-31 | 1990-03-01 | Bayer Ag | METHOD FOR THE PRODUCTION OF SUBSTITUTED N-AZINYL-N'-SULFONYL-ISOTHIO-UREAS AND N-AZINYL-IMINODITHIOCARBONIC ACID-S, S-DIESTER AS INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION |
WO1999011269A1 (en) * | 1997-09-03 | 1999-03-11 | Eli Lilly And Company | Pyrimidine derivatives |
US7473691B2 (en) | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
WO2002022602A2 (en) | 2000-09-15 | 2002-03-21 | Vertex Pharmaceuticals Incorporated | Triazole compounds useful as protein kinase inhibitors |
ES2266095T3 (en) | 2000-12-21 | 2007-03-01 | Vertex Pharmaceuticals Incorporated | PIRAZOL COMPOUNDS USED AS INHIBITORS OF PROTEIN QUINASA. |
SK9562003A3 (en) * | 2001-01-31 | 2004-04-06 | Synaptic Pharma Corp | Use of GAL3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods |
KR20040099324A (en) | 2002-03-13 | 2004-11-26 | 유로-셀티큐 에스.에이. | Aryl substituted pyrimidines and the use thereof |
ES2290436T3 (en) * | 2002-03-15 | 2008-02-16 | Ciba Specialty Chemicals Holding Inc. | USE OF 4-AMINOPIRIDINS FOR ANTIMICROBIAL SURFACE TREATMENT. |
US20040009981A1 (en) | 2002-03-15 | 2004-01-15 | David Bebbington | Compositions useful as inhibitors of protein kinases |
MY141867A (en) | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
PT1532145E (en) | 2002-08-02 | 2007-01-31 | Vertex Pharma | Pyrazole compositions useful as inhibitors of gsk-3 |
US7601718B2 (en) | 2003-02-06 | 2009-10-13 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
AU2006279376B2 (en) | 2005-08-18 | 2011-04-14 | Vertex Pharmaceuticals Incoporated | Pyrazine kinase inhibitors |
TW200736250A (en) | 2005-11-03 | 2007-10-01 | Vertex Pharma | Aminopyrimidines useful as kinase inhibitors |
MX2009004807A (en) | 2006-11-02 | 2009-06-15 | Vertex Pharma | Aminopyridines and aminopyrimidines useful as inhibitors of protein kinases. |
EP2099787B1 (en) | 2006-12-19 | 2010-07-21 | Vertex Pharmaceuticals, Inc. | Aminopyrimidines useful as inhibitors of protein kinases |
EP2134709A1 (en) | 2007-03-09 | 2009-12-23 | Vertex Pharmaceuticals, Inc. | Aminopyridines useful as inhibitors of protein kinases |
ATE526328T1 (en) | 2007-03-09 | 2011-10-15 | Vertex Pharma | AMINOPYRIMIDINES SUITABLE AS INHIBITORS OF PROTEIN KINASES |
NZ579446A (en) | 2007-03-09 | 2012-02-24 | Vertex Pharma | Aminopyrimidines useful as inhibitors of protein kinases |
NZ580343A (en) | 2007-04-13 | 2012-03-30 | Vertex Pharma | Aminopyrimidines useful as kinase inhibitors |
JP5389786B2 (en) | 2007-05-02 | 2014-01-15 | バーテックス ファーマシューティカルズ インコーポレイテッド | Aminopyrimidines useful as kinase inhibitors |
NZ580884A (en) | 2007-05-02 | 2012-02-24 | Vertex Pharma | Thiazoles and pyrazoles useful as kinase inhibitors |
JP5553751B2 (en) | 2007-07-31 | 2014-07-16 | バーテックス ファーマシューティカルズ インコーポレイテッド | Process for preparing 5-fluoro-1H-pyrazolo [3,4-b] pyridin-3-amine and its derivatives |
CN102215816A (en) | 2008-09-03 | 2011-10-12 | 沃泰克斯药物股份有限公司 | Co-crystals and pharmaceutical formulations comprising the same |
EA201692167A1 (en) * | 2008-12-09 | 2017-07-31 | Джилид Сайэнс, Инк. | MODULATORS OF TOLL-SECONDARY RECEPTORS |
KR102328682B1 (en) * | 2018-08-27 | 2021-11-18 | 주식회사 대웅제약 | Novel heterocyclicamine derivatives and pharmaceutical composition comprising the same |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE754832A (en) * | 1969-08-14 | 1971-02-15 | Beecham Group Ltd | IMINAZOLINES |
-
1980
- 1980-05-05 MA MA19025A patent/MA18829A1/en unknown
- 1980-05-13 DD DD80221082A patent/DD150609A5/en unknown
- 1980-05-14 ES ES491514A patent/ES491514A0/en active Granted
- 1980-05-15 IL IL60086A patent/IL60086A/en unknown
- 1980-05-15 NZ NZ193730A patent/NZ193730A/en unknown
- 1980-05-16 GB GB8016309A patent/GB2052487B/en not_active Expired
- 1980-05-16 FI FI801600A patent/FI801600A/en not_active Application Discontinuation
- 1980-05-16 NO NO801469A patent/NO801469L/en unknown
- 1980-05-16 ZA ZA00802909A patent/ZA802909B/en unknown
- 1980-05-16 EP EP80102724A patent/EP0019811A1/en not_active Withdrawn
- 1980-05-16 PT PT71251A patent/PT71251A/en unknown
- 1980-05-16 ZW ZW118/80A patent/ZW11880A1/en unknown
- 1980-05-16 AU AU58484/80A patent/AU5848480A/en not_active Abandoned
- 1980-05-16 GR GR61963A patent/GR68453B/el unknown
- 1980-05-16 DK DK214480A patent/DK214480A/en not_active Application Discontinuation
- 1980-05-16 IE IE1023/80A patent/IE49803B1/en unknown
- 1980-05-17 OA OA57113A patent/OA06533A/en unknown
- 1980-05-17 KR KR1019800001944A patent/KR830002757A/en unknown
- 1980-05-17 JP JP6586380A patent/JPS55154971A/en active Pending
- 1980-05-17 PL PL22431380A patent/PL224313A1/xx unknown
- 1980-05-19 AR AR281109A patent/AR228256A1/en active
Also Published As
Publication number | Publication date |
---|---|
NO801469L (en) | 1980-11-19 |
IE801023L (en) | 1980-11-18 |
ES8104279A1 (en) | 1981-04-16 |
ZW11880A1 (en) | 1980-12-17 |
NZ193730A (en) | 1982-12-21 |
PT71251A (en) | 1980-06-01 |
IE49803B1 (en) | 1985-12-25 |
GB2052487A (en) | 1981-01-28 |
MA18829A1 (en) | 1980-12-31 |
GB2052487B (en) | 1983-05-11 |
EP0019811A1 (en) | 1980-12-10 |
KR830002757A (en) | 1983-05-30 |
DK214480A (en) | 1980-11-19 |
DD150609A5 (en) | 1981-09-09 |
PL224313A1 (en) | 1981-02-13 |
AU5848480A (en) | 1980-11-20 |
GR68453B (en) | 1981-12-30 |
ZA802909B (en) | 1981-05-27 |
IL60086A0 (en) | 1980-07-31 |
ES491514A0 (en) | 1981-04-16 |
AR228256A1 (en) | 1983-02-15 |
JPS55154971A (en) | 1980-12-02 |
OA06533A (en) | 1981-07-31 |
FI801600A (en) | 1980-11-19 |
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