HUT49358A - Process for producing phosphorous compounds, pharmaceutical compositions comprising same as active ingredient and intermediaries - Google Patents

Process for producing phosphorous compounds, pharmaceutical compositions comprising same as active ingredient and intermediaries

Info

Publication number: HUT49358A
Authority: HU; Hungary
Prior art keywords: intermediaries; active ingredient; pharmaceutical compositions; same; phosphorous compounds
Prior art date: 1987-05-22

Application number

HU882614A

Other languages

Hungarian (hu)

Other versions

HU205125B (en

Inventor

Donald S Karanewsky

Scott A Biller

Eric M Gordon

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-22

Filing date

1988-05-20

Publication date

1989-09-28

1988-05-20 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1989-09-28 Publication of HUT49358A publication Critical patent/HUT49358A/en

1992-03-30 Publication of HU205125B publication Critical patent/HU205125B/en

Links

239000004480 active ingredient Substances 0.000 title 1
BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical class [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/36—Amides thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C07F9/4403—Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4407—Amides of acyclic saturated acids which can have further substituents on alkyl

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

HU882614A 1987-05-22 1988-05-20 Process for producing phosphorous compounds and pharmaceutical compositions comprising same HU205125B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5328187A	1987-05-22	1987-05-22
US10968087A	1987-10-19	1987-10-19

Publications (2)

Publication Number	Publication Date
HUT49358A true HUT49358A (en)	1989-09-28
HU205125B HU205125B (en)	1992-03-30

Family

ID=26731667

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU882614A HU205125B (en)	1987-05-22	1988-05-20	Process for producing phosphorous compounds and pharmaceutical compositions comprising same

Country Status (24)

