HUT47929A - Process for producing 4-piperidine-carboxamide derivatives and pharmaceuticals comprising same - Google Patents

Process for producing 4-piperidine-carboxamide derivatives and pharmaceuticals comprising same

Info

Publication number
HUT47929A
HUT47929A HU884849A HU484988A HUT47929A HU T47929 A HUT47929 A HU T47929A HU 884849 A HU884849 A HU 884849A HU 484988 A HU484988 A HU 484988A HU T47929 A HUT47929 A HU T47929A
Authority
HU
Hungary
Prior art keywords
piperidine
pharmaceuticals
producing
group
same
Prior art date
Application number
HU884849A
Other languages
Hungarian (hu)
Other versions
HU199830B (en
Inventor
Kunihiro Ninomiya
Ken-Ichi Saito
Shuji Morita
Akihiro Tobe
Issei Nitta
Original Assignee
Mitsubishi Chem Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Chem Ind filed Critical Mitsubishi Chem Ind
Publication of HUT47929A publication Critical patent/HUT47929A/en
Publication of HU199830B publication Critical patent/HU199830B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0825—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Glp-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A novel 4-piperidinecarboxamide derivatives represented by the general formula (I): <CHEM> wherein each R<1> and R<2> represents a hydrogen atom, or R<1> together with R<2> represents a cyclopentanespiro or cyclohexanespiro group; R<3> represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an aralkyl group or an indolylalkyl group and n is an integer of 1 or 2; is disclosed herein. The novel compound is useful as the agent for improving the impaired brain function.
HU884849A 1987-09-16 1988-09-15 Process for producing 4-piperidine carboxamide derivatives and pharmaceutical compositions comprising same HU199830B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62231591A JPH0696574B2 (en) 1987-09-16 1987-09-16 4-piperidine carboxamide derivative

Publications (2)

Publication Number Publication Date
HUT47929A true HUT47929A (en) 1989-04-28
HU199830B HU199830B (en) 1990-03-28

Family

ID=16925916

Family Applications (1)

Application Number Title Priority Date Filing Date
HU884849A HU199830B (en) 1987-09-16 1988-09-15 Process for producing 4-piperidine carboxamide derivatives and pharmaceutical compositions comprising same

Country Status (8)

Country Link
US (1) US4883802A (en)
EP (1) EP0308319B1 (en)
JP (1) JPH0696574B2 (en)
KR (1) KR970011295B1 (en)
AT (1) ATE86629T1 (en)
CA (1) CA1315473C (en)
DE (1) DE3879058T2 (en)
HU (1) HU199830B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100957147B1 (en) 2007-12-07 2010-05-11 현대자동차주식회사 Muffler of vehicle and exhaust apparatus using the same
DE102016103196A1 (en) 2015-07-22 2017-01-26 Fischerwerke Gmbh & Co. Kg Fastening arrangement and expansion anchor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE864269A (en) * 1977-03-03 1978-06-16 Parke Davis & Co NEW N- (AMINOALKYL SUBSTITUTE) -2-OXO-1-PYRROLIDINE-ACETAMIDES AND METHODS FOR PRODUCING THEM
IT1141287B (en) * 1979-06-13 1986-10-01 Nattermann A & Cie PYROLIDIN ACIDS AMIDS- (2) -ON- (1) -ILALKYL-CARBOXYLS, PROCEDURE FOR THEIR PREPARATION AND MEDICINAL PRODUCTS CONTAINING THEM
EP0115472A3 (en) * 1983-01-27 1985-10-02 Ciba-Geigy Ag Pyrrolidinon derivatives and process for their preparation
GB8332704D0 (en) * 1983-12-07 1984-01-11 Pfizer Ltd Growth promotants for animals

Also Published As

Publication number Publication date
HU199830B (en) 1990-03-28
KR970011295B1 (en) 1997-07-09
JPH0696574B2 (en) 1994-11-30
EP0308319A3 (en) 1990-07-04
EP0308319A2 (en) 1989-03-22
KR890005087A (en) 1989-05-11
DE3879058D1 (en) 1993-04-15
EP0308319B1 (en) 1993-03-10
DE3879058T2 (en) 1993-06-24
US4883802A (en) 1989-11-28
JPS6475483A (en) 1989-03-22
CA1315473C (en) 1993-03-30
ATE86629T1 (en) 1993-03-15

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee