IL114160A0 - Polypeptides expressed in yeasts and their preparation - Google Patents

Polypeptides expressed in yeasts and their preparation

Info

Publication number
IL114160A0
IL114160A0 IL11416095A IL11416095A IL114160A0 IL 114160 A0 IL114160 A0 IL 114160A0 IL 11416095 A IL11416095 A IL 11416095A IL 11416095 A IL11416095 A IL 11416095A IL 114160 A0 IL114160 A0 IL 114160A0
Authority
IL
Israel
Prior art keywords
yeasts
preparation
polypeptides expressed
polypeptides
expressed
Prior art date
Application number
IL11416095A
Other versions
IL114160A (en
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of IL114160A0 publication Critical patent/IL114160A0/en
Publication of IL114160A publication Critical patent/IL114160A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
IL114160A 1994-06-17 1995-06-15 Dna constructs encoding heterologous proteins and processes for the heterologous protein production in yeast IL114160A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK71294 1994-06-17

Publications (2)

Publication Number Publication Date
IL114160A0 true IL114160A0 (en) 1995-10-31
IL114160A IL114160A (en) 2006-12-31

Family

ID=8096676

Family Applications (1)

Application Number Title Priority Date Filing Date
IL114160A IL114160A (en) 1994-06-17 1995-06-15 Dna constructs encoding heterologous proteins and processes for the heterologous protein production in yeast

Country Status (16)

