HUE046680T2 - Javított Lov-D aciltranszferáz mediált acilezés - Google Patents

Javított Lov-D aciltranszferáz mediált acilezés

Info

Publication number
HUE046680T2
HUE046680T2 HUE16201269A HUE16201269A HUE046680T2 HU E046680 T2 HUE046680 T2 HU E046680T2 HU E16201269 A HUE16201269 A HU E16201269A HU E16201269 A HUE16201269 A HU E16201269A HU E046680 T2 HUE046680 T2 HU E046680T2
Authority
HU
Hungary
Prior art keywords
mediated acylation
lov
improved
acyltransferase mediated
acyltransferase
Prior art date
Application number
HUE16201269A
Other languages
English (en)
Inventor
Steven James Collier
Ee Ling Teo
Joly Sukumaran
Robert John Wilson
Junye Xu
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of HUE046680T2 publication Critical patent/HUE046680T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pyrane Compounds (AREA)
HUE16201269A 2009-09-30 2010-09-24 Javított Lov-D aciltranszferáz mediált acilezés HUE046680T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24725309P 2009-09-30 2009-09-30
US24727409P 2009-09-30 2009-09-30

Publications (1)

Publication Number Publication Date
HUE046680T2 true HUE046680T2 (hu) 2020-03-30

Family

ID=43826602

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE10821066A HUE030906T2 (hu) 2009-09-30 2010-09-24 Javított, LovD aciltranszferáz közvetítette acilálás
HUE16201269A HUE046680T2 (hu) 2009-09-30 2010-09-24 Javított Lov-D aciltranszferáz mediált acilezés

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HUE10821066A HUE030906T2 (hu) 2009-09-30 2010-09-24 Javított, LovD aciltranszferáz közvetítette acilálás

Country Status (8)

Country Link
US (16) US9057085B2 (hu)
EP (3) EP2483293B1 (hu)
CN (2) CN102712678B (hu)
DK (1) DK3190123T3 (hu)
ES (2) ES2524725T3 (hu)
HU (2) HUE030906T2 (hu)
SI (1) SI2483292T1 (hu)
WO (2) WO2011041233A1 (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0711889B8 (pt) 2006-05-24 2021-05-25 Univ California método para produção de sinvastatina, composição de matéria, método para fabricação de huvastatina, método para fabricação de sinvastatina, e método para fabricação de uma composição de matéria de sinvastatina ou huvastatina
ES2524725T3 (es) 2009-09-30 2014-12-11 Codexis, Inc. Polipéptidos LovD variantes y sus usos.
US9499803B2 (en) 2009-10-08 2016-11-22 The Regents Of The University Of California Variant LovD polypeptide
US8981056B2 (en) 2009-10-08 2015-03-17 The Regents Of The University Of California Variant LovD polypeptide
KR101428508B1 (ko) 2012-11-23 2014-08-12 한국생산기술연구원 아스퍼질러스 테리우스 및 이를 이용한 이타콘산의 제조 방법
CN104342416B (zh) * 2013-07-26 2020-01-17 石药集团中奇制药技术（石家庄）有限公司 含有一个或几个点突变的洛伐他汀酰基转移酶
CN104342417A (zh) * 2013-08-09 2015-02-11 南京朗恩生物科技有限公司 源于土曲霉的活性增强的酰基转移酶突变体
CN103725726B (zh) * 2013-12-24 2016-01-13 烟台只楚药业有限公司 酶法合成辛伐他汀的制备方法
CN103725727B (zh) * 2014-01-06 2016-06-08 苏州汉酶生物技术有限公司 一种辛伐他汀铵盐的制备方法
CN103772247B (zh) * 2014-01-06 2016-06-08 苏州汉酶生物技术有限公司 一种可用于合成辛伐他汀铵盐的酰基供体的制备方法
CN103772248B (zh) * 2014-01-06 2016-06-08 苏州汉酶生物技术有限公司 一种辛伐他汀侧链的酰基供体制备方法
CN106831424B (zh) * 2015-12-04 2019-08-02 浙江京新药业股份有限公司 由洛伐他汀制备辛伐他汀铵盐的方法
CN105586325A (zh) * 2016-01-29 2016-05-18 重庆西南合成制药有限公司 一种洛伐他汀酰基转移酶突变体
CN105837482A (zh) * 2016-04-06 2016-08-10 衢州信步化工科技有限公司 一种降低 α-二甲基丁酰基-S-丙酸甲酯生产成本的制备方法
CN106748928A (zh) * 2016-12-15 2017-05-31 河南豫辰药业股份有限公司 一种辛伐他汀侧链的制备方法
US10740322B2 (en) 2017-12-08 2020-08-11 Salesforce.Com, Inc. Collapsing multiple changes in a database for generating a reduced number of messages for an external system