Country	Link
JP (1)	JP2680347B2 (en)
KR (1)	KR880013958A (en)
CN (1)	CN88103091A (en)
AU (1)	AU610591B2 (en)
BE (1)	BE1004193A3 (en)
CH (1)	CH676984A5 (en)
DE (1)	DE3817375C2 (en)
DK (1)	DK277488A (en)
ES (1)	ES2009918A6 (en)
FI (1)	FI89493C (en)
FR (1)	FR2615508B1 (en)
GB (1)	GB2205837B (en)
GR (1)	GR1000959B (en)
HU (1)	HU205125B (en)
IE (2)	IE63760B1 (en)
IL (1)	IL86464A (en)
IT (1)	IT1217685B (en)
NL (1)	NL8801330A (en)
NO (1)	NO882218L (en)
NZ (1)	NZ224733A (en)
PH (1)	PH25350A (en)
PL (1)	PL154877B1 (en)
PT (1)	PT87539B (en)
SE (1)	SE503210C2 (en)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK277388A (en) *	1987-05-22	1988-11-23	Squibb & Sons Inc	PHOSPHORUS HMG-COA REDUCTASE INHIBITORS, INTERMEDIATES AND PROCEDURE
CA2007643A1 (en) *	1989-02-01	1990-08-01	Donald S. Karanewsky	Combination of an hmg coa reductase inhibitor and a squalene synthetase inhibitor and method for lowering serum cholesterol using such combination
CA2042526A1 (en) *	1990-06-11	1991-12-12	Adeoye Y. Olukotun	Method for preventing a second heart attack employing an hmg coa reductase inhibitor
US5202327A (en) *	1991-07-10	1993-04-13	E. R. Squibb & Sons, Inc.	Phosphorus-containing hmg-coa reductase inhibitors
GB9126144D0 (en) *	1991-12-10	1992-02-12	British Bio Technology	Compounds
US20010006644A1 (en)	1997-07-31	2001-07-05	David J. Bova	Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night
PL346660A1 (en)	1998-09-17	2002-02-25	Bristol Myers Squibb Co	Method for treating atherosclerosis employing an ap2 inhibitor and combination
CA2444481A1 (en)	2001-04-11	2002-10-24	Bristol-Myers Squibb Company	Amino acid complexes of c-aryl glucosides for treatment of diabetes and method
US7238671B2 (en)	2001-10-18	2007-07-03	Bristol-Myers Squibb Company	Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
CN1630709A (en)	2001-10-18	2005-06-22	百时美施贵宝公司	Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
US6806381B2 (en)	2001-11-02	2004-10-19	Bristol-Myers Squibb Company	Process for the preparation of aniline-derived thyroid receptor ligands
US7057046B2 (en)	2002-05-20	2006-06-06	Bristol-Myers Squibb Company	Lactam glycogen phosphorylase inhibitors and method of use
DE60332856D1 (en)	2002-10-23	2010-07-15	Bristol Myers Squibb Co	GLYCINNITRIL BASED DIPEPTIDYLPEPTIDASE IV INHIBITORS
US7098235B2 (en)	2002-11-14	2006-08-29	Bristol-Myers Squibb Co.	Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds
TW200504021A (en)	2003-01-24	2005-02-01	Bristol Myers Squibb Co	Substituted anilide ligands for the thyroid receptor
US7459474B2 (en)	2003-06-11	2008-12-02	Bristol-Myers Squibb Company	Modulators of the glucocorticoid receptor and method
US6995183B2 (en)	2003-08-01	2006-02-07	Bristol Myers Squibb Company	Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
US8158362B2 (en)	2005-03-30	2012-04-17	Decode Genetics Ehf.	Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
DK1725234T4 (en)	2004-03-05	2016-05-09	Univ Pennsylvania	METHODS OF TREATING DISEASES OR DISEASES CONNECTED WITH HYPERLIPIDEMIA AND HYPERCOLESTEROLYMIA WITH MINIMIZATION OF SIDE EFFECTS
US7145040B2 (en)	2004-07-02	2006-12-05	Bristol-Myers Squibb Co.	Process for the preparation of amino acids useful in the preparation of peptide receptor modulators
TW200611704A (en)	2004-07-02	2006-04-16	Bristol Myers Squibb Co	Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions
US7534763B2 (en)	2004-07-02	2009-05-19	Bristol-Myers Squibb Company	Sustained release GLP-1 receptor modulators
AR051446A1 (en)	2004-09-23	2007-01-17	Bristol Myers Squibb Co	C-ARYL GLUCOSIDS AS SELECTIVE INHIBITORS OF GLUCOSE CONVEYORS (SGLT2)
US7517991B2 (en)	2004-10-12	2009-04-14	Bristol-Myers Squibb Company	N-sulfonylpiperidine cannabinoid receptor 1 antagonists
US7635699B2 (en)	2004-12-29	2009-12-22	Bristol-Myers Squibb Company	Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
US7589088B2 (en)	2004-12-29	2009-09-15	Bristol-Myers Squibb Company	Pyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
US7361766B2 (en)	2005-01-12	2008-04-22	Bristol-Myers Squibb Company	Bicyclic heterocycles as cannabinoid receptor modulators
WO2006076598A2 (en)	2005-01-12	2006-07-20	Bristol-Myers Squibb Company	Bicyclic heterocycles as cannabinoid receptor modulators
WO2006076597A1 (en)	2005-01-12	2006-07-20	Bristol-Myers Squibb Company	Bicyclic heterocycles as cannabinoid receptor modulators
US20060160850A1 (en)	2005-01-18	2006-07-20	Chongqing Sun	Bicyclic heterocycles as cannabinoid receptor modulators
US20060235028A1 (en)	2005-04-14	2006-10-19	Li James J	Inhibitors of 11-beta hydroxysteroid dehydrogenase type I
US7521557B2 (en)	2005-05-20	2009-04-21	Bristol-Myers Squibb Company	Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods
US7452892B2 (en)	2005-06-17	2008-11-18	Bristol-Myers Squibb Company	Triazolopyrimidine cannabinoid receptor 1 antagonists
US7629342B2 (en)	2005-06-17	2009-12-08	Bristol-Myers Squibb Company	Azabicyclic heterocycles as cannabinoid receptor modulators
US7572808B2 (en)	2005-06-17	2009-08-11	Bristol-Myers Squibb Company	Triazolopyridine cannabinoid receptor 1 antagonists
