HUP9702149A2 - Tachykinin receptor antagonista heterociklikus piperazinonszármazékok, intermedierjeik, előállításuk és alkalmazásuk, valamint a vegyületeket tartalmazó gyógyászati készítmények - Google Patents

Tachykinin receptor antagonista heterociklikus piperazinonszármazékok, intermedierjeik, előállításuk és alkalmazásuk, valamint a vegyületeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP9702149A2
HUP9702149A2 HU9702149A HUP9702149A HUP9702149A2 HU P9702149 A2 HUP9702149 A2 HU P9702149A2 HU 9702149 A HU9702149 A HU 9702149A HU P9702149 A HUP9702149 A HU P9702149A HU P9702149 A2 HUP9702149 A2 HU P9702149A2
Authority
HU
Hungary
Prior art keywords
intermediates
compounds
pipe powder
preparation
tachykinin receptor
Prior art date
Application number
HU9702149A
Other languages
English (en)
Inventor
Timothy P. Burkholder
Elizabeth M. Kudlacz
Tieu-Binh Le
Original Assignee
Hoechst Marion Roussel, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel, Inc. filed Critical Hoechst Marion Roussel, Inc.
Publication of HUP9702149A2 publication Critical patent/HUP9702149A2/hu
Publication of HUP9702149A3 publication Critical patent/HUP9702149A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)

Abstract

Tachykinin receptőr antagőnista heterőciklikűs piperazinőn-származékők, intermedierjeik, előállításűk és alkalmazásűk, valamint avegyületeket tartalmazó gyógyászati készítmények. A találmány szerintiindőlil-metil-piperazinőn-származékők (1) és intermedierjeik (2)általánős képletében G1-CH2-csőpőrt vagy -C(O)-csőpőrt; Ar1 adőttesetben szűbsztitűált fenil- vagy naftilcsőpőrt; R1 hidrőgénatőm, (c)képletű csőpőrt vagy -(CH2)qAr2 vagy -CH2C(O)Ar2 képletű csőpőrt, ahőlq = 1-4 közötti szám és Ar2 adőtt esetben szűbsztitűált fenil- vagyindőlilcsőpőrt; R2 hidrőgénatőm, alkil- vagy -CHO csőpőrt; R3hidrőgénatőm vagy adőtt esetben szűbsztitűált fenil- vagynaftilcsőpőrt; R5 hidrőgénatőm, alkil- vagy benzilcsőpőrt, és R6hidrőgénatőm, alkőxi-karbőnil- vagy benzil-őxi-karbőnil-csőpőrt. ŕ
HU9702149A 1995-03-15 1996-02-06 Heterocyclic substituted piperazinone derivatives as tachykinin receptor antagonists, intermediates, preparation and use thereof, pharmaceutical compositions containing these compounds HUP9702149A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40478895A 1995-03-15 1995-03-15

Publications (2)

Publication Number Publication Date
HUP9702149A2 true HUP9702149A2 (hu) 1999-06-28
HUP9702149A3 HUP9702149A3 (en) 1999-07-28

Family

ID=23601038

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9702149A HUP9702149A3 (en) 1995-03-15 1996-02-06 Heterocyclic substituted piperazinone derivatives as tachykinin receptor antagonists, intermediates, preparation and use thereof, pharmaceutical compositions containing these compounds

Country Status (21)

Country Link
US (2) US5840726A (hu)
EP (1) EP0815105B1 (hu)
JP (1) JP3825472B2 (hu)
KR (1) KR19980703032A (hu)
CN (1) CN1067068C (hu)
AR (1) AR002715A1 (hu)
AT (1) ATE206421T1 (hu)
AU (1) AU697599B2 (hu)
CA (1) CA2215333C (hu)
DE (1) DE69615670T2 (hu)
DK (1) DK0815105T3 (hu)
ES (1) ES2164235T3 (hu)
FI (1) FI973671A0 (hu)
HU (1) HUP9702149A3 (hu)
IL (1) IL117453A (hu)
NO (1) NO314693B1 (hu)
NZ (1) NZ302948A (hu)
PT (1) PT815105E (hu)
TW (1) TW464647B (hu)
WO (1) WO1996028441A1 (hu)
ZA (1) ZA961954B (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69621831T2 (de) * 1995-12-18 2003-01-02 Fujisawa Pharmaceutical Co., Ltd. Piperazinderivative als tachykinin antagonisten
DE19939910A1 (de) * 1999-08-23 2001-03-01 Morphochem Ag Neue Verbindungen, die Tryptase-Aktivität hemmen
US20040033986A1 (en) * 2002-05-17 2004-02-19 Protopopova Marina Nikolaevna Anti tubercular drug: compositions and methods
US7456222B2 (en) * 2002-05-17 2008-11-25 Sequella, Inc. Anti tubercular drug: compositions and methods
CN101404986B (zh) * 2002-05-17 2011-09-28 赛奎拉公司 用于诊断和治疗感染性疾病的组合物和制药方法
WO2005034857A2 (en) * 2003-09-05 2005-04-21 Sequella, Inc. Methods and compositions comprising diamines as new anti-tubercular therapeutics
WO2009136965A1 (en) * 2008-05-06 2009-11-12 Sequella, Inc. Compositions and methods comprising capuramycin analogues

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3132882A1 (de) * 1981-08-20 1983-03-03 Cassella Ag, 6000 Frankfurt Neue piperazinone, ihre herstellung und verwendung
IE903957A1 (en) * 1989-11-06 1991-05-08 Sanofi Sa Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical preparations containing them
FR2676055B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
WO1994003483A1 (en) * 1992-07-30 1994-02-17 Chiron Corporation Endothelin receptor-binding compounds
GB9222486D0 (en) * 1992-10-26 1992-12-09 Merck Sharp & Dohme Therapeutic agents
AU678023B2 (en) * 1993-05-06 1997-05-15 Aventis Inc. Substituted pyrrolidin-3-yl-alkyl-piperidines useful as tachykinin antagonists
IL111730A (en) * 1993-11-29 1998-12-06 Fujisawa Pharmaceutical Co Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
EP0815105B1 (en) 2001-10-04
WO1996028441A1 (en) 1996-09-19
DK0815105T3 (da) 2002-01-21
HUP9702149A3 (en) 1999-07-28
ATE206421T1 (de) 2001-10-15
FI973671A (fi) 1997-09-12
AR002715A1 (es) 1998-04-29
CN1178529A (zh) 1998-04-08
IL117453A (en) 2000-07-26
ES2164235T3 (es) 2002-02-16
NO974205D0 (no) 1997-09-12
TW464647B (en) 2001-11-21
JPH11501917A (ja) 1999-02-16
FI973671A0 (fi) 1997-09-12
CN1067068C (zh) 2001-06-13
EP0815105A1 (en) 1998-01-07
NO314693B1 (no) 2003-05-05
KR19980703032A (ko) 1998-09-05
US5864045A (en) 1999-01-26
CA2215333A1 (en) 1996-09-19
DE69615670T2 (de) 2002-08-08
US5840726A (en) 1998-11-24
NZ302948A (en) 2001-05-25
AU4930696A (en) 1996-10-02
NO974205L (no) 1997-11-13
DE69615670D1 (de) 2001-11-08
CA2215333C (en) 2002-01-01
ZA961954B (en) 1996-09-17
PT815105E (pt) 2002-03-28
AU697599B2 (en) 1998-10-08
MX9706872A (es) 1997-11-29
JP3825472B2 (ja) 2006-09-27
IL117453A0 (en) 1996-07-23

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