HUP0003666A2 - Method for the preparation of citalopram and pharmaceutical compositions containing them - Google Patents

Method for the preparation of citalopram and pharmaceutical compositions containing them

Info

Publication number
HUP0003666A2
HUP0003666A2 HU0003666A HUP0003666A HUP0003666A2 HU P0003666 A2 HUP0003666 A2 HU P0003666A2 HU 0003666 A HU0003666 A HU 0003666A HU P0003666 A HUP0003666 A HU P0003666A HU P0003666 A2 HUP0003666 A2 HU P0003666A2
Authority
HU
Hungary
Prior art keywords
compound
citalopram
preparation
formula
pharmaceutical compositions
Prior art date
Application number
HU0003666A
Other languages
Hungarian (hu)
Inventor
Sommer Michael Bech
Klaus Peter Bogeso
Hans Petersen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Priority claimed from PCT/DK1997/000511 external-priority patent/WO1998019511A2/en
Publication of HUP0003666A2 publication Critical patent/HUP0003666A2/en
Publication of HUP0003666A3 publication Critical patent/HUP0003666A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Preparation of citalopram (1-(3-(dimethylamino)propyl)- 1-(4-fluorophenyl)-1,3-dihydro- 5-isobenzofurancarbonitrile) (I) comprises: (a) reducing a compound of formula (IV); (b) effecting ring closure of the resulting compound of formula (V) to give a compound of formula (VI); then (c) if R1 = CN, using compound (VI) directly in the next step, and if R1 = 1-6C alkyloxycarbonyl or 1-6C alkylaminocarbonyl, converting (VI) to the compound where R1 = CN; and (d) alkylating the resulting compound (VI; R1 = CN) with 3-dimethylaminopropylhalide under basic conditions to give (I), which is isolated as the base or a salt. R1 = CN, 1-6C alkyloxycarbonyl or 1-6C alkylaminocarbonyl. Compounds (V) and (VI), and step (d) are claimed per se.
HU0003666A 1997-11-10 1997-11-10 Method for the preparation of citalopram and pharmaceutical compositions containing them HUP0003666A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/DK1997/000511 WO1998019511A2 (en) 1997-11-10 1997-11-10 Method for the preparation of citalopram
CNB971825017A CN100338051C (en) 1997-11-10 1997-11-10 Method for preparation of citalopram

Publications (2)

Publication Number Publication Date
HUP0003666A2 true HUP0003666A2 (en) 2002-06-29
HUP0003666A3 HUP0003666A3 (en) 2002-12-28

Family

ID=38543967

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003666A HUP0003666A3 (en) 1997-11-10 1997-11-10 Method for the preparation of citalopram and pharmaceutical compositions containing them

Country Status (1)

Country Link
HU (1) HUP0003666A3 (en)

Also Published As

Publication number Publication date
HUP0003666A3 (en) 2002-12-28

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