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444784A (en) 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
US4582915A (en) 1983-10-11 1986-04-15 Merck & Co., Inc. Process for C-methylation of 2-methylbutyrates
US4820850A (en) 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
WO1993023547A1 (en) * 1992-05-15 1993-11-25 Syntex Pharmaceuticals International Limited ENZYMATIC PROCESS FOR PRODUCTION OF S-6-METHOXY-α-METHYL-2-NAPHTHALENEACETIC ACID
FR2704451B1 (fr) * 1993-04-30 1995-06-30 Oreal Procédé de désodorisation d'une formulation contenant au moins un composé porteur d'un groupe thiol et formulation désodorisée ainsi obtenue.
US5420024A (en) 1993-05-11 1995-05-30 Merck & Co., Inc. Process for synthesis of acylated HMG-CoA reductase inhibitors from a lactone diol precursor using Candida cylindracea
US5393893A (en) 1993-11-08 1995-02-28 Apotex, Inc. Process for producing simvastatin and analogs thereof
US5763653A (en) 1997-03-13 1998-06-09 Ranbaxy Laboratories, Ltd. Key intermediates in the manufacture of simvastatin
US5763646A (en) 1997-03-13 1998-06-09 Ranbaxy Laboratories, Ltd. Process for manufacturing simvastatin from lovastatin or mevinolinic acid
IN186880B (hu) * 1997-10-28 2001-12-01 Ranbaxy Lab Ltd
NO991045L (no) 1998-03-05 1999-09-06 Synthon Bv FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater
US6063919A (en) * 1998-08-14 2000-05-16 Keystone Biomedical, Inc. Process for the synthesis of exochelins
US6391583B1 (en) 1998-12-18 2002-05-21 Wisconsin Alumni Research Foundation Method of producing antihypercholesterolemic agents
FR2787469B1 (fr) 1998-12-21 2001-02-16 Pechiney Aluminium Procede ameliore de filtration de metal liquide sur un lit de materiau particulaire refractaire
CA2412277A1 (en) * 2000-09-08 2002-03-14 Gryphon Therapeutics, Inc. Synthetic erythropoiesis stimulating proteins
CA2543348A1 (en) 2003-10-21 2005-05-06 Diversa Corporation Methods for making simvastatin and intermediates
US20070129437A1 (en) * 2005-12-06 2007-06-07 Ferenc Korodi Process for preparing simvastatin and intermediates thereof
BRPI0711889B8 (pt) * 2006-05-24 2021-05-25 Univ California método para produção de sinvastatina, composição de matéria, método para fabricação de huvastatina, método para fabricação de sinvastatina, e método para fabricação de uma composição de matéria de sinvastatina ou huvastatina
JP5015635B2 (ja) * 2006-06-08 2012-08-29 株式会社リコー インクカートリッジ、インクカートリッジ袋、インクジェット記録装置
ES2524725T3 (es) 2009-09-30 2014-12-11 Codexis, Inc. Polipéptidos LovD variantes y sus usos.

Also Published As

Publication number Publication date
US10858680B2 (en) 2020-12-08
US20120244582A1 (en) 2012-09-27
CN102712678B (zh) 2015-05-06
ES2614804T3 (es) 2017-06-02
DK3190123T3 (da) 2019-09-30
US20110111468A1 (en) 2011-05-12
US20160304921A1 (en) 2016-10-20
EP2483292A4 (en) 2013-05-01
US9057085B2 (en) 2015-06-16
US11926857B2 (en) 2024-03-12
WO2011041233A1 (en) 2011-04-07
EP2483292B1 (en) 2014-11-12
EP2483293A1 (en) 2012-08-08
US10428360B2 (en) 2019-10-01
US20240218407A1 (en) 2024-07-04
SI2483292T1 (sl) 2015-01-30
EP2483293B1 (en) 2016-11-30
US20150259718A1 (en) 2015-09-17
US20150037851A1 (en) 2015-02-05
US8383382B2 (en) 2013-02-26
US9181570B2 (en) 2015-11-10
HUE030906T2 (hu) 2017-06-28
US20180179565A1 (en) 2018-06-28
EP3190123A1 (en) 2017-07-12
US20200157588A1 (en) 2020-05-21
ES2524725T3 (es) 2014-12-11
US20240368649A1 (en) 2024-11-07
US20190367956A1 (en) 2019-12-05
US20150240276A1 (en) 2015-08-27
WO2011041231A1 (en) 2011-04-07
US20210071216A1 (en) 2021-03-11
EP3190123B1 (en) 2019-07-24
US10590445B2 (en) 2020-03-17
CN102574896A (zh) 2012-07-11
US20170081685A1 (en) 2017-03-23
US20180187225A1 (en) 2018-07-05
US9909156B2 (en) 2018-03-06
US8846362B2 (en) 2014-09-30
EP2483293A4 (en) 2013-05-01
EP2483292A1 (en) 2012-08-08
US20130130351A1 (en) 2013-05-23
CN102712678A (zh) 2012-10-03
US9546388B2 (en) 2017-01-17
US20210277432A1 (en) 2021-09-09
CN102574896B (zh) 2015-04-08
US12060592B2 (en) 2024-08-13
US11046982B2 (en) 2021-06-29
US9399785B2 (en) 2016-07-26
US9932616B2 (en) 2018-04-03

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