Country Link
EP (1) EP0765395A1 (en)
JP (1) JP3730255B2 (en)
CN (1) CN1131312C (en)
AU (1) AU2733595A (en)
BR (1) BR9508053A (en)
CA (1) CA2192943A1 (en)
CZ (1) CZ363796A3 (en)
FI (1) FI965030A (en)
HU (1) HUT75840A (en)
IL (1) IL114160A (en)
MX (1) MX9606536A (en)
NO (1) NO965411L (en)
PL (1) PL317761A1 (en)
SG (1) SG47883A1 (en)
WO (1) WO1995035384A1 (en)
ZA (1) ZA954983B (en)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6500645B1 (en) 1994-06-17 2002-12-31 Novo Nordisk A/S N-terminally extended proteins expressed in yeast
ZA9610456B (en) * 1995-12-20 1997-06-20 Novo Nordisk As N-terminally extended proteins expressed in yeast
ATE253120T1 (en) * 1996-12-13 2003-11-15 Chiron Corp METHOD FOR EXPRESSING HETEROLOGUE PROTEINS IN YEAST
ES2258797T3 (en) * 1996-12-20 2006-09-01 Novo Nordisk A/S PROTEINS WITH N-TERMINAL EXTENSION EXPRESSED IN LEAVING.
KR20010034305A (en) * 1998-01-23 2001-04-25 한센 핀 베네드 Process for making desired polypeptides in yeast
ATE474930T1 (en) 1999-12-29 2010-08-15 Novo Nordisk As METHOD FOR PRODUCING INSULIN PRECURSORS AND ANALOGUES OF INSULIN PRECURSORS WITH IMPROVED FERMENTATION YIELD IN YEAST
AU2002355160A1 (en) * 2001-07-24 2003-02-17 Novo Nordisk A/S Method for making acylated polypeptides
US7595172B2 (en) 2001-07-24 2009-09-29 Novo Nordisk A/S Method for making acylated polypeptides
US20030082671A1 (en) 2001-07-24 2003-05-01 Thomas Hoeg-Jensen Method for making acylated polypeptides
WO2004085472A1 (en) * 2003-03-27 2004-10-07 Novo Nordisk A/S Method for making human insulin precursors and human insulin
ATE517119T1 (en) 2003-12-03 2011-08-15 Novo Nordisk As SINGLE CHAIN INSULIN
EP1917363B1 (en) 2005-08-16 2011-06-22 Novo Nordisk A/S Method for making mature insulin polypeptides
WO2008015099A2 (en) 2006-07-31 2008-02-07 Novo Nordisk A/S Pegylated, extended insulins
JP5864834B2 (en) 2006-09-22 2016-02-17 ノボ・ノルデイスク・エー／エス Protease resistant insulin analogue
EP2069502B1 (en) 2006-09-27 2014-02-26 Novo Nordisk A/S Method for making maturated insulin polypeptides
JP5404411B2 (en) 2006-11-22 2014-01-29 ノボ・ノルデイスク・エー／エス Process for producing activated carboxypeptidase
CN101743252A (en) 2007-07-16 2010-06-16 诺沃-诺迪斯克有限公司 protease stabilized, pegylated insulin analogues
ES2558930T3 (en) 2007-08-13 2016-02-09 Novo Nordisk A/S Fast-acting insulin analogs
EP2178910B1 (en) 2007-08-15 2014-10-08 Novo Nordisk A/S Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids
JP5730569B2 (en) 2007-08-15 2015-06-10 ノボ・ノルデイスク・エー／エス Insulin analogues having acyl and alkylene glycol moieties
MX2010009850A (en) 2008-03-18 2010-09-30 Novo Nordisk As Protease stabilized, acylated insulin analogues.
WO2009121884A1 (en) 2008-04-01 2009-10-08 Novo Nordisk A/S Insulin albumin conjugates
CA2764423A1 (en) 2009-06-26 2010-12-29 Novo Nordisk A/S Preparation comprising insulin, nicotinamide and an amino acid
JP5850848B2 (en) 2009-11-25 2016-02-03 ノヴォ ノルディスク アー／エス Method for producing polypeptide
EP2585483A1 (en) 2010-06-23 2013-05-01 Novo Nordisk A/S Human insulin containing additional disulfide bonds
CN102947331B (en) 2010-06-23 2016-08-03 诺沃—诺迪斯克有限公司 Comprise the insulin analog of extra disulfide bond
CN102985440B (en) 2010-06-23 2016-10-26 诺沃-诺迪斯克有限公司 Comprise the insulin derivates of extra disulfide bond
WO2012080320A1 (en) 2010-12-14 2012-06-21 Novo Nordisk A/S Fast-acting insulin in combination with long-acting insulin
CN103328006A (en) 2010-12-14 2013-09-25 诺沃—诺迪斯克有限公司 Preparation comprising insulin, nicotinamide and an amino acid
EP2720711A1 (en) 2011-06-15 2014-04-23 Novo Nordisk A/S Multi substituted insulins
WO2013186138A1 (en) 2012-06-14 2013-12-19 Novo Nordisk A/S Preparation comprising insulin, nicotinamide and arginine
WO2014088836A1 (en) 2012-12-03 2014-06-12 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues
WO2014195452A1 (en) 2013-06-07 2014-12-11 Novo Nordisk A/S Method for making mature insulin polypeptides
ES2700547T3 (en) 2014-02-28 2019-02-18 Novo Nordisk As Variants of alpha mating factor pro-peptide
CN107743494B (en) 2015-06-02 2022-04-29 诺和诺德股份有限公司 Insulin with polar recombinant extensions
TW201717998A (en) 2015-08-25 2017-06-01 諾佛 儂迪克股份有限公司 Novel insulin derivatives and the medical uses hereof
CN108368163A (en) 2015-08-25 2018-08-03 诺和诺德股份有限公司 Novel insulin derivates and its medical usage
EP3341401A1 (en) 2015-08-25 2018-07-04 Novo Nordisk A/S Novel insulin derivatives and the medical uses hereof
EP3463412A1 (en) * 2016-05-24 2019-04-10 Novo Nordisk A/S Mic-1 compounds and use thereof
WO2019034726A1 (en) 2017-08-17 2019-02-21 Novo Nordisk A/S Novel acylated insulin analogues and uses thereof
WO2020026045A2 (en) * 2018-06-18 2020-02-06 Unichem Laboratories Ltd Leader sequence for higher expression of recombinant proteins
FI4073097T3 (en) 2019-12-11 2024-08-13 Novo Nordisk As Novel insulin analogues and uses thereof
WO2023144240A1 (en) 2022-01-26 2023-08-03 Novo Nordisk Research Centre Oxford Limited Glucose sensitive insulin derivatives and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2593518B1 (en) * 1985-05-02 1989-09-08 Transgene Sa VECTORS FOR THE EXPRESSION AND SECRETION OF HIRUDIN BY TRANSFORMED YEASTS
US5010182A (en) * 1987-07-28 1991-04-23 Chiron Corporation DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides
CA1340772C (en) * 1987-12-30 1999-09-28 Patricia Tekamp-Olson Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences
DK105489D0 (en) * 1989-03-03 1989-03-03 Novo Nordisk As POLYPEPTIDE
DK300090D0 (en) * 1990-12-19 1990-12-19 Novo Nordisk As PROCEDURE FOR PREPARING LEADER SEQUENCES
WO1992013951A1 (en) * 1991-02-04 1992-08-20 The Salk Institute Biotechnology/Industrial Associates, Inc. Production of human serum albumin in methylotrophic yeast cells

Also Published As

Publication number Publication date
NO965411L (en) 1997-02-14
JP3730255B2 (en) 2005-12-21
BR9508053A (en) 1997-08-12
ZA954983B (en) 1996-02-14
EP0765395A1 (en) 1997-04-02
NO965411D0 (en) 1996-12-16
IL114160A (en) 2006-12-31
CZ363796A3 (en) 1997-05-14
SG47883A1 (en) 1998-04-17
AU2733595A (en) 1996-01-15
CA2192943A1 (en) 1995-12-28
WO1995035384A1 (en) 1995-12-28
PL317761A1 (en) 1997-04-28
FI965030A0 (en) 1996-12-16
HU9603476D0 (en) 1997-02-28
MX9606536A (en) 1997-03-29
CN1152942A (en) 1997-06-25
FI965030A (en) 1997-02-14
HUT75840A (en) 1997-05-28
JPH10501695A (en) 1998-02-17
CN1131312C (en) 2003-12-17

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