US7632837B2 (en)	2005-06-17	2009-12-15	Bristol-Myers Squibb Company	Bicyclic heterocycles as cannabinoid-1 receptor modulators
US7317012B2 (en)	2005-06-17	2008-01-08	Bristol-Myers Squibb Company	Bicyclic heterocycles as cannabinoind-1 receptor modulators
US8618115B2 (en)	2005-10-26	2013-12-31	Bristol-Myers Squibb Company	Substituted thieno[3,2-d]pyrimidinones as MCHR1 antagonists and methods for using them
EP2487154B1 (en)	2005-10-31	2013-10-16	Bristol-Myers Squibb Company	Pyrrolidinyl beta-amino amide-based inhibitors of dipeptidyl peptidase IV and methods
US7592461B2 (en)	2005-12-21	2009-09-22	Bristol-Myers Squibb Company	Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7553836B2 (en)	2006-02-06	2009-06-30	Bristol-Myers Squibb Company	Melanin concentrating hormone receptor-1 antagonists
US20100022457A1 (en)	2006-05-26	2010-01-28	Bristol-Myers Squibb Company	Sustained release glp-1 receptor modulators
US7919598B2 (en)	2006-06-28	2011-04-05	Bristol-Myers Squibb Company	Crystal structures of SGLT2 inhibitors and processes for preparing same
EP2089355A2 (en)	2006-11-01	2009-08-19	Brystol-Myers Squibb Company	Modulators of glucocorticoid receptor, ap-1, and/or nf- kappa b activity and use thereof
TW200904405A (en)	2007-03-22	2009-02-01	Bristol Myers Squibb Co	Pharmaceutical formulations containing an SGLT2 inhibitor
PE20090696A1 (en)	2007-04-20	2009-06-20	Bristol Myers Squibb Co	CRYSTALLINE FORMS OF SAXAGLIPTIN AND PROCESSES FOR PREPARING THEM
IN2009KN04568A (en)	2007-06-01	2015-08-28	Univ Princeton
US20090011994A1 (en)	2007-07-06	2009-01-08	Bristol-Myers Squibb Company	Non-basic melanin concentrating hormone receptor-1 antagonists and methods
CN101808995A (en)	2007-07-27	2010-08-18	百时美施贵宝公司	Novel glucokinase activating agents and using method thereof
RU2443699C2 (en)	2007-09-20	2012-02-27	Айрм Ллк	Compounds and compositions as gpr119 activity modulators
PE20091928A1 (en)	2008-05-29	2009-12-31	Bristol Myers Squibb Co	HAVE HYDROXYSUSTITUTED PYRIMIDINES AS NON-BASIC MELANIN-CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS
KR20110135411A (en)	2009-03-27	2011-12-16	브리스톨-마이어스 스큅 컴퍼니	Methods for preventing major adverse cardiovascular events with dpp-iv inhibitors
WO2011014520A2 (en)	2009-07-29	2011-02-03	Irm Llc	Compounds and compositions as modulators of gpr119 activity
AU2010303780B2 (en)	2009-10-09	2014-02-20	Irm Llc	Compounds and compositions as modulators of GPR119 activity
ES2856888T3 (en)	2009-11-13	2021-09-28	Astrazeneca Ab	Bilayer tablet formulations
ES2693686T3 (en)	2009-11-13	2018-12-13	Astrazeneca Ab	Immediate-release tablet formulations
US20120294936A1 (en)	2009-11-13	2012-11-22	Astrazeneca Uk Limited	Reduced mass metformin formulations
US8394858B2 (en)	2009-12-03	2013-03-12	Novartis Ag	Cyclohexane derivatives and uses thereof
TWI562775B (en)	2010-03-02	2016-12-21	Lexicon Pharmaceuticals Inc	Methods of using inhibitors of sodium-glucose cotransporters 1 and 2
CN102971313A (en)	2010-04-14	2013-03-13	百时美施贵宝公司	Novel glucokinase activators and methods of using same
JP6042330B2 (en)	2010-07-09	2016-12-14	ビーエイチヴィファーマ、インコーポレイテッド	Combined immediate / delayed delivery system for short half-life drugs including remogliflozin
US8697739B2 (en)	2010-07-29	2014-04-15	Novartis Ag	Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof
TWI631963B (en)	2011-01-05	2018-08-11	雷西肯製藥股份有限公司	Compositions comprising and methods of using inhibitors of sodium-glucose cotransporters 1 and 2
WO2014052619A1 (en)	2012-09-27	2014-04-03	Irm Llc	Piperidine derivatives and compositions as modulators of gpr119 activity
CA2891773C (en)	2012-11-20	2021-01-19	Lexicon Pharmaceuticals, Inc.	Inhibitors of sodium glucose cotransporter 1
WO2015027021A1 (en)	2013-08-22	2015-02-26	Bristol-Myers Squibb Company	Imide and acylurea derivatives as modulators of the glucocorticoid receptor
CN104610262B (en) *	2013-11-01	2017-06-06	上海医药工业研究院	Biphenyl compound, intermediate, preparation method, pharmaceutical composition and its application
WO2016176656A2 (en)	2015-04-30	2016-11-03	President And Fellows Of Harvard College	Anti-ap2 antibodies and antigen binding agents to treat metabolic disorders
SG11202100417RA (en)	2018-07-19	2021-02-25	Astrazeneca Ab	Methods of treating hfpef employing dapagliflozin and compositions comprising the same
CA3113037A1 (en)	2018-09-26	2020-04-02	Lexicon Pharmaceuticals, Inc.	Crystalline forms of n-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oopropan-2-yl)-4-(4-(2-methyl-5-(2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2h-pyran-2-yl)benzyl)phenl)butanamide and methods of their synthesis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA828650B (en) *	1981-12-01	1983-09-28	Hunt Chem Corp Philip A	Herbicidal compositions and method using phosphonalkanoic acids, esters and salts thereof
FR2596393B1 (en) *	1986-04-01	1988-06-03	Sanofi Sa	HYDROXY-3 DIHYDROXYOXOPHOSPHORIO-4 BUTANOIC ACID DERIVATIVES, THEIR PREPARATION PROCESS, THEIR USE AS MEDICAMENTS AND THE COMPOSITIONS CONTAINING THEM
DK277388A (en) *	1987-05-22	1988-11-23	Squibb & Sons Inc	PHOSPHORUS HMG-COA REDUCTASE INHIBITORS, INTERMEDIATES AND PROCEDURE

1988
- 1988-05-20 IL IL86464A patent/IL86464A/en not_active IP Right Cessation
- 1988-05-20 SE SE8801903A patent/SE503210C2/en not_active IP Right Cessation
- 1988-05-20 FI FI882384A patent/FI89493C/en not_active IP Right Cessation
- 1988-05-20 GR GR880100331A patent/GR1000959B/en unknown
- 1988-05-20 NO NO882218A patent/NO882218L/en unknown
- 1988-05-20 DE DE3817375A patent/DE3817375C2/en not_active Expired - Fee Related
- 1988-05-20 PH PH36956A patent/PH25350A/en unknown
- 1988-05-20 NZ NZ224733A patent/NZ224733A/en unknown
- 1988-05-20 ES ES8801610A patent/ES2009918A6/en not_active Expired
- 1988-05-20 GB GB8811929A patent/GB2205837B/en not_active Expired - Fee Related
- 1988-05-20 PT PT87539A patent/PT87539B/en not_active IP Right Cessation
- 1988-05-20 IE IE154388A patent/IE63760B1/en not_active IP Right Cessation
- 1988-05-20 IT IT20682/88A patent/IT1217685B/en active
- 1988-05-20 DK DK277488A patent/DK277488A/en not_active Application Discontinuation
- 1988-05-20 HU HU882614A patent/HU205125B/en not_active IP Right Cessation
- 1988-05-20 IE IE930324A patent/IE930324L/en unknown
- 1988-05-20 AU AU16508/88A patent/AU610591B2/en not_active Ceased
- 1988-05-21 PL PL1988272597A patent/PL154877B1/en unknown
- 1988-05-21 JP JP63124809A patent/JP2680347B2/en not_active Expired - Lifetime
- 1988-05-21 KR KR1019880006020A patent/KR880013958A/en not_active Application Discontinuation
- 1988-05-21 CN CN198888103091A patent/CN88103091A/en active Pending
- 1988-05-24 NL NL8801330A patent/NL8801330A/en not_active Application Discontinuation
- 1988-05-24 CH CH1967/88A patent/CH676984A5/fr not_active IP Right Cessation
- 1988-05-24 BE BE8800566A patent/BE1004193A3/en not_active IP Right Cessation
- 1988-05-24 FR FR8806885A patent/FR2615508B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PL154877B1 (en)	1991-09-30
PL272597A1 (en)	1989-03-06
PH25350A (en)	1991-05-13
PT87539B (en)	1992-09-30
DE3817375A1 (en)	1988-12-08
CN88103091A (en)	1988-12-21
FI882384A0 (en)	1988-05-20
FI89493B (en)	1993-06-30
IL86464A0 (en)	1988-11-15
IT8820682A0 (en)	1988-05-20
AU610591B2 (en)	1991-05-23
GR880100331A (en)	1989-02-23
DK277488A (en)	1988-11-23
FR2615508A1 (en)	1988-11-25
DE3817375C2 (en)	1997-04-30
GB2205837A (en)	1988-12-21
FR2615508B1 (en)	1994-11-25
IT1217685B (en)	1990-03-30
NO882218D0 (en)	1988-05-20
DK277488D0 (en)	1988-05-20
IL86464A (en)	1993-06-10
ES2009918A6 (en)	1989-10-16
NL8801330A (en)	1988-12-16
PT87539A (en)	1989-05-31
JP2680347B2 (en)	1997-11-19
IE881543L (en)	1988-11-22
NO882218L (en)	1988-11-23
FI882384A (en)	1988-11-23
JPS6456689A (en)	1989-03-03
GR1000959B (en)	1993-03-16
KR880013958A (en)	1988-12-22
CH676984A5 (en)	1991-03-28
SE8801903L (en)	1988-11-23
SE8801903D0 (en)	1988-05-20
BE1004193A3 (en)	1992-10-13
SE503210C2 (en)	1996-04-22
GB8811929D0 (en)	1988-06-22
AU1650888A (en)	1988-11-24
NZ224733A (en)	1990-12-21
IE63760B1 (en)	1995-06-14
IE930324L (en)	1988-11-22
GB2205837B (en)	1991-11-20
HU205125B (en)	1992-03-30
FI89493C (en)	1993-10-11

Legal Events

Date	Code	Title	Description
2006-02-28	MM4A	Lapse of definitive patent protection due to non-payment of fees

Publication	Publication Date	Title
HUT49358A (en)	1989-09-28	Process for producing phosphorous compounds, pharmaceutical compositions comprising same as active ingredient and intermediaries
HUT46654A (en)	1988-11-28	Process for producing substituted basic 2-amino-tetralin derivatives and pharmaceutical compositions comprising the same as active ingredient
HUT47131A (en)	1989-01-30	Process for producing steroid-5alpha-reductase inhibitors and pharmaceutical compositions comprising them as active ingredient
HUT53359A (en)	1990-10-28	Process for producing pharmaceutical compositions comprising oxooxazolinidyl cyclopentano benzene derivatives as active ingredient
HUT51222A (en)	1990-04-28	Process for producing 9-halogen-/z/-prostaglandin derivatives and pharmaceutical compositions comprising such active ingredient
HUT45844A (en)	1988-09-28	Pesticides comprising imidazole derivatives as active ingredient and process for producing the active ingredients
HUT44904A (en)	1988-05-30	Herbicides comprising 3-phenyl-uracyl derivatives as active ingredient and process for producing the active ingredients and intermediaries thereof
HUT53873A (en)	1990-12-28	Insecticides comprising nitro compounds as active ingredient and process for producing the active ingredients
HUT45850A (en)	1988-09-28	Insecticides comprising azolinone derivatives as active ingredient and process for producing the active ingredients
HUT48609A (en)	1989-06-28	Process for producing kumaran derivatives and pharmaceutical compositions comprising same as active ingredient
HUT49625A (en)	1989-10-30	Process for producing macrolid compounds and pharmaceutical compositions comprising such active ingredient
HUT48605A (en)	1989-06-28	Fungicides comprising hydroxyalkylazolyl derivatives as active ingredient and process for producing the active ingredient
HUT47123A (en)	1989-01-30	Process for producing phosphorous compounds and pharmaceutical compositions comprising them as active ingredient, as well as their intermediates
HUT47937A (en)	1989-04-28	Process for producing indoloquinoxaline derivatives and pharmaceuticals comprising these compounds as active ingredient
HUT53897A (en)	1990-12-28	Process for producing benzopyran derivatives and pharmaceutical compositions comprising such compounds as active ingredient
HUT48217A (en)	1989-05-29	Pesticides comprising 5-methylamino-1-arylpyrazole derivatives as active ingredient and process for producing the active ingredients
HUT49598A (en)	1989-10-30	Process for producing chromone derivatives and pharmaceutical compositions comprising same as active ingredient
HUT46660A (en)	1988-11-28	Process for producing 3-alkoxy-2-amino-propyl-amines and pharmaceutical compositions comprising the same as active ingredient
HUT47233A (en)	1989-02-28	Process for producing pharmaceutical comprising phenol derivatives as active ingredient and for producing the active ingredients
HUT47210A (en)	1989-02-28	Insecticide compositions and process for producing benzoyl-urea derivatives as active components
HUT49596A (en)	1989-10-30	Herbicides comprising iminophenylthiazolidine derivatives as actie ingredient and process for producing the active ingredients
HUT54358A (en)	1991-02-28	Process for producing substituted 1,3,5-triazinetrione derivatives and medical compositions comprising such compounds as active ingredient
HUT63151A (en)	1993-07-28	Process for producing new benzimidazole-2-sulfonamide and imidazopyuridine-2-sylfonamide derivatives, as well as pharmaceutical compositions comprising same as active ingredient
HUT48613A (en)	1989-06-28	Process for producing carbamoyloxylabdane derivatives, their intermediaries and pharmaceutical compositions comprising such compounds as active ingredient
HUT48871A (en)	1989-07-28	Herbicidal compositions and process for producing substituted tetrahydrophtalimide derivatives applicable as active ingredient